The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Identification of Holliday junction resolvases from humans and yeast
Open accessAbstract
Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. Here we identify nucleases from Saccharomyces cerevisiae and human cells that promote Holliday junction resolution, in a manner analogous to that shown by the Escherichia coli Holliday junction resolvase RuvC. The human Holliday junction resolvase, GEN1, and its yeast orthologue, Yen1, were independently identified using two distinct experimental approaches: GEN1 was identified by mass spectrometry following extensive fractionation of HeLa cell-free extracts, whereas Yen1 was detected by screening a yeast gene fusion library for nucleases capable of Holliday junction resolution. The eukaryotic Holliday junction resolvases represent a new subclass of the Rad2/XPG family of nucleases. Recombinant GEN1 and Yen1 resolve Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated.
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Cites
Global analysis of protein expression in yeast
Ghaemmaghami, S., Huh, W.-K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., & Weissman, J. S. (2003) · Nature · doi:10.1038/nature02046 · Cited by 3,750
EXO1-A multi-tasking eukaryotic nuclease
Tran, P. T., Erdeniz, N., Symington, L. S., & Liskay, R. M. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.05.015 · Cited by 201
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Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368
Playing the End Game: DNA Double-Strand Break Repair Pathway Choice
Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.029 · Cited by 1,625
DNA repair mechanisms in dividing and non-dividing cells
Iyama, T., & Wilson, D. M. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.04.015 · Cited by 697
Nucleases: diversity of structure, function and mechanism
Yang, W. (2011) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583510000181 · Cited by 692
Human RecQ Helicases in DNA Repair, Recombination, and Replication
Croteau, D. L., Popuri, V., Opresko, P. L., & Bohr, V. A. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035428 · Cited by 538
Metadata
- Authors
- Ip, S. C. Y., Rass, U., Blanco, M. G., Flynn, H. R., Skehel, J. M., & West, S. C.
- Venue
- Nature
- Published
- 2008-11
- Volume
- 456
- Issue
- 7220
- Pages
- 357-361
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2079027867
- Cited by
- 422
- References
- 2
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Ip, S. C. Y., Rass, U., Blanco, M. G., Flynn, H. R., Skehel, J. M., & West, S. C. (2008). Identification of Holliday junction resolvases from humans and yeast. Nature. https://doi.org/10.1038/nature07470
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