The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Genetic variation in human NPY expression affects stress response and emotion
Open accessAbstract
Understanding inter-individual differences in stress response requires the explanation of genetic influences at multiple phenotypic levels, including complex behaviours and the metabolic responses of brain regions to emotional stimuli. Neuropeptide Y (NPY) is anxiolytic and its release is induced by stress. NPY is abundantly expressed in regions of the limbic system that are implicated in arousal and in the assignment of emotional valences to stimuli and memories. Here we show that haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety. NPY haplotypes predicted levels of NPY messenger RNA in post-mortem brain and lymphoblasts, and levels of plasma NPY. Lower haplotype-driven NPY expression predicted higher emotion-induced activation of the amygdala, as well as diminished resiliency as assessed by pain/stress-induced activations of endogenous opioid neurotransmission in various brain regions. A single nucleotide polymorphism (SNP rs16147) located in the promoter region alters NPY expression in vitro and seems to account for more than half of the variation in expression in vivo. These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“tentative human genetic studies that weakly implicate variations in the NPY gene in emotional behavior and stress responses (discussed below)20, 21.”
From Neurobiology of resilience (2012) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth457 · Cited by 14,551
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842
A Comparison of Bayesian Methods for Haplotype Reconstruction from Population Genotype Data
Stephens, M., & Donnelly, P. (2003) · The American Journal of Human Genetics · doi:10.1086/379378 · Cited by 3,516
Templeton, A. R., Crandall, K. A., & Sing, C. F. (1992) · Genetics · doi:10.1093/genetics/132.2.619 · Cited by 3,319
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340
Self-citationTatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980
Self-citationAllostasis and Allostatic Load Implications for Neuropsychopharmacology
McEwen, B. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00129-3 · Cited by 1,833
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–455 of 455
Ruohonen, S. T. (2009) · UTUPub (University of Turku)
Test génétique et parodontites
Rousset, G. (2014)
Neurocircuitry of Anxiety Disorders: Focus on Panic Disorder and Post-traumatic Stress Disorder
Murrough, J. W., Schiller, D., & Charney, D. S. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849734943-00226
Gene and Metabolic Environment Interactions in Obesity and Diabetes
Liang, J., & Teng, F. (2014)
Neuropeptide Receptors as Treatment Targets in Alcohol Use Disorders
Aziz, A. M. A. (2017) · Linköping University medical dissertations · doi:10.3384/diss.diva-139884
Stress, Vulnerability, and Resilience
Koh, K. B. (2018) · Springer eBooks · doi:10.1007/978-3-030-02783-4_1
Genetic Neuroimaging of Social Perception
Faig, K. E., Nikolova, Y. S., & Hariri, A. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00161-5
Self-citationEmotional Disturbances Following Traumatic Brain Injury
Jorge, R. E., & Lin, H. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139696432.010
Integrating behavior, hormones and genes associated with the primate HPA-axis
Gutleb, D. R. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7382
Janeczek, P. (2016) · Griffith Research Online · doi:10.25904/1912/1266
Goldman, D. A., Landi, P., & Ducci, F. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00119-1
Self-citationTHESE POUR LE DOCTORAT EN MEDECINE
Demas, A. (2015)
Asokumar, A. (2015) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2015-11178
The ancient divide between molecule and self
Goldman, D. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85692-8.00009-5
Self-citationWang, F., Zhou, S., Chen, L., Shen, G., Yang, F., Sun, H., Hong, L., Zou, Y., Li, H., Chen, Y., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-863544/v1
(2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816793-9.00001-3
Schäfer, A. S. (2015) · Springer eBooks · doi:10.1007/978-3-319-17942-1_7
Spanagel, R., & Sommer, W. H. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718128582.793486872
Glicken, M. D. (2006) · Sage eBooks · doi:10.4135/9781452232539.n1
Crump, C. (2016) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2016-11447
(2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85692-8.09992-5
(2012) · Elsevier eBooks · doi:10.1016/b978-0-12-396952-1.00030-0
Rujescu, D. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.5005956.6717054
Goldman, D., Landi, P., & Ducci, F. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.05585-9
Self-citationPerspectives on Neuroscience and Behavior
(2007) · The Neuroscientist · doi:10.1177/10738584080140050201
The Genetic Basis of Addictive Disorders
Goldman, D. A., Zhou, Z., & Hodgkinson, C. A. (2017) · doi:10.1093/med/9780190681425.003.0042
Self-citationTHE GENESIS OF PSYCHOLOGICAL RESILIENCE: NATURE vs NURTURE
Faustova, A. G. (2023) · PERSONALITY IN A CHANGING WORLD HEALTH ADAPTATION DEVELOPMENT · doi:10.23888/humj20231117-20 · Cited by 1
Modulation by NPYR underlies experience-dependent, sexually dimorphic learningPreprint
Peedikayil‐Kurien, S., Haque, R., Gat, A., & Oren‐Suissa, M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.19.563073
Petrovick, M. S., Shcherbina, A., Farina, E. K., Thompson, L., Niro, P. J., McClung, J. P., & Lieberman, H. R. (2024) · Anxiety Stress & Coping · doi:10.1080/10615806.2024.2388850
The peripheral nervous system: peripheral neuropathies in the diabetic foot
Pierre-Jerome, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13328-2.00022-2
Genetic Variants in Post-traumatic Stress Disorder (PTSD)
Konjevod, M., Erjavec, G. N., Perković, M. N., Pivac, N., & Štrac, D. Š. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_85-1 · Cited by 1
Longitudinal Genome-Wide Study Reveals Genetic Architecture of Resilience Using a Novel PhenotypePreprint
Cahill, S., Mekli, K., & Hager, R. (2025) · Research Square · doi:10.21203/rs.3.rs-4861048/v1
Biological mechanisms of stress-related mental disorders
Shi, D., Wang, L., Li, X., Hu, J., Qin, S., Zhao, M., Duan, S., Wang, Y., & Wang, Z. (2025) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0346
Genetic Variants in Post-traumatic Stress Disorder (PTSD)
Konjevod, M., Erjavec, G. N., Perković, M. N., Pivac, N., & Štrac, D. Š. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_85
Schwert, H., Salur, E., Richard, M., Pöllmann, M., Lesch, K., Asan, E., & Schmitt-Böhrer, A. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.07.680627
Genetic markers of stress, resilience and success at an elite military selection course
Petrovick, M. S., Hendricks, J., Farina, E. K., Thompson, L., Knapik, J. J., Pasiakos, S. M., McClung, J. P., & Lieberman, H. R. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115150
Kumari, B. (2025) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20253744
Nemetova, D., Zhunissova, M., Nuskabayeva, G. O., Tatykayeva, U. B., Oshibayeva, A., Nurdinov, N. S., Aidarbekova, D., Turmanbayeva, A., Saruarov, Y. G., Zhagiparova, Z., et al. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22121853
Fisher, P. M. (2010) · D-Scholarship@Pitt (University of Pittsburgh)
Koh, K. B. (2026) · Springer eBooks · doi:10.1007/978-3-032-11214-9_1
Individualität und Stressanfälligkeit
Capel, P. J. A. (2026) · Springer eBooks · doi:10.1007/978-3-662-71831-5_12
Prescribed Interventions to Reduce Depression
Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_22
Awathale, S. N., Chaudhari, A., Pardeshi, G. N., Popali, C., Goyal, S. N., & Nakhate, K. T. (2026) · Neuropeptides · doi:10.1016/j.npep.2026.102620
Corriea, G., & Sibille, E. L. (2026) · Neuropeptides · doi:10.1016/j.npep.2026.102633
Neuropsychological Factors in Vitiligo: Mechanisms and Clinical Application
Ren, F., Zhou, J., & Zhang, W. (2026) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-026-09176-0
Schwert, H., Salur, E., Richard, M., Pöllmann, M., Lesch, K., Asan, E., & Schmitt-Böhrer, A. G. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03224-x
Liao, X., Yang, H., Lin, P., & Chen, S. (2026) · Materials Today Physics · doi:10.1016/j.mtphys.2026.102275
Organization of neuropeptide signaling: cross-species insights from small model organisms
Zandawala, M., Filosa, A., & Beets, I. (2026) · Trends in Neurosciences · doi:10.1016/j.tins.2026.09.012
The Neurobiology of Executive Function Under Stress and Optimization of Performance
Rasmusson, A. M., & Irvine, J. M. (2015) · Lecture notes in computer science · doi:10.1007/978-3-319-20816-9_12
The role of TACR1 genotypes in craving, depression, and alcohol dependence.
Blaine, S. K. (2011) · UNM’s Digital Repository (University of New Mexico)
ENVOLVIMENTO DO NEUROPEPTÍDEO Y NA RESILIÊNCIA AO MEDO CONDICIONADO CONTEXTUAL EM RATOS
Lach, G. (2013) · Americanae (AECID Library)
Metadata
- Authors
- Zhou, Z., Zhu, G., Hariri, A. R., Enoch, M.-A., Scott, D., Sinha, R., Virkkunen, M., Mash, D. C., Lipsky, R. H., Hu, X.-Z., Hodgkinson, C. A., Xu, K., Buzas, B., Yuan, Q., Shen, P.-H., Ferrell, R. E., Manuck, S. B., Brown, S. M., Hauger, R. L., Stohler, C. S., Zubieta, J.-K., & Goldman, D.
- Affiliations
- National Institutes of Health (US)
- University of Pittsburgh (US)
- University of Michigan (US)
- Yale University (US)
- University of Helsinki (FI)
- University of Miami (US)
- University of California San Diego (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Goldman, David
- ORCID
- Venue
- Nature
- Published
- 2008-04
- Volume
- 452
- Issue
- 7190
- Pages
- 997-1001
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2715959
- OpenAlex
- W1981364522
- Cited by
- 455
- References
- 36
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 9 · 2023: 11 · 2022: 12 · 2021: 22 · 2020: 13 · 2019: 17 · 2018: 24 · 2017: 17 · 2016: 28 · 2015: 29 · 2014: 35 · 2013: 34 · 2012: 39
- FWCI
- 19.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (Z99‐AA999999)
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000301, R01AA013892, R01-AA-13892)
- National Heart, Lung, and Blood Institute (R01HL065137, P01HL040962)
- National Institute of Mental Health (R01MH074697, K01MH072837)
- National Institute on Drug Abuse (K02 DA17232, P50DA016556, K02DA017232, R01DA016423, PL1DA024859, P50-DA16556)
- National Institute of Dental and Craniofacial Research (R01DE015396, R01 DE 15396)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- neuropeptide Y, genetic variation, haplotypes, stress response, psychological resilience, trait anxiety, amygdala activation, endogenous opioid system, limbic system, individual differences
- MeSH terms
- Alleles, Anxiety, Anxiety Disorders, Brain, Emotions, Facial Expression, Finland, Gene Expression Regulation, Haplotypes, Humans, Lymphocytes, Magnetic Resonance Imaging, Male, Neuropeptide Y, Pain, RNA, Messenger, Stress, Physiological, United States, Genetic Variation, Opioid Peptides, Polymorphism, Single Nucleotide, White People
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
