Neutralizing antibodies against AAV serotypes 1, 2, 6, and 9 in sera of commonly used animal models

Rapti, Kleopatra, Louis-Jeune, Vedell, Kohlbrenner, Erik, Ishikawa, Kiyotake, Ladage, Dennis, Zolotukhin, Sergei, Hajjar, Roger J, Weber, Thomas·2012·Molecular Therapy
DOI 10.1038/mt.2011.177

Cited by (170)

Items 101–170 of 170

  1. Development of Novel Recombinant Aav Vectors and Strategies for the Potential Gene Therapy of Hemophilia
    Zhong Li, Giridhara Rao Jayandharan, George Aslanidi · 2012 · Journal of Genetic Syndromes & Gene Therapy
  2. Type I interferon shapes the quantity and quality of the anti‐Zika virus antibody response
    Cheryl Yi‐Pin Lee, Guillaume Carissimo, Zheyuan Chen, Fok‐Moon Lum, Farhana Abu Bakar, Ravisankar Rajarethinam, Teck‐Hui Teo, Anthony Torres‐Ruesta, Laurent Rénia, Lisa F. P. Ng · 2020 · Clinical & Translational Immunology
  3. Pre-existing antibodies to candidate gene therapy vectors (adeno-associated vector serotypes) in domestic cats
    Pengfei Li, Eva Boenzli, Regina Hofmann‐Lehmann, A. Katrin Helfer-Hungerbuehler · 2019 · PLoS ONE
  4. Microneedle-delivered adeno-associated virus vaccine amplified anti-viral immunity by improving antigen-presenting cells infection
    Penghui He, Chunting He, Fuhua Wu, Yangsen Ou, Shuang Luo, Yongshun Zhang, Yu Chang, Zhaofei Guo, Xue Tang, Yuanhao Zhao et al. · 2025 · Journal of Controlled Release
  5. Gene-based therapy of Parkinson’s Disease: Translation from animal model to human clinical trial employing convection enhanced delivery
    Gurwattan S. Miranpuri, Lauren Kumbier, Angelica Hinchman, Dominic T. Schomberg, Anyi Wang, Hope Marshall, Ken Kubota, Chris Ross, Karl A. Sillay · 2012 · Annals of Neurosciences
  6. Sequential Adeno-Associated Viral Vector Serotype 9–Green Fluorescent Protein Gene Transfer Causes Massive Inflammation and Intense Immune Response in Rat Striatum
    Chun Yang, Fei Hao, Jun He, Tao Lu, Ronald L. Klein, Li‐Ru Zhao, Wei‐Ming Duan · 2016 · Human Gene Therapy
  7. Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas
    Timothy P. Day, Leah C. Byrne, John G. Flannery, David V. Schaffer · 2017 · Methods in molecular biology
  8. Neutralisation of adeno-associated virus transduction by human vitreous humour
    Andrzejewski, Sławomir, Moyle, Peter M., Stringer, Brett W., Steel, Jason C., Layton, Christopher J. · 2021 · Gene Therapy
  9. Peripherally delivered Adeno-associated viral vectors for spinal cord injury repair
    Jared D. Sydney-Smith, Aline Barroso Spejo, Philippa Mary Warren, Lawrence David Falcon Moon · 2021 · Experimental Neurology
  10. Pre-immunization with an Intramuscular Injection of AAV9-Human Erythropoietin Vectors Reduces the Vector-Mediated Transduction following Re-Administration in Rat Brain
    Chun Yang, Weihua Yang, Shasha Chen, MA Bao-feng, Bin Li, Tao Lu, Tingyu Qu, Ronald L. Klein, Li‐Ru Zhao, Wei‐Ming Duan · 2013 · PLoS ONE
  11. Adeno-associated virus-binding antibodies detected in cats living in the Northeastern United States lack neutralizing activity
    Kei Adachi, Gregory A. Dissen, Alejandro Lomniczi, Qing Xie, Sergio R. Ojeda, Hiroyuki Nakai · 2020 · Scientific Reports
  12. Membrane fusion FerA domains enhance adeno-associated virus vector transduction
    Xintao Zhang, Bui Anthony, Zheng Chai, Amanda Lee Dobbins, Roger Bryan Sutton, Chengwen Li · 2020 · Biomaterials
  13. Analysis of recombinant adeno-associated viral vector shedding in sheep following intracoronary delivery
    Melad Farraha, Michael A. Barry, Juntang Lu, Jim Pouliopoulos, Thi Yen Loan Le, Sindhu Igoor, Renuka Rao, Cindy Kok, James J.H. Chong, Eddy Kizana · 2019 · Gene Therapy
  14. Preexisting Neutralizing Antibodies against Different Adeno-Associated Virus Serotypes in Humans and Large Animal Models for Gene Therapy
    Divya Ail, Deniz Dalkara · 2023 · Advances in experimental medicine and biology
  15. Multiomics Approach Reveals an Important Role of BNIP3 in Myocardial Remodeling and the Pathogenesis of Heart Failure with Reduced Ejection Fraction
    Antoine H. Chaanine, LeeAnn Higgins, Lothar Lauterboeck, Todd W. Markowski, Qinglin Yang, Patrice Delafontaine · 2022 · Cells
  16. Hyaluronic acid synthase-2 gene transfer into the joints of Beagles by use of recombinant adeno-associated viral vectors
    Sirkka Kyostio-Moore, Patricia Berthelette, Cathleen Sookdeo, Bindu Nambiar, Monica Dias Figueiredo · 2018 · American Journal of Veterinary Research
  17. Gene therapy for the heart: encapsulated viruses to the rescue
    Uma Maheswari Deshetty, Susmita Sil, Shilpa J. Buch · 2024 · Extracellular Vesicles and Circulating Nucleic Acids
  18. Optogenetics for light control of biological systems
    2022 · Nature Reviews Methods Primers
  19. Molecular Therapies for Muscular Dystrophies
    Ava Yun Lin, Leo H. Wang · 2018 · Current Treatment Options in Neurology
  20. Current regulatory requirements for assessment of immunogenicity for gene therapy medicinal products
    Christopher J. Mann, Jon Giblin, Manuela Braun, Felicitas Schmid, Maria Rathmann Sørensen, Paolo Caferra, Anett Hudák, Tamás Letoha, Núria Coderch, Timothy Paul Hickling et al. · 2025 · Cell Reports Medicine
  21. Analysis of Adeno-Associated Virus Serotype 8 (AAV8)-antibody complexes using epitope mapping by molecular imprinting leads to the identification of Fab peptides that potentially evade AAV8 neutralisation
    Elena V. Piletska, Philippe Veron, Bérangère Bertin, Federico Mingozzi, Donald J. L. Jones, Rachel L. Norman, Joseph Earley, Kal Karim, Álvaro García‐Cruz, Sergey A. Piletsky · 2023 · Nanomedicine Nanotechnology Biology and Medicine
  22. Safety Evaluation of Ocular Drugs
    Meg Ferrell Ramos, Mayssa Attar, Jennifer R. Seals, Keith A. Luhrs · 2024 · Elsevier eBooks
  23. Lama1 upregulation prolongs the lifespan of the dyH/dyH mouse model of LAMA2-related congenital muscular dystrophy
    Yidan Liu, Dandan Tan, Kaiyue Ma, Huaxia Luo, Jingping Mao, Jihang Luo, Qiang Shen, Luzheng Xu, Shiqi Yang, Ge Lin et al. · 2024 · Journal of genetics and genomics/Journal of Genetics and Genomics
  24. AAV Vector-Based Gene Therapy, Progress and Current Challenges
    Klaudia Kuranda, Federico Mingozzi · 2017 · Springer eBooks
  25. Recent Advances in Canine Medicine
    Carlos Eduardo Fonseca‐Alves · 2022 · Veterinary medicine and science
  26. AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery
    Darrick L. Yu, Laura P. van Lieshout, Brenna A. Y. Stevens, Kelsie J. Near, Jenny K. Stodola, Kevin J. Stinson, Ðurđa Slavić, Sarah K. Wootton · 2023 · Viruses
  27. Challenges and prospects in geriatric epilepsy treatment: the role of the blood–brain barrier in pharmacotherapy and drug delivery
    Xin Chen, Juan Luo, Min Song, Liang Pan, Zhichuang Qu, Bo Huang, Sixun Yu, Haifeng Shu · 2024 · Frontiers in Aging Neuroscience
  28. Adeno-associated virus mediates gene transduction after static cold storage treatment in rodent lung transplantation
    Samuel J. Kesseli, Madison K. Krischak, Qimeng Gao, Trevor J. Gonzalez, Min Zhang, Samantha E. Halpern, Riley Kahan, Mingqing Song, Niki Huffman, Hongzhi Xu et al. · 2022 · Journal of Thoracic and Cardiovascular Surgery
  29. Muscle Gene Therapy for Hemophilia
    Denise E. Sabatino, Valder R. Arruda · 2013 · Journal of Genetic Syndromes & Gene Therapy
  30. Adeno-associated virus neutralising antibodies in type 1 diabetes mellitus
    Sławomir Andrzejewski, Aparna Murali, Charmaine A. Ramlogan‐Steel, Katie P. Edwards, Nathan Efron, Jason C. Steel, Christopher J. Layton · 2019 · Gene Therapy
  31. What's in a cure: designing a broad-spectrum HIV gene therapy
    Rachel E. Berman, Will Dampier, Michael R. Nonnemacher, Brian L. Wigdahl · 2024 · Current Opinion in HIV and AIDS
  32. Fiber Photometry Analysis of Spontaneous Dopamine Signals: The Z -Scored Data Are Not the Data
    Conner W. Wallace, Emily K. DiMarco, Clare Y Slinkard, Rachael Shaughnessy, Katherine M. Holleran, Samuel W. Centanni, Christopher C. Lapish, Sara R. Jones · 2025 · ACS Chemical Neuroscience
  33. Novel Approaches to Deliver Molecular Therapeutics in Cardiac Disease Using Adeno-Associated Virus Vectors
    Kleopatra Rapti, Roger J. Hajjar, Thomas Weber · 2012 · Humana Press eBooks
  34. Fusion of Anthopleurin-B to AAV2 increases specificity of cardiac gene transfer
    Jose Emanuel Finet, Xiaoping Wan, J. Kevin Donahue · 2017 · Virology
  35. Considerations on Preclinical Neuromuscular Disease Gene Therapy Studies
    Dongsheng Duan · 2019 · Springer eBooks
  36. A step closer to cardiac optogenetics in vivo
    Emilia G. Entcheva · 2015 · Cardiovascular Research
  37. Overcoming matrix effects in AAV neutralization assays with a constant serum concentration approach
    Beatrix Kovács, Viktória Szabó, Domonkos Horváth, Attila Balázs Dobos, Zoltán Zsolt Nagy, Wim Vanduffel, Zsuzsanna Szemlaky, Áron Szepesi, István Ulbert, Balázs József Rózsa et al. · 2025 · Gene Therapy
  38. Prevalence of Antibodies against Adeno-Associated Viruses (AAVs) in Göttingen Minipigs and Its Implications for Gene Therapy and Xenotransplantation
    Kirsten Rosenmay Jacobsen, Javier Mota, Michelle Salerno, Alexis Willis, Dennis Pitts, Joachim Denner · 2024 · Viruses
  39. Challenges in Humoral Immune Response to Adeno-Associated Viruses Determination
    Daria A. Naumova, Tatyana Krokunova, Denis O. Maksimov, Olga N. Mityaeva, Ekaterina A. Astakhova, Pavel Volchkov · 2025 · International Journal of Molecular Sciences
  40. Rescuing AAV gene transfer from antibody neutralization with an IgG-degrading enzyme
    Zachary C. Elmore, Daniel K. Oh, Katherine E. Simon, Marco M. Fanous, Aravind Asokan · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Serotype-specific transduction of canine joint tissue explants and cultured monolayers by self-complementary adeno-associated viral vectors
    Ahyoung Kim, Felix M. Duerr, Jennifer Nikki Phillips, Richard Jude Samulski, Joshua C. Grieger, Laurie R. Goodrich · 2022 · Gene Therapy
  42. Low Seroprevalence of Neutralizing Antibodies Targeting Two Clade F AAV in Humans
    Jeff L. Ellsworth, Michael OCallaghan, Hillard L. Rubin, Albert B. Seymour · 2018 · Human Gene Therapy Clinical Development
  43. Optical opening of the blood-brain barrier for targeted and ultra-sparse viral infection of cells in mouse cortex
    Patrick L. Reeson, Roobina Boghozian, Ana Paula Cota, Craig E. Brown · 2023 · Cell Reports Methods
  44. Murine toxicology assessment of avgn7.2, a novel gene therapeutic for inclusion body myositis and other muscle wasting diseases
    Sarah K. Herring, Buel D. Rodgers · 2025 · Gene Therapy
  45. A Step-By-Step Method to Detect Neutralizing Antibodies Against AAV using a Colorimetric Cell-Based Assay
    Sebastian Bass-Stringer, Colleen J. Thomas, Clive Newton May, Paul Gregorevic, Kate L. Weeks, Julie R. McMullen · 2021 · Journal of Visualized Experiments
  46. AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model
    Melanie Willimann, Amita Tiyaboonchai, Kei Adachi, Bin Li, Lea Waldburger, Hiroyuki Nakai, Markus Grompe, Beat Thöny · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  47. The role of Connexin45 in the pathogenesis of ventricular tachyarrhythmia
    Peter Fahmy · 2015 · The Sydney eScholarship Repository (The University of Sydney)
  48. The Effects of Prolyl Oligopeptidase Inhibition in α-Synuclein Based Mouse Models of Parkinson's Disease
    Mari H. Savolainen · 2015 · Työväentutkimus Vuosikirja
  49. Adeno-associated Virus Vector as a Tool for the Analysis of in vivo Ovine Betaretroviral Gene Expression, and its use as a Vector for Therapeutic Gene Delivery
    Darrick L. Yu · 2015 · The Atrium (University of Guelph)
  50. Targeting the ubiquitin proteasome system to develop novel therapeutic approaches for spinal muscular atrophy
    Rachael A. Powis · 2016 · Edinburgh Research Archive (University of Edinburgh)
  51. Adeno-associated virus-mediated gene therapy in central nervous system genetic disorders
    Widler Casy, Qinglan Ling, Frances C. Shaffo, Sarah E. Sinnett, Steven James Gray · 2020 · Elsevier eBooks
  52. Gene Therapy
    Federico Mingozzi, Norman Junge · 2021 · Elsevier eBooks
  53. Targeted local combination therapy with checkpoint inhibitors and CAR-NK cells in glioblastoma using DARPin-linked AAV vectors
    Maja Strecker · 2022
  54. Parvovirus Vectors: The Future of Gene Therapy
    Megha Gupta · 2022 · Veterinary medicine and science
  55. Goats with low levels of AAV antibody may serve as candidates for large animal gene therapy
    Huirong Pan, Yufen Liu, Yuting Luo, Lili Chen, Bingyan Shen, Shihan Song, Mingyue Liu, Zhuowei Wang, Wencan Wu, Mengyun Li et al. · 2023 · Experimental Eye Research
  56. Blood-brain barrier-directed gene therapy as a strategy to treat Niemann-Pick type C2 disease
    Charlotte Laurfelt Munch Rasmussen · 2022
  57. Delivery of mRNA encoding an anti-tau monoclonal antibody and engineered scFv intrabody results in functional antibody expression in SH-SY5Y cells
    Patricia Wongsodirdjo, Alayna C. Caruso, Alicia Yong, Madeleine A. Lester, Laura J. Vella, Ya Hui Hung, Rebecca M. Nisbet · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Intrathecal Delivery of Viral Vector-Mediated Gene Therapy
    Orion P. Keifer · 2023 · Springer eBooks
  59. Development of an Enzyme-Linked Immunosorbent Spot Assay for the Assessment of Adeno-Associated Virus Peptides to Examine Immune Safety
    Sara Rose Krivoshik, Lindsey Dzielak, April R. Masters, Jennifer L. Hall, Alison Joy Johnson · 2024 · Human Gene Therapy
  60. Bioanalytical Methods to Detect Preexisting and Post‐administration Humoral Immune Responses Against AAV Capsid Proteins
    Christian Vettermann, Boris Gorovits · 2024 · Wiley eBooks
  61. Prevalence of antibodies against adeno-associated viruses (AAVs) in Göttingen Minipigs: Implications for Gene Therapy and Xenotransplantation
    Kirsten Rosenmay Jacobsen, Javier Mota, Michelle Salerno, Alexis Willis, Dennis Pitts, Joachim Denner · 2024 · Research Square
  62. Adeno-associated virus-mediated gene therapy in central nervous system genetic disorders
    Qinglan Ling, Andrea Boitnott, Irvin T. Garza, Widler Casy, Frances C. Shaffo, Sarah E. Sinnett, Steven James Gray · 2024 · Elsevier eBooks
  63. Lessons Learned from Monitoring Adeno-Associated Virus-9 Neutralizing Antibody (AAV9-NAb) Seroconversion in a Cohort of Cynomolgus Macaques (Macaca fascicularis)
    Rosemary V. Santos, Arpana Khatri, Kate E. Breyer, Jan Bernal, Judith Franco, Rajeev K. Dhawan, Conner Balzer, Marla Bazile, Maureen Hargaden, Mikele D. Simkins et al. · 2025 · Journal of the American Association for Laboratory Animal Science
  64. A single versus multi-vector approach to treating post-traumatic osteoarthritis using scAAV2 IL-1ra or scAAV2 IL-1ra/IGF-I in an equine preclinical model
    Jaiden Oropallo, Parvathy Thampi, Jennifer Nikki Phillips, Myra F. Barrett, K. A. Seabaugh, Lyndah Chow, Ann Hess, Lynn Marie Pezzanite, Lester Suárez-Amarán, Constance R. Chu et al. · 2026 · Research Square
  65. Adeno-associated virus (AAV) mediated advanced therapeutic interventions for inherited and non-inherited cardiac disorders
    Indu Singh, Anil Kumar, Awdhesh Kumar Chaudhary, Jasbir Singh Dalal, Anusha Sharma, Juhi Sharma, Arun Ratn, Megh Singh Dhakad, Divakar Sharma · 2026 · Journal of the Renin-Angiotensin-Aldosterone System
  66. Recombinant Adeno-Associated Viruses : process development and gene transfer application for muscular dystrophy
    Gabriella Dias Florencio Leite · 2017
  67. Caractérisation des réponses immunitaires systémiques induites par injection sous-rétinienne : du fondamental au transfert de gène par virus adéno-associé recombinant
    Julie Vendomèle · 2018 · theses.fr (ABES)
  68. Gene therapy approach on Charcot-Marie-Tooth type 1A rats
    Hélène Hajjar · 2018 · theses.fr (ABES)
  69. Targeted integration of a chimeric antigen receptor into natural killer cells (CAR-NK) : specific optimization of the transgene design and the integration loci
    Vincent Allain · 2024 · theses.fr (ABES)
  70. Environmental and developmental factors shape anti-AAV immunity in pigs
    Godwin I. Iroanya, Ilangovan Raju, Chandra Shekhar Boosani, Pradeep N. Subramanyam, Addison K. Byrne, Kevin D. Wells, Jonathan A. Green · 2026 · Gene Therapy