Melanoma biology and new targeted therapy

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.

Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650 · see citing works

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · cited 1× · see citing works

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts

Fry, D. W., Harvey, P. J., Keller, P. R., Elliott, W. L., Meade, M., Trachet, E., Albassam, M., Zheng, X., Leopold, W. R., Pryer, N. K., et al. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1427.3.11 · Cited by 1,236 · see citing works

The pathogenesis of melanoma induced by ultraviolet radiation

Gilchrest, B. A., Eller, M. S., Geller, A. C., & Yaar, M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904293401707 · Cited by 876 · see citing works

Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche

Nishimura, E. K., Granter, S. R., & Fisher, D. E. (2005) · Science · doi:10.1126/science.1099593 · Cited by 750 · see citing works

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., Gonzalez, R., Robert, C., Schadendorf, D., Hassel, J. C., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003466 · Cited by 15,155 · see citing works

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

Sosman, J. A., Kim, K. B., Schuchter, L., Gonzalez, R., Pavlick, A. C., Weber, J. S., McArthur, G. A., Hutson, T. E., Moschos, S. J., Flaherty, K. T., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1112302 · Cited by 2,156 · see citing works

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M., & Green, M. R. (2008) · Cell · doi:10.1016/j.cell.2007.12.032 · Cited by 903 · see citing works

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

Haq, R., Shoag, J., Andreu-Perez, P., Yokoyama, S., Edelman, H., Rowe, G. C., Frederick, D. T., Hurley, A. D., Nellore, A., Kung, A. L., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.003 · Cited by 818 · see citing works

Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

Junttila, M. R., Li, S., & Westermarck, J. (2008) · The FASEB Journal · doi:10.1096/fj.06-7859rev · Cited by 826 · see citing works

Lysosome-mediated processing of chromatin in senescence

Ivanov, A., Pawlikowski, J., Manoharan, I., van Tuyn, J., Nelson, D. M., Rai, T. S., Shah, P. P., Hewitt, G., Korolchuk, V. I., Passos, J. F., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201212110 · Cited by 539 · see citing works

The supramolecular structure of melanin

Watt, A. A. R., Bothma, J. P., & Meredith, P. (2009) · Soft Matter · doi:10.1039/b902507c · Cited by 308 · see citing works

Mechanisms of resistance to BRAF and MEK inhibitors and clinical update of US Food and Drug Administration-approved targeted therapy in advanced melanoma

Kakadia, S., Yarlagadda, N., Awad, R., Kundranda, M., Niu, J., Naraev, B., Mina, L., Dragovich, T., Gimbel, M., & Mahmoud, F. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s182721 · Cited by 277 · see citing works

Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy

Lee, C.-H., Wu, S.-B., Hong, C.-H., Yu, H.-S., & Wei, Y.-H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036414 · Cited by 271 · see citing works

Targeting Protein-Protein Interaction by Small Molecules

Jin, L., Wang, W., & Fang, G. (2014) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-140028 · Cited by 195 · see citing works

Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth

Schöckel, L., Glasauer, A., Basit, F., Bitschar, K., Truong, H., Erdmann, G., Algire, C., Hägebarth, A., Willems, P. H., Kopitz, C., et al. (2015) · Cancer & Metabolism · doi:10.1186/s40170-015-0138-0 · Cited by 161 · see citing works

The photoreactive free radical in eumelanin

Mostert, A. B., Rienecker, S. B., Noble, C., Hanson, G. R., & Meredith, P. (2018) · Science Advances · doi:10.1126/sciadv.aaq1293 · Cited by 124 · see citing works

Expression of vitamin D receptor decreases during progression of pigmented skin lesions

Brożyna, A. A., Jozwicki, W., Janjetovic, Z., & Slominski, A. T. (2011) · Human Pathology · doi:10.1016/j.humpath.2010.09.014 · Cited by 120 · see citing works

Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells

Vilgelm, A. E., Pawlikowski, J. S., Liu, Y., Hawkins, O. E., Davis, T. A., Smith, J., Weller, K. P., Horton, L. W., McClain, C. M., Ayers, G. D., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2405 · Cited by 115 · see citing works

Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression

Chaube, B., Malvi, P., Singh, S. V., Mohammad, N., Meena, A. S., & Bhat, M. K. (2015) · Oncotarget · doi:10.18632/oncotarget.6134 · Cited by 80 · see citing works

KCa2.3 channel-dependent hyperpolarization increases melanoma cell motility

Chantome, A., Girault, A., Potier, M., Collin, C., Vaudin, P., Pagès, J.-C., Vandier, C., & Joulin, V. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.07.021 · Cited by 78 · see citing works

Cyclooxygenase-dependent signaling is causally linked to non-melanoma skin carcinogenesis: Pharmacological, genetic, and clinical evidence

Müller-Decker, K. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9306-z · Cited by 73 · see citing works

Sex disparities in melanoma outcomes: The role of biology

Nosrati, A., & Wei, M. L. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.06.018 · Cited by 66 · see citing works

Vitamin C at high concentrations induces cytotoxicity in malignant melanoma but promotes tumor growth at low concentrations

Yang, G., Yan, Y., Ma, Y., & Yang, Y. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22654 · Cited by 54 · see citing works

An intra-patient placebo-controlled phase I trial to evaluate the safety and tolerability of intradermal IMM-101 in melanoma

Stebbing, J., Dalgleish, A., Gifford-Moore, A., Martin, A., Gleeson, C., Wilson, G., Brunet, L. R., Grange, J., & Mudan, S. (2012) · Annals of Oncology · doi:10.1093/annonc/mdr363 · Cited by 55 · see citing works

An update on the implications of cyclin D1 in melanomas

González‐Ruiz, L., González‐Moles, M. Á., González‐Ruiz, I., Ruiz‐Ávila, I., Ayén, Á., & Ramos‐García, P. (2020) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12874 · Cited by 49 · see citing works

The Dual RAF/MEK Inhibitor CH5126766/RO5126766 May Be a Potential Therapy for RAS-Mutated Tumor Cells

Wada, M., Horinaka, M., Yamazaki, T., Katoh, N., & Sakai, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113217 · Cited by 50 · see citing works

Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies

Mimeault, M., & Batra, S. K. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00885.x · Cited by 38 · see citing works

Toward wearable healthcare: a miniaturized 3d imager with coherent frequency-domain photoacoustics

Liu, S., Tang, K., Feng, X., Jin, H., Gao, F., & Zheng, Y. (2019) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2019.2940243 · Cited by 25 · see citing works

1,3-bis(3,5-dichlorophenyl) Urea Compound ‘COH-SR4’ Inhibits Proliferation and Activates Apoptosis in Melanoma

Singhal, S. S., Figarola, J., Singhal, J., Leake, K., Nagaprashantha, L., Lincoln, C., Gabriel Gugiu, B., Horne, D., Jove, R., Awasthi, S., et al. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.08.020 · Cited by 20 · see citing works

Optimization of tetrahydronaphthalene inhibitors of Raf with selectivity over hERG

Huang, S.-C., Adhikari, S., Afroze, R., Brewer, K., Calderwood, E. F., Chouitar, J., England, D. B., Fisher, C., Galvin, K. M., Gaulin, J., et al. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.01.049 · Cited by 10 · see citing works