Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport

Hirokawa, Nobutaka

doi:10.1126/science.279.5350.519

Cited by 1,686

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Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport

Hirokawa, Nobutaka·1998·Science

DOI 10.1126/science.279.5350.519

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Abstract

Cells transport and sort proteins and lipids, after their synthesis, to various destinations at appropriate velocities in membranous organelles and protein complexes. Intracellular transport is thus fundamental to cellular morphogenesis and functioning. Microtubules serve as a rail on which motor proteins, such as kinesin and dynein superfamily proteins, convey their cargoes. This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins.

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Authors: Hirokawa, N.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-01-23
Volume: 279
Issue: 5350
Pages: 519-526
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.279.5350.519
OpenAlex: W2061272721
Cited by: 1,686
References: 10
FWCI: 44.22
Type: journal article
Language: en
Open access: closed

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Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport

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