Cited by 2,742Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysImmune Response and Inflammation

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The immunopathogenesis of sepsis

Cohen, Jonathan·2002·Nature

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Abstract

Sepsis is a condition that results from a harmful or damaging host response to infection. Many of the components of the innate immune response that are normally concerned with host defences against infection can, under some circumstances, cause cell and tissue damage and hence multiple organ failure, the clinical hallmark of sepsis. Because of the high mortality of sepsis in the face of standard treatment, many efforts have been made to improve understanding of the dysregulation of the host response in sepsis. As a result, much has been learnt of the basic principles governing bacterial-host interactions, and new opportunities for therapeutic intervention have been revealed.

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Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
Intensive insulin therapy in critically ill patients.
Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137
Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
Bernard, G. R., Vincent, J., Laterre, P., LaRosa, S. P., Dhainaut, J.-F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441001 · Cited by 6,124
CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
Toll-like receptors in the induction of the innate immune response
Aderem, A. A., & Ulevitch, R. J. (2000) · Nature · doi:10.1038/35021228 · Cited by 3,082
Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock
Annane, D. (2002) · JAMA · doi:10.1001/jama.288.7.862 · Cited by 3,075
MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4
Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., & Kimoto, M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.11.1777 · Cited by 2,187
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
Ozinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L. A., & Aderem, A. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250476497 · Cited by 2,086
Disseminated Intravascular Coagulation
Levi, M. M., & Cate, H. T. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908193410807 · Cited by 2,035
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
Bauer, S., Kirschning, C. J., Häcker, H., Redecke, V., Hausmann, S., Akira, S., Wagner, H., & Lipford, G. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161293498 · Cited by 1,527
Association between mitochondrial dysfunction and severity and outcome of septic shock
Brealey, D. A., Brand, M. P., Hargreaves, I. P., Heales, S., Land, J. M., Smolenski, R. T., Davies, N. A., Cooper, C. E., & Singer, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09459-x · Cited by 1,518
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
Hotchkiss, R. S., Swanson, P. E., Freeman, B. D., Tinsley, K. W., Cobb, J. P., Matuschak, G. M., Buchman, T. G., & Karl, I. E. (1999) · Critical Care Medicine · doi:10.1097/00003246-199907000-00002 · Cited by 1,341
Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
Bouchon, A., Dietrich, J., & Colonna, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.10.4991 · Cited by 1,284
Monocyte deactivation in septic patients: Restoration by IFN-γ treatment
Döcke, W.-D., Randow, F., Syrbe, U., Krausch, D., Asadullah, K., Reinke, P., Volk, H.-D., & Kox, W. (1997) · Nature Medicine · doi:10.1038/nm0697-678 · Cited by 1,190
MIF as a glucocorticoid-induced modulator of cytokine production
Calandra, T., Bernhagen, J., Metz, C. N., Spiegel, L. A., Bacher, M., Donnelly, T. M., Cerami, A., & Bucala, R. (1995) · Nature · doi:10.1038/377068a0 · Cited by 1,148
The Pathogenesis of Vasodilatory Shock
Landry, D. W., & Oliver, J. A. (2001) · New England Journal of Medicine · doi:10.1056/nejmra002709 · Cited by 1,144
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
Bouchon, A., Facchetti, F., Weigand, M. A., & Colonna, M. (2001) · Nature · doi:10.1038/35074114 · Cited by 1,092
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
Nagai, Y., Akashi, S., Nagafuku, M., Ogata, M., Iwakura, Y., Akira, S., Kitamura, T., Kosugi, A., Kimoto, M., & Miyake, K. (2002) · Nature Immunology · doi:10.1038/ni809 · Cited by 1,021
Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study
Alberti, C., Brun‐Buisson, C., Burchardi, H., Martin, C. M., Goodman, S. V., Artigas, A., Sicignano, A., Palazzo, M. G. A., Moreno, R. P., Boulmé, R., et al. (2001) · Intensive Care Medicine · doi:10.1007/s00134-001-1143-z · Cited by 976
Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans
Hotchkiss, R. S., Tinsley, K. W., Swanson, P. E., Schmieg, R. E., Hui, J. J., Chang, K. C., Osborne, D. F., Freeman, B. D., Cobb, J. P., Buchman, T. G., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6952 · Cited by 939
Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway
Riewald, M., Petrovan, R. J., Donner, A. J., Mueller, B. M., & Ruf, W. (2002) · Science · doi:10.1126/science.1071699 · Cited by 832
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Michel, T., Reichhart, J., Hoffmann, J. A., & Royet, J. (2001) · Nature · doi:10.1038/414756a · Cited by 818
Relevance of Mutations in the TLR4 Receptor in Patients With Gram-Negative Septic Shock
Lorenz, E., Mira, J. P., Frees, K. L., & Schwartz, D. A. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.9.1028 · Cited by 726
Protection from septic shock by neutralization of macrophage migration inhibitory factor
Calandra, T., Echtenacher, B., Roy, D. L., Pugin, J., Metz, C. N., Hültner, L., Heumann, D., Männel, D. N., Bucala, R., & Glauser, M. P. (2000) · Nature Medicine · doi:10.1038/72262 · Cited by 724
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Gottar, M., Gobert, V., Michel, T., Belvin, M. P., Duyk, G. M., Hoffmann, J. A., Ferrandon, D., & Royet, J. (2002) · Nature · doi:10.1038/nature734 · Cited by 715
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
Rämet, M., Manfruelli, P., Pearson, A. M., Mathey-Prévôt, B., & Ezekowitz, R. A. B. (2002) · Nature · doi:10.1038/nature735 · Cited by 705
CD14 Is a pattern recognition receptor
Pugin, J., Heumann, D., Tomasz, A., Kravchenko, V. V., Akamatsu, Y., Nishijima, M., Glauser, M. P., Tobias, P. S., & Ulevitch, R. J. (1994) · Immunity · doi:10.1016/1074-7613(94)90093-0 · Cited by 699
Dysfunction of Endothelial Protein C Activation in Severe Meningococcal Sepsis
Faust, S. N., Levin, M., Harrison, O. B., Goldin, R. D., Lockhart, M. S., Kondaveeti, S., Laszik, Z. G., Esmon, C. T., & Heyderman, R. S. (2001) · New England Journal of Medicine · doi:10.1056/nejm200108093450603 · Cited by 694
Human CD14 mediates recognition and phagocytosis of apoptotic cells
Devitt, A., Moffatt, O., Raykundalia, C., Capra, J. D., Simmons, D. L., & Gregory, C. D. (1998) · Nature · doi:10.1038/33169 · Cited by 681
Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila
Choe, K., Werner, T., Stöven, S., Hultmark, D., & Anderson, K. V. (2002) · Science · doi:10.1126/science.1070216 · Cited by 606
A Novel Polymorphism in the Toll-Like Receptor 2 Gene and Its Potential Association with Staphylococcal Infection
Lorenz, E., Mira, J. P., Cornish, K. L., Arbour, N. C., & Schwartz, D. A. (2000) · Infection and Immunity · doi:10.1128/iai.68.11.6398-6401.2000 · Cited by 598
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Bozza, M. T., Satoskar, A. R., Lin, G., Lu, B., Humbles, A. A., Gerard, C. J., & David, J. R. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.341 · Cited by 551
A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster
Werner, T., Liu, G., Kang, D., Ekengren, S. K., Steiner, H., & Hultmark, D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.25.13772 · Cited by 547
Human Nod1 Confers Responsiveness to Bacterial Lipopolysaccharides
Inohara, N., Ogura, Y., Chen, F. F., Muto, A., & Núñez, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009728200 · Cited by 532
The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
Bowie, A., & O'Neill, L. A. J. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.4.508 · Cited by 506
Proinflammatory and Anti-inflammatory Cytokines as Mediators in the Pathogenesis of Septic Shock
Dinarello, C. A. (1997) · CHEST Journal · doi:10.1378/chest.112.6_supplement.321s · Cited by 505
Structure–Function Relationship of Cytokine Induction by Lipoteichoic Acid fromStaphylococcus aureus
Morath, S., Geyer, A., & Härtung, T. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.3.393 · Cited by 476
Prevention of lymphocyte cell death in sepsis improves survival in mice
Hotchkiss, R. S., Tinsley, K. W., Swanson, P. E., Chang, K. C., Cobb, J. P., Buchman, T. G., Korsmeyer, S. J., & Karl, I. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14541 · Cited by 452
Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study
Hampe, J., Grebe, J., Nikolaus, S., Solberg, C., Croucher, P. J. P., Mascheretti, S., Jahnsen, J., Moum, B. A., Klump, B., Krawczak, M., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08590-2 · Cited by 409
Bacterial DNA causes septic shock
Sparwasser, T. D., Miethke, T., Lipford, G. B., Borschert, K., Häcker, H., Heeg, K. M., & Wagner, H. (1997) · Nature · doi:10.1038/386336a0 · Cited by 407
Peptidoglycan Recognition Proteins
Liu, C., Xu, Z., Gupta, D., & Dziarski, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105566200 · Cited by 398
Protective role of phospholipid oxidation products in endotoxin-induced tissue damage
Bochkov, V. N., Kadl, A., Huber, J., Грубер, Ф., Binder, B. R., & Leitinger, N. (2002) · Nature · doi:10.1038/nature01023 · Cited by 367
Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ: a molecular basis for priming and synergism with bacterial lipopolysaccharide
Bosisio, D., Polentarutti, N., Sironi, M., Bernasconi, S., Miyake, K., Webb, G. R., Martin, M. U., Mantovani, A., & Muzio, M. (2002) · Blood · doi:10.1182/blood.v99.9.3427 · Cited by 288
Bacterial pyrogenic exotoxins as superantigens
Kotb, M. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.3.411 · Cited by 282
Flagellin, a Novel Mediator of Salmonella -Induced Epithelial Activation and Systemic Inflammation: IκBα Degradation, Induction of Nitric Oxide Synthase, Induction of Proinflammatory Mediators, and Cardiovascular Dysfunction
Eaves-Pyles, T. D., Murthy, K. G. K., Liaudet, L., Virág, L., Ross, G. F., Soriano, F. G., Szabó, C., & Salzman, A. L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.1248 · Cited by 270
Introduction: The role of innate immunity in the adaptive immune response
Janeway, C. A., & Medzhitov, R. M. (1998) · Seminars in Immunology · doi:10.1006/smim.1998.0142 · Cited by 245
Nods: a family of cytosolic proteins that regulate the host response to pathogens
Inohara, N. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00289-8 · Cited by 240
Toll Receptors: a Central Element in Innate Immune Responses
Vasselon, T., & Detmers, P. A. (2002) · Infection and Immunity · doi:10.1128/iai.70.3.1033-1041.2002 · Cited by 236
Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria
Calandra, T., Spiegel, L. A., Metz, C. N., & Bucala, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11383 · Cited by 235
Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids.
Yu, B., Hailman, E., & Wright, S. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119160 · Cited by 225
Activation of the contact-phase system on bacterial surfaces—a clue to serious complications in infectious diseases
Herwald, H., Mörgelin, M., Olsén, A., Rhen, M., Dahlbäck, B., Müller‐Esterl, W., & Björck, L. (1998) · Nature Medicine · doi:10.1038/nm0398-298 · Cited by 207
Peptidoglycan and Lipoteichoic Acid fromStaphylococcus aureusInduce Tumor Necrosis Factor Alpha, Interleukin 6 (IL-6), and IL-10 Production in Both T Cells and Monocytes in a Human Whole Blood Model
Wang, J. E., Jørgensen, P. F., Almlöf, M., Thiemermann, C., Foster, S. J., Aasen, A. O., & Solberg, R. (2000) · Infection and Immunity · doi:10.1128/iai.68.7.3965-3970.2000 · Cited by 201
Increased Circulating Soluble Cd14 Is Associated With High Mortality In Gram-Negative Septic Shock
Landmann, R., Zimmerli, W., Sansano, S., Link, S., Hahn, A., Glauser, M. P., & Calandra, T. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/171.3.639 · Cited by 201
Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity
Seydel, U., Oikawa, M., Fukase, K., Kusumoto, S., & Brandenburg, K. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2000.01326.x · Cited by 180
Antibodies against CD14 protect primates from endotoxin-induced shock.
Leturcq, D. J., Moriarty, A. M., Talbott, G., Winn, R. K., Martin, T. R., & Ulevitch, R. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118945 · Cited by 148
HMG-1 REDISCOVERED AS A CYTOKINE
Yang, H., Wang, H., & Tracey, K. J. (2001) · Shock · doi:10.1097/00024382-200115040-00001 · Cited by 145
Regulation of inflammatory responses by natural anticoagulants
Okajima, K. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1840123.x · Cited by 141
Evidence for Superantigen Involvement in Severe Group A Streptococcal Tissue Infections
Norrby‐Teglund, A., Thulin, P., Gan, B. S., Kotb, M., McGeer, A., Andersson, J., & Low, D. E. (2001) · The Journal of Infectious Diseases · doi:10.1086/323443 · Cited by 128
Microbial superantigens: from structure to function
Papageorgiou, A. C., Acharya, K. R., & Acharya, K. R. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01793-5 · Cited by 110
Bench-to-bedside review: Toll-like receptors and their role in septic shock.
Opal, S. M., & Huber, C. E. (2002) · Critical Care · doi:10.1186/cc1471 · Cited by 102
The Bacterial Superantigen Streptococcal Mitogenic Exotoxin Z Is the Major Immunoactive Agent of Streptococcus pyogenes
Unnikrishnan, M., Altmann, D. M., Proft, T., Wahid, F. N., Cohen, J., Fraser, J. D., & Sriskandan, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2561 · Cited by 87
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Majcherczyk, P. A., Langen, H., Heumann, D., Fountoulakis, M., Glauser, M. P., & Moreillon, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12537 · Cited by 76
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Lavoie, P. M., Thibodeau, J., Erard, F., & Sékaly, R. (1999) · Immunological Reviews · doi:10.1111/j.1600-065x.1999.tb01297.x · Cited by 71
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Diaeresis]BER, F. S. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v12suppl_1s60 · Cited by 55
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Müller‐Alouf, H., Proft, T., Zollner, T. M., Gerlach, D., Champagne, É., Desreumaux, P., Fitting, C., Geoffroy, C., ALOUF, J. E., & Cavaillon, J. (2001) · Infection and Immunity · doi:10.1128/iai.69.6.4141-4145.2001 · Cited by 32
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Authors: Cohen, J.
Affiliations: Brighton and Sussex Medical School (GB)
Corresponding author: Cohen, Jonathan
ORCID: Cohen, Jonathan
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-12
Volume: 420
Issue: 6917
Pages: 885-891
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01326
OpenAlex: W2088220499
Cited by: 2,742
References: 74
Citations by year: 2026: 31 · 2025: 58 · 2024: 63 · 2023: 59 · 2022: 96 · 2021: 115 · 2020: 120 · 2019: 113 · 2018: 108 · 2017: 135 · 2016: 124 · 2015: 149 · 2014: 205 · 2013: 223 · 2012: 153
FWCI: 10.59
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: sepsis, immunopathogenesis, innate immune response, host response to infection, multiple organ failure, host-bacteria interactions, sepsis mortality, therapeutic interventions
MeSH terms: Animals, Bacterial Infections, Host-Parasite Interactions, Humans, Inflammation, Multiple Organ Failure, Polymorphism, Genetic, Signal Transduction, Sepsis, Genetic Predisposition to Disease

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The immunopathogenesis of sepsis

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