The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Neurotrophin-evoked depolarization requires the sodium channel NaV1.9
Abstract
Brain-derived neurotrophic factor (BDNF) and other neurotrophins are essential for normal brain function. Many types of neurons in the central nervous system are excited by BDNF or neurotrophin-4/5, an action that has recently been implicated in synaptic plasticity. The mechanisms involved in this transmitter-like action of neurotrophins remains unclear. Here, by screening candidate genes with an antisense messenger RNA expression approach and by co-expressing the receptor tyrosine kinase TrkB and various sodium channels, we demonstrate that the tetrodotoxin-insensitive sodium channel Na(V)1.9 underlies the neurotrophin-evoked excitation. These results establish the molecular basis of neurotrophin-evoked depolarization and reveal a mechanism of ligand-mediated sodium channel activation.
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“Bath application of a low concentration (20 ng/ ml) of BDNF did not by itself induce spine-head enlargement (n = 30) (Fig. 4A) or inward currents (0.5 ± 1.2 pA, n = 5) (Fig. 4B) (19, 20).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [19]
In the citing paper
“Bath application of a low concentration (20 ng/ ml) of BDNF did not by itself induce spine-head enlargement (n = 30) (Fig. 4A) or inward currents (0.5 ± 1.2 pA, n = 5) (Fig. 4B) (19, 20).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [19]
Citations
Cites
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Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
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Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775
Nomenclature of Voltage-Gated Sodium Channels
Goldin, A. L., Barchi, R. L., Caldwell, J. H., Hofmann, F. B., Howe, J. R., Hunter, J. C., Kallen, R. G., Mandel, G., Meisler, M. H., Berwald‐Netter, Y., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00116-1 · Cited by 1,484
The Trk family of neurotrophin receptors
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Research works printed but not linked: 1
- Kafitz, K. W., Lepier, A., Thoenen, H. & Konnerth, A. Saxitoxin-sensitivity of neurotrophin-induced rapid excitation and neurite growth. Pfluegers Arch. 441, R125 (2001)
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Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193
TrkB signalling pathways in LTP and learning
Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055
The neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 978
Metadata
- Authors
- Blum, R., Kafitz, K. W., & Konnerth, A.
- Affiliations
- Physiologisches Institut (DE)
- Corresponding author
- Konnerth, Arthur
- Venue
- Nature
- Published
- 2002-10
- Volume
- 419
- Issue
- 6908
- Pages
- 687-693
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2070568755
- Cited by
- 266
- References
- 45
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 9 · 2017: 6 · 2016: 10 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 15
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- neurotrophins, brain-derived neurotrophic factor, neurotrophin-4/5, TrkB receptor, synaptic plasticity, neuronal excitation
- MeSH terms
- Animals, Cell Line, Cells, Cultured, Cloning, Molecular, Electric Conductivity, Hippocampus, Humans, Molecular Sequence Data, Nerve Growth Factors, Neuroblastoma, Neurons, Neuropeptides, RNA, Messenger, Saxitoxin, Sodium, Sodium Channels, RNA, Antisense, Rats, Wistar, Brain-Derived Neurotrophic Factor, Receptor, trkB, Rats, NAV1.9 Voltage-Gated Sodium Channel
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