A Second Canon
Open accessAbstract
More is becoming known about so-called noncanonical Wnt pathways that signal independently of beta-catenin. Here we review recent developments in both the functions and mechanisms of noncanonical Wnt signaling. We also discuss some unresolved and vexing questions. How many noncanonical Wnt pathways are there? How extensive are the parallels between Drosophila planar polarization and vertebrate convergence and extension? Last, we will outline some challenges and difficulties we foresee for this exciting but still very young field.
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The non-canonical Wnt pathway regulates both cell polarity and movements of dorsal mesodermal cells during convergent extension and later during neural tube closure.
“The non-canonical Wnt pathway was shown to regulate both cell polarity and movements of dorsal mesodermal cells during convergent extension and later during neural tube closure.64”
From Wnt signal transduction pathways (2008) · cites this paper as [64]
The answer to whether a specific Wnt ligand may selectively activate one particular branch of signaling remains unresolved since some Wnt ligands can activate both canonical and non-canonical pathways.
“However, the answer to this question remains unresolved since some Wnt ligands can activate both canonical and non-canonical pathways.7,64,113”
From Wnt signal transduction pathways (2008) · cites this paper as [64]
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- Authors
- Veeman, M. T., Axelrod, J. D., & Moon, R. T.
- Affiliations
- Howard Hughes Medical Institute (US)
- Stanford Medicine (US)
- Corresponding author
- Moon, Randall T
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 5
- Issue
- 3
- Pages
- 367-377
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2015974087
- Cited by
- 1,359
- References
- 93
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 33 · 2023: 29 · 2022: 37 · 2021: 46 · 2020: 36 · 2019: 28 · 2018: 44 · 2017: 52 · 2016: 39 · 2015: 45 · 2014: 69 · 2013: 72 · 2012: 70
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3607 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Defense Advanced Research Projects Agency
- Natural Sciences and Engineering Research Council of Canada
- National Institutes of Health
- American Cancer Society
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Keywords
- non-canonical Wnt signaling, Wnt signaling, β-catenin-independent signaling, planar cell polarity, Drosophila, convergence and extension, vertebrate development, cell polarity
- MeSH terms
- Animals, Calcium, Cytoskeletal Proteins, Drosophila, Proto-Oncogene Proteins, Signal Transduction, Trans-Activators, Gene Expression Regulation, Developmental, Insect Proteins, Mitogen-Activated Protein Kinases, Zebrafish Proteins, Wnt Proteins, beta Catenin
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