The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation
Open accessAbstract
Palmitoylation regulates diverse aspects of neuronal protein trafficking and function. Here a global characterization of rat neural palmitoyl-proteomes identifies most of the known neural palmitoyl proteins—68 in total, plus more than 200 new palmitoyl-protein candidates, with further testing confirming palmitoylation for 21 of these candidates. The new palmitoyl proteins include neurotransmitter receptors, transporters, adhesion molecules, scaffolding proteins, as well as SNAREs and other vesicular trafficking proteins. Of particular interest is the finding of palmitoylation for a brain-specific Cdc42 splice variant. The palmitoylated Cdc42 isoform (Cdc42-palm) differs from the canonical, prenylated form (Cdc42-prenyl), both with regard to localization and function: Cdc42-palm concentrates in dendritic spines and has a special role in inducing these post-synaptic structures. Furthermore, assessing palmitoylation dynamics in drug-induced activity models identifies rapidly induced changes for Cdc42 as well as for other synaptic palmitoyl proteins, suggesting that palmitoylation may participate broadly in the activity-driven changes that shape synapse morphology and function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics
Liu, H., Sadygov, R. G., & Yates, J. R. (2004) · Analytical Chemistry · doi:10.1021/ac0498563 · Cited by 2,500
Direct analysis of protein complexes using mass spectrometry
Link, A. J., Eng, J., Schieltz, D. M., Carmack, E., Mize, G. J., Morris, D. R., Garvik, B. M., & Yates, J. R. (1999) · Nature Biotechnology · doi:10.1038/10890 · Cited by 2,237
Palmitoylation: policing protein stability and traffic
Linder, M. E., & Deschenes, R. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2084 · Cited by 1,185
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977
Rapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905
Palmitoylation of Intracellular Signaling Proteins: Regulation and Function
Smotrys, J. E., & Linder, M. E. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073954 · Cited by 610
Lipid Rafts in the Maintenance of Synapses, Dendritic Spines, and Surface AMPA Receptor Stability
Hering, H., Lin, C.-C., & Sheng, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03262.2003 · Cited by 601
Synaptic Strength Regulated by Palmitate Cycling on PSD-95
El-Husseini, A. E.-D., Schnell, E., Dakoji, S., Sweeney, N., Zhou, Q., Prange, O., Gauthier-Campbell, C., Aguilera-Moreno, A., Nicoll, R. A., & Bredt, D. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00683-9 · Cited by 568
Self-citationGlobal Analysis of Protein Palmitoylation in Yeast
Roth, A. F., Wan, J., Bailey, A. O., Sun, B., Kuchar, J. A., Green, W. N., Phinney, B. S., Yates, J. R., & Davis, N. G. (2006) · Cell · doi:10.1016/j.cell.2006.03.042 · Cited by 543
Self-citationMiniature synaptic events maintain dendritic spines via AMPA receptor activation
McKinney, R. A., Capogna, M., Dürr, R., Gähwiler, B. H., & Thompson, A. S. M. (1999) · Nature Neuroscience · doi:10.1038/4548 · Cited by 523
Cited by
Rab GTPases as coordinators of vesicle traffic
Stenmark, H. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2728 · Cited by 3,413
The Postsynaptic Organization of Synapses
Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603
Siegel, G., Obernosterer, G., Fiore, R., Oehmen, M., Bicker, S., Christensen, M., Khudayberdiev, S., Leuschner, P. F., Busch, C. J. L., Kane, C., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1876 · Cited by 500
22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia
Karayiorgou, M., Simon, T. J., & Gogos, J. A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2841 · Cited by 474
Greasing Their Way: Lipid Modifications Determine Protein Association with Membrane Rafts
Levental, I., Grzybek, M., & Simons, K. (2010) · Biochemistry · doi:10.1021/bi100882y · Cited by 420
Metadata
- Authors
- Kang, R., Wan, J., Arstikaitis, P., Takahashi, H., Huang, K., Bailey, A. O., Thompson, J. X., Roth, A. F., Drisdel, R. C., Mastro, R., Green, W. N., Yates III, J. R., Davis, N. G., & El-Husseini, A.
- Venue
- Nature
- Published
- 2008-12
- Volume
- 456
- Issue
- 7224
- Pages
- 904-909
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2051808752
- Cited by
- 537
- References
- 31
- FWCI
- 15.02
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. https://app.cochat.ai/papers/10.1038/nature07605
- The paper
- Kang, R., Wan, J., Arstikaitis, P., Takahashi, H., Huang, K., Bailey, A. O., Thompson, J. X., Roth, A. F., Drisdel, R. C., Mastro, R., Green, W. N., Yates III, J. R., Davis, N. G., & El-Husseini, A. (2008). Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. Nature. https://doi.org/10.1038/nature07605
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
