Neurotrophin signal transduction in the nervous system

Kaplan, David R; Miller, Freda D

doi:10.1016/s0959-4388(00)00092-1

Cited by 1,944Nerve injury and regenerationCell death mechanisms and regulationNeurogenesis and neuroplasticity mechanisms

Neurotrophin signal transduction in the nervous system

Kaplan, David R, Miller, Freda D·2000·Current Opinion in Neurobiology

DOI 10.1016/s0959-4388(00)00092-1

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Abstract

Neurotrophins use two types of receptors, the Trk tyrosine kinase receptors and the p75 neurotrophin receptor (p75NTR), to regulate the growth, development, survival and repair of the nervous system. These receptors can either collaborate with or inhibit each other's actions to mediate neurotrophin effects. The development and survival of neurons is thus based upon the functional interplay of the signals generated by Trk and p75NTR. In the past two years, the signaling pathways used by these receptors, including Akt and MAPK-induced signaling via Trk, and JNK, p53, and NF-kappaB signaling via p75NTR, have been identified. In addition, a number of novel p75NTR-interacting proteins have been identified that transmit growth, survival, and apoptotic signals.

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BDNF regulates many different cellular processes involved in the development and maintenance of normal brain function by binding and activating TrkB.
“It regulates many different cellular processes involved in the development and maintenance of normal brain function by binding and activating the TrkB, a member of the larger family of Trk receptors.”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [86]
BDNF signals through the TrkB receptor and the low-affinity p75 neurotrophin receptor (p75NTR).
“BDNF signals through the tropomycin receptor kinase B (TrkB) and the low affinity p75 neurotrophin receptor (p75NTR).”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [86]
Both proBDNF and mBDNF are active, eliciting opposing effects via the p75 neurotrophin receptor (p75NTR) and TrkB receptor, respectively.
“Both proBDNF and mBDNF are active, eliciting opposing effects via the p75 neurotrophin receptor (p75NTR), a member of the tumor necrosis factor (TNF) receptor family and TrkB receptor, respectively.”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [86]
mBDNF binds with the high-affinity TrkB receptor, the receptor dimerizes, and the intracellular tyrosine residues are autophosphorylated.
“mBDNF binds with the high-affinity TrkB receptor, the receptor dimerizes, and the intracellular tyrosine residues are autophosphorylated [86].”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [86]
BDNF in the hippocampus is implicated in plasticity mechanisms hypothesized to underlie learning.
“where it is implicated in plasticity mechanisms hypothesized to underlie learning6.”
From Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease (2009) · cites this paper as [6]

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Creedon, D. J., Johnson, E. M., & Lawrence, J. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20713 · Cited by 174 · see citing works
Functionally Antagonistic Interactions between the TrkA and p75 Neurotrophin Receptors Regulate Sympathetic Neuron Growth and Target Innervation
Kohn, J., Aloyz, R. S., Toma, J. G., Haak‐Frendscho, M., & Miller, F. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05393.1999 · Cited by 173 · see citing works
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Insulin Receptor Substrate (IRS)-1 and IRS-2 Are Tyrosine-phosphorylated and Associated with Phosphatidylinositol 3-Kinase in Response to Brain-derived Neurotrophic Factor in Cultured Cerebral Cortical Neurons
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Role of Apoptosis Signal-Regulating Kinase in Regulation of the c-Jun N-Terminal Kinase Pathway and Apoptosis in Sympathetic Neurons
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Oligodendrocyte Apoptosis Mediated by Caspase Activation
Gu, C., Casaccia‐Bonnefil, P., Srinivasan, A. N., & Chao, M. V. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-03043.1999 · Cited by 162 · see citing works
Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons
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Ras Regulates Sympathetic Neuron Survival by Suppressing the p53-Mediated Cell Death Pathway
Mazzoni, I. E., Said, F. A., Aloyz, R. S., Miller, F. D., & Kaplan, D. R. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09716.1999 · Cited by 147 · see citing works
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Endogenous BDNF Protein Is Increased in Adult Rat Hippocampus after a Kainic Acid Induced Excitotoxic Insult but Exogenous BDNF Is Not Neuroprotective
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p75NTR: A study in contrasts
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Akt-Dependent Potentiation of L Channels by Insulin-Like Growth Factor-1 Is Required for Neuronal Survival
Blair, L. A. C., Bence, K. K., Mehta, S., Franke, T. F., Kaplan, D. R., & Marshall, J. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01940.1999 · Cited by 137 · see citing works
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Neurotrophins: the biological paradox of survival factors eliciting apoptosis
Casaccia‐Bonnefil, P., Kong, H., & Chao, M. V. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400377 · Cited by 137 · see citing works
Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor
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The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death
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Activation of Phosphatidylinositol 3‐Kinase, but Not Extracellular‐Regulated Kinases, Is Necessary to Mediate Brain‐Derived Neurotrophic Factor‐Induced Motoneuron Survival
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p75 Neurotrophin Receptor Expression on Adult Human Oligodendrocytes: Signaling without Cell Death in Response to NGF
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Nerve Growth Factor Signaling through p75 Induces Apoptosis in Schwann Cells via a Bcl-2-Independent Pathway
Soilu‐Hänninen, M., Ekert, P. G., Bucci, T., Syroid, D. E., Bartlett, P. F., & Kilpatrick, T. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04828.1999 · Cited by 126 · see citing works
The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo
Brennan, C., Rivas-Plata, K., & Landis, S. C. (1999) · Nature Neuroscience · doi:10.1038/11158 · Cited by 126 · see citing works
Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons.
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p21 Ras and Phosphatidylinositol-3 Kinase Are Required for Survival of Wild-Type and NF1 Mutant Sensory Neurons
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The role of p75NTR in modulating neurotrophin survival effects in developing motoneurons
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Regulation of Raf‐1 kinase by TNF via its second messenger ceramide and cross‐talk with mitogenic signalling
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Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75
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Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade
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Inhibition of p42 and p44 Mitogen‐Activated Protein Kinase Activity by PD98059 Does Not Suppress Nerve Growth Factor‐Induced Survival of Sympathetic Neurones
Virdee, K., & Tolkovsky, A. M. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67051801.x · Cited by 99 · see citing works
TrkB signalling inhibits p75-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons
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p75NTR and the concept of cellular dependence: seeing how the other half die
Bredesen, D. E., Ye, X., Tasinato, A., Sperandio, S., Wang, J. J., Assa‐Munt, N., & Rabizadeh, S. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400378 · Cited by 97 · see citing works
The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth
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Neutralizing Anti‐p21ras Fabs Suppress Rat Sympathetic Neuron Survival Induced by NGF, LIF, CNTF and cAMP
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Gab1 Mediates Neurite Outgrowth, DNA Synthesis, and Survival in PC12 Cells
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Seasonal plasticity of the song control system in wild Nuttall's white-crowned sparrows
Brenowitz, E. A., Baptista, L. F., Lent, K. L., & Wingfield, J. C. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199801)34:1 · Cited by 78 · see citing works
Elevation of Ceramide within Distal Neurites Inhibits Neurite Growth in Cultured Rat Sympathetic Neurons
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Enhanced Neurotrophin-Induced Axon Growth in Myelinated Portions of the CNS in Mice Lacking the p75 Neurotrophin Receptor
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Evidence for and against a Pivotal Role of PI 3-Kinase in a Neuronal Cell Survival Pathway
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Neuronal life and death decisions: functional antagonism between the Trk and p75 neurotrophin receptors
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The Csk Homologous Kinase Associates with TrkA Receptors and Is Involved in Neurite Outgrowth of PC12 Cells
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The anti-apoptotic protein ITA is essential for NGF-mediated survival of embryonic chick neurons
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In sympathetic but not sensory neurones, phosphoinositide-3 kinase is important for NGF-dependent survival and the retrograde transport of 125I-βNGF
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Nerve growth factor promotes activation of the α, β and γ isoforms of protein kinase B in PC12 pheochromocytoma cells
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Nerve growth factor (NGF) induces motoneuron apoptosis in rat embryonic spinal cord in vitro
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A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation.
Wright, J. H., Drueckes, P., Bartoe, J. L., Zhao, Z., Shen, S. H., & Krebs, E. G. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.8.1575 · Cited by 61 · see citing works
Activation of mitogen-activated protein kinase and p70S6 kinase is not correlated with cerebellar granule cell survival
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Improved survival of injured sciatic nerve Schwann cells in mice lacking the p75 receptor
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The Survival of Sympathetic Neurons Promoted by Potassium Depolarization, but Not by Cyclic AMP, Requires Phosphatidylinositol 3‐Kinase and Akt
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Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons
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The anti-p75 antibody, MC192, and brain-derived neurotrophic factor inhibit nerve growth factor-dependent neurite growth from adult sensory neurons
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Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro
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The Survival of Sympathetic Neurons Promoted by Potassium Depolarization, but Not by Cyclic AMP, Requires Phosphatidylinositol 3-Kinase and Akt
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Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394 · see citing works
Physiology of Microglia
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547 · see citing works
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537 · see citing works
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298 · see citing works
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195 · see citing works
Flavonoids: antioxidants or signalling molecules?
Williams, R. J., Spencer, J. P. E., & Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.001 · Cited by 2,016 · see citing works
The GDNF family: Signalling, biological functions and therapeutic value
Airaksinen, M. S., & Saarma, M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn812 · Cited by 1,832 · see citing works
Brain-derived neurotrophic factor and its clinical Implications
Bathina, S., & Das, U. N. (2015) · Archives of Medical Science · doi:10.5114/aoms.2015.56342 · Cited by 1,381 · see citing works
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359 · see citing works
The yin and yang of neurotrophin action
Lu, B., Pang, P. T., & Woo, N. H. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1726 · Cited by 1,356 · see citing works
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193 · see citing works
TrkB signalling pathways in LTP and learning
Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055 · see citing works
Trk receptors: mediators of neurotrophin action
Patapoutian, A., & Reichardt, L. F. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00208-7 · Cited by 1,070 · see citing works
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system.Preprint
Bibel, M., & Barde, Y. (2000) · Genes & Development · doi:10.1101/gad.841400 · Cited by 1,097 · see citing works
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
Nagahara, A. H., Merrill, D. A., Coppola, G., Tsukada, S., Schroeder, B. E., Shaked, G. M., Wang, L., Blesch, A., Kim, A., Conner, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1912 · Cited by 1,034 · see citing works
Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer
Colucci-D’Amato, L., Speranza, L., & Volpicelli, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207777 · Cited by 991 · see citing works
The neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 963 · see citing works
BDNF and Activity-Dependent Synaptic Modulation: Figure 1.
Lu, B. (2003) · Learning & Memory · doi:10.1101/lm.54603 · Cited by 945 · see citing works
Melatonin: Nature’s most versatile biological signal?
Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875 · see citing works
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
Nagahara, A. H., & Tuszynski, M. H. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3366 · Cited by 867 · see citing works
Mouse and rat <i>BDNF</i> gene structure and expression revisited
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943 · see citing works
Kindling and status epilepticus models of epilepsy: rewiring the brain
Morimoto, K., Fahnestock, M. L., & Racine, R. J. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.009 · Cited by 840 · see citing works
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
Jones, D., Hutter, B., Jäger, N., Korshunov, A., Kool, M., Warnatz, H.-J., Zichner, T., Lambert, S. R., Ryzhova, M. V., Khuong-Quang, D.-A., et al. (2013) · Nature Genetics · doi:10.1038/ng.2682 · Cited by 819 · see citing works
Sequential Treatment of SH‐SY5Y Cells with Retinoic Acid and Brain‐Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor‐Dependent, Human Neuron‐Like Cells
Encinas, M., Iglesias, M., Liu, Y., Wang, H., Muhaisen, A., Ceña, V., Gallego, C., & Comella, J. X. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750991.x · Cited by 822 · see citing works
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815 · see citing works
Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects
Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800 · see citing works
Interaction between BDNF and Serotonin: Role in Mood Disorders
Martinowich, K., & Lu, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301571 · Cited by 793 · see citing works
Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation of<i>Arc</i>Synthesis
Ying, S.-W., Futter, M., Rosenblum, K., Webber, M. J., Hunt, S. P., Bliss, T. V. P., & Bramham, C. R. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01532.2002 · Cited by 784 · see citing works
Diabetic neuropathy: Mechanisms to management
Edwards, J. L., Vincent, A. M., Cheng, H. T., & Feldman, E. L. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.05.005 · Cited by 797 · see citing works
A simple role for BDNF in learning and memory?
Cunha, C. (2010) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.001.2010 · Cited by 778 · see citing works
NGF rapidly increases membrane expression of TRPV1 heat‐gated ion channels
Zhang, X., Huang, J., & McNaughton, P. A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600893 · Cited by 750 · see citing works
Neurotrophin Signaling Through the P75 Neurotrophin Receptor
Roux, P. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00016-3 · Cited by 717 · see citing works
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
Jang, S., Liu, X., Yepes, M., Shepherd, K. R., Miller, G. W., Liu, Y., Wilson, W. D., Xiao, G., Blanchi, B., Sun, Y. E., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913572107 · Cited by 689 · see citing works
Neurotrophin secretion: current facts and future prospects
Leßmann, V., Gottmann, K., & Malcangio, M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00019-4 · Cited by 664 · see citing works
BDNF is essential to promote persistence of long-term memory storage
Bekinschtein, P., Cammarota, M., Katche, C., Slipczuk, L. N., Rossato, J. I., Goldin, A. P., Izquierdo, I., & Medina, J. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711863105 · Cited by 658 · see citing works
Novel functions and signalling pathways for GDNF
Sariola, H. V., & Saarma, M. (2003) · Journal of Cell Science · doi:10.1242/jcs.00786 · Cited by 648 · see citing works
Neurotrophin signalling in health and disease
Chao, M. V., Rajagopal, R., & Lee, F. S. (2006) · Clinical Science · doi:10.1042/cs20050163 · Cited by 626 · see citing works
Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications
Mufson, E. J., Counts, S., Perez, S. E., & Ginsberg, S. D. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.11.1703 · Cited by 589 · see citing works
Brain-Derived Neurotrophic Factor/TrkB Signaling in Memory Processes
Yamada, K., & Nabeshima, T. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.91.267 · Cited by 585 · see citing works
New insights into brain BDNF function in normal aging and Alzheimer disease
Tapia‐Arancibia, L., Aliaga, E., Silhol, M., & Arancibia, S. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.07.007 · Cited by 571 · see citing works
Neurotrophic Factors and Their Receptors in Axonal Regeneration and Functional Recovery After Peripheral Nerve Injury
Boyd, J. G., & Gordon, T. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:3:277 · Cited by 515 · see citing works
BDNF as a Promising Therapeutic Agent in Parkinson’s Disease
Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504 · see citing works
Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies
Jurcău, A., & Simion, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010014 · Cited by 515 · see citing works
Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
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Authors: Kaplan, D. R., & Miller, F. D.
Affiliations: Montreal Neurological Institute and Hospital (CA)
Corresponding author: Kaplan, David R
Miller, Freda D
ORCID: Kaplan, David R
Miller, Freda D
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 2000-06
Volume: 10
Issue: 3
Pages: 381-391
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/s0959-4388(00)00092-1
OpenAlex: W2128960139
Cited by: 1,944
References: 122
Citations by year: 2026: 18 · 2025: 35 · 2024: 41 · 2023: 44 · 2022: 44 · 2021: 38 · 2020: 51 · 2019: 45 · 2018: 49 · 2017: 53 · 2016: 66 · 2015: 53 · 2014: 91 · 2013: 79 · 2012: 68
FWCI: 11.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: neurotrophins, signal transduction, Trk receptors, p75 neurotrophin receptor, neurotrophin receptor signaling, Akt signaling, MAPK signaling, JNK signaling, p53 pathway, NF-κB signaling, neuronal survival, neuronal development, apoptosis
MeSH terms: Animals, Nerve Growth Factors, Nervous System Physiological Phenomena, Neurons, Signal Transduction

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Neurotrophin signal transduction in the nervous system

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