The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses
Open accessAbstract
At least five arenaviruses cause viral haemorrhagic fevers in humans. Lassa virus, an Old World arenavirus, uses the cellular receptor α-dystroglycan to infect cells. Machupo, Guanarito, Junin and Sabia viruses are New World haemorrhagic fever viruses that do not use α-dystroglycan. Here we show a specific, high-affinity association between transferrin receptor 1 (TfR1) and the entry glycoprotein (GP) of Machupo virus. Expression of human TfR1, but not human transferrin receptor 2, in hamster cell lines markedly enhanced the infection of viruses pseudotyped with the GP of Machupo, Guanarito and Junin viruses, but not with those of Lassa or lymphocytic choriomeningitis viruses. An anti-TfR1 antibody efficiently inhibited the replication of Machupo, Guanarito, Junin and Sabia viruses, but not that of Lassa virus. Iron depletion of culture medium enhanced, and iron supplementation decreased, the efficiency of infection by Junin and Machupo but not Lassa pseudoviruses. These data indicate that TfR1 is a cellular receptor for New World haemorrhagic fever arenaviruses.
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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
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Self-citationTransferrin receptor on endothelium of brain capillaries
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Self-citationHemorrhagic Fever Viruses as Biological Weapons: Medical and Public Health Management
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Arenaviruses other than Lassa virus
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Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax
Gruszczyk, J., Kanjee, U., Chan, L.-J., Menant, S., Malleret, B., Lim, N. T. Y., Schmidt, C. Q., Mok, Y.-F., Lin, K.-M., Pearson, R. D., et al. (2018) · Science · doi:10.1126/science.aan1078 · Cited by 212
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Metadata
- Authors
- Radoshitzky, S. R., Abraham, J., Spiropoulou, C. F., Kuhn, J. H., Nguyen, D., Li, W., Nagel, J., Schmidt, P. J., Nunberg, J. H., Andrews, N. C., Farzan, M., & Choe, H.
- Venue
- Nature
- Published
- 2007-02-07
- Volume
- 446
- Issue
- 7131
- Pages
- 92-96
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2130276289
- Cited by
- 438
- References
- 23
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- green
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