Cited by 1,359Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationHippo pathway signaling and YAP/TAZ

A Second Canon

Open access
Veeman, Michael T, Axelrod, Jeffrey D, Moon, Randall T·2003·Developmental Cell

Abstract

More is becoming known about so-called noncanonical Wnt pathways that signal independently of beta-catenin. Here we review recent developments in both the functions and mechanisms of noncanonical Wnt signaling. We also discuss some unresolved and vexing questions. How many noncanonical Wnt pathways are there? How extensive are the parallels between Drosophila planar polarization and vertebrate convergence and extension? Last, we will outline some challenges and difficulties we foresee for this exciting but still very young field.

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Crossref · 10.1016/s1534-5807(03)00266-1

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93 of 93 references verified0 citation errors · 0 not checkable

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  • The non-canonical Wnt pathway regulates both cell polarity and movements of dorsal mesodermal cells during convergent extension and later during neural tube closure.

    “The non-canonical Wnt pathway was shown to regulate both cell polarity and movements of dorsal mesodermal cells during convergent extension and later during neural tube closure.64”

    From Wnt signal transduction pathways (2008) · cites this paper as [64]

  • The answer to whether a specific Wnt ligand may selectively activate one particular branch of signaling remains unresolved since some Wnt ligands can activate both canonical and non-canonical pathways.

    “However, the answer to this question remains unresolved since some Wnt ligands can activate both canonical and non-canonical pathways.7,64,113”

    From Wnt signal transduction pathways (2008) · cites this paper as [64]

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Authors
Veeman, M. T., Axelrod, J. D., & Moon, R. T.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Stanford Medicine (US)
Corresponding author
Moon, Randall T
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2003-09
Volume
5
Issue
3
Pages
367-377
ISSN
1534-5807 (ISSN-L)
OpenAlex
W2015974087
Cited by
1,359
References
93
Citations by year
2026: 9 · 2025: 15 · 2024: 33 · 2023: 29 · 2022: 37 · 2021: 46 · 2020: 36 · 2019: 28 · 2018: 44 · 2017: 52 · 2016: 39 · 2015: 45 · 2014: 69 · 2013: 72 · 2012: 70
FWCI
7.34
Type
journal article
Language
en
Open access
Locations
  • Developmental Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Defense Advanced Research Projects Agency
  • Natural Sciences and Engineering Research Council of Canada
  • National Institutes of Health
  • American Cancer Society
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords
non-canonical Wnt signaling, Wnt signaling, β-catenin-independent signaling, planar cell polarity, Drosophila, convergence and extension, vertebrate development, cell polarity
MeSH terms
Animals, Calcium, Cytoskeletal Proteins, Drosophila, Proto-Oncogene Proteins, Signal Transduction, Trans-Activators, Gene Expression Regulation, Developmental, Insect Proteins, Mitogen-Activated Protein Kinases, Zebrafish Proteins, Wnt Proteins, beta Catenin

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