The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683 · see citing works

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198 · see citing works

PARP inhibitors: Synthetic lethality in the clinic

Lord, C. J., & Ashworth, A. (2017) · Science · doi:10.1126/science.aam7344 · Cited by 2,932 · see citing works

fitdistrplus : An R Package for Fitting Distributions

Delignette‐Muller, M. L., & Dutang, C. (2015) · Journal of Statistical Software · doi:10.18637/jss.v064.i04 · Cited by 2,391 · see citing works

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., et al. (2016) · Nature · doi:10.1038/nature17676 · Cited by 2,218 · see citing works

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671 · see citing works

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Hart, T., Chandrashekhar, M., Aregger, M., Steinhart, Z., Brown, K. R., MacLeod, G., Mis, M., Zimmermann, M., Fradet-Turcotte, A., Sun, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.015 · Cited by 1,571 · see citing works

BRCA1 and BRCA2: different roles in a common pathway of genome protection

Roy, R., Chun, J., & Powell, S. N. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3181 · Cited by 1,479 · see citing works

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

Behan, F. M., Iorio, F., Picco, G., Gonçalves, E., Beaver, C. M., Migliardi, G., Santos, R., Rao, Y., Sassi, F., Pinnelli, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1103-9 · Cited by 1,338 · see citing works

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

Bouwman, P., Aly, A., Escandell, J. M., Pieterse, M., Bartkova, J., van der Gulden, H., Hiddingh, S., Thanasoula, M., Kulkarni, A., Yang, Q., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1831 · Cited by 1,001 · see citing works

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

Moynahan, M. E., & Jasin, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2851 · Cited by 923 · see citing works

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

Ceccaldi, R., Liu, J., Amunugama, R., Hajdú, I., Primack, B., Petalcorin, M. I. R., O’Connor, K. W., Konstantinopoulos, P. A., Elledge, S. J., Boulton, S. J., et al. (2015) · Nature · doi:10.1038/nature14184 · Cited by 908 · see citing works

A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules

Banaszynski, L. A., Chen, L.-C., Maynard-Smith, L. A., Ooi, A. G. L., & Wandless, T. J. (2006) · Cell · doi:10.1016/j.cell.2006.07.025 · Cited by 902 · see citing works

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

Mateos‐Gómez, P. A., Gong, F., Nair, N., Miller, K. M., Denchi, E. L., & Sfeir, A. J. (2015) · Nature · doi:10.1038/nature14157 · Cited by 758 · see citing works

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

Shanbhag, N. M., Rafalska-Metcalf, I. U., Balane-Bolivar, C., Janicki, S. M., & Greenberg, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.04.038 · Cited by 737 · see citing works

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.

Hakem, R., de la Pompa, J. L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81302-1 · Cited by 680 · see citing works

CIP2A inhibits PP2A in human malignancies

Junttila, M. R., Puustinen, P., Niemelä, M., Ahola, R., Arnold, H., Böttzauw, T., Ala-aho, R., Nielsen, C., Ivaska, J., Taya, Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.044 · Cited by 677 · see citing works

The shieldin complex mediates 53BP1-dependent DNA repair

Noordermeer, S. M., Adam, S., Setiaputra, D., Barazas, M., Pettitt, S. J., Ling, A. K., Olivieri, M., Álvarez-Quilón, A., Moatti, N., Zimmermann, M., et al. (2018) · Nature · doi:10.1038/s41586-018-0340-7 · Cited by 651 · see citing works

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

Hart, T., Tong, A. H. Y., Chan, K., Van Leeuwen, J., Seetharaman, A., Aregger, M., Chandrashekhar, M., Hustedt, N., Seth, S., Noonan, A., et al. (2017) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.117.041277 · Cited by 599 · see citing works

A Genetic Map of the Response to DNA Damage in Human Cells

Olivieri, M., Cho, T., Álvarez-Quilón, A., Li, K., Schellenberg, M. J., Zimmermann, M., Hustedt, N., Rossi, S. E., Adam, S., Melo, H., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.040 · Cited by 551 · see citing works

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.Preprint

Ludwig, T. E., Chapman, D. L., Papaioannou, V. E., & Efstratiadis, A. (1997) · Genes & Development · doi:10.1101/gad.11.10.1226 · Cited by 539 · see citing works

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

Gowen, L. C., Johnson, B. L., Latour, A. M., Sulik, K. K., & Koller, B. H. (1996) · Nature Genetics · doi:10.1038/ng0296-191 · Cited by 480 · see citing works

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

Zimmermann, M., Murina, O., Reijns, M. A. M., Agathanggelou, A., Challis, R. C., Tarnauskaitė, Ž., Muir, M., Fluteau, A., Aregger, M., McEwan, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0291-z · Cited by 405 · see citing works

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

Bhowmick, R., Minocherhomji, S., & Hickson, I. D. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.037 · Cited by 379 · see citing works

Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell LinesPreprint

Dempster, J. M., Rossen, J., Kazachkova, M., Pan, J., Kugener, G., Root, D., & Tsherniak, A. (2019) · bioRxiv · doi:10.1101/720243 · Cited by 348 · see citing works

BRCA1 Mutation Analysis of 41 Human Breast Cancer Cell Lines Reveals Three New Deleterious Mutants

Elstrodt, F., Hollestelle, A., Nagel, J. H. A., Gorin, M. A., Wasielewski, M., van den Ouweland, A., Merajver, S. D., Ethier, S. P., & Schutte, M. E. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2853 · Cited by 306 · see citing works

BAGEL: a computational framework for identifying essential genes from pooled library screens

Hart, T., & Moffat, J. (2016) · BMC Bioinformatics · doi:10.1186/s12859-016-1015-8 · Cited by 285 · see citing works

Molecular mechanisms of sister-chromatid exchange

Wilson, D. M., & Thompson, L. H. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.11.017 · Cited by 278 · see citing works

Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation

Hakem, R., de la Pompa, J. L., Elia, A., Potter, J., & Mak, T. W. (1997) · Nature Genetics · doi:10.1038/ng0797-298 · Cited by 252 · see citing works

Segmentation and quantification of subcellular structures in fluorescence microscopy images using Squassh

Rizk, A., Paul, G., Incardona, P., Bugarski, M., Mansouri, M., Niemann, A., Ziegler, U., Berger, P., & Sbalzarini, I. F. (2014) · Nature Protocols · doi:10.1038/nprot.2014.037 · Cited by 228 · see citing works

Synthetic Lethality in Cancer Therapeutics: The Next Generation

Setton, J. S., Zinda, M. J., Riaz, N., Durocher, D., Zimmermann, M., Koehler, M. T., Reis-Filho, J. S., & Powell, S. N. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1503 · Cited by 207 · see citing works

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

Mengwasser, K. E., Adeyemi, R. O., Leng, Y., Choi, M. Y., Clairmont, C. S., D’Andrea, A. D., & Elledge, S. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.12.008 · Cited by 198 · see citing works

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination

Becker, J. R., Clifford, G., Bonnet, C., Groth, A., Wilson, M. D., & Chapman, J. R. (2021) · Nature · doi:10.1038/s41586-021-03776-w · Cited by 175 · see citing works

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination

Feng, W., & Jasin, M. (2017) · Nature Communications · doi:10.1038/s41467-017-00634-0 · Cited by 155 · see citing works

Cancerous Inhibitor of Protein Phosphatase 2A, an Emerging Human Oncoprotein and a Potential Cancer Therapy Target

Khanna, A., Pimanda, J. E., & Westermarck, J. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1994 · Cited by 154 · see citing works

ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells

Verma, P., Zhou, Y., Cao, Z., Deraska, P. V., Deb, M., Arai, E., Li, W., Shao, Y., Puentes, L. N., Li, Y. H., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-020-00624-3 · Cited by 144 · see citing works

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis

Leimbacher, P.-A., Jones, S. E., Shorrocks, A.-M. K., Zompit, M. D. M., Day, M. W., Blaauwendraad, J., Bundschuh, D., Bonham, S., Fischer, R., Fink, D. A., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.014 · Cited by 136 · see citing works

Improved analysis of CRISPR fitness screens and reduced off-target effects with the BAGEL2 gene essentiality classifier

Kim, E., & Hart, T. (2021) · Genome Medicine · doi:10.1186/s13073-020-00809-3 · Cited by 135 · see citing works

Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease

Álvarez-Quilón, A., Wojtaszek, J. L., Mathieu, M., Patel, T., Appel, C. D., Hustedt, N., Rossi, S. E., Wallace, B. D., Setiaputra, D., Adam, S., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.021 · Cited by 117 · see citing works

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

van der Weegen, Y., de Lint, K., van den Heuvel, D., Nakazawa, Y., Mevissen, T. E. T., van Schie, J. J. M., San Martin Alonso, M., Boer, D. E. C., González-Prieto, R., Narayanan, I. V., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00688-9 · Cited by 114 · see citing works

Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer

Liu, Z., Ma, L., Wen, Z., Hu, Z., Wu, F., Li, W., Liu, J., & Zhou, G. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt395 · Cited by 105 · see citing works

A consensus set of genetic vulnerabilities to ATR inhibition

Hustedt, N., Álvarez-Quilón, A., McEwan, A., Yuan, J. Y., Cho, T., Koob, L., Hart, T., & Durocher, D. (2019) · Open Biology · doi:10.1098/rsob.190156 · Cited by 104 · see citing works

Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56

Wang, J., Okkeri, J., Pavic, K., Wang, Z., Kauko, O., Halonen, T., Sarek, G., Ojala, P. M., Rao, Z., Xu, W., et al. (2017) · The EMBO Reports · doi:10.15252/embr.201642788 · Cited by 95 · see citing works

The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks

Blessing, C., Mandemaker, I. K., Gonzalez-Leal, C., Preißer, J., Schomburg, A., & Ladurner, A. G. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.10.009 · Cited by 88 · see citing works

How Cells Respond to DNA Breaks in Mitosis

Blackford, A. N., & Stucki, M. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2019.12.010 · Cited by 82 · see citing works

TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution

Broderick, R., Nieminuszczy, J., Blackford, A. N., Winczura, A., & Niedźwiedź, W. (2015) · Nature Communications · doi:10.1038/ncomms7572 · Cited by 80 · see citing works

CIP2A Modulates Cell-Cycle Progression in Human Cancer Cells by Regulating the Stability and Activity of Plk1

Kim, J., Kim, E. J., Oh, J. S., Park, I., & Hwang, S. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0888 · Cited by 79 · see citing works

Pathways for maintenance of telomeres and common fragile sites during DNA replication stress

Özer, Ö., & Hickson, I. D. (2018) · Open Biology · doi:10.1098/rsob.180018 · Cited by 77 · see citing works

Erlotinib derivative inhibits hepatocellular carcinoma by targeting CIP2A to reactivate protein phosphatase 2A

Yu, H.-C., Hung, M.-H., Chen, Y.-L., Chu, P.-Y., Wang, C. Y., Chao, T.-T., Liu, C.-Y., Shiau, C.-W., & Chen, K.-F. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.325 · Cited by 63 · see citing works

Clinical use and mechanisms of resistance for PARP inhibitors in homologous recombination-deficient cancers

Janysek, D. C., Kim, J. S., Duijf, P. H. G., & Dray, E. V. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101012 · Cited by 62 · see citing works

CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice

Ventelä, S., Côme, C., Mäkelä, J.-A., Hobbs, R. M., Mannermaa, L., Kallajoki, M., Chan, E. K., Pandolfi, P. P., Toppari, J., & Westermarck, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033209 · Cited by 58 · see citing works

CIP2A interacts with TopBP1 and is selectively essential for DNA damage-induced basal-like breast cancer tumorigenesis

Laine, A., Nagelli, S. G., Farrington, C., Butt, U., Cvrljevic, A. N., Vainonen, J. P., Feringa, F. M., Grönroos, T. J., Gautam, P., Khan, S., et al. (2020) · doi:10.1101/2020.08.27.269902 · Cited by 54 · see citing works

Dealing with DNA lesions: When one cell cycle is not enough

Lezaja, A., & Altmeyer, M. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2020.11.001 · Cited by 39 · see citing works

Functions of TopBP1 in preserving genome integrity during mitosis

Bagge, J., Oestergaard, V. H., & Lisby, M. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.08.009 · Cited by 38 · see citing works

Genome-scale chemogenomic CRISPR screens in human cells using the TKOv3 library

Olivieri, M., & Durocher, D. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100321 · Cited by 38 · see citing works

Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) Protein Is Involved in Centrosome Separation through the Regulation of NIMA (Never In Mitosis Gene A)-related Kinase 2 (NEK2) Protein Activity

Jeong, A. L., Lee, S., Park, J. S., Han, S., Jang, C., Lim, J., Lee, M. S., & Yang, Y. D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.507954 · Cited by 34 · see citing works

Human TopBP1 localization to the mitotic centrosome mediates mitotic progression

Bang, S. W., Ko, M. J., Kang, S., Kim, G. S., Kang, D., Lee, J., & Hwang, D. S. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.01.022 · Cited by 27 · see citing works

A consensus set of genetic vulnerabilities to ATR inhibitionPreprint

Hustedt, N., Álvarez-Quilón, A., McEwan, A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/574533 · Cited by 16 · see citing works

ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cellsPreprint

Verma, P., Zhou, Y., Cao, Z., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.16.422851 · Cited by 14 · see citing works

The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosisPreprint

Zompit, M. D. M., Mooser, C., Adam, S., Rossi, S. E., Jeanrenaud, A., Leimbacher, P.-A., Fink, D. A., Durocher, D., & Stucki, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.08.430274 · Cited by 12 · see citing works

MolBioLib: a C++11 framework for rapid development and deployment of bioinformatics tasks

Ohsumi, T. K., & Borowsky, M. L. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts458 · Cited by 9 · see citing works

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylationPreprint

van der Weegen, Y., de Lint, K., van den Heuvel, D., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.25.432427 · Cited by 6 · see citing works

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

Cong, K., Peng, M., Kousholt, A. N., Lee, W. T. C., Lee, S., Nayak, S. U., Krais, J. J., VanderVere-Carozza, P. S., Pawelczak, K. S., Calvo, J. A., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.06.011 · Cited by 348 · see citing works

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition

Gallo, D., Young, J. T. F., Fourtounis, J., Martino, G., Álvarez-Quilón, A., Bernier, C., Duffy, N. M., Papp, R., Roulston, A., Stocco, R., et al. (2022) · Nature · doi:10.1038/s41586-022-04638-9 · Cited by 246 · see citing works

DNA repair defects in cancer and therapeutic opportunitiesPreprint

Hopkins, J. L., Lan, L., & Zou, L. (2022) · Genes & Development · doi:10.1101/gad.349431.122 · Cited by 204 · see citing works

RHINO directs MMEJ to repair DNA breaks in mitosis

Brambati, A., Sacco, O., Porcella, S. Y., Heyza, J. R., Kareh, M., Schmidt, J. C., & Sfeir, A. J. (2023) · Science · doi:10.1126/science.adh3694 · Cited by 143 · see citing works

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

Gelot, C., Kovacs, M. T., Miron, S. M., Mylne, E., Haan, A., Boeffard-Dosierre, L., Ghouil, R., Popova, T. G., Dingli, F., Loew, D., et al. (2023) · Nature · doi:10.1038/s41586-023-06506-6 · Cited by 138 · see citing works

CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer

Tsujino, T., Takai, T., Hinohara, K., Gui, F., Tsutsumi, T., Bai, X. F., Miao, C., Feng, C., Gui, B., Sztupinszki, Z. M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-35880-y · Cited by 130 · see citing works

Exploiting replication gaps for cancer therapy

Cong, K., & Cantor, S. B. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.04.023 · Cited by 104 · see citing works

Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions

Schmid, E. W., & Walter, J. C. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.01.034 · Cited by 120 · see citing works

Mitotic clustering of pulverized chromosomes from micronuclei

Lin, Y.-F., Hu, Q., Mazzagatti, A., Valle-Inclán, J. E., Maurais, E. G., Dahiya, R., Guyer, A., Sanders, J. T., Engel, J. L., Nguyen, G., et al. (2023) · Nature · doi:10.1038/s41586-023-05974-0 · Cited by 81 · see citing works

Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens

Awwad, S. W., Serrano-Benítez, A., Thomas, J. C., Gupta, V., & Jackson, S. P. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00571-x · Cited by 87 · see citing works

Mitotic tethering enables inheritance of shattered micronuclear chromosomes

Trivedi, P., Steele, C. D., Au, F. K. C., Alexandrov, L. B., & Cleveland, D. W. (2023) · Nature · doi:10.1038/s41586-023-06216-z · Cited by 73 · see citing works

Boveri and beyond: Chromothripsis and genomic instability from mitotic errors

Mazzagatti, A., Engel, J. L., & Ly, P. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.11.002 · Cited by 76 · see citing works

Synthetic lethal strategies for the development of cancer therapeutics

Ngoi, N. Y. L., Gallo, D., Torrado, C., Nardo, M., Durocher, D., & Yap, T. A. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00966-z · Cited by 78 · see citing works

The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis

Zompit, M. D. M., Esteban, M. T., Mooser, C., Adam, S., Rossi, S. E., Jeanrenaud, A., Leimbacher, P.-A., Fink, D. A., Shorrocks, A.-M. K., Blackford, A. N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31865-5 · Cited by 66 · see citing works

DNA repair as a shared hallmark in cancer and ageing

Clarke, T. L., & Mostoslavsky, R. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13285 · Cited by 68 · see citing works

Comprehensive interrogation of synthetic lethality in the DNA damage response

Fielden, J., Siegner, S. M., Gallagher, D. N., Schröder, M., Stritto, M. R. D., Lam, S., Kobel, L., Schlapansky, M. F., Jackson, S. P., Ćejka, P., et al. (2025) · Nature · doi:10.1038/s41586-025-08815-4 · Cited by 66 · see citing works

Shaping the BRCAness mutational landscape by alternative double-strand break repair, replication stress and mitotic aberrancies

Stok, C., Kok, Y. P., van den Tempel, N., & van Vugt, M. A. T. M. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab151 · Cited by 61 · see citing works

Guiding ATR and PARP inhibitor combinations with chemogenomic screens

Zimmermann, M., Bernier, C., Kaiser, B., Fournier, S., Li, L., Desjardins, J., Skeldon, A. M., Rimkunas, V. M., Veloso, A., Young, J. T. F., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111081 · Cited by 60 · see citing works

The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining

Fleury, H., MacEachern, M. K., Stiefel, C. M., Anand, R., Sempeck, C., Nebenfuehr, B., Maurer-Alcalá, K., Ball, K., Proctor, B., Belan, O., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.03.017 · Cited by 52 · see citing works

Microhomology-Mediated End-Joining Chronicles: Tracing the Evolutionary Footprints of Genome Protection

Sfeir, A., Tijsterman, M., & McVey, M. (2024) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111822-014426 · Cited by 53 · see citing works

EXO1 protects BRCA1-deficient cells against toxic DNA lesions

van de Kooij, B., Schreuder, A., Pavani, R., Garzero, V., Uruci, S., Wendel, T. J., van Hoeck, A., Alonso, M. S. M., Everts, M., Koerse, D., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2023.12.039 · Cited by 46 · see citing works

CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer

Liang, L.-J., Yang, F., Wang, D., Zhang, Y., Yu, H., Wang, Z., Sun, B., Liu, Y., Wang, G., & Zhou, G. (2024) · Cell Discovery · doi:10.1038/s41421-023-00633-0 · Cited by 46 · see citing works

Mechanisms of genome stability maintenance during cell division

Zompit, M. D. M., & Stucki, M. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103215 · Cited by 42 · see citing works

Perturbomics: CRISPR–Cas screening-based functional genomics approach for drug target discovery

Park, B.-S., Lee, M., Kim, J. Y., & Kim, T. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01487-0 · Cited by 41 · see citing works

Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

Pavic, K., Gupta, N., Omella, J. D., Derua, R., Aakula, A., Huhtaniemi, R., Määttä, J. A., Höfflin, N., Okkeri, J., Wang, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36693-9 · Cited by 36 · see citing works

Perspectives on cancer therapy—synthetic lethal precision medicine strategies, molecular mechanisms, therapeutic targets and current technical challenges

Peng, S., Long, M., Chen, Q.-S., Yin, Z., Zeng, C., Zhang, W., Wen, Q., Zhang, X., Ke, W., & Wu, Y. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02418-8 · Cited by 33 · see citing works

Targeting DNA damage response pathways in tumor drug resistance: Mechanisms, clinical implications, and future directions

Zhu, H., Tian, Y., Chen, H., Qian, Y., Li, J., Niu, D., Zhao, W., Wu, Y., Zhang, X., Tang, T., et al. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101287 · Cited by 30 · see citing works

A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levels and activates the DNA damage response

Prabhakar, A. T., James, C. D., Youssef, A. H., Hossain, R. A., Hill, R. D., Bristol, M. L., Wang, X., Dubey, A., Karimi, E., & Morgan, I. M. (2024) · mBio · doi:10.1128/mbio.00676-24 · Cited by 27 · see citing works

(Single-stranded DNA) gaps in understanding BRCAness

Schreuder, A., Wendel, T. J., Dorresteijn, C. G. V., & Noordermeer, S. M. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.04.013 · Cited by 25 · see citing works

Multiple functions of PARP1 in the repair of DNA double strand breaks

Ortega, R., Bitler, B. G., & Arnoult, N. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103873 · Cited by 27 · see citing works

A comprehensive review on targeted therapies for triple negative breast cancer: an evidence-based treatment guideline

Emara, H. M., Allam, N. K., & Youness, R. A. (2025) · Discover Oncology · doi:10.1007/s12672-025-02227-6 · Cited by 25 · see citing works

Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A–MDC1–TOPBP1 complex from spindle pole to chromosomes

Leem, J., Kim, J., & Oh, J. S. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad213 · Cited by 25 · see citing works

Profound synthetic lethality between SMARCAL1 and FANCM

Feng, S., Liu, K., Shang, J., Hoeg, L., Pastore, G., Yang, W. E., Roy, S., Sastre-Moreno, G., Young, J. T. F., Wu, W., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.10.016 · Cited by 24 · see citing works

FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

Cong, K., MacGilvary, N. J., Lee, S., MacLeod, S. G., Calvo, J. A., Peng, M., Kousholt, A. N., Day, T. A., & Cantor, S. B. (2024) · Nature Communications · doi:10.1038/s41467-024-46824-5 · Cited by 23 · see citing works

Synthetic lethality in cancer drug discovery: challenges and opportunities

Gonçalves, E., Ryan, C. J., & Adams, D. J. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01273-7 · Cited by 24 · see citing works

CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response

Nagelli, S. G., & Westermarck, J. K. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.09.001 · Cited by 22 · see citing works

A small-molecule inhibitor of TopBP1 exerts anti-MYC activity and synergy with PARP inhibitors

Lin, F., Liu, K., Garan, L. A. W., Folly-Kossi, H., Song, Y., Lin, S., & Lin, W.-C. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2307793120 · Cited by 21 · see citing works

POLQ to the rescue for double-strand break repair during mitosis

van Vugt, M. A. T. M., & Tijsterman, M. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01168-4 · Cited by 21 · see citing works

Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma

Machour, F. E., Abu‐Zhayia, E. R., Kamar, J., Barisaac, A. S., Simon, I., & Ayoub, N. (2024) · Nature Communications · doi:10.1038/s41467-024-50882-0 · Cited by 20 · see citing works

Processing DNA lesions during mitosis to prevent genomic instability

Audrey, A., de Haan, L., van Vugt, M. A. T. M., & de Boer, H. R. (2022) · Biochemical Society Transactions · doi:10.1042/bst20220049 · Cited by 19 · see citing works

BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution

Tsukada, K., Jones, S. E., Bannister, J. V., Durin, M.-A., Vendrell, I., Fawkes, M., Fischer, R., Kessler, B. M., Chapman, J. R., & Blackford, A. N. (2024) · Molecular Cell · doi:10.1016/j.molcel.2023.12.040 · Cited by 18 · see citing works

The transcriptomic architecture of common cancers reflects synthetic lethal interactions

Haider, S. A., Brough, R., Madera, S., Iacovacci, J., Gulati, A., Wicks, A. J., Alexander, J. J., Pettitt, S. J., Tutt, A. N. J., & Lord, C. J. (2025) · Nature Genetics · doi:10.1038/s41588-025-02108-2 · Cited by 17 · see citing works

The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ

Martin, P. R., Nieminuszczy, J., Kozik, Z., Jakub, N., Kowalski, S., Lecot, M., Vorhauser, J., Lane, K. A., Κανέλλου, Α., Mansfeld, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65594-2 · Cited by 17 · see citing works

Sideroflexin-1 promotes progression and sensitivity to lapatinib in triple-negative breast cancer by inhibiting TOLLIP-mediated autophagic degradation of CIP2A

Andriani, L., Ling, Y.-X., Yang, S., Zhao, Q., Ma, X.-Y., Huang, M.-Y., Zhang, Y., Zhang, F.-L., Li, D., & Shao, Z. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217008 · Cited by 16 · see citing works

Recent insights into the causes and consequences of chromosome mis-segregation

Devillers, R., dos Santos, A., Destombes, Q., Laplante, M., & Elowe, S. (2024) · Oncogene · doi:10.1038/s41388-024-03163-5 · Cited by 15 · see citing works

Cyclin F–EXO1 axis controls cell cycle–dependent execution of double-strand break repair

Yang, H., Fouad, S., Smith, P., Bae, E. Y., Ji, Y., Lan, X., Ess, A. V., Buffa, F. M., Fischer, R., Vendrell, I., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado0636 · Cited by 15 · see citing works

Chromothripsis: an emerging crossroad from aberrant mitosis to therapeutic opportunities

Ejaz, U., Dou, Z., Yao, P. Y., Wang, Z., Liu, X., & Yao, X. (2024) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjae016 · Cited by 12 · see citing works

Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers

Moser, S. C., & Jonkers, J. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-1326 · Cited by 12 · see citing works

Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells

Martino, J., Siri, S. O., Calzetta, N. L., Paviolo, N. S., Garro, C., Pansa, M. F., Carbajosa, S., Brown, A. C., Bocco, J. L., Gloger, I., et al. (2023) · eLife · doi:10.7554/elife.80254 · Cited by 12 · see citing works

CIP2A mediates mitotic recruitment of SLX4/MUS81/XPF to resolve replication stress-induced DNA lesions

de Haan, L., Dijt, S. J., García-López, A., Ruan, D., Martzios, P., Bakker, F. J., Everts, M., Warner, H. M., Mol, F. N., Chapman, J. R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66549-3 · Cited by 11 · see citing works

From Basic Science to Clinical Practice: The Role of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A)/p90 in Cancer

Chen, B., Hu, H., & Chen, X. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1110656 · Cited by 11 · see citing works

TopBP1 coordinates DNA repair synthesis in mitosis via recruitment of the nuclease scaffold SLX4

Bagge, J., Petersen, K. V., Karakus, S. N., Nielsen, T. M., Rask, J., Brøgger, C. R., Jensen, J., Skouteri, M., Carr, A. M., Hendriks, I. A., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08442-9 · Cited by 11 · see citing works

NFATC2IP is a mediator of SUMO-dependent genome integrityPreprint

Cho, T., Hoeg, L., Setiaputra, D., & Durocher, D. (2024) · Genes & Development · doi:10.1101/gad.350914.123 · Cited by 11 · see citing works

Two decades of PARP inhibitor synthetic lethality in cancer

Lord, C. J., Tutt, A. N. J., & Ashworth, A. (2026) · Nature · doi:10.1038/s41586-026-10404-y · Cited by 10 · see citing works

Unpaved roads: How the DNA damage response navigates endogenous genotoxins

Thada, V., & Greenberg, R. A. (2022) · DNA repair · doi:10.1016/j.dnarep.2022.103383 · Cited by 13 · see citing works

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

Ingham, A., Vega, I. A., Morlot, L., Gittens, W. H., Hendriks, I. A., Kakulidis, E. S., Freire, R., Davey, N. E., Duxin, J. P., Nielsen, M. L., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.04.006 · Cited by 10 · see citing works

Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency

Guantay, L., Garro, C., Siri, S. O., Pansa, M. F., Ghidelli, S., Paviolo, N. S., Racca, A. C., Nicotra, V. E., Radu, C. G., Bocco, J. L., et al. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100932 · Cited by 10 · see citing works

RHINO restricts MMEJ activity to mitosisPreprint

Brambati, A., Sacco, O., Porcella, S. Y., Heyza, J. R., Kareh, M., Schmidt, J. C., & Sfeir, A. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.16.532763 · Cited by 10 · see citing works

Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines

Dodson, A. E., Shenker, S., Sullivan, P., Nayak, S. U., Middleton, C., McGuire, M. S., Chipumuro, E., Mishina, Y., Tobin, E. R., Cadzow, L., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0316 · Cited by 9 · see citing works

The mitotic CIP2A-TOPBP1 axis facilitates mitotic pathway choice between MiDAS and MMEJPreprint

Martin, P. R., Nieminuszczy, J., Kozik, Z., Jakub, N., Lecot, M., Vorhauser, J., Lane, K. A., Κανέλλου, Α., Mansfeld, J., Pearl, L. H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.12.621593 · Cited by 8 · see citing works

Emerging roles of the CIP2A–TopBP1 complex in genome integrity

Ummethum, H., Li, J., Lisby, M., & Oestergaard, V. H. (2023) · NAR Cancer · doi:10.1093/narcan/zcad052 · Cited by 7 · see citing works

PP2A inhibition causes synthetic lethality in BRCA2-mutated prostate cancer models via spindle assembly checkpoint reactivation

Wang, J., Chen, Y., Li, S., Liu, W., Zhou, X. A., Luo, Y., Xu, Z., Xiong, Y., Cheng, K., Ruan, M., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci172137 · Cited by 8 · see citing works

The reckoning of chromosomal instability: past, present, future

Lynch, A., Bradford, S., & Burkard, M. E. (2024) · Chromosome Research · doi:10.1007/s10577-024-09746-y · Cited by 5 · see citing works

Tools for Decoding Ubiquitin Signaling in DNA Repair

Foster, B., Attwood, M., & Gibbs‐Seymour, I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.760226 · Cited by 5 · see citing works

Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR ‐based screens

Wilson, J., & Loizou, J. I. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13272 · Cited by 6 · see citing works

A comprehensive review of current therapeutic strategies in cancers targeting DNA damage response mechanisms in head and neck squamous cell cancer

Kono, T., & Ozawa, H. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189255 · Cited by 5 · see citing works

Disruption of microhomology-mediated end joining in Ewing sarcoma

Asada, S., Zhu, G., Abeykoon, J. P., Tanaka, Y., Nguyen, H., Hirohashi, Y., Iyer, D., Ashton, N. W., Mukkavalli, S., Velazquez, M., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.06.038 · Cited by 5 · see citing works

Broken chromosomes heading into mitosis: More than one way to patch a flat tire

Messer, C. L., & Fox, D. T. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202401085 · Cited by 5 · see citing works

A mutational scar-based genome-wide map of DNA double-strand break repair

Barazas, M., van Schendel, R., & Tijsterman, M. (2026) · Nature Communications · doi:10.1038/s41467-026-72744-7 · Cited by 8 · see citing works

TTF2 processes sites of incomplete DNA replication during mitosis via sister-chromatid exchanges.

Fujisawa, R., & Labib, K. P. M. (2026) · Science · doi:10.1126/science.aeh2300 · Cited by 2 · see citing works

Novel BRCA1–PLK1–CIP2A axis orchestrates homologous recombination-mediated DNA repair to maintain chromosome integrity during oocyte meiosis

Lee, C., & Oh, J. S. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1207 · Cited by 4 · see citing works

The impact of TOPBP1 mutations in human cancers on the DNA damage response

Yan, Z., Ge, X., Wang, J., Xu, F., Li, M., Liu, X., Yu, X., & Wu, C. (2022) · Genome Instability & Disease · doi:10.1007/s42764-022-00072-3 · Cited by 4 · see citing works

A mitotic glue for shattered chromosomes

Xue, Y., & Durocher, D. (2023) · Nature · doi:10.1038/d41586-023-01890-5 · Cited by 4 · see citing works

CIP2A and TOPBP1: Molecular lassos that herd pulverized micronuclear chromosomes

Vedula, C. P., & Ganem, N. J. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.05.032 · Cited by 3 · see citing works

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cellsPreprint

van de Kooij, B., Schreuder, A., Pavani, R., Garzero, V., van Hoeck, A., Alonso, M. S. M., Koerse, D., Wendel, T. J., Callen, E., Boom, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.24.529205 · Cited by 4 · see citing works

CIP2A is required for mitotic recruitment of the SLX1/XPF/MUS81 tri-nuclease complex to replication stress-induced DNA lesions to maintain genome integrityPreprint

de Haan, L., Dijt, S. J., López, A. G., Ruan, D., Bakker, F. J., Everts, M., Warner, H. M., Mol, F. N., de Boer, H. R., Veld, P. J. H. I. ’., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.03.647079 · Cited by 4 · see citing works

Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation

Nebenfuehr, B., Sanford, L., Taylor, E. R., Ball, K. A., Woods-Killam, C. E., Ghasemi, H. I., Proctor, B., Ortega, R., Sempeck, C., Dowell, R. D., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116850 · Cited by 3 · see citing works

CIP2A recruits SLX4-MUS81-XPF in mitosis and protects against replication stress

Meroni, A., Pellizzari, A., Varisco, N., Leone, F., Greco, G., Hänel, A., Brasier-Lutz, P., Witzel, I., Sartori, A. A., & Stucki, M. (2026) · EMBO Reports · doi:10.1038/s44319-026-00807-3 · Cited by 3 · see citing works

DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development

Tsukada, K., Lototska, L., 塚田, 絢., Sarusie, M. V., Gönenç, I. I., Sherlaw‐Sturrock, C., Kanade, M., Palek, M., Oliver, A. W., Jones, S. E., et al. (2026) · Cell · doi:10.1016/j.cell.2026.07.041 · Cited by 5 · see citing works

A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levelsPreprint

Prabhakar, A. T., James, C. D., Youssef, A. H., Hossain, R. A., Hill, R. D., Bristol, M. L., Wang, X., Dubey, A., & Morgan, I. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.15.575713 · Cited by 3 · see citing works

Mutational signature catalogue (MUSIC) of DNA double-strand break repairPreprint

Barazas, M., van Schendel, R., & Tijsterman, M. (2025) · bioRxiv · doi:10.1101/2025.04.29.650617 · Cited by 3 · see citing works

E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cycles

Prabhakar, A. T., James, C. D., Nguyen, A., Bridy, P. V., Wang, X., Zoldork, R. J., Roe, J. D., Witt, A. J., Panidepu, S. S., Giri, S., et al. (2026) · Cell Reports · doi:10.1101/2025.10.15.682653 · Cited by 3 · see citing works

Synthetic lethality in cancer: a protocol for scoping review of gene interactions from synthetic lethal screens and functional studies

Chauhan, R., Damerla, R. R., & Dhyani, V. S. (2025) · Systematic Reviews · doi:10.1186/s13643-025-02814-2 · Cited by 2 · see citing works

Mitotic single-stranded DNA suppression by DDIAS.

Xue, Y., Rashed, F. B., Mao, D. Y. L., Abe, K., Lin, Z.-Y., Krastev, D., Setiaputra, D., Hoeg, L., Bonnet, C., Kumar, A., et al. (2026) · Molecules and Cells · doi:10.1016/j.molcel.2026.07.034 · Cited by 1 · see citing works

Context-dependent synthetic lethality — an emerging precision therapeutic approach

Chang, L., Shaw, K. L., Vázquez, F., & Sellers, W. R. (2026) · Nature reviews. Cancer · doi:10.1038/s41568-026-00929-9 · Cited by 4 · see citing works

Advances in Synthetic Lethality in Potential Oncology Therapeutic Approaches

Yang, F., Wang, H., Fan, S., Qiu, H., Li, X., Shi, G., Li, Z., Luan, X., & Wu, H. (2025) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266349547241231051447 · Cited by 2 · see citing works

EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers

Maric, M., Segura-Bayona, S., Kuthethur, R., Takaki, T., Borel, V., Stanage, T. H., Ivanov, M. P., Parnandi, N., Hewitt, G., Millar, R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63349-7 · Cited by 2 · see citing works

Mutational and Functional Heterogeneity of Homology-Directed Repair Deficiency and Clinical ImplicationsPreprint

Zhao, S. J., Koh, C. C., Brough, R., Krastev, D. B., Tripathi, V., Song, F., Choi, S. S. A., Black, D., Boushaki, S., Badja, C., et al. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6946704 · Cited by 3 · see citing works

Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer

Túrós, D., Decollogny, M., Moyseos, A., Chanfon, A., Siffert, M., Bousmar, J., Romanens, L., Tille, J., Trédan, O., Labidi‐Galy, S. I., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-74125-6 · Cited by 1 · see citing works

A PP2A-mtATR-tBid axis links DNA damage-induced CIP2A degradation to apoptotic dormancy and therapeutic resistance in PDAC

Luo, Y., Biswas, H., Makinwa, Y., Liu, S., Dong, Z., Liu, J., Zhang, J., & Zou, Y. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217790 · Cited by 1 · see citing works

Targeting MAT2A synergistically induces DNA damage in osteosarcoma cells through EZH2-mediated H3K27me3 modification

Yang, B., Wang, H., Tao, Y., Yang, X., Mu, H., Liu, Y., Jiang, Y., Wang, Z., Zhang, R., Cai, Z., et al. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.09.007 · Cited by 1 · see citing works

Biomimetic PD-1 macrophage nanoplatform for Cip2a silencing and immune activation in oral squamous cell carcinoma

Zhang, C. L., Yuan, Z., Zhou, J., Yan, H., Liu, Z., Zhang, X., Zhang, Y., Zhang, S., Zhu, L., Wang, D., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04469-0 · Cited by 1 · see citing works

CIP2A–TOPBP1 complex and PP2A dynamically regulate Polθ recruitment and phosphorylation at mitotic DNA double-strand breaks

Zhao, X., Chen, B., Xu, F., Zhang, J., Yao, Z., Wang, R., Zhang, J., Zhou, S., Hou, Y., Xu, S., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2600248123 · Cited by 1 · see citing works

The BRCA1 coiled-coil domain is dispensable for suppression of tandem duplications and tolerance of FANCM loss

Nilavar, N. M., Marín-González, A., Menghi, F., Nguyen, D., Willis, N. A., Wientjens, E., Xia, B., Jonkers, J., Liu, E. T., & Scully, R. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00913-x · Cited by 1 · see citing works

DDIAS shields vulnerable single-stranded DNA to direct neurogenesis and protect cancer cells

Venkitaraman, A. R. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.08.026 · Cited by 1 · see citing works

Targeting BRCA-mutated tumors in mitosis

Menolfi, D., & Zha, S. (2021) · Nature Cancer · doi:10.1038/s43018-021-00293-7 · Cited by 1 · see citing works

A conserved PLK1 docking site in TopBP1 maintains genome integrity during mitosisPreprint

Li, J., Bagge, J., Lisby, M., Nilsson, J., & Oestergaard, V. H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.30.486397 · Cited by 1 · see citing works

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosisPreprint

Tsukada, K., Lototska, L., Tsukada, A., Gönenç, I. I., Sherlaw-Sturrock, C. A., Kanade, M., Oliver, A. W., Jones, S. E., Jhujh, S. S., Bannister, J., et al. (2026) · bioRxiv · doi:10.1101/2025.09.09.675193 · Cited by 2 · see citing works

CIP2A Mediates the Recruitment of the SLX4-MUS81-XPF Tri-Nuclease Complex in Mitosis and Protects Against Replication StressPreprint

Meroni, A., Pellizzari, A., Hänel, A., Varisco, N., Brasier-Lutz, P., Witzel, I., Sartori, A. A., & Stucki, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.19.677284 · Cited by 1 · see citing works

Defective BRCA1-mediated DNA end resection drives tandem duplication formation and FANCM synthetic lethalityPreprint

Nilavar, N. M., Marín-González, A., Menghi, F., Nguyen, D., Willis, N. A., Wientjens, E., Xia, B., Jonkers, J., Liu, E. T., & Scully, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.20.706968 · Cited by 1 · see citing works

CIP2A is a prime synthetic-lethal target for BRCA-mutated cancersPreprint

Adam, S., Rossi, S. E., Moatti, N., Zompit, M. D. M., Ng, T. F., Álvarez-Quilón, A., Desjardins, J., Bhaskaran, V., Martino, G., Setiaputra, D., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.08.430060 · Cited by 17 · see citing works

Targeting BRCA-mutated tumors in mitosis

Menolfi, D., & Zha, S. (2021) · Nature Cancer · doi:10.1038/s43018-021-00293-7 · Cited by 1 · see citing works

Emerging roles of the CIP2A–TopBP1 complex in genome integrity

Ummethum, H., Li, J., Lisby, M., & Oestergaard, V. H. (2023) · NAR Cancer · doi:10.1093/narcan/zcad052 · Cited by 7 · see citing works

CRISPR/Cas9 Dropout Screen Identifies MEPCE as a Novel Vulnerability in BRCA1-mutated Cancers

Algouneh, A. (2020) · TSpace (University of Toronto)

Abstract PO3-24-06: Integrative genomic and CRISPR screen analysis identifies synthetic viability interactions in BRCA1/2 cancers

Zhu, Y., Pei, X., Novaj, A., Setton, J. S., Derakhshan, F. N., Selenica, P., McDermott, N., Sinha, S., Khan, A. J., Powell, S. N., et al. (2024) · Cancer Research · doi:10.1158/1538-7445.sabcs23-po3-24-06