The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Co-translational mRNA decay in Saccharomyces cerevisiae
Open accessAbstract
The rates of RNA decay and transcription determine the steady-state levels of all messenger RNA and both can be subject to regulation. Although the details of transcriptional regulation are becoming increasingly understood, the mechanism(s) controlling mRNA decay remain unclear. In yeast, a major pathway of mRNA decay begins with deadenylation followed by decapping and 5′–3′ exonuclease digestion. Importantly, it is hypothesized that ribosomes must be removed from mRNA before transcripts are destroyed. Contrary to this prediction, here we show that decay takes place while mRNAs are associated with actively translating ribosomes. The data indicate that dissociation of ribosomes from mRNA is not a prerequisite for decay and we suggest that the 5′–3′ polarity of mRNA degradation has evolved to ensure that the last translocating ribosome can complete translation.
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Cites
P-body formation is a consequence, not the cause, of RNA-mediated gene silencing
Eulalio, A., Behm-Ansmant, I., Schweizer, D., & Izaurralde, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00128-07 · Cited by 710
Cited by
Regulation of mRNA Translation and Stability by microRNAs
Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-103103 · Cited by 3,214
Towards a molecular understanding of microRNA-mediated gene silencing
Jonas, S., & Izaurralde, E. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3965 · Cited by 1,872
Codon Optimality Is a Major Determinant of mRNA Stability
Presnyak, V., Alhusaini, N., Chen, Y.-H., Martin, S., Morris, N., Kline, N., Olson, S., Weinberg, D., Baker, K. E., Graveley, B. R., et al. (2015) · Cell · doi:10.1016/j.cell.2015.02.029 · Cited by 1,078
“Northern RNA Analysis and Sucrose Density Gradients Northern RNA analysis of GAL-driven reporters and sucrose density gradients for polyribosome analysis were performed as previously described (Hu et al., 2009).”
InfluentialSelf-citationCodon optimality, bias and usage in translation and mRNA decay
Hanson, G., & Coller, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.91 · Cited by 825
Self-citationNMD: a multifaceted response to premature translational termination
Kervestin, S., & Jacobson, A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3454 · Cited by 572
Metadata
- Authors
- Hu, W., Sweet, T. J., Chamnongpol, S., Baker, K. E., & Coller, J.
- Venue
- Nature
- Published
- 2009-08-23
- Volume
- 461
- Issue
- 7261
- Pages
- 225-229
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2034774838
- Cited by
- 334
- References
- 1
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Hu, W., Sweet, T. J., Chamnongpol, S., Baker, K. E., & Coller, J. (2009). Co-translational mRNA decay in Saccharomyces cerevisiae. Nature. https://doi.org/10.1038/nature08265
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