Pharmaco-metabonomic phenotyping and personalized drug treatment

Andrew Clayton, T., Lindon, John C., Cloarec, Olivier, Antti, Henrik, Charuel, Claude, Hanton, Gilles, Provost, Jean-Pierre, Le Net, Jean-Loïc +4 more·2006·Nature

Cited by (747)

Items 601–700 of 747

  1. Pharmacometabolomics in Endogenous Drugs: A New Approach for Predicting the Individualized Pharmacokinetics of Cholic Acid.
    Zhi-Xin Zhang, Hao Gu, Hui-Zhen Zhao, Yue-Hong Liu, Shuang Fu, Mei-Ling Wang, Wenjuan Zhou, Zi-Ye Xie, Honghong Yu, Zhenghai Huang et al. · 2017 · Journal of Proteome Research
  2. Predose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in Rats
    Xiao-Yan Lu, Bin Hu, Jie Zheng, C. Ji, Xiaohui Fan, Yue Gao · 2015 · PLoS ONE
  3. Gut Microbiota-targeted, Whole-Body Systems Biology for Understanding Traditional Chinese Medicine
    Xu Zhang, Yufeng Zhao, Yiyang Hu, Ping Liu, Zhao Liping · 2011 · World Science and Technology
  4. [Hepatic tissue engineering].
    H. Fiegel, U. Kneser, D. Kluth, U. Rolle · 2010 · Handchirurgie, Mikrochirurgie, Plastische Chirurgie
  5. La genómica y la proteómica en la investigación de la insuficiencia cardiaca
    Arantxa González, Begoña López, Javier Beaumont, S. Ravassa, T. Arias, N. Hermida, Amaia Zudaire, J. Díez · 2009
  6. New Aquaculture Technology Based on Host-Symbiotic Co-metabolism
    Miyuki Mekuchi, Taiga Asakura, Jun Kikuchi · 2019 · Springer eBooks
  7. Metabonomics: a developing platform for better understanding Chinese herbal teas as a complementary therapy
    Rong You, Yan-Qing Guan, Lin Li · 2017
  8. Metabotyping
    Lorraine Brennan · 2014 · Elsevier eBooks
  9. Genetics Meets Metabolomics
    K. Suhre · 2012 · Springer: New York
  10. The -Omics in Drug Development
    M. Moridani, R. P. Araújo, Caroline H. Johnson, J. Lindon · 2011
  11. Metabolomic Evaluation of N-Acetyl-p-Benzoquinone Imine Protein Adduct Formation with Therapeutic Acetaminophen Administration: Sex-based Physiologic Differences
    C. Arnold, Layne Dylla, Andrew A. Monte, K. Heard, S. Heard, Angelo D'Alessandro, K. Reynolds, R. Dart, B. Rumack, Brandon J Sonn · 2022 · Journal of Medical Toxicology
  12. Characterization of Marker Compounds in Curcuma zanthorrhiza Using NMR
    A. Saputra, Y. Rinanto, J. Ariyanto, C. D. Sari, Q. Binti · 2020 · IOP Conference Series: Earth and Environment
  13. Integration analysis of metabolites and single nucleotide polymorphisms improves the prediction of drug response of celecoxib
    Xiaoqing Xing, Peng-Cheng Ma, Qing Huang, Xie-Min Qi, B. Zou, Jun Wei, Lei Tao, Ling-Jun Li, Guo-Hua Zhou, Qin-Xin Song · 2020 · Metabolomics
  14. Trends in Metabolomics Research:A Scientometric Analysis (1992–2017)
    Shanshan Guo, Jin Tian, Bin Zhu, Shu Yang, Kefu Yu, Zhi-Gang Zhao · 2018 · Current Science
  15. Role of Gut Microbiome in the Modulation of Environmental Toxicants and Therapeutic Agents
    Ashfaque Hossain, Godfred Antony Menezes, Mohammad Al, Ibraheem Ashankyty · 2016 · CRC Press eBooks
  16. NMR-based Pharmacometabonomics: A New Approach to Personalized Medicine
    Jeremy Ramsey Everett · 2015 · Wiley eBooks
  17. Can Pharmacometabolomics and LC-HRMS develop a new Concept for Therapeutic Drug Monitoring?
    O. Beck · 2015
  18. Metabonomics in Understanding Drug Metabolism and Toxicology
    Bo Wen · 2012 · Encyclopedia of Drug Metabolism and Interactions
  19. Multiple sclerosis: pharmacogenomics and personalised drug treatment
    V. Annibali, G. Ristori, S. Cannoni, S. Romano, A. Visconti, A. Ghazaryan, L. Talamanca, M. Salvetti, R. Mechelli · 2006 · Neurological Sciences
  20. Study of metabolites dynamic variation during vine tea (Ampelopsis grossedentata) processing by untargeted metabolomics
    Qianqian Li, Chaoyang Zhang, Huawei Wang, Shengfan Chen, Lijun Wu, Yi Li, Jianxun Li · 2024 · Industrial Crops and Products
  21. Enhancement of acetaminophen-induced chronic hepatotoxicity in spontaneously diabetic torii (SDT) rats
    Kazuma Kondo, Naohito Yamada, Yusuke Suzuki, Tatsuji Hashimoto, Kaoru Toyoda, Tadakazu Takahashi, Akio Kobayashi, Shoichiro Sugai, Kouichi Yoshinari · 2020 · The Journal of Toxicological Sciences
  22. Hepatic Tissue Engineering
    Jing Shan, Kelly R. Stevens, Kartik Trehan, Gregory H. Underhill, Alice A. Chen, Sangeeta N. Bhatia · 2010 · Molecular pathology library
  23. Pan-metabolomics and its applications
    Li Bao, Xiaofeng Liu · 2020 · Elsevier eBooks
  24. Metabolomics
    G. A. Nagana Gowda, Leiddy Z. Alvarado, Daniel Raftery · 2017 · Elsevier eBooks
  25. Pharmacometabonomics and Predictive Metabonomics
    Jeremy Ramsey Everett, John C. Lindon, Jeremy Kirk Nicholson · 2016 · Elsevier eBooks
  26. Nuclear Magnetic Resonance Spectroscopy in Nanomedicine
    Ping-Chang Lin · 2015 · Progress in optical science and photonics
  27. Using metabolomics to analyse the role of gut microbiota in nutrition and disease
    Guoxiang Xie, Wei Ping Jia · 2014 · Elsevier eBooks
  28. Exhaled breath condensate: metabolomics
    S. Carraro, G. Giordano, M. Stocchero, E. Baraldi · 2010
  29. Translational Medicine: Application of Omics for Drug Target Discovery and Validation
    Xuewu Zhang, Wei Wang, Kai-Jun Xiao, Lei Shi · 2010
  30. Surface-Enhanced Raman Spectroscopy: A Game Changer for Metabolomics Research.
    Xin-Yuan Bi, Xing-Yi Ling, Jian Ye · 2026 · Nano letters (Print)
  31. Plant Metabolome Between Root and Aerial Parts of Cichorium intybus L. and Anti-Hyperuricemia Mechanisms Based on Cell Metabolomics
    Jing-Bo Wang, Shi Shen, Qi Zhao, Xin Shen, Qin Zhuo · 2025 · Metabolites
  32. Serum metabolic profiling analysis of chronic gastritis and gastric cancer by untargeted metabolomics
    Hadiya Afzal, Ayesha F. Shaukat, Muhammad Zain Ul Haq, Nawal Khaliq, Maha Zahid, Laiba Shakeel, Muhammad Abdul Wasay Zuberi, Aymar Akilimali · 2024 · Annals of Medicine and Surgery
  33. Evaluating the nutritional value of functional molecules for food processing using tissue and organoid models
    Andrew C.A. Wan · 2024 · Trends in Food Science & Technology
  34. Biochemical Mechanisms in Drug Metabolism: Implications for Personalized Pharmacotherapy in Pharmacy Practice
    Ali Hofan Hassan Alshamrani, Hanan Muntaha Hassan Al-Moashi, M. Alqunfdi, Ibrahim Ali Alhaqwe, Asaad Hamdan Alruwaili, Bdreh Hamdan Alenezi, Mutlaq Master Almutiry, Abdullah Aqili, Mona Abdullah ALDwsari, Ahed Mohammed Algarfan et al. · 2024 · Egyptian Journal of Chemistry
  35. Pharmacometabolomics-Based Translational Biomarkers: How to Navigate the Data Ocean
    Vivi Bafiti, Θεοδώρα Κάτσιλα · 2022 · OMICS A Journal of Integrative Biology
  36. METABOLOMICS ANALYSIS OF LIPID METABOLIZING ENZYME ACTIVITY
    Timothy B. Ware, Myungsun Shin, Ku-Lung Hsu · 2019 · Methods in Enzymology
  37. Applications of Metabolic Phenotyping in Pharmaceutical Research and Development
    Jeremy Ramsey Everett · 2018 · Elsevier eBooks
  38. Cross fitted partial least squares (CF‐PLS): an alternative algorithm for a more reliable PLS
    O. Cloarec · 2011
  39. The Promise of Individualized Therapy
    Michael Oettel · 2010 · Pharmaceutical Sciences Encyclopedia
  40. NMR Spectroscopy of Biofluids, Tissues, and Tissue Extracts
    J. Lindon, E. Holmes · 2008
  41. Construction et utilisation d'une base de connaissances pharmacogénomique pour l'intégration de données et la découverte de connaissances. (Construction and use of a pharmacogenomic knowledge base for data integration and knowledge discovery)
    Adrien Coulet · 2008
  42. The Ratio of Specific Polychlorinated Biphenyls as a Surrogate Biomarker of Cytochrome P4501A2 Activity—A Pharmaco-Metabonomic Study in Humans
    Xi-Biao Ye, E. Fitzgerald, Marta I. Gomez, G. Lambert, M. Longnecker · 2008 · Cancer Epidemiology, Biomarkers and Prevention
  43. Métabonomique et cartographie génétique
    Dominique Gauguier, M. Dumas · 2007
  44. Metabolomics and Other “-Omic” Approaches to Characterize Perioperative Trajectories
    Mihai V. Podgoreanu · 2020 · Springer eBooks
  45. NMR Analysis of Molecular Complexity
    Jun Kikuchi · 2017 · Springer eBooks
  46. NMR-based Metabolic Phenotyping Techniques and Applications
    J. Lindon · 2017
  47. Origin of Chinmedomics
    Xi-Jun Wang, A. Zhang, Hui Sun, Guang-Li Yan · 2015
  48. The Role of Integrated Omics in Elucidating the Gut Microbiota Health Potentials
    Wanping Aw, Shinji Fukuda · 2015 · Microbiology monographs
  49. Chapter 2.1.2 – “Omics” Technologies: Promises and Benefits for Molecular Medicine
    D. Pereira, João C. Fernandes, P. Valentão, P. Andrade · 2015 · Elsevier eBooks
  50. Toxicogenomics – A Drug Development Perspective
    Yuping Wang, Jürgen T. Borlak, Weida Tong · 2013 · Elsevier eBooks
  51. The Application of Toxicogenomics to the Interpretation of Toxicologic Pathology
    W. Foster, D. Robertson, B. Car · 2013 · Elsevier eBooks
  52. Emerging Concepts and Strategies for Genomics and Breeding
    Akshay Talukdar, Pranab Talukdar · 2013 · Springer eBooks
  53. Research Methods for Clinical Trials in Personalized Medicine: A Systematic Review
    Zheng Ren, Marie Davidian, Stephen L. George, Richard M. Goldberg, Fred A. Wright, Anastasios A. Tsiatis, Michael R. Kosorok · 2014 · WORLD SCIENTIFIC eBooks
  54. Characterisation of the immuno-metabolic interface in porcine models of nutritional intervention
    C. Merrifield · 2011
  55. Systemic elevation of gut derived p-cresol during one year in space: implications for brain, heart, bone, liver and microbiome in astronauts
    Michael A. Schmidt, Caleb M. Schmidt, Julian C. Schmidt, Cem Meydan, Evan E. Afshin, Eliah G. Overbey, JangKeun Kim, Ruth Subhash Singh, Afshin Beheshti, Christopher E. Mason · 2026 · Frontiers in Physiology
  56. Expanding the Therapeutic Window in Oncology: Modern Strategies and Future Directions
    Shital Dange, Mohammed Musharraf Ali, Mamatha Gavisiddaiah, Jaffer Sadik Mohamed, Nasreen Sulthana, Roja Pathakota, Chandrika Balija · 2026 · Cancer Biotherapy and Radiopharmaceuticals
  57. Implantable electrochemical sensors for continuous blood monitoring
    Kuangyi Zou, Yuanzhen Wang, Haidong Wang, Y Zhang · 2026 · FlexMat.
  58. Predicting and monitoring treatment response via 1-H NMR metabolomics of plasma, serum, and urine
    Shashikant Kotwal, Jong-Dae Shin, Tedros Bezabeh · 2025 · Biophysical Reviews
  59. MMT-fgMDI: Metapath-driven multimodal transformer framework for predicting fine-grained metabolite-drug interactions
    Wen-Zhi Liu, Peng-Li Lu, Yun-Tian Chen · 2025 · Knowledge-Based Systems
  60. Dose, Kidney Function, and a Drug–Excipient Interaction Impair Mycophenolate Mofetil Prodrug Activation in Kidney Transplant Recipients
    Fleur B. Nijdam, Marieke A. J. Hof, Daan Kremer, Tim J. Knobbe, Gérard Hopfgartner D, Stephan J. L. Bakker, Eelko Hak, Frank Klont, TransplantLines Investigators · 2025 · European Journal of Drug Metabolism and Pharmacokinetics
  61. A HILIC‐IM‐MS‐Based Pharmacometabodynamic Study of the Effects of Orally Administered Gefitinib on the Polar Urinary Metabolic Phenotypes of C57Bl6 Mice
    Adam M. King, L. Gethings, Robert S. Plumb, Ian D. Wilson · 2025 · Journal of Separation Science
  62. Impact of Advanced Metabonomic Technologies on Surgical Interventions: A Comprehensive Review
    Ficm Ahac · 2024 · Egyptian Journal of Chemistry
  63. The Diurnal Blood Metabolome and Effects of Vitamin D Supplementation: A Randomised Crossover Trial in Postmenopausal Women
    Rasmus Espersen, Banny Silva Barbosa Correia, Lars Rejnmark, Hanne Christine Bertram · 2022 · International Journal of Molecular Sciences
  64. Independent and Interactive Effects of Genetic Background and Sex on Tissue Metabolomes of Adipose, Skeletal Muscle, and Liver in Mice
    Ann E. Wells, William T. Barrington, Stephen P. Dearth, N. Milind, G. Carter, D. Threadgill, S. Campagna, B. Voy · 2022 · Metabolites
  65. Role of Metabolomics in Personalized Medicine
    K. Jain · 2020 · Textbook of Personalized Medicine
  66. Alteration of Amino Acid Profiling Influenced by the Active Ingredients of DanHong Injection After Prescription Optimization
    Zhi-li Guo, Yan Zhu, Wen-Juan Xu, Kaitao Luo, H. Xiao, Zhong-Lin Wang · 2019 · Drug Design, Development and Therapy
  67. Metabolomics applications in disease diagnosis, treatment, and drug discovery
    H. Ghanem, Mai O. Kadry, Rehab M. Abdel-Megeed, A. Abdel-Hamid · 2019 · Egyptian Pharmaceutical Journal
  68. La métabolomique : applications médicales
    S. Ellero-Simatos, Sandrine P. Claus, H. Guillou · 2019 · Médecine des Maladies Métaboliques
  69. Pharmacometabolomics
    Constantina Chalikiopoulou, George P. Patrinos, Θεοδώρα Κάτσιλα · 2019 · Encyclopedia of Life Sciences
  70. Bioactive host–microbial metabolites in human nutrition with a focus on aromatic amino acid co‐metabolism
    François‐Pierre Martin, Martin Kussmann · 2017
  71. Maturation, pharmacogenomics and metabolomics as factors determining pharmacokinetic and pharmacodynamics profile of alpha‑agonist in pediatric intensive care unit patients
    J. Bartkowiak-Wieczorek, Justyna Mocarska, A. Bartkowska-Śniatkowska, J. Matysiak, Agnieszka Klupczyńska, Z. Kokot, P. Wiczling, E. Grześkowiak, A. Bienert · 2016
  72. “Big Data and Dynamics”—The Mathematical Toolkit Towards Personalized Medicine
    Lisa Turnhoff, Nina Kusch, Andreas Schuppert · 2017 · Springer proceedings in mathematics & statistics
  73. Cell culture methods for acute toxicology testing
    Frank A Barile · 2013 · CRC Press eBooks
  74. A new approach to characterization of insulin derived from different species using 1H-NMR coupled with multivariate analysis.
    Akiko Ohno, T. Kawanishi, H. Okuda, K. Fukuhara · 2012 · Chemical and pharmaceutical bulletin
  75. La métabolomique: un nouvel outil pour la recherche translationnelle en cancérologie
    Elodie Jobard, O. Trédan, B. Elena, B. Blaise, T. Bachelot · 2010 · ONCOLOGIE
  76. L’analyse métabolomique par spectrométrie de masse: un nouvel outil pour la biochimie clinique ?
    C. Junot · 2010
  77. Antileukemic drug effects in childhood acute lymphoblastic leukemia
    Nicolas Pottier, Meyling Hua-Chen Cheok, Leo Kager · 2008 · Expert Review of Clinical Pharmacology
  78. Mathematical Modeling In Drug DiscoveryAnd Development
    R. Miftahof, N. Akhmadeev · 2007
  79. Risk-Based and Diagnostics-Linked Personalized Medicine for Cancer
    Sudhir Srivastava, Paul Daniel Wagner · 2007 · Personalized Medicine
  80. Research Progress of Urine Biomarkers in the Diagnosis, Treatment, and Prognosis of Bladder Cancer
    Feng Jin, Muhammad Shahid, Jayoung Kim · 2021 · Advances in experimental medicine and biology
  81. Pharmacometabolomics in Drug Discovery and Development
    Cátia F. Marques, M. Matilde Marques · 2020 · Elsevier eBooks
  82. Metabolic Biomarkers of Pancreatic Cancer
    Ujjwal Mukund Mahajan, Qi Li, Beate Kamlage, Markus M. Lerch, Julia V. Mayerle · 2020 · Molecular and translational medicine
  83. Metabolic Phenotyping: History, Status, and Prospects
    J. Lindon, E. Holmes, J. Nicholson · 2019 · The Handbook of Metabolic Phenotyping
  84. 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY REVEALS SECONDARY METABOLIC VARIATIONS OF SPECIAL TEA (MONSONIA BURKEANA PLANCH. EX HARV) POPULATIONS FROM THREE SELECTED LOCATIONS IN SOUTH AFRICA
    L. Nnzeru · 2019 · Applied Ecology and Environmental Research
  85. Extracting Knowledge from MS Clinical Metabolomic Data: Processing and Analysis Strategies.
    J. Boccard, S. Rudaz · 2018 · Methods in molecular biology
  86. Emerging Applications of Metabolomics in Drug Development
    Junli Ma, Ningning Zheng, Guo-Xiang Xie, Hou-Kai Li · 2018 · Journal of Metabolomics & Systems Biology
  87. NMR Metabolic Phenotyping in Clinical Studies
    B. Jiménez, D. MacIntyre · 2017
  88. Future Visions for Clinical Metabolic Phenotyping: Prospects and Challenges
    J. Lindon, J. Nicholson, E. Holmes, A. Darzi · 2016
  89. Introduction to Metabonomics in Systems Biology Research
    François‐Pierre Martin, Sunil Kochhar · 2014 · Molecular and integrative toxicology
  90. Metabonomics in Translational Research for Personalized Medicine and Nutrition
    G. Xie, Wei Jia · 2015 · Molecular and integrative toxicology
  91. Metabolomics data analysis – processing and analysis of a dataset
    Miroslava Čuperlović‐Culf · 2013 · Elsevier eBooks
  92. Beyond Pharmacogenetics
    Roberto Canaparo · 2012 · InTech eBooks
  93. Bioinformatic and Computational Analysis for Genomic Medicine
    Atul Janardhan Butte · 2010 · Elsevier eBooks
  94. 4 – Chemical Toxicology
    H. Zeliger · 2008
  95. Individual features of the pharmacokinetics of fludarabin phosphate in the treatment of patients with chronic lymphocytic leukemia
    G. Rodionov, I. Shantyr, V. B. Vasilyuk, E. Kolobova, E. Svetkina, M. V. Faraponova, A. V. Verveda, G. Syraeva, K. Zakharov · 2021 · Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice
  96. Intermediate-half-life metabolites as systemic relay nodes in metabolic disease
    Sang-Seop Lee, Byung Soo Lee, Hwan‐Woo Park, Kyu Jae Kim, Yung Choon Yoo · 2026 · Molecular Aspects of Medicine
  97. Recent advances in metabolomics of mycobacteria and tuberculosis: From species differentiation to pharmacometabolomics and personalized therapy
    M. Ziomek, Ł. Świątek, L. Mihaylova, M. Savova, M. Georgiev, E. Sieniawska · 2026 · Journal of Pharmaceutical Analysis
  98. The gut microbiome organ
    Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu et al. · 2026 · iMeta
  99. Plasma and urinary NMR metabolic profiling of the phenylalanine-tyrosine pathway in nitisinone-treated alkaptonuria: comparison of two dosing regimens and identification of a candidate pharmacodynamic biomarker
    Daniela Grasso, Valentina Balloni, Elena Bianchi, Andrea Mazzon, Marco Bardelli, Gabriella Iacomelli, Luana Peruzzi, Bruno Frediani, Annalisa Santucci, Andrea Bernini · 2026 · Molecular Genetics and Metabolism
  100. Identifying Biomarkers for Chronic Obstructive Pulmonary Disease in the Salivary Metabolome
    D. Asandei, K. O'Shea, Rachel Paes de Araujo, Adrian Mironas, Ricardo Tavares da Costa, T. Asibey-Berko, Subhamay Ghosh, Chuan Lu, Scott O'Rourke, L. Mur et al. · 2026 · International Journal of COPD