Cited by 1,831Inflammasome and immune disordersinterferon and immune responsesImmune Response and Inflammation

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Open access

Fernandes-Alnemri, Teresa, Yu, Je-Wook, Datta, Pinaki, Wu, Jianghong, Alnemri, Emad S.·2009·Nature

Open this paper in CoChat — free account

Abstract

Host- and pathogen-associated cytoplasmic double-stranded DNA triggers the activation of a NALP3 (also known as cryopyrin and NLRP3)-independent inflammasome, which activates caspase-1 leading to maturation of pro-interleukin-1beta and inflammation. The nature of the cytoplasmic-DNA-sensing inflammasome is currently unknown. Here we show that AIM2 (absent in melanoma 2), an interferon-inducible HIN-200 family member that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding domain, senses cytoplasmic DNA by means of its oligonucleotide/oligosaccharide-binding domain and interacts with ASC (apoptosis-associated speck-like protein containing a CARD) through its pyrin domain to activate caspase-1. The interaction of AIM2 with ASC also leads to the formation of the ASC pyroptosome, which induces pyroptotic cell death in cells containing caspase-1. Knockdown of AIM2 by short interfering RNA reduced inflammasome/pyroptosome activation by cytoplasmic DNA in human and mouse macrophages, whereas stable expression of AIM2 in the non-responsive human embryonic kidney 293T cell line conferred responsiveness to cytoplasmic DNA. Our results show that cytoplasmic DNA triggers formation of the AIM2 inflammasome by inducing AIM2 oligomerization. This study identifies AIM2 as an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to activation of the ASC pyroptosome and caspase-1.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature07710

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441
NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder
Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
Eisenbarth, S. C., Colegio, O. R., O’Connor, W., Sutterwala, F. S., & Flavell, R. A. (2008) · Nature · doi:10.1038/nature06939 · Cited by 1,542
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
Fernandes-Alnemri, T., Wu, J., Yu, J.-W., Datta, P., Miller, B., Jankowski, W., Rosenberg, S., Zhang, J., & Alnemri, E. S. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402194 · Cited by 1,026
Self-citation
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
Muruve, D. A., Pétrilli, V., Zaiss, A. K., White, L. R., Clark, S. A., Ross, P. J., Parks, R. J., & Tschopp, J. (2008) · Nature · doi:10.1038/nature06664 · Cited by 965
The inflammasome: a danger sensing complex triggering innate immunity
Pétrilli, V., Dostert, C., Muruve, D. A., & Tschopp, J. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.09.002 · Cited by 700
The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1
Srinivasula, S. M., Poyet, J.-L., Razmara, M., Datta, P., Zhang, Z., & Alnemri, E. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200179200 · Cited by 573
Self-citation
The Nlrp3 inflammasome is critical for aluminium hydroxide‐mediated IL‐1β secretion but dispensable for adjuvant activity
Franchi, L., & Núñez, G. (2008) · European Journal of Immunology · doi:10.1002/eji.200838549 · Cited by 462

Flagged first, then by citations

Show all 18 references

Sorted by citations

Items 601–700 of 1,001

Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon‐inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation
Kondo, Y., Nagai, K., Nakahata, S., Saito, Y., Ichikawa, T., Suekane, A., Taki, T., Iwakawa, R., Enari, M., Taniwaki, M., et al. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02211.x · Cited by 77
Inflammasomes and Their Activation
Khare, S., Luc, N., Dorfleutner, A., & Stehlik, C. (2010) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v30.i5.50 · Cited by 77
Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases
Shi, W., Xu, G., Zhan, X., Gao, Y., Wang, Z., Fu, S., Qin, N., Hou, X., Ai, Y., Wang, C., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2460-x · Cited by 76
Bacterial Outer Membrane Vesicle-Mediated Cytosolic Delivery of Flagellin Triggers Host NLRC4 Canonical Inflammasome Signaling
Yang, J., Hwang, I., Lee, E., Shin, S. J., Lee, E., Rhee, J. H., & Yu, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.581165 · Cited by 76
Self-citation
Intracellular Staphylococcus aureus triggers pyroptosis and contributes to inhibition of healing due to perforin-2 suppression
Pastar, I., Sawaya, A. P., Marjanović, J., Burgess, J. L., Strbo, N., Rivas, K. E., Wikramanayake, T. C., Head, C. R., Stone, R. C., Jozic, I., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci133727 · Cited by 77
A comprehensive review of sensors of radiation‐induced damage, radiation‐induced proximal events, and cell death
Saini, S., & Gurung, P. (2024) · Immunological Reviews · doi:10.1111/imr.13409 · Cited by 84
Nucleic acid driven sterile inflammation
Ablasser, A., Hertrich, C., Wassermann, R., & Hornung, V. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.01.003 · Cited by 79
The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice
Tsutsui, H., Imamura, M., Fujimoto, J., & Nakanishi, K. (2010) · Gastroenterology Research and Practice · doi:10.1155/2010/641865 · Cited by 76
Cutting Edge: Mutation of Francisella tularensis mviN Leads to Increased Macrophage Absent in Melanoma 2 Inflammasome Activation and a Loss of Virulence
Ulland, T. K., Buchan, B. W., Ketterer, M. R., Fernandes‐Alnemri, T., Meyerholz, D. K., Apicella, M. A., Alnemri, E. S., Jones, B. D., Nauseef, W. M., & Sutterwala, F. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001610 · Cited by 76
Self-citation
Interferons and inflammasomes: Cooperation and counterregulation in disease
Labzin, L. I., Lauterbach, M., & Latz, E. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.010 · Cited by 77
Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production
Ahn, H., Jeon, E., Kim, J., Kang, S. G., Yoon, S., Ko, H., Kim, P.-H., & Lee, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-01462-4 · Cited by 77
The allosteric activation of cGAS underpins its dynamic signaling landscape
Hooy, R. M., & Sohn, J. (2018) · eLife · doi:10.7554/elife.39984 · Cited by 76
Innate immunity in allergy
Maeda, K., Caldez, M. J., & Akira, S. (2019) · Allergy · doi:10.1111/all.13788 · Cited by 79
Recent advances in ZBP1-derived PANoptosis against viral infections
Oh, S., & Lee, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1148727 · Cited by 76
Signal-induced NLRP3 phase separation initiates inflammasome activation
Zou, G., Tang, Y., Yang, J., Fu, S., Li, Y., Ren, X., Zhou, N., Zhao, W., Gao, J., Ruan, Z., et al. (2025) · Cell Research · doi:10.1038/s41422-025-01096-6 · Cited by 78
Structure, interactions and self-assembly of ASC-dependent inflammasomes
de Alba, E. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.05.023 · Cited by 77
Pyroptosis in development, inflammation and disease
Pan, Y., Cai, W., Huang, J., Cheng, A., Wang, M., Yin, Z., & Jia, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.991044 · Cited by 74
Inflammasomes and viruses: cellular defence versus viral offence
Gram, A. M., Frenkel, J., & Ressing, M. E. (2012) · Journal of General Virology · doi:10.1099/vir.0.042978-0 · Cited by 74
Activation of the NLRP3 inflammasome by intracellular poly I:C
Rajan, J. V., Warren, S. E., Miao, E. A., & Aderem, A. A. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.10.036 · Cited by 74
Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition
Baker, P. J., Nardo, D. D., Moghaddas, F., Tran, L. S., Bachem, A., Nguyen, T. A., Hayman, T. J., Tye, H., Vince, J. E., Bedoui, S., et al. (2017) · Physiological Reviews · doi:10.1152/physrev.00026.2016 · Cited by 75
HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition
Vaccari, M., Fourati, S., Gordon, S. N., Brown, D. R., Bissa, M., Schifanella, L., de Castro, I. S., Doster, M. N., Galli, V., Omsland, M., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0025-7 · Cited by 76
Caspase‐11: arming the guards against bacterial infection
Stowe, I. B., Lee, B. L., & Kayagaki, N. (2015) · Immunological Reviews · doi:10.1111/imr.12292 · Cited by 76
AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA
Nakaya, Y., Lilue, J., Stavrou, S., Moran, E. A., & Ross, S. R. (2017) · mBio · doi:10.1128/mbio.00944-17 · Cited by 75
AIM2 promotes non‐small‐cell lung cancer cell growth through inflammasome‐dependent pathway
Zhang, M., Jin, C.-Y., Yang, Y., Wang, K., Zhou, Y., Zhou, Y., Wang, R., Li, T., & Hu, R. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28617 · Cited by 73
A comprehensive guide to studying inflammasome activation and cell death
Tweedell, R. E., Malireddi, R. K. S., & Kanneganti, T. (2020) · Nature Protocols · doi:10.1038/s41596-020-0374-9 · Cited by 75
The Emerging Role of Nuclear Viral DNA Sensors
Diner, B. A., Lum, K. K., & Cristea, I. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.652289 · Cited by 74
The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines
Hauenstein, A. V., Zhang, L., & Wu, H. (2015) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2015.03.014 · Cited by 75
NLRP7: From inflammasome regulation to human disease
Carrière, J., Dorfleutner, A., & Stehlik, C. (2021) · Immunology · doi:10.1111/imm.13372 · Cited by 78
The machinery of Nod‐like receptors: refining the paths to immunity and cell death
Saleh, M. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01045.x · Cited by 74
Defining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation
Komori, H. K., Hart, T., LaMere, S. A., Chew, P. V., & Salomon, D. R. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401162 · Cited by 74
Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens
Zannetti, C., Roblot, G., Charrier, E., Ainouze, M., Tout, I., Briat, F., Isorce, N., Faure‐Dupuy, S., Michelet, M., Marotel, M., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502301 · Cited by 71
Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of dampened inflammation in bats
Goh, G., Ahn, M., Zhu, F., Lee, L. B., Luo, D., Irving, A. T., & Wang, L. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003352117 · Cited by 71
Comparative 'omics analyses differentiate Mycobacterium tuberculosis and Mycobacterium bovis and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilli
Malone, K. M., Rue-Albrecht, K., Magee, D. A., Conlon, K. M., Schubert, O. T., Nalpas, N., Browne, J. A., Smyth, A., Gormley, E. P., Aebersold, R. H., et al. (2018) · Microbial Genomics · doi:10.1099/mgen.0.000163 · Cited by 72
Pyroptosis: The missing puzzle among innate and adaptive immunity crosstalk
Hachim, M. Y., Khalil, B. A., Elemam, N. M., & Maghazachi, A. A. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mir0120-625r · Cited by 71
Human NLRP1: From the shadows to center stage
Bauernfried, S., & Hornung, V. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20211405 · Cited by 72
Deletion of ripA Alleviates Suppression of the Inflammasome and MAPK by Francisella tularensis
Huang, M. T.-H., Mortensen, B. L., Taxman, D. J., Craven, R. R., Taft-Benz, S., Kijek, T. M., Fuller, J. R., Davis, B. K., Allen, I. C., Brickey, W. J., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002154 · Cited by 72
Self-Complementary AAV9 Gene Delivery Partially Corrects Pathology Associated with Juvenile Neuronal Ceroid Lipofuscinosis (CLN3)
Bosch, M. E., Aldrich, A. L., Fallet, R. W., Odvody, J., Burkovetskaya, M. E., Schuberth, K., Fitzgerald, J. A., Foust, K. D., & Kielian, T. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1635-16.2016 · Cited by 71
Interferons in Autoimmune and Inflammatory Diseases: Regulation and Roles
Choubey, D., & Moudgil, K. D. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0101 · Cited by 69
DNA vaccines against cancer come of age
Stevenson, F. K., Ottensmeier, C. H. H., & Rice, J. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.019 · Cited by 72
Type I Interferon Signaling Regulates Activation of the Absent in Melanoma 2 Inflammasome during Streptococcus pneumoniae Infection
Fang, R., Hara, H., Sakai, S., Hernández-Cuellar, E., Mitsuyama, M., Kawamura, I., & Tsuchiya, K. (2014) · Infection and Immunity · doi:10.1128/iai.01572-14 · Cited by 69
HMGB1–DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE
Liu, L., Yang, M., Kang, R., Dai, Y., Yu, Y., Gao, F., Wang, H., Sun, X., Li, X., Li, J., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.06.074 · Cited by 69
Cytoplasmic nucleic acid sensors in antiviral immunity
Ranjan, P., Bowzard, J. B., Schwerzmann, J., Jeisy-Scott, V., Fujita, T., & Sambhara, S. R. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.003 · Cited by 72
Francisella tularensis Reveals a Disparity between Human and Mouse NLRP3 Inflammasome Activation
Atianand, M., Duffy, E. B., Shah, A., Kar, S., Malik, M., & Harton, J. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.244079 · Cited by 73
The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus
Cheng, W., He, X., Jia, H., Chen, G.-H., Jin, Q., Long, Z.-L., & Jing, Z. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01297 · Cited by 69
Inflammasome-Dependent Cytokines at the Crossroads of Health and Autoinflammatory DiseasePreprint
Gorp, H. V., Opdenbosch, N. V., & Lamkanfi, M. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028563 · Cited by 69
The nucleic acid‐sensing inflammasomes
Xiao, T. S. (2015) · Immunological Reviews · doi:10.1111/imr.12281 · Cited by 71
DEAD/H-box helicases:Anti-viral and pro-viral roles during infections
Ullah, R., Li, J., Fang, P., Xiao, S., & Fang, L. (2021) · Virus Research · doi:10.1016/j.virusres.2021.198658 · Cited by 69
The interferon-inducible HIN-200 gene family in apoptosis and inflammation: Implication for autoimmunity
Mondini, M., Costa, S. F., Sponza, S., Gugliesi, F., Gariglio, M., & Landolfo, S. (2010) · Autoimmunity · doi:10.3109/08916930903510922 · Cited by 68
Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS
Kato, K., Ishii, R., Gotō, E., Ishitani, R., Tokunaga, F., & Nureki, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076983 · Cited by 68
DNA-dependent Activator of Interferon-regulatory Factors (DAI) Promotes Lupus Nephritis by Activating the Calcium Pathway
Zhang, W., Zhou, Q., Xu, W., Cai, Y., Yin, Z., Gao, X., & Xiong, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.457218 · Cited by 69
Cytosolic DNA-Activated Human Dendritic Cells Are Potent Activators of the Adaptive Immune Response
Kis‐Tóth, K., Szántó, A., Thai, T., & Tsokos, G. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100469 · Cited by 73
Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming
Hoyle, C., Rivers‐Auty, J., Lemarchand, E., Vranic, S., Wang, E., Buggio, M., Rothwell, N. J., Allan, S. M., Kostarelos, K., & Brough, D. (2018) · ACS Nano · doi:10.1021/acsnano.8b03642 · Cited by 68
Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases
Paget, C., Doz, E., Winter, N., & Briard, B. (2022) · Cells · doi:10.3390/cells11071188 · Cited by 70
Two signal models in innate immunity
Fontana, M. F., & Vance, R. E. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01037.x · Cited by 70
Thalidomide Inhibits Activation of Caspase-1
Keller, M., Sollberger, G., & Beer, H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900476 · Cited by 67
DHX15 Senses Double-Stranded RNA in Myeloid Dendritic Cells
Lu, H., Lu, N., Weng, L., Yuan, B., Liu, Y., & Zhang, Z. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303322 · Cited by 67
Emerging Significance of NLRs in Inflammatory Bowel Disease
Davis, B. K., Philipson, C. W., Hontecillas, R., Eden, K. B., Bassaganya-Riera, J., & Allen, I. C. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000151 · Cited by 69
Sensing Adenovirus Infection: Activation of Interferon Regulatory Factor 3 in RAW 264.7 Cells
Stein, S. C., & Falck-Pedersen, E. (2012) · Journal of Virology · doi:10.1128/jvi.07071-11 · Cited by 67
Significant Role of IL-1 Signaling, but Limited Role of Inflammasome Activation, in Oviduct Pathology during Chlamydia muridarum Genital Infection
Nagarajan, U. M., Sikes, J. D., Yeruva, L., & Prantner, D. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103461 · Cited by 68
Inflammation-related induction of absent in melanoma 2 (AIM2) in vascular cells and atherosclerotic lesions suggests a role in vascular pathogenesis
Hakimi, M., Peters, A. S., Becker, A., Böckler, D., & Dihlmann, S. (2013) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2013.03.048 · Cited by 67
Sensing the enemy, containing the threat: cell-autonomous immunity toChlamydia trachomatis
Finethy, R., & Coers, J. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw027 · Cited by 68
Digital signaling network drives the assembly of the AIM2-ASC inflammasome
Matyszewski, M., Morrone, S. R., & Sohn, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712860115 · Cited by 70
Copper Regulates the Canonical NLRP3 Inflammasome
Deigendesch, N., Zychlinsky, A., & Meissner, F. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700712 · Cited by 68
Measuring the Inflammasome
Groß, O. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-527-5_15 · Cited by 68
An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression
Doody, G. M., Care, M. A., Burgoyne, N. J., Bradford, J. R., Bota, M., Bonifer, C., Westhead, D. R., & Tooze, R. M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq268 · Cited by 66
Induction of type I interferon by adenovirus-encoded small RNAs
Yamaguchi, T., Kawabata, K., Kouyama, E., Ishii, K. J., Katayama, K., Suzuki, T., Kurachi, S., Sakurai, F., Akira, S., & Mizuguchi, H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009823107 · Cited by 66
Cofactor-independent antiphospholipid antibodies activate the NLRP3-inflammasome via endosomal NADPH-oxidase: implications for the antiphospholipid syndrome
Müller‐Calleja, N., Köhler, A., Siebald, B., Canisius, A., Orning, C., Radsak, M. P., Stein, P., Mönnikes, R., & Lackner, K. J. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-07-0628 · Cited by 67
Role of the Inflammasome in Myocardial Infarction
Takahashi, M. (2011) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.02.002 · Cited by 66
Intracellular Nucleic Acid Sensors and Autoimmunity
Theofilopoulos, A. N., Kono, D. H., Beutler, B., & Baccalà, R. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0092 · Cited by 66
AIM2 Mediates Inflammation-Associated Renal Damage in Hepatitis B Virus-Associated Glomerulonephritis by Regulating Caspase-1, IL-1β, and IL-18
Zhen, J., Zhang, L., Pan, J., Ma, S., Yu, X.-J., Li, X., Chen, S., & Du, W. (2014) · Mediators of Inflammation · doi:10.1155/2014/190860 · Cited by 65
Inflammasomes: Key Mediators of Lung Immunity
Howrylak, J. A., & Nakahira, K. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105229 · Cited by 67
The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome
Haneklaus, M., O’Neil, J. D., Clark, A. R., Masters, S. L., & O'Neill, L. A. J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.772947 · Cited by 66
Canonical and Non-canonical Inflammasome Activation by Outer Membrane Vesicles Derived From Bordetella pertussis
Elizagaray, M. L., Gomes, M. T. R., Guimarães, E. S., Rumbo, M., Hozbor, D. F., Oliveira, S. C., & Moreno, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01879 · Cited by 67
Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway
Jing, R., Hu, Z., Lin, F., he, S. T., Zhang, S., Ge, W., Dai, H., Du, X., Lin, J., & Pan, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00819 · Cited by 64
Parthanatos: Mechanisms, modulation, and therapeutic prospects in neurodegenerative disease and stroke
Liu, Y., Guttman, L. C., Dawson, V. L., & Dawson, T. M. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116174 · Cited by 66
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2
Zeng, F., Zhang, Y., Wang, Z., Zhang, H., Meng, X.-T., Wu, Y., Qian, Z., Ding, Y., Li, J., Ma, T., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01239-2 · Cited by 64
NLR proteins and parasitic disease
Clay, G. M., Sutterwala, F. S., & Wilson, M. E. (2014) · Immunologic Research · doi:10.1007/s12026-014-8544-x · Cited by 67
Evidence For Multiple Cell Death Pathways during Development of Experimental Cytomegalovirus Retinitis in Mice with Retrovirus-Induced Immunosuppression: Apoptosis, Necroptosis, and Pyroptosis
Chien, H., & Dix, R. D. (2012) · Journal of Virology · doi:10.1128/jvi.01275-12 · Cited by 64
Mitochondrial DNA is Released in Urine of SIRS Patients With Acute Kidney Injury and Correlates With Severity of Renal Dysfunction
Jansen, M. P. B., Pulskens, W. P. C., Butter, L. M., Florquin, S., Juffermans, N. P., Roelofs, J. J. T. H., & Leemans, J. C. (2017) · Shock · doi:10.1097/shk.0000000000000967 · Cited by 64
The Absent in Melanoma 2-Like Receptor IFN-Inducible Protein 16 as an Inflammasome Regulator in Systemic Lupus Erythematosus: The Dark Side of Sensing Microbes
Caneparo, V., Landolfo, S., Gariglio, M., & Andrea, M. D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01180 · Cited by 68
Dihydroartemisinin, an antimalarial drug, induces absent in melanoma 2 inflammasome activation and autophagy in human hepatocellular carcinoma HepG2215 cells
Shi, X., Wang, L., Ren, L., Li, J., Li, S., Cui, Q., & Li, S. (2019) · Phytotherapy Research · doi:10.1002/ptr.6332 · Cited by 64
Mitochondrial ros potentiates indirect activation of the aim2 inflammasome
Crane, D. D., Bauler, T. J., Wehrly, T. D., & Bosio, C. M. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00438 · Cited by 63
Zebrafish (Danio rerio) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases
Franza, M., Varricchio, R., Alloisio, G., Simone, G. D., Bella, S. D., Ascenzi, P., & di Masi, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212008 · Cited by 63
DNA vaccines for prostate cancer
Zahm, C. D., Colluru, V. T., & McNeel, D. G. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.016 · Cited by 63
Advanced glycation end products impair NLRP3 inflammasome–mediated innate immune responses in macrophages
Son, S., Hwang, I., Han, S. H., Shin, J., Shin, O. S., & Yu, J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.806307 · Cited by 64
Self-citation
Promising targets based on pattern recognition receptors for cancer immunotherapy
Bai, L., Li, W., Zheng, W., Xu, D., Chen, N., & Cui, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105017 · Cited by 67
CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition
Zhang, T., Wu, D., Luo, P.-W., Liu, T., Han, R., Deng, S., He, M., Zhao, Y., & Xu, Y. X. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04561-x · Cited by 62
The Receptor for Advanced Glycation End Products Activates the AIM2 Inflammasome in Acute Pancreatitis
Kang, R., Chen, R., Xie, M., Cao, L., Lotze, M. T., Tang, D., & Zeh, H. J. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502340 · Cited by 62
Relevance of Caspase-1 and Nlrp3 Inflammasome on Inflammatory Bone Resorption in A Murine Model of Periodontitis
Rocha, F. R. G., Delitto, A. E., de Souza, J. A. C., Gonzalez-Maldonado, L., Wallet, S. M., & Rossa, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-64685-y · Cited by 64
Plant extracellular self-DNA inhibits growth and induces immunity via the jasmonate signaling pathway
Zhou, X., Gao, H., Zhang, X., Rahman, M. K. U., Mazzoleni, S., Du, M., & Wu, F. (2023) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiad195 · Cited by 61
Inflammasome-Mediated IL-1β Production in Humans with Cystic Fibrosis
Tang, A., Sharma, A., Jen, R., Hirschfeld, A. F., Chilvers, M. A., Lavoie, P. M., & Turvey, S. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037689 · Cited by 61
DNA-responsive inflammasomes and their regulators in autoimmunity
Choubey, D. (2011) · Clinical Immunology · doi:10.1016/j.clim.2011.12.007 · Cited by 61
Sensing Cytoplasmic Danger Signals by the Inflammasome
Alnemri, E. S. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9419-0 · Cited by 64
Self-citation
Regulation Where Autophagy Intersects the Inflammasome
Rodgers, M. A., Bowman, J. W., Liang, Q., & Jung, J. U. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5347 · Cited by 62
TNF-Α May Mediate Inflammasome Activation in the Absence of Bacterial Infection in More than One Way
Álvarez, S., & Muñoz‐Fernández, M. Á. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071477 · Cited by 63
Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice
DeSantis, D., Ko, C.-W., Liu, Y., Liu, X., Hise, A. G., Núñez, G., & Croniger, C. M. (2013) · Mediators of Inflammation · doi:10.1155/2013/751374 · Cited by 61
The AIM2 Inflammasome Is Involved in Macrophage Activation During Infection With Virulent Mycobacterium bovis Strain
Yang, Y., Zhou, X., Kouadir, M., Shi, F., Ding, T., Liu, C., Liu, J., Wang, M., Yang, L., Yin, X., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit347 · Cited by 61
Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons
Wang, Y., Li, W., Wu, Y., Yin, Y., Dong, L., Chen, Z., & Wu, W. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0465-7 · Cited by 63
Cross talk between intracellular pathogens and cell death
Demarco, B., Chen, K. W., & Brož, P. (2020) · Immunological Reviews · doi:10.1111/imr.12892 · Cited by 62
Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses
Wang, Y., Wang, Y., Luo, W., Song, X., Huang, L., Xiao, J., Jin, F., Ren, Z., & Wang, Y. (2020) · Theranostics · doi:10.7150/thno.48520 · Cited by 61

Authors: Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S.
Affiliations: Thomas Jefferson University (US)
Corresponding author: Alnemri, Emad S.
ORCID: Yu, Je-Wook
Alnemri, Emad S.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2009-01-21
Volume: 458
Issue: 7237
Pages: 509-513
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature07710
PMC: PMC2862225
OpenAlex: W2042288276
Cited by: 1,831
References: 18
Citations by year: 2026: 56 · 2025: 78 · 2024: 96 · 2023: 108 · 2022: 110 · 2021: 101 · 2020: 102 · 2019: 112 · 2018: 114 · 2017: 111 · 2016: 105 · 2015: 109 · 2014: 92 · 2013: 126 · 2012: 100
FWCI: 54.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
The Medicine Forum (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG14357, R01AG014357)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-055398, R01AR055398)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: AIM2, cytosolic DNA sensing, inflammasome, pyroptosis, caspase-1, ASC, pyrin domain, innate immunity, macrophages, NF-κB, IL-1β
MeSH terms: Animals, Cell Line, Cytoplasm, Cytoskeletal Proteins, DNA, DNA-Binding Proteins, Enzyme Activation, Humans, Inflammation, Nuclear Proteins, Protein Binding, Cell Death, Caspase 1, Apoptosis Regulatory Proteins, Mice, CARD Signaling Adaptor Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks