The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Structure of the Nuclear Pore Complex (An Update)
Open accessAbstract
The nuclear pore complex (NPC) serves as the sole bidirectional gateway of macromolecules in and out of the nucleus. Owing to its size and complexity (∼1,000 protein subunits, ∼110 MDa in humans), the NPC has remained one of the foremost challenges for structure determination. Structural studies have now provided atomic-resolution crystal structures of most nucleoporins. The acquisition of these structures, combined with biochemical reconstitution experiments, cross-linking mass spectrometry, and cryo–electron tomography, has facilitated the determination of the near-atomic overall architecture of the symmetric core of the human, fungal, and algal NPCs. Here, we discuss the insights gained from these new advances and outstanding issues regarding NPC structure and function. The powerful combination of bottom-up and top-down approaches toward determining the structure of the NPC offers a paradigm for uncovering the architectures of other complex biological machines to near-atomic resolution.
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GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
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Identification of long-lived proteins reveals exceptional stability of essential cellular structures
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The Human Nuclear Pore Complex as Revealed by Cryo-Electron Tomography
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AI-based structure prediction empowers integrative structural analysis of human nuclear pores
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Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold
Fontana, P., Dong, Y., Pi, X., Tong, A. B., Hecksel, C. W., Wang, L., Fu, T.-M., Bustamante, C., & Wu, H. (2022) · Science · doi:10.1126/science.abm9326 · Cited by 195
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD
Coyne, A. N., Zaepfel, B. L., Hayes, L., Fitchman, B., Salzberg, Y., Luo, E.-C., Bowen, K., Trost, H., Aigner, S., Rigo, F., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.027 · Cited by 156
Coyne, A. N., Baskerville, V., Zaepfel, B. L., Dickson, D. W., Rigo, F., Bennett, F., Lusk, C. P., & Rothstein, J. D. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe1923 · Cited by 143
Nuclear pore complexes — a doorway to neural injury in neurodegeneration
Coyne, A. N., & Rothstein, J. D. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00653-6 · Cited by 96
Metadata
- Authors
- Lin, D. H., & Hoelz, A.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2019-06-20
- Volume
- 88
- Issue
- 1
- Pages
- 725-783
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2921042206
- Cited by
- 478
- References
- 9
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- green
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