The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Genetic variation in human NPY expression affects stress response and emotion
Open accessAbstract
Understanding inter-individual differences in stress response requires the explanation of genetic influences at multiple phenotypic levels, including complex behaviours and the metabolic responses of brain regions to emotional stimuli. Neuropeptide Y (NPY) is anxiolytic and its release is induced by stress. NPY is abundantly expressed in regions of the limbic system that are implicated in arousal and in the assignment of emotional valences to stimuli and memories. Here we show that haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety. NPY haplotypes predicted levels of NPY messenger RNA in post-mortem brain and lymphoblasts, and levels of plasma NPY. Lower haplotype-driven NPY expression predicted higher emotion-induced activation of the amygdala, as well as diminished resiliency as assessed by pain/stress-induced activations of endogenous opioid neurotransmission in various brain regions. A single nucleotide polymorphism (SNP rs16147) located in the promoter region alters NPY expression in vitro and seems to account for more than half of the variation in expression in vivo. These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“tentative human genetic studies that weakly implicate variations in the NPY gene in emotional behavior and stress responses (discussed below)20, 21.”
From Neurobiology of resilience (2012) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth457 · Cited by 14,551
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842
A Comparison of Bayesian Methods for Haplotype Reconstruction from Population Genotype Data
Stephens, M., & Donnelly, P. (2003) · The American Journal of Human Genetics · doi:10.1086/379378 · Cited by 3,516
Templeton, A. R., Crandall, K. A., & Sing, C. F. (1992) · Genetics · doi:10.1093/genetics/132.2.619 · Cited by 3,319
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340
Self-citationTatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980
Self-citationAllostasis and Allostatic Load Implications for Neuropsychopharmacology
McEwen, B. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00129-3 · Cited by 1,833
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 455
FKBP5 genotype interacts with early life trauma to predict heavy drinking in college students
Lieberman, R., Armeli, S., Scott, D. M., Kranzler, H. R., Tennen, H. A., & Covault, J. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32460 · Cited by 26
Self-citationThe neurobiology of obsessive–compulsive personality disorder: a systematic review
Marincowitz, C., Löchner, C., & Stein, D. J. (2021) · CNS Spectrums · doi:10.1017/s1092852921000754 · Cited by 30
Light, K. C., White, A. T., Tadler, S. C., Iacob, E., & Light, A. R. (2011) · Pain Research and Treatment · doi:10.1155/2012/427869 · Cited by 26
Neuropeptide Y polymorphisms and ischemic stroke in Chinese population
Yu, J., Yu, N., Gao, S.-S., Song, J., Ma, T., Wang, N., Tang, Y.-C., Zhang, N., & Tan, L. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.11.011 · Cited by 26
Replication in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity
Avinun, R., Nevo, A., Knodt, A. R., Elliott, M. L., & Hariri, A. R. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.010 · Cited by 25
Self-citationCould a blood test for PTSD and depression be on the horizon?
Aspesi, D., & Pinna, G. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1544894 · Cited by 26
Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic‐Pituitary‐Adrenal Axis
Borrow, A. P., Stranahan, A. M., Suchecki, D., & Yunes, R. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12403 · Cited by 27
Farber, M. J., Kim, M. J., Knodt, A. R., & Hariri, A. R. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2019.100711 · Cited by 28
Self-citationForbes, S. C., & Cox, H. M. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12428 · Cited by 25
Neuropeptide Y associated with asthma in young adults
Lu, Y., Andiappan, A. K., Lee, B. T. K., Ho, R., Lim, T. K., Kuan, W. S., Goh, D. Y. T., Mahadevan, M., Sim, T. B., Wang, D. Y., et al. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.07.003 · Cited by 24
Garcia, S. E., Tully, E. C., Tarantino, N., South, S. C., Iacono, W. G., & McGue, M. K. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.05.046 · Cited by 32
Naidoo, N. S., Azar, A. J., Khamis, A. H., Gholami, M., Lindsbro, M., Alsheikh-Ali, A. A. A., & Banerjee, Y. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.726814 · Cited by 26
Wasserman, D., Terenius, L. Y., Wasserman, J., & Sokolowski, M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.113 · Cited by 22
Repeated gastric distension alters food intake and neuroendocrine profiles in rats
Hargrave, S. L., & Kinzig, K. P. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.11.006 · Cited by 23
Neuropeptide Y in noradrenergic neurons induces obesity in transgenic mouse models
Vähätalo, L. H., Ruohonen, S. T., Ailanen, L., & Savontaus, E. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.11.088 · Cited by 24
The missing hallmark of health: psychosocial adaptation
López-Otín, C., & Kroemer, G. (2024) · Cell Stress · doi:10.15698/cst2024.03.294 · Cited by 27
Jayabalan, P. S., Gustafson, J. A., Sowa, G., Piva, S. R., & Farrokhi, S. (2018) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000001068 · Cited by 22
Michaelson, S. D., Tapia, A. P. M., McKinty, A., Villarroel, H. S., Mackay, J. P., Urban, J. H., & Colmers, W. F. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2621-19.2020 · Cited by 26
Cross talk about the role of Neuropeptide Y in CNS disorders and diseases
Bale, R., & Doshi, G. (2023) · Neuropeptides · doi:10.1016/j.npep.2023.102388 · Cited by 21
Framing Ethnic Variations in Alcohol Outcomes from Biological Pathways to Neighborhood Context
Chartier, K. G., Scott, D. M., Wall, T. L., Covault, J., Karriker‐Jaffe, K. J., Mills, B. A., Luczak, S. E., Caetano, R., & Arroyo, J. A. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12304 · Cited by 21
Self-citationSex-Specific Role for Adenylyl Cyclase Type 7 in Alcohol Dependence
Desrivières, S., Pronko, S. P., Lourdusamy, A., Ducci, F., Hoffman, P. L., Wodarz, N., Ridinger, M., Rietschel, M., Zélénika, D., Lathrop, M. G., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.037 · Cited by 21
Maymon, N., Zer‐Aviv, T. M., Sabban, E. L., & Akirav, I. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107804 · Cited by 21
Painsipp, E., Sperk, G., Herzog, H., & Holzer, P. D. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109104851 · Cited by 21
Mindscape: A convergent perspective on life, mind, consciousness and happiness
Niculescu, A. B., Schork, N. J., & Salomon, D. R. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.06.022 · Cited by 22
Neuropeptide Y and Pain: Insights from Brain Research
Nelson, T. S., Allen, H. N., & Khanna, R. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00333 · Cited by 20
Stuber, E. F., Baumgartner, C., Dingemanse, N. J., Kempenaers, B., & Mueller, J. C. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.024216 · Cited by 21
Katus, U., Villa, I., Ringmets, I., Veidebaum, T., & Harro, J. (2021) · Peptides · doi:10.1016/j.peptides.2021.170524 · Cited by 21
Hohmann, S., Buchmann, A. F., Witt, S. H., Rietschel, M., Jennen-Steinmetz, C., Schmidt, M. H., Esser, G., Banaschewski, T., & Laucht, M. (2012) · Pediatric Obesity · doi:10.1111/j.2047-6310.2012.00069.x · Cited by 20
Mutschler, J., Abbruzzese, E., Wiedemann, K., von der Goltz, C., Dinter, C., Mobascher, A., Thiele, H., Diaz-Lacava, A. N., Dahmen, N., Gallinat, J., et al. (2013) · Annals of Nutrition and Metabolism · doi:10.1159/000346799 · Cited by 20
Aplysia Locomotion: Network and Behavioral Actions of GdFFD, a D-Amino Acid-Containing Neuropeptide
Yang, C.-Y., Yu, K. W., Wang, Y., Chen, S.-A., Liu, D.-D., Wang, Z.-Y., Su, Y.-N., Yang, S.-Z., Chen, T.-T., Livnat, I., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147335 · Cited by 20
Jaakkola, U.-M., Kakko, T., Juonala, M., Lehtimäki, T. J., Viikari, J. S. A., Jääskeläinen, A., Mononen, N., Kähönen, M. A. P., Koskinen, T., Keltikangas‐Järvinen, L., et al. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.09.005 · Cited by 20
The Basics of the Stress Response: A Historical Context and Introduction
Thiel, K. J., & Dretsch, M. N. (2011) · doi:10.1002/9781118083222.ch1 · Cited by 20
Das, K., Ogawa, S., Kitahashi, T., & Parhar, I. S. (2018) · Peptides · doi:10.1016/j.peptides.2018.10.009 · Cited by 19
Dombrowski, M. E., Olsen, A. S., Vaudreuil, N. J., Couch, B. K., Dong, Q. D., Tucci, M. A., Lee, J. Y., Vo, N. V., & Sowa, G. (2020) · Neurospine · doi:10.14245/ns.2040046.023 · Cited by 19
Sato, N., Kageyama, S., Chen, R., Suzuki, M., Mori, H., Tanioka, F., Yamada, H., Kamo, T., Tao, H., Shinmura, K., et al. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2010.108 · Cited by 19
Morales‐Medina, J. C., Domínguez-López, S., Gobbi, G., Beck‐Sickinger, A. G., & Quirion, R. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.015 · Cited by 19
Chang, H., Fang, W., Chang, T.-C., Huang, S., & Chang, C.-C. (2016) · Scientific Reports · doi:10.1038/srep31683 · Cited by 19
Reijnen, A., Geuze, E., Eekhout, I. E., Maihofer, A. X., Nievergelt, C. M., Baker, D. G., & Vermetten, E. H. G. J. M. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.02.008 · Cited by 19
Rossouw, J. G., Rossouw, P., Paynter, C., Ward, A., & Khnana, P. (2017) · International Journal of Neuropsychotherapy · doi:10.12744/ijnpt.2017.1.0025-0040 · Cited by 18
The role of resilience in the relationship between stress and alcohol
Schwandt, M. L., Cullins, E., & Ramchandani, V. A. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100644 · Cited by 20
Frisch, C., Hanke, J., Kleinerüschkamp, S., Röske, S., Kaaden, S., Elger, C. E., Schramm, J., Yilmazer‐Hanke, D., & Helmstaedter, C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.025 · Cited by 18
Endocrine Aspects of PTSD: Hypothalamic-Pituitary-Adrenal (HPA) Axis and Beyond
Daskalakis, N. P., McGill, M. A., Lehrner, A. L., & Yehuda, R. (2015) · Springer eBooks · doi:10.1007/978-3-319-08613-2_130-1 · Cited by 18
Muráni, E., Ponsuksili, S., Srikanchai, T., Maak, S., & Wimmers, K. (2008) · Animal Genetics · doi:10.1111/j.1365-2052.2008.01811.x · Cited by 18
Mutschler, J., Abbruzzese, E., von der Goltz, C., Dinter, C., Mobascher, A., Thiele, H., Diaz-Lacava, A., Dahmen, N., Gallinat, J., Majic, T., et al. (2012) · European Addiction Research · doi:10.1159/000338276 · Cited by 17
Qi, Y., Ni, S., Heng, X., Qu, S., Ge, P., Zhao, X., Yao, Z., Guo, R., Yang, N., Zhang, Q., et al. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s342028 · Cited by 17
Parizadeh, S. A., Jamialahmadi, K., Rooki, H., Zaim-Kohan, H., Mirhafez, S. R., Hosseini, N., Mohiti-Ardakani, J., Moohebati, M., Masoudi-Kazemabad, A., Ferns, G. A., et al. (2014) · Annals of Human Biology · doi:10.3109/03014460.2014.916750 · Cited by 17
Lu, Y., & Ho, R. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.11.091 · Cited by 16
Palla, S., & Farella, M. (2010) · Springer eBooks · doi:10.1007/978-3-642-05468-6_7 · Cited by 16
The gut peptide neuropeptide Y and post-traumatic stress disorder
Rasmusson, A. M. (2016) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000301 · Cited by 16
Affective enhancement of working memory is maintained in depression.
Schweizer, S., Navrady, L. B., Breakwell, L., Howard, R. M., Golden, A.-M. J., Werner‐Seidler, A., & Dalgleish, T. (2017) · Emotion · doi:10.1037/emo0000306 · Cited by 17
Neuropeptide Y Gene × Environment Interaction Predicts Resilience and Positive Future Focus
Gan, Y., Chen, Y., Han, X., Yu, N. X., & Wang, L. (2019) · Applied Psychology Health and Well-Being · doi:10.1111/aphw.12162 · Cited by 18
Trait anxiety, a personality risk factor associated with Alzheimer’s Disease
Li, S., Wang, C., Wang, W., & Tan, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110124 · Cited by 21
Opmeer, E. M., Kortekaas, R., van Tol, M., van der Wee, N. J. A., Woudstra, S., van Buchem, M. A., Penninx, B. W. J. H., Veltman, D. J., & Aleman, A. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nst025 · Cited by 20
Short photoperiod condition increases susceptibility to stress in adolescent male rats
Xu, L., Liu, L.-J., Yuan, M., Li, S., Yue, X., Lai, J. C. L., & Lü, L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.002 · Cited by 16
Endocrine Aspects of PTSD: Hypothalamic-Pituitary-Adrenal (HPA) Axis and Beyond
Daskalakis, N. P., McGill, M. A., Lehrner, A. L., & Yehuda, R. (2016) · Springer eBooks · doi:10.1007/978-3-319-08359-9_130 · Cited by 16
Ullmann, E., Chrousos, G. P., Perry, S. W., Wong, M., Licinio, J., Bornstein, S. R., Tseilikman, O. B., Komelkova, M. V., Lapshin, M. S., Vasilyeva, M., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207440 · Cited by 15
Lach, G., Bicca, M. A., Hoeller, A. A., Santos, E. C. D. S., Costa, A. P., & de Lima, T. C. M. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.10.001 · Cited by 15
Is there an association between NPY and neuroticism?
Cotton, C., Jonathan Flint, C., & Campbell, T. G. (2009) · Nature · doi:10.1038/nature07927 · Cited by 15
Xu, K., Hong, K., Zhou, Z., Hauger, R. L., Goldman, D. A., & Sinha, R. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.08.005 · Cited by 15
Self-citationImaging neuropeptide effects on human brain function
Lefèvre, A., Hurlemann, R., & Grinevich, V. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2899-6 · Cited by 16
Understanding the pharmacogenetics of selective serotonin reuptake inhibitors
Fabbri, C., Minarini, A., Niitsu, T., & Serretti, A. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.928693 · Cited by 14
Neuropeptide Y and representation of salience in human nucleus accumbens
Warthen, K., Sanford, B., Walker, K. A., Jones, K. G., Angstadt, M., Sripada, C., Goldman, D. A., Zubieta, J.-K., Welsh, R. C., Burmeister, M., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0230-6 · Cited by 14
Self-citationHistory of chronic stress modifies acute stress-evoked fear memory and acoustic startle in male rats
Schmeltzer, S. N., Vollmer, L. L., Rush, J., Weinert, M., Dolgas, C. M., & Sah, R. (2015) · Stress · doi:10.3109/10253890.2015.1016495 · Cited by 16
Effect of Experimental Stress in 2 Different Pain Conditions Affecting the Facial Muscles
Woda, A., L’Heveder, G., Ouchchane, L., & Bodere, C. (2013) · Journal of Pain · doi:10.1016/j.jpain.2012.12.008 · Cited by 13
Amygdala in Action: Functional Connectivity during Approach and Avoidance Behaviors
Leitão, J., Burckhardt, M., & Vuilleumier, P. O. (2021) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01800 · Cited by 16
Sympathetic Activation in Resistant Hypertension: Theory and Therapy
Oliva, R., & Bakris, G. L. (2014) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2014.08.009 · Cited by 13
Genetics of Stress: Gene–Stress Correlation and Interaction
Manuck, S. B., & McCaffery, J. M. (2010) · Springer eBooks · doi:10.1007/978-0-387-09488-5_31 · Cited by 14
Self-citationLandefeld, C. C., Hodgkinson, C. A., Spagnolo, P. A., Marietta, C. A., Shen, P., Sun, H., Zhou, Z., Lipska, B. K., & Goldman, D. A. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0120-z · Cited by 13
Self-citationTheisen, C. C., Reyes, B. A. S., Sabban, E. L., & Bockstaele, E. J. V. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.04.043 · Cited by 11
Noè, F. M., Sørensen, A. T., Kokaia, M., & Vezzani, A. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199746545.003.0089 · Cited by 13
Kokita, T., Takahashi, S., & Kumada, H. (2013) · Molecular Ecology · doi:10.1111/mec.12184 · Cited by 13
Xia, R., Peng, H., Zhu, X., Suolang, W., Pambayi, S. T. L., Yang, X., Zeng, Y., & Shen, B. (2025) · Orthopaedic Surgery · doi:10.1111/os.70010 · Cited by 12
Potential benefits of intranasal neuropeptide Y include sustained extinction of fear memory
Sabban, E. L., Serova, L. I., Nahvi, R. J., & Liu, X. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13279 · Cited by 12
Καπρίτσου, Μ., Papathanassoglou, E. D. E., Bozas, E., Korkolis, D. P., Konstantinou, E. A., Kaklamanos, I. G., & Giannakopoulou, M. D. (2016) · Biological Research For Nursing · doi:10.1177/1099800416682617 · Cited by 13
Anxiety and Alcohol Use Disorders
Pandey, S. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405941-2.00022-5 · Cited by 12
Yeo, S., Hodgkinson, C. A., Zhou, Z., Jung, J., Leung, M., Yuan, Q., & Goldman, D. A. (2016) · BMC Genomics · doi:10.1186/s12864-016-2922-9 · Cited by 12
Self-citationMelas, P. A., Guban, P., Rahman, M. S., Lavebratt, C., & Forsell, Y. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.02.041 · Cited by 12
Neuropeptide Y – Its role in human performance and extreme environments
Kienast, C., Gunga, H., & Steinach, M. (2019) · REACH · doi:10.1016/j.reach.2019.100032 · Cited by 12
NPY2-receptor variation modulates iconic memory processes
Arning, L., Stock, A., Kloster, E., Epplen, J. T., & Beste, C. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.003 · Cited by 12
Polymorphic variation as a driver of differential neuropeptide gene expression
Quinn, J. P., Warburton, A., Myers, P., Pfaff, A. L., & Bubb, V. J. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.003 · Cited by 11
Leitermann, R. J., Sajdyk, T. J., & Urban, J. H. (2012) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2012.07.005 · Cited by 11
Evolutionary Signatures of Common Human Cis-Regulatory Haplotypes
Ouyang, C., Smith, D. D., & Krontiris, T. G. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003362 · Cited by 11
Shi, C., Xu, S., Huang, C., Wang, Z., Wang, W., Ming, D., Yin, X., Liu, H., & Wang, F. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.878541 · Cited by 10
Watkins, L. E., Han, S., Krystal, J. H., Southwick, S. M., Gelernter, J. E., & Pietrzak, R. H. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.17l11646 · Cited by 10
Raffagnato, A., Raicich, A., Paiusco, L., Coser, G., Bonemazzi, I., Gazzin, A., Pelizza, M. F., Ancora, C., & Toldo, I. (2025) · Genes · doi:10.3390/genes16111362 · Cited by 12
Savontaus, E., Ruohonen, S. T., & Pesonen, U. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105574 · Cited by 11
Haley, G. E., McGuire, A., Berteau-Pavy, D., Weiss, A. R., Patel, R. A., Messaoudi, I., Urbanski, H. F., & Raber, J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.014 · Cited by 11
Transcriptomic analysis of gene expression in mice treated with troxerutin
Wang, Y., Wei, S., Chen, L., Pei, J., Wu, H., Pei, Y., Chen, Y., & Wang, D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188261 · Cited by 9
Schaaf, S., Huang, W., Perera, S., Conley, Y. P., Belfer, I., Jayabalan, P. S., Tremont, K., Coelho, P., Ernst, S., Cortazzo, M. H., et al. (2020) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000001514 · Cited by 9
Stone, L. A., Girgenti, M. J., Wang, J., Ji, D., Zhao, H., Krystal, J. H., & Duman, R. S. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa072 · Cited by 9
Wei, X., Cai, F., Zhou, S., Zhang, J., Xu, K., Shen, G., Sun, H., Yang, F., Hong, L., Zou, Y., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1012850 · Cited by 9
Self-citationPain Imaging in the Emerging Era of Molecular Medicine
Stohler, C. S., & Zubieta, J.-K. (2010) · Methods in molecular biology · doi:10.1007/978-1-60327-323-7_38 · Cited by 9
Self-citationCarlson, D. E., Le, W., Chiu, W. C., & Hoffman, G. E. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.046 · Cited by 9
Gene × Environment Interactions in Complex Behavior: First, Build a Telescope
Goldman, D. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.005 · Cited by 9
Self-citationPhosducin — a candidate gene for stress-dependent hypertension
Grassi, G. M. (2009) · Journal of Clinical Investigation · doi:10.1172/jci41508 · Cited by 9
Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning
Peedikayil‐Kurien, S., Haque, R., Gat, A., & Oren‐Suissa, M. (2025) · Nature Communications · doi:10.1038/s41467-025-55950-7 · Cited by 8
Statello, R., Carnevali, L., Paterlini, S., Gioiosa, L., Bertocchi, I., Oberto, A., Eva, C. E., Palanza, P., & Sgoifo, A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.07.017 · Cited by 8
Neurogenetik emotionaler Prozesse
Dannlowski, U., Konrad, C., Arolt, V., & Suslow, T. (2009) · Der Nervenarzt · doi:10.1007/s00115-009-2828-8 · Cited by 8
Fadel, J. R. (2013) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.s4-014 · Cited by 7
Kiive, E., Kanarik, M., Veidebaum, T., & Harro, J. (2023) · Acta Neuropsychiatrica · doi:10.1017/neu.2023.23 · Cited by 7
Metadata
- Authors
- Zhou, Z., Zhu, G., Hariri, A. R., Enoch, M.-A., Scott, D., Sinha, R., Virkkunen, M., Mash, D. C., Lipsky, R. H., Hu, X.-Z., Hodgkinson, C. A., Xu, K., Buzas, B., Yuan, Q., Shen, P.-H., Ferrell, R. E., Manuck, S. B., Brown, S. M., Hauger, R. L., Stohler, C. S., Zubieta, J.-K., & Goldman, D.
- Affiliations
- National Institutes of Health (US)
- University of Pittsburgh (US)
- University of Michigan (US)
- Yale University (US)
- University of Helsinki (FI)
- University of Miami (US)
- University of California San Diego (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Goldman, David
- ORCID
- Venue
- Nature
- Published
- 2008-04
- Volume
- 452
- Issue
- 7190
- Pages
- 997-1001
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2715959
- OpenAlex
- W1981364522
- Cited by
- 455
- References
- 36
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 22 · 2020: 13 · 2019: 17 · 2018: 24 · 2017: 17 · 2016: 28 · 2015: 29 · 2014: 35 · 2013: 34 · 2012: 39
- FWCI
- 19.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (Z99‐AA999999)
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000301, R01AA013892, R01-AA-13892)
- National Heart, Lung, and Blood Institute (R01HL065137, P01HL040962)
- National Institute of Mental Health (R01MH074697, K01MH072837)
- National Institute on Drug Abuse (K02 DA17232, P50DA016556, K02DA017232, R01DA016423, PL1DA024859, P50-DA16556)
- National Institute of Dental and Craniofacial Research (R01DE015396, R01 DE 15396)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- neuropeptide Y, genetic variation, haplotypes, stress response, psychological resilience, trait anxiety, amygdala activation, endogenous opioid system, limbic system, individual differences
- MeSH terms
- Alleles, Anxiety, Anxiety Disorders, Brain, Emotions, Facial Expression, Finland, Gene Expression Regulation, Haplotypes, Humans, Lymphocytes, Magnetic Resonance Imaging, Male, Neuropeptide Y, Pain, RNA, Messenger, Stress, Physiological, United States, Genetic Variation, Opioid Peptides, Polymorphism, Single Nucleotide, White People
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review