Toward wearable healthcare: a miniaturized 3d imager with coherent frequency-domain photoacoustics
Abstract
Medical monitoring is undergoing a translation from the hospital-based system to the personalized home-based system. With the aim of wearable application of photoacoustic technique, we propose a miniaturized photoacoustic 3D imager for superficial medical imaging. By employing the compact continuous-wave laser diode based optical irradiation and an ultrathin 2D matrix array based photoacoustic detection in the coherent frequency domain, a wearable imaging probe with a size of about 80 × 25 × 24 mm3and a weight of 21 g is developed. At the backend, an FPGA controlled Howland current source drives the laser diodes to excite linear frequency modulated optical irradiation. Recorded by a portable multichannel data acquisition system, the generated photoacoustic responses are firstly compressed with the coherent frequency domain photoacoustic method and then extrapolated in the wavenumber-frequency domain for fast image reconstruction. With three-wavelength (450 nm, 638 nm, and 808 nm) laser irradiation, photoacoustic imaging can be operated multispectrally, endowing the developed imager with functional imaging capability in 3D space. With the imager worn on the human forearm, hemoglobin oxygen saturation level in superficial arm vasculature can be long-term monitored with high stability. When the imager is applied for imaging in a relatively large area (e.g., early melanoma detection in the human breast), flexible scanning in a handheld manner can be performed. This work opens the application potential of photoacoustic technique in a broad range of areas, including personalized healthcare, home health monitoring, and long-term physiologic monitoring.
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3D scanning in conjunction with 3D printing is critical in the surgical and dentistry disciplines.
“3D scanning in conjunction with 3D printing is critical in the surgical and dentistry disciplines.”
From Medical 4.0 technologies for healthcare: Features, capabilities, and applications (2022) · cites this paper as [264]
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2019 Index IEEE Transactions on Biomedical Circuits and Systems Vol. 13
(2019) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2020.2966339
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- Authors
- Liu, S., Tang, K., Feng, X., Jin, H., Gao, F., & Zheng, Y.
- Affiliations
- Nanyang Technological University (SG)
- Zhejiang University (CN)
- ShanghaiTech University (CN)
- Venue
- IEEE Transactions on Biomedical Circuits and Systems
- Published
- 2019-12
- Volume
- 13
- Issue
- 6
- Pages
- 1417-1424
- ISSN
- 1932-4545 (ISSN-L)
- 1940-9990
- OpenAlex
- W2972832939
- Cited by
- 25
- References
- 27
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 2 · 2019: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- IEEE Transactions on Biomedical Circuits and Systems (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Keywords
- 3D photoacoustic imaging, multispectral photoacoustic imaging, melanoma detection, home health monitoring, portable data acquisition
- MeSH terms
- Wearable Electronic Devices, Diagnostic Imaging, Equipment Design, Humans, Miniaturization, Phantoms, Imaging, Imaging, Three-Dimensional, Photoacoustic Techniques
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