The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
Open accessAbstract
The proto-oncoprotein c-Jun is a component of the AP-1 transcription factor, the activity of which is augmented in many tumour types. An important mechanism in the stimulation of AP-1 function is amino-terminal phosphorylation of c-Jun by the c-Jun N-terminal kinases (JNKs). Phosphorylated c-Jun is biologically more active, partially because it acquires the ability to interact with binding partners. Here we show that phosphorylated c-Jun interacts with the HMG-box transcription factor TCF4 to form a ternary complex containing c-Jun, TCF4 and β-catenin. Chromatin immunoprecipitation assays revealed JNK-dependent c-Jun–TCF4 interaction on the c-jun promoter, and c-Jun and TCF4 cooperatively activated the c-jun promoter in reporter assays in a β-catenin-dependent manner. In the ApcMin mouse model of intestinal cancer, genetic abrogation of c-Jun N-terminal phosphorylation or gut-specific conditional c-jun inactivation reduced tumour number and size and prolonged lifespan. Therefore, the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/β-catenin, two distinct pathways activated by WNT signalling.
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Cites
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β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
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Tissue‐specific and inducible Cre‐mediated recombination in the gut epithelium
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Self-citation
Cited by
The JNK signal transduction pathway
Weston, C. R., & Davis, R. J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.001 · Cited by 1,021
JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut
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β4 Integrin Amplifies ErbB2 Signaling to Promote Mammary Tumorigenesis
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Loss of Cell Polarity Drives Tumor Growth and Invasion through JNK Activation in Drosophila
Igaki, T., Pagliarini, R. A., & Xu, T. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.042 · Cited by 370
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Metadata
- Authors
- Nateri, A. S., Spencer-Dene, B., & Behrens, A.
- Venue
- Nature
- Published
- 2005-07-10
- Volume
- 437
- Issue
- 7056
- Pages
- 281-285
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2017937615
- Cited by
- 375
- References
- 24
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- green
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