EXO1-A multi-tasking eukaryotic nuclease

Tran, Phuoc T.; Erdeniz, Naz; Symington, Lorraine S.; Liskay, R.Michael

doi:10.1016/j.dnarep.2004.05.015

Cited by 201DNA Repair MechanismsDNA and Nucleic Acid ChemistryFungal and yeast genetics research

EXO1-A multi-tasking eukaryotic nuclease

Tran, Phuoc T., Erdeniz, Naz, Symington, Lorraine S., Liskay, R.Michael·2004·DNA Repair

DOI 10.1016/j.dnarep.2004.05.015

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Abstract

Exo1 was first isolated as a 5' --> 3' exonuclease activity induced during meiosis in fission yeast and since that time has been implicated in a multitude of eukaryotic DNA metabolic pathways that include DNA repair, recombination, replication, and telomere integrity. Involvement in multiple pathways affecting genomic stability makes EXO1 a logical target for mutation during oncogenesis. Here, we review studies in several experimental systems that shed light on the role of Exo1 in these DNA transaction pathways, particularly those that may relate to oncogenesis.

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“Experiments performed in yeast cells have suggested that in CLUV conditions no checkpoint is activated, not even during S phase; indeed, checkpoint deficient strains do not exhibit sensitivity to CLUV treatment [62].”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [62]
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“Experiments performed in yeast cells have suggested that in CLUV conditions no checkpoint is activated, not even during S phase; indeed, checkpoint deficient strains do not exhibit sensitivity to CLUV treatment [62].”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [62]
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From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [62]

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A Mutation in EXO1 Defines Separable Roles in DNA Mismatch Repair and a DNA Mismatch Repair-independent DNA Damage Tolerance Pathway
Tran, P. T., Fey, J. P., Gellon, L., Boiteux, S., Chen, Y.-X., Koong, A. C., & Liskay, R. M. (2005) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2005.07.245
Self-citation
EXO1: A tightly regulated nuclease
Sertic, S., Quadri, R., Lazzaro, F., & Muzi-Falconi, M. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102929 · Cited by 58 · see citing works
Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice
Wang, S., Lee, K., Gray, S., Zhang, Y., Tang, C., Morrish, R. B., Tosti, E., van Oers, J., Amin, M. R., Cohen, P. E., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac616 · Cited by 23 · see citing works
Exonuclease 1 and its versatile roles in DNA repair
Keijzers, G., Liu, D., & Rasmussen, L. J. (2016) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2016.1215407 · Cited by 65 · see citing works
Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes
Schaetzlein, S., Chahwan, R., Avdievich, E., Roa, S., Wei, K., Eoff, R. L., Sellers, R. S., Clark, A. B., Kunkel, T. A., Scharff, M. D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308512110 · Cited by 75 · see citing works

Authors: Tran, P. T., Erdeniz, N., Symington, L. S., & Liskay, R. M.
Affiliations: St. Mary's Medical Center (US)
Oregon Health & Science University (US)
Columbia University (US)
Corresponding author: Liskay, R.Michael
ORCID: Tran, Phuoc T.
Symington, Lorraine S.
Venue: DNA Repair
Publisher: Elsevier BV
Published: 2004-12
Volume: 3
Issue: 12
Pages: 1549-1559
ISSN: 1568-7856 (ISSN-L)
1568-7864
DOI: 10.1016/j.dnarep.2004.05.015
OpenAlex: W2019394964
Cited by: 201
References: 79
Citations by year: 2026: 4 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 2 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 5 · 2017: 13 · 2016: 10 · 2015: 14 · 2014: 16 · 2013: 14 · 2012: 9
FWCI: 0.63
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: DNA repair (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (GM41784, GM 45413, R01GM045413, R01GM041784)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: EXO1, exonuclease, DNA recombination, DNA replication, telomere integrity, genome stability, carcinogenesis, meiosis, Schizosaccharomyces pombe, DNA metabolism
MeSH terms: Amino Acid Sequence, Animals, DNA Repair, Exodeoxyribonucleases, Humans, Molecular Sequence Data, Mutation, Neoplasms, Recombination, Genetic, Saccharomyces cerevisiae, Telomere, Protein Structure, Tertiary, DNA Repair Enzymes

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EXO1-A multi-tasking eukaryotic nuclease

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