Cited by 385Cancer-related Molecular PathwaysDevelopmental Biology and Gene RegulationUbiquitin and proteasome pathways

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

NUMB controls p53 tumour suppressor activity

Colaluca, Ivan N., Tosoni, Daniela, Nuciforo, Paolo, Senic-Matuglia, Francesca, Galimberti, Viviana, Viale, Giuseppe, Pece, Salvatore, Di Fiore, Pier Paolo·2008·Nature

DOI 10.1038/nature06412

Open this paper in CoChat — free account

Abstract

NUMB is a cell fate determinant, which, by asymmetrically partitioning at mitosis, controls cell fate choices by antagonising the activity of the plasma membrane receptor of the NOTCH family. NUMB is also an endocytic protein, and the NOTCH-NUMB counteraction has been linked to this function. There might be, however, additional functions of NUMB, as witnessed by its proposed role as a tumour suppressor in breast cancer. Here we describe a previously unknown function for human NUMB as a regulator of tumour protein p53 (also known as TP53). NUMB enters in a tricomplex with p53 and the E3 ubiquitin ligase HDM2 (also known as MDM2), thereby preventing ubiquitination and degradation of p53. This results in increased p53 protein levels and activity, and in regulation of p53-dependent phenotypes. In breast cancers there is frequent loss of NUMB expression. We show that, in primary breast tumour cells, this event causes decreased p53 levels and increased chemoresistance. In breast cancers, loss of NUMB expression causes increased activity of the receptor NOTCH. Thus, in these cancers, a single event-loss of NUMB expression-determines activation of an oncogene (NOTCH) and attenuation of the p53 tumour suppressor pathway. Biologically, this results in an aggressive tumour phenotype, as witnessed by findings that NUMB-defective breast tumours display poor prognosis. Our results uncover a previously unknown tumour suppressor circuitry.

Integrity signals

Registry

Crossref · 10.1038/nature06412

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
Lowe, S. W., Ruley, H. E., Jacks, T., & Housman, D. E. (1993) · Cell · doi:10.1016/0092-8674(93)90719-7 · Cited by 2,911
A Randomized Comparison of Sentinel-Node Biopsy with Routine Axillary Dissection in Breast Cancer
Veronesi, U., Paganelli, G., Viale, G., Luini, A., Zurrida, S., Galimberti, V. E., Intra, M., Veronesi, P., Robertson, C., Maisonneuve, P., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa012782 · Cited by 2,204
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098
Amplification of a gene encoding a p53-associated protein in human sarcomas
Oliner, J. D., Kinzler, K. W., Meltzer, P. S., George, D. L., & Vogelstein, B. (1992) · Nature · doi:10.1038/358080a0 · Cited by 1,949

Flagged first, then by citations

Show all 33 references

Sorted by citations

Items 201–300 of 382

p53 regulation by MDM2 contributes to self‐renewal and differentiation of basal stem cells in mouse and human airway epithelium
Garrido-Jiménez, S., Barrera-López, J. F., Díaz-Chamorro, S., Mateos-Quirós, C. M., Rodriguez‐Blanco, I., Márquez-Pérez, F. L., Lorenzo, M. J., Centeno, F., Román, Á., & Carvajal-González, J. M. (2021) · The FASEB Journal · doi:10.1096/fj.202100638r · Cited by 20
Numb inhibits migration and promotes proliferation of colon cancer cells via RhoA/ROCK signaling pathway repression
Yang, Y., Li, L., He, H., Shi, M., He, L., Liang, S., Qi, J., & Chen, W. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.113004 · Cited by 20
UBE2S and UBE2C confer a poor prognosis to breast cancer via downregulation of Numb
Guo, Y., Chen, X., Zhang, X., & Hu, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.992233 · Cited by 20
Notch and the p53 Clan of Transcription Factors
Roemer, K. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0899-4_17 · Cited by 20
Unconventional Functions for Clathrin, ESCRTs, and Other Endocytic Regulators in the Cytoskeleton, Cell Cycle, Nucleus, and Beyond: Links to Human DiseasePreprint
Brodsky, F. M., Sosa, R. T., Ybe, J. A., & O'Halloran, T. J. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017004 · Cited by 20
Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment
Pérez, M., García-Heredia, J. M., Felipe‐Abrio, B., Muñoz-Galván, S., Martín‐Broto, J., & Carnero, A. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00246-z · Cited by 19
Overexpression of Numb suppresses growth, migration, and invasion of human clear cell renal cell carcinoma cells
Sima, J., Bao, Z., Yu, Y., Sima, X., & Mao, Y. (2014) · Tumor Biology · doi:10.1007/s13277-014-2918-5 · Cited by 19
Adaptor Proteins Intersectin 1 and 2 Bind Similar Proline-Rich Ligands but Are Differentially Recognized by SH2 Domain-Containing Proteins
Novokhatska, O., Dergai, M., Tsyba, L., Skrypkina, I., Filonenko, V. V., Moreau, J., & Rynditch, A. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070546 · Cited by 19
Targeting of miR‐31/96/182 to the Numb gene during head and neck oncogenesis
Chou, C., Tu, H., Kao, S., Chiang, C. F., Liu, C., Chang, K., & Lin, S. (2018) · Head & Neck · doi:10.1002/hed.25063 · Cited by 19
Numb is involved in the non-random segregation of subcellular vesicles in colorectal cancer stem cells
Hwang, W., & Yang, M. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1218101 · Cited by 19
Numb Promotes Cell Proliferation and Correlates with Poor Prognosis in Hepatocellular Carcinoma
Wu, J., Shen, S., Chen, B., Nie, J., & Peng, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095849 · Cited by 18
NUMB regulates the endocytosis and activity of the anaplastic lymphoma kinase in an isoform-specific manner
Wei, R., Liu, X., Voss, C., Qin, W., Dagnino, L., Li, L., Vigny, M., & Li, S. S. ‐. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz003 · Cited by 17
NUMB does not impair growth and differentiation status of experimental gliomas
Euskirchen, P., Skaftnesmo, K.-O., Huszthy, P. C., Brekkå, N., Bjerkvig, R., Jacobs, A. H., & Miletić, H. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.09.002 · Cited by 18
p53 and Cell Fate: Sensitizing Head and Neck Cancer Stem Cells to Chemotherapy
Rodriguez-Ramirez, C., & Nor, J. E. (2018) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2018027353 · Cited by 17
Aberrant alternative splicing in cancer: Splicing events and their regulatory mechanisms (Review)
Sun, Y., & Hu, X. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5678 · Cited by 17
The Molecular and Pathophysiological Functions of Members of the LNX/PDZRN E3 Ubiquitin Ligase Family
Hong, J., Won, M., & Ro, H. (2020) · Molecules · doi:10.3390/molecules25245938 · Cited by 17
IFT20 Mediates the Transport of Cell Migration Regulators From the Trans-Golgi Network to the Plasma Membrane in Breast Cancer Cells
Yang, H., Zhang, F., Long, H., Lin, Y.-W., Liao, J., Xia, H., & Huang, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.632198 · Cited by 17
Numb exon 9 inclusion regulates Integrinβ5 surface expression and promotes breast cancer metastasis
Zhang, Y., Dho, S. E., Othman, K., Simpson, C. D., Lapierre, J., Bondoc, A., & McGlade, C. J. (2022) · Oncogene · doi:10.1038/s41388-022-02225-w · Cited by 17
The mortal strand hypothesis: Non-random chromosome inheritance and the biased segregation of damaged DNA
Charville, G. W., & Rando, T. A. (2013) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.05.006 · Cited by 19
Endocytosis, signaling and cancer, much more than meets the eye
Fiore, P. P. D. (2009) · Molecular Oncology · doi:10.1016/j.molonc.2009.06.002 · Cited by 17
Tumoricidal activities of pterostilbene depend upon destabilizing the MTA1-NuRD complex and enhancing P53 acetylation in hepatocellular carcinoma
Qian, Y.-Y., Liu, Z., Pan, D., & Li, K. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4923 · Cited by 17
From endocytosis to tumors through asymmetric cell division of stem cells
Coumailleau, F., & González‐Gaitán, M. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.03.007 · Cited by 17
Numb has distinct function in lung adenocarcinoma and squamous cell carcinoma
Kikuchi, H., Sakakibara‐Konishi, J., Furuta, M., Kikuchi, E., Kikuchi, J., Oizumi, S., Hida, Y., Kaga, K., Kinoshita, I., Dosaka‐Akita, H., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25585 · Cited by 16
A review of alcohol–pathogen interactions: New insights into combined disease pathomechanisms
Osna, N. A., New‐Aaron, M., Dagur, R. S., Thomes, P. G., Simon, L., Levitt, D. E., McTernan, P. M., Molina, P. E., Choi, H. Y., Machida, K., et al. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14777 · Cited by 16
A Regulatory Loop Composed of RAP80-HDM2-p53 Provides RAP80-enhanced p53 Degradation by HDM2 in Response to DNA Damage
Yan, J., Menéndez, D., Yang, X.-P., Resnick, M. A., & Jetten, A. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.013102 · Cited by 16
Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling
Liu, L., Lanner, F., Lendahl, U., & Das, D. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.108 · Cited by 15
Numb Protects Human Renal Tubular Epithelial Cells From Bovine Serum Albumin‐Induced Apoptosis Through Antagonizing CHOP/PERK Pathway
Ding, X., Ma, M., Teng, J., Shao, F., Wu, E., & Wang, X. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25261 · Cited by 16
Role of Numb expression and nuclear translocation in endometrial cancer
Wang, C., Cui, T., Feng, W., Li, H., & Hu, L. (2015) · Oncology Letters · doi:10.3892/ol.2015.2901 · Cited by 16
Epsins’ novel role in cancer cell invasion
Coon, B. G., DiRenzo, D. M., Konieczny, S. F., & Aguilar, R. C. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.14129 · Cited by 16
Molecular alterations in signal pathways of melanoma and new personalized treatment strategies: Targeting of Notch
Mozūraitienė, J., Bielskienė, K., Atkočius, V., & Labeikytė, D. (2015) · Medicina · doi:10.1016/j.medici.2015.06.002 · Cited by 15
Interactome Mapping Uncovers a General Role for Numb in Protein Kinase Regulation
Wei, R., Kaneko, T., Liu, X., Liu, H., Li, L., Voss, C., Liu, E. V., He, N., & Li, S. S. ‐. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000114 · Cited by 15
NUMB and NUMBL differences in gene regulation
García-Heredia, J. M., & Carnero, A. (2018) · Oncotarget · doi:10.18632/oncotarget.24186 · Cited by 15
The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells
Izumi, H., Kaneko, Y., & Nakagawara, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.570815 · Cited by 15
Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool
Filippone, M. G., Freddi, S., Zecchini, S., Restelli, S., Colaluca, I. N., Bertalot, G., Pece, S., Tosoni, D., & Fiore, P. P. D. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202112001 · Cited by 15
Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer
Chiaradonna, F., Barozzi, I., Miccolo, C., Bucci, G., Palorini, R., Fornasari, L., Botrugno, O. A., Pruneri, G., Masullo, M., Passafaro, A., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6189 · Cited by 15
Mitotic Diversity in Homeostatic Human Interfollicular Epidermis
Nöske, K., Stark, H., Nevařil, L., Berning, M., Langbein, L., Goyal, A., Diederichs, S., & Boukamp, P. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020167 · Cited by 17
Glycine Regulates Neural Stem Cell Proliferation During Development via Lnx1-Dependent Notch Signaling
Bekri, A., Liao, M., & Drapeau, P. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00044 · Cited by 15
Decreased p53 is associated with a decline in asymmetric stem cell self‐renewal in aged human epidermis
Charruyer, A., Weisenberger, T., Li, H., Khalifa, A., Schroeder, A., Belzer, A., & Ghadially, R. (2021) · Aging Cell · doi:10.1111/acel.13310 · Cited by 16
Aberrant activation of p53/p66Shc-mInsc axis increases asymmetric divisions and attenuates proliferation of aged mammary stem cells
Priami, C., Montariello, D., de Michele, G., Ruscitto, F., Polazzi, A., Ronzoni, S., Bertalot, G., Binelli, G., Gambino, V., Luzi, L., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01029-5 · Cited by 14
NUMB alternative splicing and isoform-specific functions in development and disease
Dho, S. E., Othman, K., Zhang, Y., & McGlade, C. J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108215 · Cited by 13
Notch4 Signaling Confers Susceptibility to TRAIL‐Induced Apoptosis in Breast Cancer Cells
Naik, S., MacFarlane, M., & Sarin, A. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25094 · Cited by 14
Approaches for targeting self-renewal pathways in cancer stem cells: implications for hematological treatments
Horne, G. A., & Copland, M. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1303477 · Cited by 13
The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice
Stoddart, A., Tennant, T. R., Fernald, A. A., Anastasi, J., Brodsky, F. M., & Beau, M. M. L. (2011) · Oncogene · doi:10.1038/onc.2011.251 · Cited by 14
Rewired Notch/p53 by Numb’ing Mdm2
Kim, H., & Ronai, Z. A. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201712007 · Cited by 14
Nandrolone-induced nuclear accumulation of MyoD protein is mediated by Numb, a Notch inhibitor, in C2C12 myoblasts
Liu, X.-H., Gasperi, R. D., Bauman, W. A., & Cardozo, C. P. (2018) · Physiological Reports · doi:10.14814/phy2.13520 · Cited by 14
Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis
Tucci, F. A., Pennisi, R., Rigiracciolo, D. C., Filippone, M. G., Bonfanti, R., Romeo, F., Freddi, S., Guerrera, E., Soriani, C., Rodighiero, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54246-6 · Cited by 14
Ectopic expression of Ligand-of-Numb protein X promoted TGF-β induced epithelial to mesenchymal transition of proximal tubular epithelial cells
Nie, J., Wu, Q., Liu, W., Zhu, F., Qiu, F., Zhou, Q., Fan, J., Dong, X., & Yu, X. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.11.013 · Cited by 13
Epsins' novel role in cancer cell invasion.
Coon, B. G., DiRenzo, D. M., Konieczny, S. F., & Aguilar, R. C. (2011) · Europe PMC (PubMed Central) · doi:10.4161/cib.4.1.14129 · Cited by 13
Numb and Alzheimer’s Disease: The Current Picture
Ntelios, D., Berninger, B., & Tzimagiorgis, G. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00145 · Cited by 13
Reciprocal positive regulation between TRPV6 and NUMB in PTEN-deficient prostate cancer cells
Kim, S.-Y., Hong, C., Wie, J., Kim, E., Kim, B. J., Ha, K., Cho, N., Kim, I. G., Jeon, J., & So, I. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.03.123 · Cited by 12
Cancer stem cells: Culprits in endocrine resistance and racial disparities in breast cancer outcomes
Mavingire, N., Campbell, P. S., Wooten, J. V., Aja, J., Davis, M. B., Loaiza‐Perez, A., & Brantley, E. J. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.12.014 · Cited by 12
Mutation and copy number analysis of LNX1 and Numbl in nervous system tumors
Blom, T., Roselli, A., Tanner, M., & Nupponen, N. N. (2008) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2008.07.003 · Cited by 12
Numb/Notch Signaling Plays an Important Role in Cerebral Ischemia-induced Apoptosis
Ma, M., Wang, X., Ding, X., Teng, J., Shao, F., & Zhang, J. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0914-y · Cited by 12
Numb modulates the paracellular permeability of intestinal epithelial cells through regulating apical junctional complex assembly and myosin light chain phosphorylation
Yang, Y., Chen, L., Tian, Y., Ye, J., Liu, Y., Song, L., Pan, Q., He, Y., Chen, W., Peng, Z., et al. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.07.003 · Cited by 12
Numb Deletion in POMC-Expressing Cells Impairs Pituitary Intermediate Lobe Cell Adhesion, Progenitor Cell Localization, and Neuro-Intermediate Lobe Boundary Formation
Moran, T. B., Goldberg, L. B., Serviss, S. L., & Raetzman, L. T. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0248 · Cited by 12
Chemoresistance Mechanisms in Non-Small Cell Lung Cancer—Opportunities for Drug Repurposing
Kaur, R., & Suresh, P. K. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04595-7 · Cited by 12
Notch-Regulation upon Dll4-Stimulation of TGFb-Induced Apoptosis and Gene Expression in Human B-Cell Non-Hodgkin Lymphomas
Hajdú, M., Kopper, L., & SebestyÃ©n, A. (2009) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2009.02346.x · Cited by 11
dp53 Restrains Ectopic Neural Stem Cell Formation in the Drosophila Brain in a Non-Apoptotic Mechanism Involving Archipelago and Cyclin E
Ouyang, Y., Song, Y., & Lu, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028098 · Cited by 10
The Expression and Function of NUMB in Endometrial Cancer and the Interaction with HDM2 and P53
Wang, C., Feng, W., & Zhang, C. (2015) · Journal of Cancer · doi:10.7150/jca.11970 · Cited by 11
Numb Expression Contributes to the Maintenance of an Undifferentiated State in Human Epidermis
Iannolo, G., Sciuto, M. R., Buccheri, S., Colarossi, C., Maria, R. D., Memeo, L., & Conaldi, P. G. (2016) · Cell Transplantation · doi:10.3727/096368915x688245 · Cited by 11
Exon 3 of theNUMBGene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2
Confalonieri, S., Colaluca, I. N., Basile, A., Pece, S., & Fiore, P. P. D. (2019) · G3 Genes Genomes Genetics · doi:10.1534/g3.119.400494 · Cited by 9
Numb downregulation suppresses cell growth and is associated with a poor prognosis of human hepatocellular carcinoma
Xie, C., Lu, Z., Liu, G., Yu, F., LIU, J., Huang, Z., Wang, F., Wu, X., Lei, X., Li, X., et al. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2279 · Cited by 10
Exclusion of NUMB Exon12 Controls Cancer Cell Migration through Regulation of Notch1-SMAD3 Crosstalk
Zheng, Z., Yuan, N., You, X., Meng, K., Sha, R., Wang, Z., Peng, Q., Xie, Z., Chen, R., & Feng, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084363 · Cited by 10
A new insight into the diverse facets of microRNA-31 in oral squamous cell carcinoma
Kavitha, M., Dorairaj, J., Aishwarya, S. Y., Younus, P. M., Venugopal, A., Babu, H. W. S., Ajay, E., Sanjana, M., Arul, N., & Vellingiri, B. (2022) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-022-00361-2 · Cited by 10
Progress in the research of p53 tumour suppressor activity controlled by Numb in triple‐negative breast cancer
Xian, J., Cheng, Y., Qin, X. Y., Luo, Y., Cao, Y., & Cao, Y. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15366 · Cited by 9
Tracing the protectors path from the germ line to the genome
Coutandin, D., Ou, H. D., Löhr, F., & Dötsch, V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001069107 · Cited by 10
Human NUMB6 Induces Epithelial-Mesenchymal Transition and Enhances Breast Cancer Cells Migration and Invasion
Karaczyn, A. A., Adams, T. L., Cheng, R. Y. S., Matluk, N. N., & Verdi, J. M. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25628 · Cited by 10
NUMB as a Therapeutic Target for Melanoma
Hristova, D. M., Fukumoto, T., Takemori, C., Gao, L., Hua, X., Wang, J. X., Li, L., Beqiri, M., Watters, A. K., Vultur, A., et al. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.11.027 · Cited by 9
Regulating the regulator: Numb acts upstream of p53 to control mammary stem and progenitor cell
Faraldo, M. M., & Glukhova, M. A. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201510104 · Cited by 9
Molecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy.
Mukherjee, S., & Brat, D. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-53150-2_18 · Cited by 8
LNX1 contributes to tumor growth by down‐regulating p53 stability
Park, R., Kim, H., Jang, M., Jo, D., Park, Y., Namkoong, S., Lee, J. I., Jang, I., & Park, J. (2019) · The FASEB Journal · doi:10.1096/fj.201900366r · Cited by 9
NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout
Chi, J., Chen, Y., Li, C., Liu, S., Che, K., Kong, Z., Guo, Z., Chu, Y., Huang, Y., Yang, L., et al. (2024) · Cell Discovery · doi:10.1038/s41421-024-00708-6 · Cited by 8
Pathogenic Mutations in Cancer-Predisposing Genes: A Survey of 300 Patients with Whole-Genome Sequencing and Lifetime Electronic Health Records
He, K., Zhao, Y., McPherson, E. W., Li, Q., Xia, F., Weng, C., Wang, K., & He, M. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167847 · Cited by 8
Increased Numb protein expression predicts poor clinical outcomes in esophageal squamous cell carcinoma patients
Liu, Z., Luo, C., Yang, W., Wang, K., Hu, C., Zou, J., Hua Zhu, C., Fu, L., Nie, J., & Cheng, C. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2016.1276131 · Cited by 8
Decreased Sp1 Expression Mediates Downregulation of SHIP2 in Gastric Cancer Cells
Yan, Y., Xue, Q., Xiao, M., Shao, Y., Li, G., Liao, D., Da, J., Zhang, L., & Xu, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010220 · Cited by 8
Numb Promotes Autophagy through p53 Pathway in Acute Kidney Injury Induced by Cisplatin
Liu, Z., Li, Y., He, Y., & Wang, J. (2022) · Analytical Cellular Pathology · doi:10.1155/2022/8213683 · Cited by 8
Retracted
Prognostic Biomarker NUMB Is Inhibited by Breast Cancer Cell Exosomes to Promote Breast Cancer Progression
Qin, X. Y., & Cao, Y. (2022) · Journal of Immunology Research · doi:10.1155/2022/6032076 · Cited by 7
Protein Segregation Between Dividing Hematopoietic Progenitor Cells in the Determination of the Symmetry/Asymmetry of Cell Division
Nteliopoulos, G., & Gordon, M. Y. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0467 · Cited by 7
Tubular Numb promotes renal interstitial fibrosis via modulating HIF-1α protein stability
Zhu, F., Li, H. R., Long, T., Zhou, M., Wan, J., Tian, J., Zhou, Z., Hu, Z., & Nie, J. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166081 · Cited by 6
MiR-543/Numb promotes proliferation, metastasis, and stem-like cell traits of prostate cancer cells.
Wang, X., Yang, J., Cai, J., Zhang, D., Zhao, L., Luo, L., Xiong, Y., Zhang, T., & Jin, M. (2021) · PubMed Central · Cited by 7
Zika Virus Induces Degradation of the Numb Protein Required through Embryonic Neurogenesis
He, J., Yang, L., Chang, P., Yang, S., Wang, Y., Lin, S., Tang, Q., & Zhang, Y. (2023) · Viruses · doi:10.3390/v15061258 · Cited by 7
Adaptive Models for Gene Networks
Shin, Y.-J., Sayed, A. H., & Shen, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031657 · Cited by 7
New partners of TKS4 scaffold protein
Kropyvko, S. V. (2015) · Biopolymers and Cell · doi:10.7124/bc.0008fc · Cited by 7
Inactivation of Numb and Numblike in spermatogonial stem cells by cell-permeant Cre recombinase
Grisanti, L., Corallini, S., Fera, S., Muciaccia, B., Stefanini, M., Witke, W., & Vicini, E. (2009) · Differentiation · doi:10.1016/j.diff.2009.05.005 · Cited by 7
Interplay between Numb and Notch in epithelial cancers: Role for dual oxidase maturation factor
Ostrakhovitch, E. A. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.05.019 · Cited by 7
KCTD10 functions as a tumor suppressor in hepatocellular carcinoma by triggering the Notch signaling pathway.
Ma, T., Wang, D., Wu, J., Xiao, Y., Fan, A., Cao, X., Cao, J., & Ren, K. (2023) · PubMed Central · Cited by 6
Numb-dependent integration of pre-TCR and p53 function in T-cell precursor development
Martín-Blanco, N., Checquolo, S., Gaudio, F. D., Palermo, R., Franciosa, G., Marcotullio, L. D., Gulino, A., Cañelles, M., & Screpanti, I. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.438 · Cited by 6
The ubiquitin-proteasome system in normal hearing and deafness
Pouyo, R., Chung, K., Delacroix, L., & Malgrange, B. (2021) · Hearing Research · doi:10.1016/j.heares.2021.108366 · Cited by 6
ACBD3 Bioinformatic Analysis and Protein Expression in Breast Cancer Cells
Houghton-Gisby, J., Kerslake, R., Karteris, E., Mokbel, K., & Harvey, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168881 · Cited by 6
The Role of FBXW Subfamily of F-box Proteins in Tumorigenesis
Lau, A. W., Liu, Y., Tron, A. E., Inuzuka, H., & Wei, W. (2014) · Springer eBooks · doi:10.1007/978-3-319-05026-3_2 · Cited by 6
Frequency Domain Analysis Reveals External Periodic Fluctuations Can Generate Sustained p53 Oscillation
Shin, Y.-J., Hencey, B., Lipkin, S. M., & Shen, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022852 · Cited by 6
Gene Expression Profiles Resulting from Stable Loss of p53 Mirrors Its Role in Tissue Differentiation
Couture, O. P., Lombardi, E., Davis, K., Hays, E., & Chandar, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082494 · Cited by 6
Crossing Paths in Human Renal Cell Carcinoma (hRCC)
Gallego, G. A., Villaamil, V. M., Grande, E., Caínzos, I. S., & Aparicio, L. A. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131012710 · Cited by 6
Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer
Wang, G., Sheng, W., Tang, J., Li, X., Zhou, J., & Dong, M. (2020) · Bioscience Reports · doi:10.1042/bsr20191488 · Cited by 6
Two Sides of The Same Coin: Normal and Tumoral Stem Cells, The Relevance of In Vitro Models and Therapeutic Approaches: The Experience with Zika Virus in Nervous System Development and Glioblastoma Treatment
Tinnirello, R., Chinnici, C. M., Miceli, V., Busà, R., Bulati, M., Gallo, A., Zito, G., Conaldi, P. G., & Iannolo, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713550 · Cited by 6
NumbL is essential for Xenopusprimary neurogenesis
Nieber, F., Hedderich, M., Jahn, O., Pieler, T., & Henningfeld, K. A. (2013) · BMC Developmental Biology · doi:10.1186/1471-213x-13-36 · Cited by 6
Associating GWAS Information with the Notch Signaling Pathway Using Transcription Profiling
Hicks, C., Pannuti, A., & Miele, L. (2011) · Cancer Informatics · doi:10.4137/cin.s6072 · Cited by 6
Expression of Numb and Gli1 in malignant pleural mesothelioma and their clinical significance
Zhang, W., Kang, Y., Ma, R., Chen, F., Chen, F., & Dong, X. (2016) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.180614 · Cited by 5
MDM2 is involved in the regulation of p53 expression in the immune response of oyster Crassostrea hongkongensis
Zhang, A., Yang, Y., Zeng, L., Zhao, Z., Zhou, Y., Yang, Z. H., Liao, Q., Xiao, S., Ma, H., Li, J., et al. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104321 · Cited by 5
Experimental model for safe in vitro- and in vivo-influence of internal and external factors of cell differentiation
Sainova, I. V. (2011) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp11.222 · Cited by 5

Authors: Colaluca, I. N., Tosoni, D., Nuciforo, P., Senic-Matuglia, F., Galimberti, V., Viale, G., Pece, S., & Di Fiore, P. P.
Affiliations: IFOM (IT)
European Institute of Oncology (IT)
University of Milan (IT)
Corresponding author: Pece, Salvatore
ORCID: Colaluca, Ivan N.
Tosoni, Daniela
Nuciforo, Paolo
Senic-Matuglia, Francesca
Galimberti, Viviana
Viale, Giuseppe
Pece, Salvatore
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-01
Volume: 451
Issue: 7174
Pages: 76-80
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06412
OpenAlex: W2072555538
Cited by: 385
References: 33
Citations by year: 2026: 4 · 2025: 10 · 2024: 9 · 2023: 25 · 2022: 19 · 2021: 19 · 2020: 15 · 2019: 12 · 2018: 18 · 2017: 19 · 2016: 22 · 2015: 22 · 2014: 27 · 2013: 25 · 2012: 36
FWCI: 18.16
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Fondazione Cariplo
Ministero dell’Istruzione, dell’Università e della Ricerca
Associazione Italiana per la Ricerca sul Cancro
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: Numb, p53, MDM2, tumour suppressor, breast cancer, Notch receptor, ubiquitination, protein stability, chemoresistance, prognosis, asymmetric cell division, endocytosis, oncogene activation
MeSH terms: Breast Neoplasms, Cells, Cultured, DNA Damage, Humans, Membrane Proteins, Nerve Tissue Proteins, Prognosis, Protein Binding, Tumor Suppressor Protein p53, Drug Resistance, Neoplasm, Gene Silencing, Cell Line, Tumor, Proto-Oncogene Proteins c-mdm2, Ubiquitination

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NUMB controls p53 tumour suppressor activity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks