The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
Open accessAbstract
Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the mouse, and to ensure that each is represented in a physical collection of clones. Here we report the manual annotation of 60,770 full-length mouse complementary DNA sequences. These are clustered into 33,409 'transcriptional units', contributing 90.1% of a newly established mouse transcriptome database. Of these transcriptional units, 4,258 are new protein-coding and 11,665 are new non-coding messages, indicating that non-coding RNA is a major component of the transcriptome. 41% of all transcriptional units showed evidence of alternative splicing. In protein-coding transcripts, 79% of splice variations altered the protein product. Whole-transcriptome analyses resulted in the identification of 2,431 sense-antisense pairs. The present work, completely supported by physical clones, provides the most comprehensive survey of a mammalian transcriptome so far, and is a valuable resource for functional genomics.
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Metadata
- Authors
- The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I & II Team*
- Venue
- Nature
- Published
- 2002-12
- Volume
- 420
- Issue
- 6915
- Pages
- 563-573
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1986234964
- Cited by
- 1,642
- References
- 50
- FWCI
- 43.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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