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Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
Open accessAbstract
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur. Here we report the complete genomic sequence of a representative virulent serovar type strain (Lai) of Leptospira interrogans serogroup Icterohaemorrhagiae consisting of a 4.33-megabase large chromosome and a 359-kilobase small chromosome, with a total of 4,768 predicted genes. In terms of the genetic determinants of physiological characteristics, the facultatively parasitic L. interrogans differs extensively from two other strictly parasitic pathogenic spirochaetes, Treponema pallidum and Borrelia burgdorferi, although similarities exist in the genes that govern their unique morphological features. A comprehensive analysis of the L. interrogans genes for chemotaxis/motility and lipopolysaccharide synthesis provides a basis for in-depth studies of virulence and pathogenesis. The discovery of a series of genes possibly related to adhesion, invasion and the haematological changes that characterize leptospirosis has provided clues about how an environmental organism might evolve into an important human pathogen.
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Cites
Base-Calling of Automated Sequencer Traces Using Phred. II. Error Probabilities
Ewing, B., & Green, P. (1998) · Genome Research · doi:10.1101/gr.8.3.186 · Cited by 5,439
Cited by
McBride, A. J., Athanazio, D. A., Reis, M. G., & Ko, A. I. (2005) · Current Opinion in Infectious Diseases · doi:10.1097/01.qco.0000178824.05715.2c · Cited by 518
Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans
Malmström, J., Beck, M., Schmidt, A., Lange, V., Deutsch, E. W., & Aebersold, R. (2009) · Nature · doi:10.1038/nature08184 · Cited by 421
Quantification of mRNA and protein and integration with protein turnover in a bacterium
Maier, T., Schmidt, A., Güell, M., Kühner, S., Gavin, A., Aebersold, R., & Serrano, L. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.38 · Cited by 297
Gao, Y., Shen, L., & Honzatko, R. B. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.548586 · Cited by 11
Metadata
- Authors
- Ren, S.-X., Fu, G., Jiang, X.-G., Zeng, R., Miao, Y.-G., Xu, H., Zhang, Y.-X., Xiong, H., Lu, G., Lu, L.-F., Jiang, H.-Q., Jia, J., Tu, Y.-F., Jiang, J.-X., Gu, W.-Y., Zhang, Y.-Q., Cai, Z., Sheng, H.-H., Yin, H.-F., Zhang, Y., Zhu, G.-F., Wan, M., Huang, H.-L., Qian, Z., Wang, S.-Y., Ma, W., Yao, Z.-J., Shen, Y., Qiang, B.-Q., Xia, Q.-C., Guo, X.-K., Danchin, A., Saint Girons, I., Somerville, R. L., Wen, Y.-M., Shi, M.-H., Chen, Z., Xu, J.-G., & Zhao, G.-P.
- Venue
- Nature
- Published
- 2003-04
- Volume
- 422
- Issue
- 6934
- Pages
- 888-893
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2070407853
- Cited by
- 612
- References
- 1
- FWCI
- 29.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Ren, S.-X., Fu, G., Jiang, X.-G., Zeng, R., Miao, Y.-G., Xu, H., Zhang, Y.-X., Xiong, H., Lu, G., Lu, L.-F., Jiang, H.-Q., Jia, J., Tu, Y.-F., Jiang, J.-X., Gu, W.-Y., Zhang, Y.-Q., Cai, Z., Sheng, H.-H., Yin, H.-F., . . . Zhao, G.-P. (2003). Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature. https://doi.org/10.1038/nature01597
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