Cited by 445DNA Repair MechanismsBacterial Genetics and BiotechnologyGenomics and Phylogenetic Studies

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Reassembly of shattered chromosomes in Deinococcus radiodurans

Zahradka, Ksenija, Slade, Dea, Bailone, Adriana, Sommer, Suzanne, Averbeck, Dietrich, Petranovic, Mirjana, Lindner, Ariel B., Radman, Miroslav·2006·Nature

DOI 10.1038/nature05160

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Abstract

Dehydration or desiccation is one of the most frequent and severe challenges to living cells. The bacterium Deinococcus radiodurans is the best known extremophile among the few organisms that can survive extremely high exposures to desiccation and ionizing radiation, which shatter its genome into hundreds of short DNA fragments. Remarkably, these fragments are readily reassembled into a functional 3.28-megabase genome. Here we describe the relevant two-stage DNA repair process, which involves a previously unknown molecular mechanism for fragment reassembly called 'extended synthesis-dependent strand annealing' (ESDSA), followed and completed by crossovers. At least two genome copies and random DNA breakage are requirements for effective ESDSA. In ESDSA, chromosomal fragments with overlapping homologies are used both as primers and as templates for massive synthesis of complementary single strands, as occurs in a single-round multiplex polymerase chain reaction. This synthesis depends on DNA polymerase I and incorporates more nucleotides than does normal replication in intact cells. Newly synthesized complementary single-stranded extensions become 'sticky ends' that anneal with high precision, joining together contiguous DNA fragments into long, linear, double-stranded intermediates. These intermediates require RecA-dependent crossovers to mature into circular chromosomes that comprise double-stranded patchworks of numerous DNA blocks synthesized before radiation, connected by DNA blocks synthesized after radiation.

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Authors: Zahradka, K., Slade, D., Bailone, A., Sommer, S., Averbeck, D., Petranovic, M., Lindner, A. B., & Radman, M.
Affiliations: Inserm (FR)
Université Paris-Sud (FR)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Radman, Miroslav
ORCID: Zahradka, Ksenija
Slade, Dea
Averbeck, Dietrich
Lindner, Ariel B.
Radman, Miroslav
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2006-09-27
Volume: 443
Issue: 7111
Pages: 569-573
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature05160
OpenAlex: W2036099589
Cited by: 444
References: 30
Citations by year: 2026: 13 · 2025: 16 · 2024: 14 · 2023: 27 · 2022: 12 · 2021: 24 · 2020: 24 · 2019: 21 · 2018: 19 · 2017: 13 · 2016: 18 · 2015: 19 · 2014: 26 · 2013: 22 · 2012: 22
FWCI: 12.85
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: Deinococcus radiodurans, radioresistance (biology), DNA repair, homologous recombination, DNA polymerase I, single-stranded DNA synthesis, genome fragmentation, desiccation tolerance, extremophiles
MeSH terms: Bromodeoxyuridine, Chromosomes, Bacterial, Desiccation, DNA Damage, DNA Polymerase I, DNA Repair, DNA Replication, DNA, Bacterial, Models, Genetic, Photolysis, Radiation Tolerance, Genome, Bacterial, Deinococcus

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Reassembly of shattered chromosomes in Deinococcus radiodurans

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