Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, Hannah, McCabe, Nuala, Lord, Christopher J., Tutt, Andrew N. J., Johnson, Damian A., Richardson, Tobias B., Santarosa, Manuela, Dillon, Krystyna J. +6 more·2005·Nature
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- Emerging cancer therapeutic opportunities target DNA-repair systemsJian Ding, Ze‐Hong Miao, Linghua Meng, Meiyu Geng · 2006 · Trends in Pharmacological Sciences
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- “Contextual” Synthetic Lethality and/or Loss of Heterozygosity: Tumor Hypoxia and Modification of DNA RepairNorman Hok Ling Chan, Robert Glen Bristow · 2010 · Clinical Cancer Research
- Hereditary Breast Cancer: Clinical, Pathological and Molecular CharacteristicsMartin Jakob Larsen, Mads Thomassen, Anne‐Marie Gerdes, Torben Arvid Kruse · 2014 · Breast Cancer Basic and Clinical Research
- Update on PARP Inhibitors in Breast CancerAlexandra S. Zimmer, Mitchell Gillard, Stanley Lipkowitz, Jung‐Min Lee · 2018 · Current Treatment Options in Oncology