Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

Sheehy, A. M., Gaddis, N., Choi, J. D., & Malim, M. H. (2002) · Nature · doi:10.1038/nature00939 · Cited by 2,330 · see citing works

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

Zufferey, R., Nagy, D., Mandel, R. J., Naldini, L., & Trono, D. (1997) · Nature Biotechnology · doi:10.1038/nbt0997-871 · Cited by 1,977 · see citing works

A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine

Powell, L. M., Wallis, S. C., Pease, R. J., Edwards, Y. H., Knott, T. J., & Scott, J. (1987) · Cell · doi:10.1016/0092-8674(87)90510-1 · Cited by 1,039 · see citing works

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

Chaudhuri, J., Tian, M., Khuong, C., Chua, K. F., Pinaud, E., & Alt, F. W. (2003) · Nature · doi:10.1038/nature01574 · Cited by 746 · see citing works

An Anthropoid-Specific Locus of Orphan C to U RNA-Editing Enzymes on Chromosome 22

Jarmuz, A., Chester, A., Bayliss, J., Gisbourne, J., Dunham, I., Scott, J., & Navaratnam, N. (2002) · Genomics · doi:10.1006/geno.2002.6718 · Cited by 711 · see citing works

A quantitative assay for HIV DNA integration in vivo

Butler, S. L., Hansen, M. S., & Bushman, F. D. (2001) · Nature Medicine · doi:10.1038/87979 · Cited by 688 · see citing works

Molecular Cloning of an Apolipoprotein B Messenger RNA Editing Protein

Teng, B.-B., Burant, C., & Davidson, N. O. (1993) · Science · doi:10.1126/science.8511591 · Cited by 626 · see citing works

RNA Editing Enzyme APOBEC1 and Some of Its Homologs Can Act as DNA Mutators

Harris, R. S., Petersen‐Mahrt, S. K., & Neuberger, M. S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00742-6 · Cited by 604 · see citing works

Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes

Gabuzda, D. H., Lawrence, K., Langhoff, E., Terwilliger, E., Dorfman, T., Haseltine, W. A., & Sodroski, J. (1992) · Journal of Virology · doi:10.1128/jvi.66.11.6489-6495.1992 · Cited by 444 · see citing works

Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells

von Schwedler, U. K., Song, J., Aiken, C., & Trono, D. (1993) · Journal of Virology · doi:10.1128/jvi.67.8.4945-4955.1993 · Cited by 441 · see citing works

HIV-1 Reverse Transcription A Termination Step at the Center of the Genome

Charneau, P., Mirambeau, G., Roux, P., Paulous, S., BUC, H. C., & Clavel, F. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1542 · Cited by 388 · see citing works

Transmission of antiretroviral-drug-resistant HIV-1 variants

Yerly, S., Kaiser, L., Race, E., Bru, J.-P., Clavel, F., & Perrin, L. (1999) · The Lancet · doi:10.1016/s0140-6736(98)12262-6 · Cited by 383 · see citing works

Selection, recombination, and G----A hypermutation of human immunodeficiency virus type 1 genomes

Vartanian, J., Meyerhans, A., Åsjö, B., & Wain–Hobson, S. (1991) · Journal of Virology · doi:10.1128/jvi.65.4.1779-1788.1991 · Cited by 340 · see citing works

Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations.

Pathak, V. K., & Temin, H. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6019 · Cited by 279 · see citing works

Stable gene transfer to the nervous system using a non-primate lentiviral vector

Mitrophanous, K. A., Yoon, S., Rohll, J. B., Patil, D., Wilkes, F. J., Kim, V. N., Kingsman, S. M., Kingsman, A. J., & Mazarakis, N. D. (1999) · Gene Therapy · doi:10.1038/sj.gt.3301023 · Cited by 277 · see citing works

Highly Purified Human Immunodeficiency Virus Type 1 Reveals a Virtual Absence of Vif in Virions

Dettenhofer, M., & Yu, X.-F. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1460-1467.1999 · Cited by 239 · see citing works

A Rev-Independent Human Immunodeficiency Virus Type 1 (HIV-1)-Based Vector That Exploits a Codon-Optimized HIV-1 gag-pol Gene

Kotsopoulou, E., Kim, V. N., Kingsman, A. J., Kingsman, S. M., & Mitrophanous, K. A. (2000) · Journal of Virology · doi:10.1128/jvi.74.10.4839-4852.2000 · Cited by 228 · see citing works

Cytoplasmic Recruitment of INI1 and PML on Incoming HIV Preintegration Complexes

Turelli, P., Doucas, V., Craig, E., Mangeat, B., Klages, N., Evans, R. M., Kalpana, G. V., & Trono, D. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00255-6 · Cited by 223 · see citing works

Characterization of novel safe lentiviral vectors derived from simian immunodeficiency virus (SIVmac251) that efficiently transduce mature human dendritic cells

Négre, D., Mangeot, P.-E., Duisit, G., Blanchard, S., Vidalain, P., Leissner, P., Winter, A.-J., Rabourdin‐Combe, C., Mehtali, M., Moullier, P., et al. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301292 · Cited by 206 · see citing works

The human immunodeficiency virus type 1 Vif protein modulates the postpenetration stability of viral nucleoprotein complexes

Simon, J. H., & Malim, M. H. (1996) · Journal of Virology · doi:10.1128/jvi.70.8.5297-5305.1996 · Cited by 188 · see citing works

Mutagenesis of apobec-1, the Catalytic Subunit of the Mammalian Apolipoprotein B mRNA Editing Enzyme, Reveals Distinct Domains That Mediate Cytosine Nucleoside Deaminase, RNA Binding, and RNA Editing Activity

MacGinnitie, A. J., Anant, S., & Davidson, N. O. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14768 · Cited by 130 · see citing works

The genetic fate of molecularly cloned simian immunodeficiency virus in experimentally infected macaques

Johnson, P. R., Hamm, T. E., Goldstein, S. C., Kitov, S., & Hirsch, V. M. (1991) · Virology · doi:10.1016/0042-6822(91)90769-8 · Cited by 117 · see citing works

Naturally Occurring Hepatitis B Virus Genomes Bearing the Hallmarks of Retroviral G → A Hypermutation

Günther, S., Sommer, G., Plikat, U., Iwanska, A., Wain–Hobson, S., Will, H., & Meyerhans, A. (1997) · Virology · doi:10.1006/viro.1997.8676 · Cited by 86 · see citing works

In Vivo Analysis of Human T-Cell Leukemia Virus Type 1 Reverse Transcription Accuracy

Mansky, L. M. (2000) · Journal of Virology · doi:10.1128/jvi.74.20.9525-9531.2000 · Cited by 85 · see citing works

Incorporation of Uracil into Minus Strand DNA Affects the Specificity of Plus Strand Synthesis Initiation during Lentiviral Reverse Transcription

Klarmann, G. J., Chen, X., North, T. W., & Preston, B. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207223200 · Cited by 77 · see citing works

dUTPase-minus caprine arthritis-encephalitis virus is attenuated for pathogenesis and accumulates G-to-A substitutions

Turelli, P., Guiguen, F., Mornex, J., Vigne, R., & Quérat, G. (1997) · Journal of Virology · doi:10.1128/jvi.71.6.4522-4530.1997 · Cited by 77 · see citing works

Erratic G → A Hypermutation within a Complete Caprine Arthritis-Encephalitis Virus (CAEV) Provirus

Wain–Hobson, S., Sonigo, P., Guyader, M., Gazit, A., & Henry, M. (1995) · Virology · doi:10.1006/viro.1995.1261 · Cited by 52 · see citing works

A Highly Defective HIV-1 Group O Provirus: Evidence for the Role of Local Sequence Determinants in G → A Hypermutation during Negative-Strand Viral DNA Synthesis

Borman, A. M., Quillent, C., Charneau, P., Kean, K. M., & Clavel, F. (1995) · Virology · doi:10.1006/viro.1995.1191 · Cited by 51 · see citing works

Rates of evolutionary change in viruses: patterns and determinants

Duffy, S., Shackelton, L. A., & Holmes, E. C. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2323 · Cited by 1,548 · see citing works

Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

Yu, X., Yu, Y., Liu, B., Luo, K., Kong, W., Mao, P., & Yu, X.-F. (2003) · Science · doi:10.1126/science.1089591 · Cited by 1,194 · see citing works

Type I Interferons in Host Defense

Stetson, D. B., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.08.007 · Cited by 1,194 · see citing works

The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif

Sheehy, A. M., Gaddis, N., & Malim, M. H. (2003) · Nature Medicine · doi:10.1038/nm945 · Cited by 961 · see citing works

Mechanisms of viral mutation

Sanjuán, R., & Domingo‐Calap, P. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2299-6 · Cited by 952 · see citing works

Quasispecies Theory and the Behavior of RNA Viruses

Lauring, A. S., & Andino, R. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001005 · Cited by 840 · see citing works

HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation

Marin, M., Rose, K. M., Kozak, S. L., & Kabat, D. (2003) · Nature Medicine · doi:10.1038/nm946 · Cited by 794 · see citing works

HIV-1 Vif Blocks the Antiviral Activity of APOBEC3G by Impairing Both Its Translation and Intracellular Stability

Stopak, K., de Noronha, C. M. C., Yonemoto, W. M., & Greene, W. C. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00353-8 · Cited by 723 · see citing works

Retroviral restriction by APOBEC proteins

Harris, R. S., & Liddament, M. T. (2004) · Nature reviews. Immunology · doi:10.1038/nri1489 · Cited by 657 · see citing works

Cytidine Deamination of Retroviral DNA by Diverse APOBEC Proteins

Bishop, K. N., Holmes, R. K., Sheehy, A. M., Davidson, N. O., Cho, S., & Malim, M. H. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.057 · Cited by 613 · see citing works

Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

Yu, Q., König, R., Pillai, S. K., Chiles, K., Kearney, M. F., Palmer, S., Richman, D., Coffin, J. M., & Landau, N. R. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb758 · Cited by 596 · see citing works

The AID/APOBEC family of nucleic acid mutators

Conticello, S. G. (2008) · Genome biology · doi:10.1186/gb-2008-9-6-229 · Cited by 544 · see citing works

Intrinsic antiviral immunity

Yan, N., & Chen, Z. J. (2012) · Nature Immunology · doi:10.1038/ni.2229 · Cited by 535 · see citing works

APOBECs and virus restriction

Harris, R. S., & Dudley, J. P. (2015) · Virology · doi:10.1016/j.virol.2015.03.012 · Cited by 518 · see citing works

HIV-1 Reverse TranscriptionPreprint

Hu, W.-S., & Hughes, S. H. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006882 · Cited by 515 · see citing works

Evolution of the AID/APOBEC Family of Polynucleotide (Deoxy)cytidine Deaminases

Conticello, S. G., Thomas, C. J. F., Petersen‐Mahrt, S. K., & Neuberger, M. S. (2004) · Molecular Biology and Evolution · doi:10.1093/molbev/msi026 · Cited by 489 · see citing works

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G

Sawyer, S. L., Emerman, M., & Malik, H. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020275 · Cited by 485 · see citing works

Antiviral Function of APOBEC3G Can Be Dissociated from Cytidine Deaminase Activity

Newman, E. N. C., Holmes, R. K., Craig, H. M., Klein, K. C., Lingappa, J. R., Malim, M. H., & Sheehy, A. M. (2005) · Current Biology · doi:10.1016/j.cub.2004.12.068 · Cited by 480 · see citing works

HIV Restriction Factors and Mechanisms of EvasionPreprint

Malim, M. H., & Bieniasz, P. D. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006940 · Cited by 474 · see citing works

Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway

Mehle, A., Strack, B., Ancuța, P., Zhang, C., McPike, M. P., & Gabuzda, D. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313093200 · Cited by 470 · see citing works

The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3G

Conticello, S. G., Harris, R. S., & Neuberger, M. S. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.034 · Cited by 468 · see citing works

A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV‐1 and HIV‐2 Vif proteins

Wiegand, H. L., Doehle, B., Bogerd, H. P., & Cullen, B. R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600246 · Cited by 466 · see citing works

Intrinsic immunity: a front-line defense against viral attack

Bieniasz, P. D. (2004) · Nature Immunology · doi:10.1038/ni1125 · Cited by 450 · see citing works

APOBEC3F Properties and Hypermutation Preferences Indicate Activity against HIV-1 In Vivo

Liddament, M. T., Brown, W. L., Schumacher, A. J., & Harris, R. S. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.050 · Cited by 437 · see citing works

Inhibition of Hepatitis B Virus Replication by APOBEC3G

Turelli, P., Mangeat, B., Jost, S., Vianin, S., & Trono, D. (2004) · Science · doi:10.1126/science.1092066 · Cited by 432 · see citing works

Human APOBEC3F Is Another Host Factor That Blocks Human Immunodeficiency Virus Type 1 Replication

Zheng, Y., Irwin, D., Kurosu, T., Tokunaga, K., Sata, T., & Peterlin, B. M. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.6073-6076.2004 · Cited by 430 · see citing works

The structural biology of HIV-1: mechanistic and therapeutic insights

Engelman, A., & Cherepanov, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2747 · Cited by 426 · see citing works

The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous Retroelements

Chiu, Y., & Greene, W. C. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090350 · Cited by 417 · see citing works

APOBEC3A Is a Potent Inhibitor of Adeno-Associated Virus and Retrotransposons

Chen, H., Lilley, C. E., Yu, Q., Lee, D. V., Chou, J., Narvaiza, I., Landau, N. R., & Weitzman, M. D. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.031 · Cited by 385 · see citing works

Cellular inhibitors of long interspersed element 1 and Alu retrotransposition

Bogerd, H. P., Wiegand, H. L., Hulme, A. E., Garcia-Perez, J. L., O’Shea, K., Moran, J. V., & Cullen, B. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603313103 · Cited by 372 · see citing works

Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5α

Hatziioannou, T., Pérez-Caballero, D., Yang, A., Cowan, S., & Bieniasz, P. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402361101 · Cited by 371 · see citing works

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

Refsland, E. W., Stenglein, M. D., Shindo, K., Albin, J. S., Brown, W. L., & Harris, R. S. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq174 · Cited by 356 · see citing works

The role of mutational robustness in RNA virus evolution

Lauring, A. S., Frydman, J., & Andino, R. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3003 · Cited by 354 · see citing works

APOBEC3 Proteins Inhibit Human LINE-1 Retrotransposition

Muckenfuß, H., Hamdorf, M., Held, U., Perković, M., Löwer, J., Cichutek, K., Flory, E., Schumann, G. G., & Münk, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601716200 · Cited by 353 · see citing works

The human and African green monkey TRIM5α genes encode Ref1 and Lv1 retroviral restriction factor activities

Keckesova, Z., Ylinen, L. M. J., & Towers, G. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402474101 · Cited by 342 · see citing works

APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses

Esnault, C., Heidmann, O., Delebecque, F., Dewannieux, M., Ribet, D., Hance, A. J., Heidmann, T., & Schwartz, O. (2005) · Nature · doi:10.1038/nature03238 · Cited by 341 · see citing works

HIV-1 Vif, APOBEC, and Intrinsic Immunity

Goila-Gaur, R., & Strebel, K. (2008) · Retrovirology · doi:10.1186/1742-4690-5-51 · Cited by 341 · see citing works

APOBEC-Mediated Cytosine Deamination Links PIK3CA Helical Domain Mutations to Human Papillomavirus-Driven Tumor Development

Henderson, S. R., Chakravarthy, A., Su, X., Boshoff, C., & Fenton, T. R. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.012 · Cited by 340 · see citing works

Animal models for HIV/AIDS research

Hatziioannou, T., & Evans, D. T. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2911 · Cited by 338 · see citing works

Comparison of the Differential Context-dependence of DNA Deamination by APOBEC Enzymes: Correlation with Mutation Spectra in Vivo

Beale, R. C. L., Petersen‐Mahrt, S. K., Watt, I. N., Harris, R. S., Rada, C. A., & Neuberger, M. S. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.01.046 · Cited by 337 · see citing works

Defining APOBEC3 Expression Patterns in Human Tissues and Hematopoietic Cell Subsets

Koning, F. A., Newman, E. N. C., Kim, E., Kunstman, K., Wolinsky, S. M., & Malim, M. H. (2009) · Journal of Virology · doi:10.1128/jvi.01089-09 · Cited by 334 · see citing works

Evidence for Editing of Human Papillomavirus DNA by APOBEC3 in Benign and Precancerous Lesions

Vartanian, J., Guétard, D., Henry, M., & Wain–Hobson, S. (2008) · Science · doi:10.1126/science.1153201 · Cited by 327 · see citing works

APOBEC3G Inhibits Elongation of HIV-1 Reverse Transcripts

Bishop, K. N., Verma, M., Kim, E., Wolinsky, S. M., & Malim, M. H. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000231 · Cited by 326 · see citing works

APOBEC3 proteins mediate the clearance of foreign DNA from human cells

Stenglein, M. D., Burns, M. B., Li, M., Lengyel, J., & Harris, R. S. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1744 · Cited by 326 · see citing works

Cellular Proteins in Influenza Virus Particles

Shaw, M. L., Stone, K. L., Colangelo, C. M., Gulcicek, E. E., & Palese, P. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000085 · Cited by 324 · see citing works

Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G

Iwatani, Y., Chan, D., Wang, F., Stewart-Maynard, K. M., Sugiura, W., Gronenborn, A. M., Rouzina, I. F., Williams, M. C., Musier‐Forsyth, K., & Levin, J. G. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm750 · Cited by 321 · see citing works

DNA precursor metabolism and genomic stability

Mathews, C. K. (2006) · The FASEB Journal · doi:10.1096/fj.06-5730rev · Cited by 311 · see citing works

Reconstitution of an Infectious Human Endogenous Retrovirus

Lee, Y. N., & Bieniasz, P. D. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030010 · Cited by 311 · see citing works

No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2

van Dorp, L., Richard, D., Tan, C. C. S., Shaw, L. P., Acman, M., & Balloux, F. (2020) · Nature Communications · doi:10.1038/s41467-020-19818-2 · Cited by 310 · see citing works

A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif)

Schröfelbauer, B., Chen, D., & Landau, N. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307132101 · Cited by 309 · see citing works

The Human Immunodeficiency Virus Type 1 Vif Protein Reduces Intracellular Expression and Inhibits Packaging of APOBEC3G (CEM15), a Cellular Inhibitor of Virus Infectivity

Kao, S., Khan, M. A., Miyagi, E., Plishka, R. J., Buckler-White, A. J., & Strebel, K. (2003) · Journal of Virology · doi:10.1128/jvi.77.21.11398-11407.2003 · Cited by 309 · see citing works

Complementary function of the two catalytic domains of APOBEC3G

Navarro, F., Bollman, B., Chen, H., König, R., Yu, Q., Chiles, K., & Landau, N. R. (2005) · Virology · doi:10.1016/j.virol.2005.01.011 · Cited by 308 · see citing works

APOBEC3F Can Inhibit the Accumulation of HIV-1 Reverse Transcription Products in the Absence of Hypermutation

Holmes, R. K., Koning, F. A., Bishop, K. N., & Malim, M. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607298200 · Cited by 306 · see citing works

Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases in vitro and in vivo

Suspène, R., Guétard, D., Henry, M., Sommer, P., Wain–Hobson, S., & Vartanian, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408223102 · Cited by 305 · see citing works

APOBEC3G DNA deaminase acts processively 3′ → 5′ on single-stranded DNA

Chelico, L., Pham, P., Calabrese, P. P., & Goodman, M. F. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1086 · Cited by 305 · see citing works

Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteinesPreprint

Yu, Y., Xiao, Z., Ehrlich, E. S., Yu, X., & Yu, X.-F. (2004) · Genes & Development · doi:10.1101/gad.1250204 · Cited by 302 · see citing works

A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor

Bogerd, H. P., Doehle, B., Wiegand, H. L., & Cullen, B. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307713101 · Cited by 295 · see citing works

Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradationPreprint

Mehle, A., Gonçalves, J., Santa‐Marta, M., McPike, M. P., & Gabuzda, D. H. (2004) · Genes & Development · doi:10.1101/gad.1249904 · Cited by 294 · see citing works

Antiviral Potency of APOBEC Proteins Does Not Correlate with Cytidine Deamination

Bishop, K. N., Holmes, R. K., & Malim, M. H. (2006) · Journal of Virology · doi:10.1128/jvi.00839-06 · Cited by 292 · see citing works

APOBEC3B and APOBEC3C Are Potent Inhibitors of Simian Immunodeficiency Virus Replication

Yu, Q., Chen, D., König, R., Mariani, R., Unutmaz, D., & Landau, N. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408802200 · Cited by 290 · see citing works

Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti–HIV-1 activity

Peng, G., Lei, K. J., Jin, W., Greenwell‐Wild, T., & Wahl, S. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051512 · Cited by 290 · see citing works

HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis

Mirabello, L. J., Yeager, M., Yu, K. F., Clifford, G. M., Xiao, Y., Zhu, B., Cullen, M., Boland, J. F., Wentzensen, N., Nelson, C. W., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.001 · Cited by 285 · see citing works

Isolation and Characterization of Replication-Competent Human Immunodeficiency Virus Type 1 from a Subset of Elite Suppressors

Blankson, J. N., Bailey, J. R., Thayil, S. M., Yang, H., Lassen, K. G., Lai, J., Gandhi, S. K., Siliciano, J. D., Williams, T. M., & Siliciano, R. F. (2006) · Journal of Virology · doi:10.1128/jvi.02165-06 · Cited by 282 · see citing works

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

Coiras, M., López‐Huertas, M. R., Pérez‐Olmeda, M., & Alcamı́, J. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2223 · Cited by 281 · see citing works

Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection

Isaacson, M. K., & Ploegh, H. L. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.012 · Cited by 281 · see citing works

Maintenance of viral suppression in HIV-1–infected HLA-B*57+ elite suppressors despite CTL escape mutations

Bailey, J. R., Williams, T. M., Siliciano, R. F., & Blankson, J. N. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052319 · Cited by 281 · see citing works

The Restriction Factors of Human Immunodeficiency Virus

Harris, R. S., Hultquist, J. F., & Evans, D. T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.416925 · Cited by 281 · see citing works

Role and Mechanism of Action of the APOBEC3 Family of Antiretroviral Resistance Factors

Cullen, B. R. (2006) · Journal of Virology · doi:10.1128/jvi.80.3.1067-1076.2006 · Cited by 280 · see citing works

APOBEC-mediated viral restriction: not simply editing?

Holmes, R. K., Malim, M. H., & Bishop, K. N. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.01.004 · Cited by 278 · see citing works

APOBEC3G Incorporation into Human Immunodeficiency Virus Type 1 Particles

Zennou, V., Pérez-Caballero, D., Göttlinger, H. G., & Bieniasz, P. D. (2004) · Journal of Virology · doi:10.1128/jvi.78.21.12058-12061.2004 · Cited by 278 · see citing works

Macrophages and their relevance in Human Immunodeficiency Virus Type I infection

Koppensteiner, H., Brack‐Werner, R., & Schindler, M. (2012) · Retrovirology · doi:10.1186/1742-4690-9-82 · Cited by 278 · see citing works

Mammalian transposable elements and their impacts on genome evolution

Platt, R. N., Vandewege, M. W., & Ray, D. A. (2018) · Chromosome Research · doi:10.1007/s10577-017-9570-z · Cited by 278 · see citing works

APOBEC3B and APOBEC3F Inhibit L1 Retrotransposition by a DNA Deamination-independent Mechanism

Stenglein, M. D., & Harris, R. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602367200 · Cited by 277 · see citing works

APOBEC proteins and intrinsic resistance to HIV-1 infection

Malim, M. H. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0185 · Cited by 276 · see citing works

Antiviral Protein APOBEC3G Localizes to Ribonucleoprotein Complexes Found in P Bodies and Stress Granules

Gallois‐Montbrun, S., Kramer, B., Swanson, C. M., Byers, H. L., Lynham, S., Ward, M. A., & Malim, M. H. (2006) · Journal of Virology · doi:10.1128/jvi.02287-06 · Cited by 276 · see citing works

Human Immunodeficiency Virus Type 1 cDNAs Produced in the Presence of APOBEC3G Exhibit Defects in Plus-Strand DNA Transfer and Integration

Mbisa, J. L., Barr, R., Thomas, J. A., Vandegraaff, N., Dorweiler, I. J., Svarovskaia, E. S., Brown, W. L., Mansky, L. M., Gorelick, R. J., Harris, R. S., et al. (2007) · Journal of Virology · doi:10.1128/jvi.00272-07 · Cited by 273 · see citing works

Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories

Peter Simmonds, K. (2020) · mSphere · doi:10.1128/msphere.00408-20 · Cited by 271 · see citing works

C-Terminal Deletion of AID Uncouples Class Switch Recombination from Somatic Hypermutation and Gene Conversion

Barreto, V. M., Reina‐San‐Martin, B., Ramiro, A. R., McBride, K. M., & Nussenzweig, M. C. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00309-5 · Cited by 270 · see citing works

APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells

Bogerd, H. P. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj416 · Cited by 270 · see citing works

Human Apolipoprotein B mRNA-editing Enzyme-catalytic Polypeptide-like 3G (APOBEC3G) Is Incorporated into HIV-1 Virions through Interactions with Viral and Nonviral RNAs

Svarovskaia, E. S., Xu, H., Mbisa, J. L., Barr, R., Gorelick, R. J., Ono, A., Freed, E. O., Hu, W.-S., & Pathak, V. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405761200 · Cited by 267 · see citing works

Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication

Abram, M. E., Ferris, A. L., Shao, W., Alvord, W. G., & Hughes, S. H. (2010) · Journal of Virology · doi:10.1128/jvi.00915-10 · Cited by 264 · see citing works

Intrinsic host restrictions to HIV-1 and mechanisms of viral escape

Simon, V. R., Bloch, N., & Landau, N. R. (2015) · Nature Immunology · doi:10.1038/ni.3156 · Cited by 260 · see citing works

Going Wild: Lessons from Naturally Occurring T-Lymphotropic Lentiviruses

VandeWoude, S., & Apetrei, C. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00009-06 · Cited by 260 · see citing works

The Developmental Control of Transposable Elements and the Evolution of Higher Species

Friedli, M., & Trono, D. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125514 · Cited by 258 · see citing works

The Evolution of Endogenous Viral Elements

Holmes, E. C. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.09.002 · Cited by 255 · see citing works

Identification of APOBEC3DE as Another Antiretroviral Factor from the Human APOBEC Family

Dang, Y., Wang, X., Esselman, W. J., & Zheng, Y. (2006) · Journal of Virology · doi:10.1128/jvi.01123-06 · Cited by 255 · see citing works

Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination

Pecori, R., Giorgio, S. D., Lorenzo, J. P., & Papavasiliou, F. N. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00459-8 · Cited by 254 · see citing works

Interferon‐inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication†

Bonvin, M., Achermann, F., Greeve, I., Stroka, D., Keogh, A., Inderbitzin, D., Candinas, D., Sommer, P., Wain–Hobson, S., Vartanian, J., et al. (2006) · Hepatology · doi:10.1002/hep.21187 · Cited by 252 · see citing works

High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition

Chiu, Y., Witkowska, H. E., Hall, S. C., Santiago, M. L., Soros, V. B., Esnault, C., Heidmann, T., & Greene, W. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604524103 · Cited by 244 · see citing works

Human Tripartite Motif 5α Domains Responsible for Retrovirus Restriction Activity and Specificity

Pérez-Caballero, D., Hatziioannou, T., Yang, A., Cowan, S., & Bieniasz, P. D. (2005) · Journal of Virology · doi:10.1128/jvi.79.14.8969-8978.2005 · Cited by 244 · see citing works

The Interaction between HIV-1 Gag and APOBEC3G

Cen, S., Guo, F., Niu, M., Saadatmand, J., Deflassieux, J., & Kleiman, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402062200 · Cited by 242 · see citing works

APOBEC3G Is Incorporated into Virus-like Particles by a Direct Interaction with HIV-1 Gag Nucleocapsid Protein

Alce, T. M., & Popik, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400235200 · Cited by 239 · see citing works

A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion

氏家, 和., 石丸, 健., Barr, R., Zhang, Y., Khan, M. A., Strebel, K., & Pathak, V. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400830101 · Cited by 238 · see citing works

A Single Amino Acid Determinant Governs the Species-specific Sensitivity of APOBEC3G to Vif Action

Mangeat, B., Turelli, P., Liao, S., & Trono, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400060200 · Cited by 237 · see citing works

Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif

Doehle, B., Schäfer, A., & Cullen, B. R. (2005) · Virology · doi:10.1016/j.virol.2005.06.005 · Cited by 227 · see citing works

Cytidine Deaminases APOBEC3G and APOBEC3F Interact with Human Immunodeficiency Virus Type 1 Integrase and Inhibit Proviral DNA Formation

Luo, K., Wang, T., Liu, B., Tian, C., Xiao, Z., Kappes, J. C., & Yu, X.-F. (2007) · Journal of Virology · doi:10.1128/jvi.02584-06 · Cited by 224 · see citing works

Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor

Schäfer, A., Bogerd, H. P., & Cullen, B. R. (2004) · Virology · doi:10.1016/j.virol.2004.08.006 · Cited by 223 · see citing works

Highly Active Antiretroviral Therapy: Current State of the Art, New Agents and Their Pharmacological Interactions Useful for Improving Therapeutic Outcome

Bárbaro, G., Scozzafava, A., Mastrolorenzo, A., & Supuran, C. T. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053764869 · Cited by 222 · see citing works

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

Chen, K., Harjes, E., Gross, P. J., Fahmy, A., Lu, Y., Shindo, K., Harris, R. S., & Matsuo, H. (2008) · Nature · doi:10.1038/nature06638 · Cited by 218 · see citing works

BROAD ANTIRETROVIRAL DEFENSE BY HUMAN APOBEC3G THROUGH LETHAL EDITING OF NASCENT REVERSE TRANSCRIPTS

Church, J. A. (2004) · PEDIATRICS · doi:10.1542/peds.114.s1.552a

Death and the retrovirus

Vartanian, J., Sommer, P., & Wain–Hobson, S. (2003) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2003.08.008 · Cited by 36 · see citing works

The Role of the APOBEC3 Family of Cytidine Deaminases in Innate Immunity, G-to-A Hypermutation, and Evolution of Retroviruses

Santiago, M. L., & Greene, W. C. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374153-0.00008-4 · Cited by 11 · see citing works

Cytidine Deamination of Retroviral DNA by Diverse APOBEC Proteins

Bishop, K. N., Holmes, R. K., Sheehy, A. M., Davidson, N. O., Cho, S., & Malim, M. H. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.057 · Cited by 613 · see citing works

[Advances in the study of molecular mechanism of APOBEC3G anti-HIV-1].

Fan, B., Cen, S., & Jiang, J.-D. (2008) · PubMed