Regulation of mRNA Translation and Stability by microRNAs

MicroRNAs: Target Recognition and Regulatory Functions

Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works

Most mammalian mRNAs are conserved targets of microRNAs

Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462 · see citing works

Untitled work

(2008) · doi:10.1038/nrg2290 · Cited by 5,199 · see citing works

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755 · see citing works

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766 · see citing works

The impact of microRNAs on protein output

Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592 · see citing works

Widespread changes in protein synthesis induced by microRNAs

Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429 · cited 3× · see citing works

Biogenesis of small RNAs in animals

Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 3,181 · see citing works

Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation

Vasudevan, S., Tong, Y., & STEITZ, J. A. (2007) · Science · doi:10.1126/science.1149460 · Cited by 2,806 · see citing works

Many roads to maturity: microRNA biogenesis pathways and their regulation

Winter, J. J., Jung, S., Keller, S., Gregory, R. I., & Diederichs, S. (2009) · Nature Cell Biology · doi:10.1038/ncb0309-228 · Cited by 2,646 · see citing works

microRNA Functions

Bushati, N., & Cohen, S. M. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123406 · Cited by 2,563 · see citing works

Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA

Jopling, C. L., Yi, M., Lancaster, A. M., Lemon, S. M., & Sarnow, P. (2005) · Science · doi:10.1126/science.1113329 · Cited by 2,503 · see citing works

Argonaute2 is the catalytic engine of mammalian RNAi

Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J.-J., Hammond, S. M., Joshua-Tor, L., & Hannon, G. J. (2004) · Science · doi:10.1126/science.1102513 · Cited by 2,353 · see citing works

Small silencing RNAs: an expanding universe

Ghildiyal, M., & Zamore, P. D. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2504 · Cited by 2,314 · see citing works

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

Pelletier, J., & Sonenberg, N. (1988) · Nature · doi:10.1038/334320a0 · Cited by 1,953 · see citing works

Specificity of microRNA target selection in translational repressionPreprint

Doench, J. G., & Sharp, P. A. (2004) · Genes & Development · doi:10.1101/gad.1184404 · Cited by 1,642 · see citing works

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling

Kedersha, N., Stoecklin, G., Ayodele, M. O., Yacono, P. W., Lykke‐Andersen, J., Fritzler, M. J., Scheuner, D. L., Kaufman, R. J., Golan, D. E., & Anderson, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200502088 · Cited by 1,494 · see citing works

The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

Farh, K. K.-H., Grimson, A., Jan, C., Lewis, B. P., Johnston, W. K., Lim, L. P., Burge, C. B., & Bartel, D. P. (2005) · Science · doi:10.1126/science.1121158 · Cited by 1,484 · see citing works

Widespread translational inhibition by plant miRNAs and siRNAs

Brodersen, P., Sakvarelidze-Achard, L., Bruun-Rasmussen, M., Dunoyer, P., Yamamoto, Y. Y., Sieburth, L., & Voinnet, O. (2008) · Science · doi:10.1126/science.1159151 · Cited by 1,477 · see citing works

Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F. (2006) · Science · doi:10.1126/science.1122689 · Cited by 1,436 · see citing works

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

Pillai, R. S., Bhattacharyya, S. N., Artus-Revel, C. G., Zoller, T., Cougot, N., Basyuk, E. I., Bertrand, É., & Filipowicz, W. (2005) · Science · doi:10.1126/science.1115079 · Cited by 1,431 · see citing works

MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation

Ørom, U. A., Nielsen, F. C., & Lund, A. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.001 · Cited by 1,384 · see citing works

Translational control of gene expression

Sonenberg, N., Hershey, J. W. B., & Mathews, M. B. (2000) · Cold Spring Harbor Laboratory eBooks · Cited by 1,379 · see citing works

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

Jang, S. K., Kräusslich, H., Nicklin, M. J. H., Duke, G. M., Palmenberg, A. C., & Wimmer, E. (1988) · Journal of Virology · doi:10.1128/jvi.62.8.2636-2643.1988 · Cited by 1,363 · see citing works

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

Bagga, S., Bracht, J. R., Hunter, S. E., Massirer, K. B., Holtz, J., Eachus, R., & Pasquinelli, A. E. (2005) · Cell · doi:10.1016/j.cell.2005.07.031 · Cited by 1,347 · see citing works

P bodies and the control of mRNA translation and degradation

Parker, R., & Sheth, U. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.011 · Cited by 1,335 · see citing works

Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress

Bhattacharyya, S. N., Habermacher, R., Martiné, U., Closs, E. I., & Filipowicz, W. (2006) · Cell · doi:10.1016/j.cell.2006.04.031 · Cited by 1,332 · see citing works

Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways

Lee, Y. S., Nakahara, K., Pham, J. W., Kim, K., He, Z., Sontheimer, E. J., & Carthew, R. W. (2004) · Cell · doi:10.1016/s0092-8674(04)00261-2 · Cited by 1,287 · see citing works

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

Liu, J., Valencia-Sanchez, M. A., Hannon, G. J., & Parker, R. (2005) · Nature Cell Biology · doi:10.1038/ncb1274 · Cited by 1,234 · see citing works

Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR

Lytle, J., Yario, T. A., & STEITZ, J. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703820104 · Cited by 1,196 · see citing works

Translational control of gene expression

Hannig, E. M. (2001) · BioEssays · doi:10.1002/bies.1108 · Cited by 1,194 · see citing works

MicroRNAs direct rapid deadenylation of mRNA

Wu, L., Fan, J., & Belasco, J. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510928103 · Cited by 1,135 · see citing works

Getting to the Root of miRNA-Mediated Gene Silencing

Eulálio, A., Huntzinger, E., & Izaurralde, E. (2008) · Cell · doi:10.1016/j.cell.2007.12.024 · Cited by 1,071 · see citing works

AU-rich elements and associated factors: are there unifying principles?

Barreau, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki1012 · Cited by 1,033 · see citing works

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesPreprint

Behm‐Ansmant, I., Rehwinkel, J., Doerks, T., Stark, A., Bork, P., & Izaurralde, E. (2006) · Genes & Development · doi:10.1101/gad.1424106 · Cited by 1,030 · see citing works

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

Gibbings, D., Ciaudo, C., Erhardt, M., & Voinnet, O. (2009) · Nature Cell Biology · doi:10.1038/ncb1929 · Cited by 990 · see citing works

Internal ribosome entry sites in eukaryotic mRNA moleculesPreprint

Hellen, C. U. T., & Sarnow, P. (2001) · Genes & Development · doi:10.1101/gad.891101 · Cited by 977 · see citing works

The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation

Olsen, P. H., & Ambros, V. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9523 · Cited by 969 · see citing works

P bodies: at the crossroads of post-transcriptional pathways

Eulálio, A., Behm‐Ansmant, I., & Izaurralde, E. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2080 · Cited by 939 · see citing works

Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability

Jing, Q., Huang, S., Guth, S., Zarubin, T., Motoyama, A. B., Chen, J., Padova, F. D., Lin, S., Gram, H., & Han, J. (2005) · Cell · doi:10.1016/j.cell.2004.12.038 · Cited by 849 · see citing works

Biological principles of microRNA-mediated regulation: shared themes amid diversity

Flynt, A. S., & Lai, E. C. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2455 · Cited by 778 · see citing works

Short RNAs Repress Translation after Initiation in Mammalian Cells

Petersen, C. P., Bordeleau, M.-È., Pelletier, J., & Sharp, P. A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.031 · Cited by 755 · see citing works

A three-dimensional view of the molecular machinery of RNA interference

Jínek, M., & Doudna, J. A. (2008) · Nature · doi:10.1038/nature07755 · Cited by 746 · see citing works

RNA-Binding Protein Dnd1 Inhibits MicroRNA Access to Target mRNA

Kedde, M., Strasser, M. J., Boldajipour, B. A., Vrielink, J. A. F. O., Slanchev, K., le Sage, C., Nagel, R., Voorhoeve, P. M., van Duijse, J., Ørom, U. A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.11.034 · Cited by 733 · see citing works

P-body formation is a consequence, not the cause, of RNA-mediated gene silencing

Eulalio, A., Behm-Ansmant, I., Schweizer, D., & Izaurralde, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00128-07 · Cited by 710 · see citing works

Argonaute Proteins: Mediators of RNA Silencing

Peters, L., & Meister, G. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.001 · Cited by 695 · see citing works

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF‐4G.

Tarun, S. Z., & Sachs, A. B. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01108.x · Cited by 690 · see citing works

microRNA‐122 stimulates translation of hepatitis C virus RNA

Henke, J. I., Goergen, D., Zheng, J., Song, Y., Schüttler, C. G., Fehr, C., Jünemann, C., & Niepmann, M. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.244 · Cited by 677 · see citing works

Mammalian Stress Granules and Processing Bodies

Kedersha, N., & Anderson, P. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)31005-7 · Cited by 664 · see citing works

AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2

Vasudevan, S., & Steitz, J. A. (2007) · Cell · doi:10.1016/j.cell.2007.01.038 · Cited by 656 · see citing works

MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

Humphreys, D. T., Westman, B. J., Martin, D. I. K., & Preiß, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506482102 · Cited by 655 · see citing works

MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F

Mathonnet, G., Fabian, M., Svitkin, Y., Parsyan, A., Huck, L., Murata, T., Biffo, S., Merrick, W., Darżynkiewicz, E., Pillai, R., et al. (2007) · Science · doi:10.1126/science.1146067 · Cited by 636 · see citing works

Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells

Chekulaeva, M., & Filipowicz, W. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.04.009 · Cited by 595 · see citing works

Diverse molecular functions of Hu proteins

Hinman, M. N., & Lou, H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8252-6 · Cited by 587 · see citing works

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex

Wang, Y., Juranek, S., Li, H., Sheng, G., Tuschl, T., & Patel, D. J. (2008) · Nature · doi:10.1038/nature07666 · Cited by 577 · see citing works

Mechanisms of microRNA-mediated gene regulation in animal cells

Nilsen, T. W. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.02.011 · Cited by 574 · see citing works

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

Kim, J., Krichevsky, A. M., Grad, Y. H., Hayes, G. D., Kosik, K. S., Church, G. M., & Ruvkun, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2333854100 · Cited by 570 · see citing works

Molecular Basis for Target RNA Recognition and Cleavage by Human RISC

Ameres, S. L., Martı̂nez, J., & Schroeder, R. (2007) · Cell · doi:10.1016/j.cell.2007.04.037 · Cited by 559 · see citing works

Identification of Novel Argonaute-Associated Proteins

Meister, G., Landthaler, M., Peters, L., Chen, P., Urlaub, H., Lührmann, R., & Tuschl, T. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.048 · Cited by 554 · see citing works

HuR recruits let-7/RISC to repress c-Myc expressionPreprint

Kim, H. H., Kuwano, Y., Srikantan, S., Lee, E. K., Martindale, J. L., & Gorospe, M. (2009) · Genes & Development · doi:10.1101/gad.1812509 · Cited by 544 · see citing works

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G. S., Tuschl, T., & Patel, D. J. (2009) · Nature · doi:10.1038/nature08434 · Cited by 542 · see citing works

Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex

Parker, J. S., Roe, S. M., & Barford, D. (2005) · Nature · doi:10.1038/nature03462 · Cited by 531 · see citing works

Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54

Chu, C., & Rana, T. M. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040210 · Cited by 521 · see citing works

MicroRNA silencing through RISC recruitment of eIF6

Chendrimada, T. P., Finn, K. J., Ji, X., Baillat, D., Gregory, R. I., Liebhaber, S. A., Pasquinelli, A. E., & Shiekhattar, R. (2007) · Nature · doi:10.1038/nature05841 · Cited by 509 · see citing works

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

Rehwinkel, J., Behm‐Ansmant, I., Gatfield, D., & Izaurralde, E. (2005) · RNA · doi:10.1261/rna.2191905 · Cited by 493 · see citing works

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms

Kahvejian, A., Svitkin, Y. V., Sukarieh, R., M'Boutchou, M.-N., & Sonenberg, N. (2005) · Genes & Development · doi:10.1101/gad.1262905 · Cited by 491 · see citing works

A <i>Drosophila</i> fragile X protein interacts with components of RNAi and ribosomal proteins

Ishizuka, A., Siomi, M. C., & Siomi, H. (2002) · Genes &amp; Development · doi:10.1101/gad.1022002 · Cited by 486 · see citing works

Eukaryotic mRNA Decapping

Coller, J., & Parker, R. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074032 · Cited by 484 · see citing works

dead end, a Novel Vertebrate Germ Plasm Component, Is Required for Zebrafish Primordial Germ Cell Migration and Survival

Weidinger, G., Stebler, J., Slanchev, K., Dumstrei, K., Wise, C., Lovell-Badge, R. H., Thisse, C., Thisse, B., & Raz, E. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00537-2 · Cited by 472 · see citing works

Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

Yamashita, A., Chang, T.-C., Yamashita, Y., Zhu, W., Zhong, Z., Chen, C. A., & Shyu, A. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1016 · Cited by 472 · see citing works

Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae

Decker, C. J., Teixeira, D., & Parker, R. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704147 · Cited by 468 · see citing works

An mRNA m7G Cap Binding-like Motif within Human Ago2 Represses Translation

Kiriakidou, M., Tan, G. S., Lamprinaki, S., Planell-Saguer, M. D., Nelson, P. T., & Mourelatos, Z. (2007) · Cell · doi:10.1016/j.cell.2007.05.016 · Cited by 462 · see citing works

Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs

Gu, S., Jin, L., Zhang, F., Sarnow, P., & Kay, M. A. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1552 · Cited by 461 · see citing works

Human let-7a miRNA blocks protein production on actively translating polyribosomes

Nottrott, S., Simard, M. J., & Richter, J. D. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1173 · Cited by 459 · see citing works

Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

Kawamura, Y., Saito, K., Taishin Kin, A., Ono, Y., Asai, K., Sunohara, T., Okada, T. N., Siomi, M. C., & Siomi, H. (2008) · Nature · doi:10.1038/nature06938 · Cited by 450 · see citing works

The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTRPreprint

Vella, M. C., Choi, E.-Y., Lin, S.-Y., Reinert, K. L., & Slack, F. J. (2004) · Genes & Development · doi:10.1101/gad.1165404 · Cited by 442 · see citing works

Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1

Förstemann, K., Horwich, M. D., Wee, L. M., Tomari, Y., & Zamore, P. D. (2007) · Cell · doi:10.1016/j.cell.2007.05.056 · Cited by 440 · see citing works

Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly

Ceci, M., Gaviraghi, C., Gorrini, C., Sala, L. A., Offenhäuser, N., Marchisio, P. C., & Biffo, S. (2003) · Nature · doi:10.1038/nature02160 · Cited by 437 · see citing works

Deadenylation is a widespread effect of miRNA regulation

Eulálio, A., Huntzinger, E., Nishihara, T., Rehwinkel, J., Fauser, M., & Izaurralde, E. (2008) · RNA · doi:10.1261/rna.1399509 · Cited by 429 · see citing works

Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules

Leung, A., Calabrese, J. M., & Sharp, P. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0608845103 · Cited by 428 · see citing works

Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome

Jopling, C. L., Schütz, S., & Sarnow, P. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.013 · Cited by 426 · see citing works

GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

Eulálio, A., Huntzinger, E., & Izaurralde, E. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1405 · Cited by 414 · see citing works

Let Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs

Wu, L., & Belasco, J. G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.010 · Cited by 409 · see citing works

The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors

Schwamborn, J. C., Berezikov, E., & Knoblich, J. A. (2009) · Cell · doi:10.1016/j.cell.2008.12.024 · Cited by 408 · see citing works

New initiation factor activity required for globin mRNA translation.

GRIFO, J. A., Tahara, S. M., Morgan, M. A., Shatkin, A. J., & Merrick, W. C. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)81965-6 · Cited by 406 · see citing works

A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies

Andrei, M. A., Ingelfinger, D., Heintzmann, R., Achsel, T., Rivera-Pomar, R. V., & Lührmann, R. (2005) · RNA · doi:10.1261/rna.2340405 · Cited by 406 · see citing works

Two Genetic Circuits Repress the Caenorhabditis elegans Heterochronic Gene lin-28 after Translation Initiation

Seggerson, K., Tang, L., & Moss, E. G. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0563 · Cited by 398 · see citing works

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis

Pillai, R. S., Artus-Revel, C. G., & Filipowicz, W. (2004) · RNA · doi:10.1261/rna.7131604 · Cited by 390 · see citing works

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

Fabian, M. R., Mathonnet, G., Sundermeier, T. R., Mathys, H., Zipprich, J. T., Svitkin, Y. V., Rivas, F. V., Jínek, M., Wohlschlegel, J. A., Doudna, J. A., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.08.004 · Cited by 388 · see citing works

Sorting of Drosophila Small Silencing RNAs

Tomari, Y., Du, T., & Zamore, P. D. (2007) · Cell · doi:10.1016/j.cell.2007.05.057 · Cited by 383 · see citing works

Cellular MicroRNA and P Bodies Modulate Host-HIV-1 Interactions

Nathans, R. S., Chu, C., Serquiña, A., Lu, C., Cao, H., & Rana, T. M. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.003 · Cited by 373 · see citing works

Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

Craig, A. W., Haghighat, A., Yu, A. T. K., & Sonenberg, N. (1998) · Nature · doi:10.1038/33198 · Cited by 367 · see citing works

Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling

Paroo, Z., Ye, X., Chen, S., & Liu, Q. (2009) · Cell · doi:10.1016/j.cell.2009.06.044 · Cited by 366 · see citing works

The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours

Youngren, K. K., Coveney, D., Peng, X., Bhattacharya, C., Schmidt, L. S., Nickerson, M. L., Lamb, B. T., Deng, J. M., Behringer, R. R., Capel, B., et al. (2005) · Nature · doi:10.1038/nature03595 · Cited by 365 · see citing works

Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs

Weinmann, L., Höck, J., Ivacevic, T., Ohrt, T., Mütze, J., Schwille, P., Kremmer, E., Beneš, V., Urlaub, H., & Meister, G. (2009) · Cell · doi:10.1016/j.cell.2008.12.023 · Cited by 365 · see citing works

A Phosphorylated Cytoplasmic Autoantigen, GW182, Associates with a Unique Population of Human mRNAs within Novel Cytoplasmic Speckles

Eystathioy, T., Chan, E. K. L., Tenenbaum, S. A., Keene, J. D., Griffith, K. J., & Fritzler, M. J. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-11-0544 · Cited by 363 · see citing works

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

Landthaler, M., Gaidatzis, D., Rothballer, A., Chen, P., Soll, S. J., Dinic, L., Ojo, T., Hafner, M., Zavolan, M., & Tuschl, T. (2008) · RNA · doi:10.1261/rna.1351608 · Cited by 355 · see citing works

mRNA poly(A) tail, a 3' enhancer of translational initiation.

Munroe, D. J., & Jacobson, A. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3441 · Cited by 351 · see citing works

RNA and microRNAs in fragile X mental retardation

Jin, P., Alisch, R. S., & Warren, S. T. (2004) · Nature Cell Biology · doi:10.1038/ncb1104-1048 · Cited by 344 · see citing works

A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathwayPreprint

O’Carroll, D., Mecklenbräuker, I., Das, P. P., Santana, A., Koenig, U., Enright, A. J., Miska, E. A., & Tarakhovsky, A. (2007) · Genes & Development · doi:10.1101/gad.1565607 · Cited by 343 · see citing works

Evidence that microRNAs are associated with translating messenger RNAs in human cells

Maroney, P. A., Yu, Y., Fisher, J., & Nilsen, T. W. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1174 · Cited by 342 · see citing works

Messenger RNA Turnover in Eukaryotes: Pathways and Enzymes

Meyer, S., Temme, C., & Wahle, E. (2004) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230490513991 · Cited by 342 · see citing works

Silencing by small RNAs is linked to endosomal trafficking

Lee, Y. S., Pressman, S., Andress, A. P., Kim, K., White, J. L., Cassidy, J. J., Li, X., Lubell, K., Lim, D., Cho, I. S., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1930 · Cited by 338 · see citing works

Co-translational mRNA decay in Saccharomyces cerevisiae

Hu, W., Sweet, T. J., Chamnongpol, S., Baker, K. E., & Coller, J. M. (2009) · Nature · doi:10.1038/nature08265 · Cited by 334 · see citing works

Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related componentsPreprint

El‐Shami, M., Pontier, D., Lahmy, S., Braun, L., Picart, C., Véga, D., Hakimi, M., Jacobsen, S. E., Cooke, R., & Lagrange, T. (2007) · Genes & Development · doi:10.1101/gad.451207 · Cited by 321 · see citing works

Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation

Tarun, S. Z., Wells, S. E., Deardorff, J. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9046 · Cited by 316 · see citing works

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Thermann, R., & Hentze, M. W. (2007) · Nature · doi:10.1038/nature05878 · Cited by 314 · see citing works

Inhibition of Ribosome Recruitment Induces Stress Granule Formation Independently of Eukaryotic Initiation Factor 2α Phosphorylation

Mazrouï, R., Sukarieh, R., Bordeleau, M.-È., Kaufman, R. J., Northcote, P. T., Tanaka, J., Gallouzi, I., & Pelletier, J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-04-0318 · Cited by 314 · see citing works

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells

Höck, J., Weinmann, L., Ender, C., Rüdel, S., Kremmer, E., Raabe, M., Urlaub, H., & Meister, G. (2007) · The EMBO Reports · doi:10.1038/sj.embor.7401088 · Cited by 310 · see citing works

Biochemical Evidence for Translational Repression by Arabidopsis MicroRNAs

Lanet, E., Delannoy, É., Sormani, R., Floris, M., Brodersen, P., Crété, P., Voinnet, O., & Robaglia, C. (2009) · The Plant Cell · doi:10.1105/tpc.108.063412 · Cited by 305 · see citing works

Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free systemPreprint

Wakiyama, M., Takimoto, K., Ohara, O., & Yokoyama, S. (2007) · Genes & Development · doi:10.1101/gad.1566707 · Cited by 304 · see citing works

The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules

Wilczynska, A., Aigueperse, C., Kress, M., Dautry, F., & Barbieri-Weill, D. (2005) · Journal of Cell Science · doi:10.1242/jcs.01692 · Cited by 302 · see citing works

Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencingPreprint

Eulálio, A., Rehwinkel, J., Stricker, M., Huntzinger, E., Yang, S.-F., Doerks, T., Dorner, S., Peer Bork, B., Boutros, M., & Izaurralde, E. (2007) · Genes & Development · doi:10.1101/gad.443107 · Cited by 297 · see citing works

A Mechanism for Translationally Coupled mRNA Turnover

Grosset, C., Chen, C.-Y. A., Xu, N., Sonenberg, N., Jacquemin-Sablon, H., & Shyu, A.-B. (2000) · Cell · doi:10.1016/s0092-8674(00)00102-1 · Cited by 295 · see citing works

Differential Regulation of Germline mRNAs in Soma and Germ Cells by Zebrafish miR-430

Mishima, Y., Giraldez, A. J., Takeda, Y., Fujiwara, T., Sakamoto, H., Schier, A. F., & Inoue, K. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.086 · Cited by 276 · see citing works

Factorless Ribosome Assembly on the Internal Ribosome Entry Site of Cricket Paralysis Virus

Jan, E., & Sarnow, P. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)01099-9 · Cited by 270 · see citing works

Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human Ribosomes

Spahn, C. M. T., Jan, E., Mulder, A. M., Grassucci, R. A., Sarnow, P., & Frank, J. (2004) · Cell · doi:10.1016/j.cell.2004.08.001 · Cited by 266 · see citing works

Comparative Analysis of mRNA Targets for Human PUF-Family Proteins Suggests Extensive Interaction with the miRNA Regulatory System

Galgano, A., Forrer, M., Jaśkiewicz, Ł., Kanitz, A., Zavolan, M., & Gerber, A. P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003164 · Cited by 266 · see citing works

The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans

Lei, D., Spencer, A., Morita, K., & Han, M. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.013 · Cited by 263 · see citing works

Micro-RNA Regulation of the Mammalian lin-28 Gene during Neuronal Differentiation of Embryonal Carcinoma Cells

Wu, L., & Belasco, J. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9198-9208.2005 · Cited by 263 · see citing works

Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.

Sonenberg, N., Rupprecht, K. M., Hecht, S. M., & Shatkin, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4345 · Cited by 261 · see citing works

Isolation of microRNA targets by miRNP immunopurification

Easow, G., Teleman, A. A., & Cohen, S. M. (2007) · RNA · doi:10.1261/rna.563707 · Cited by 252 · see citing works

Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing

Azuma-Mukai, A., Oguri, H., Mitsuyama, T., Qian, Z. R., Asai, K., Siomi, H., & Siomi, M. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800334105 · Cited by 249 · see citing works

Prolyl 4-hydroxylation regulates Argonaute 2 stability

Qi, H. H., Ongusaha, P. P., Myllyharju, J., Cheng, D., Pakkanen, O., Shi, Y. G., Lee, S. W., Peng, J., & Shi, Y. (2008) · Nature · doi:10.1038/nature07186 · Cited by 248 · see citing works

A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

Till, S., Lejeune, E., Thermann, R., Bortfeld‐Miller, M., Hothorn, M., Enderle, D., Heinrich, C., Hentze, M. W., & Ladurner, A. G. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1302 · Cited by 242 · see citing works

Systematic Identification of C. elegans miRISC Proteins, miRNAs, and mRNA Targets by Their Interactions with GW182 Proteins AIN-1 and AIN-2

Zhang, L., Lei, D., Cheung, T. H., Dong, M., Chen, J., Sewell, A. K., Liu, X., Yates, J. R., & Han, M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.014 · Cited by 238 · see citing works

Essential and overlapping functions for mammalian Argonautes in microRNA silencingPreprint

Su, H. H., Trombly, M. I., Chen, J., & Wang, X. (2009) · Genes & Development · doi:10.1101/gad.1749809 · Cited by 237 · see citing works

Eukaryotic Initiation Factor 6 is rate-limiting in translation, growth and transformation

Gandin, V., Miluzio, A., Barbieri, A., Beugnet, A., Kiyokawa, H., Marchisio, P., & Biffo, S. (2008) · Nature · doi:10.1038/nature07267 · Cited by 235 · see citing works

New Tricks for Animal MicroRNAs: Targeting of Amino Acid Coding Regions at Conserved and Nonconserved Sites

Rigoutsos, I. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0352 · Cited by 234 · see citing works

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

Zeng, Y., Sankala, H. M., Zhang, X., & Graves, P. R. (2008) · Biochemical Journal · doi:10.1042/bj20080599 · Cited by 225 · see citing works

Substrate requirements for let-7 function in the developing zebrafish embryo

Kloosterman, W. P., Wienholds, E., Ketting, R. F., & Plasterk, R. H. A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw173 · Cited by 223 · see citing works

Involvement of eukaryotic initiation factor 4A in the cap recognition process.

Edery, I., Hümbelin, M., Darveau, A., Lee, K. A. W., Milburn, S. C., Hershey, J. W. B., Trachsel, H., & Sonenberg, N. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44431-0 · Cited by 221 · see citing works

A Novel Role of the Mammalian GSPT/eRF3 Associating with Poly(A)-binding Protein in Cap/Poly(A)-dependent Translation

Uchida, N., Hoshino, S.-I., Imataka, H., Sonenberg, N., & Katada, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203029200 · Cited by 220 · see citing works

Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

Tahbaz, N., Kolb, F. A., Zhang, H., Jaronczyk, K., Filipowicz, W., & Hobman, T. C. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400070 · Cited by 220 · see citing works

Translational Repression by a Novel Partner of Human Poly(A) Binding Protein, Paip2

Khaleghpour, K., Svitkin, Y. V., Craig, A. W., DeMaria, C. T., Deo, R. C., Burley, S. K., & Sonenberg, N. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00168-x · Cited by 212 · see citing works

miRNP:mRNA association in polyribosomes in a human neuronal cell line

Nelson, P. T., Hatzigeorgiou, A. G., & MOURELATOS, Z. (2004) · RNA · doi:10.1261/rna.5181104 · Cited by 210 · see citing works

Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells

Schmitter, D., Filkowski, J. N., Sewer, A., Pillai, R. S., Oakeley, E. J., Zavolan, M., Svoboda, P., & Filipowicz, W. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl646 · Cited by 208 · see citing works

The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing

Eulálio, A., Tritschler, F., & Izaurralde, E. (2009) · RNA · doi:10.1261/rna.1703809 · Cited by 207 · see citing works

The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene

Kong, Y. W., Cannell, I. G., de Moor, C. H., Hill, K., Garside, P. G., Hamilton, T. L., Meijer, H. A., Dobbyn, H. C., Stoneley, M., Spriggs, K. A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800650105 · Cited by 206 · see citing works

Substrate requirements for let-7 function in the developing zebrafish embryo

Kloosterman, W. P. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh968 · Cited by 206 · see citing works

Translation Eukaryotic Initiation Factor 4G Recognizes a Specific Structural Element within the Internal Ribosome Entry Site of Encephalomyocarditis Virus RNA

KOLUPAEVA, V. G., Pestova, T. V., Hellen, C. U. T., & Shatsky, I. N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18599 · Cited by 204 · see citing works

MicroRNA function in neuronal development, plasticity and disease

Fiore, R., Siegel, G., & Schratt, G. M. (2007) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2007.12.006 · Cited by 202 · see citing works

Drosophila Argonaute1 and Argonaute2 Employ Distinct Mechanisms for Translational Repression

Iwasaki, S., Kawamata, T., & Tomari, Y. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.010 · Cited by 193 · see citing works

Cell cycle control of microRNA-mediated translation regulation

Vasudevan, S., Tong, Y., & STEITZ, J. A. (2008) · Cell Cycle · doi:10.4161/cc.7.11.6018 · Cited by 187 · see citing works

The Silencing Domain of GW182 Interacts with PABPC1 To Promote Translational Repression and Degradation of MicroRNA Targets and Is Required for Target Release

Zekri, L., Huntzinger, E., Heimstädt, S., & Izaurralde, E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01081-09 · Cited by 186 · see citing works

Characterization of endogenous human argonautes and their miRNA partners in RNA silencing

向井, あ., & 東, あ. (2008) · Medical Entomology and Zoology · Cited by 179 · see citing works

Recapitulation of Short RNA-Directed Translational Gene Silencing In Vitro

Wang, B., Love, T. M., Call, M. E., Doench, J. G., & Novina, C. D. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.034 · Cited by 178 · see citing works

nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans

Hammell, C. M., Lubin, I., Boag, P. R., Blackwell, T. K., & Ambros, V. (2009) · Cell · doi:10.1016/j.cell.2009.01.053 · Cited by 176 · see citing works

Poly(A)-Binding Protein-Interacting Protein 1 Binds to Eukaryotic Translation Initiation Factor 3 To Stimulate Translation

Martineau, Y., Derry, M. C., Wang, X.-S., Yanagiya, A., Berlanga, J., Shyu, A., Imataka, H., Gehring, K., & Sonenberg, N. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00738-08 · Cited by 163 · see citing works

Argonaute Loading Improves the 5′ Precision of Both MicroRNAs and Their miRNA∗ Strands in Flies

Seitz, H., Ghildiyal, M., & Zamore, P. D. (2008) · Current Biology · doi:10.1016/j.cub.2007.12.049 · Cited by 154 · see citing works

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

Lazzaretti, D., Tournier, I., & Izaurralde, E. (2009) · RNA · doi:10.1261/rna.1606309 · Cited by 153 · see citing works

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing

Lian, S. L., Li, S., Abadal, G. X., Pauley, B. A., Fritzler, M. J., & Chan, E. K. L. (2009) · RNA · doi:10.1261/rna.1229409 · Cited by 150 · see citing works

Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein

Parker, J. S., Parizotto, E. A., Wang, M., Roe, S. M., & Barford, D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.012 · Cited by 149 · see citing works

Paip1 Interacts with Poly(A) Binding Protein through Two Independent Binding Motifs

Roy, G., Crescenzo, G. D., Khaleghpour, K., Kahvejian, A., O'Connor‐McCourt, M. D., & Sonenberg, N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3769-3782.2002 · Cited by 145 · see citing works

Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression

Zipprich, J. T., Bhattacharyya, S., Mathys, H., & Filipowicz, W. (2009) · RNA · doi:10.1261/rna.1448009 · Cited by 135 · see citing works

Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins

Ding, X. C., & Großhans, H. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.275 · Cited by 131 · see citing works

Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression

Takimoto, K., Wakiyama, M., & Yokoyama, S. (2009) · RNA · doi:10.1261/rna.1363109 · Cited by 130 · see citing works

A C-terminal silencing domain in GW182 is essential for miRNA function

Eulálio, A., Helms, S., Fritzsch, C., Fauser, M., & Izaurralde, E. (2009) · RNA · doi:10.1261/rna.1605509 · Cited by 130 · see citing works

MicroRNAs repress translation of m7Gppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylationPreprint

Standart, N., & Jackson, R. J. (2007) · Genes & Development · doi:10.1101/gad.1591507 · Cited by 127 · see citing works

Formation of GW bodies is a consequence of microRNA genesis

Pauley, K. M., Eystathioy, T., Jakymiw, A., Hamel, J. C., Fritzler, M. J., & Chan, E. K. L. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400783 · Cited by 124 · see citing works

Derepression of MicroRNA-mediated Protein Translation Inhibition by Apolipoprotein B mRNA-editing Enzyme Catalytic Polypeptide-like 3G (APOBEC3G) and Its Family Members

Huang, J., Liang, Z.-H., Yang, B., Tian, H., Ma, J., & Zhang, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705116200 · Cited by 121 · see citing works

MicroRNA-repressed mRNAs contain 40S but not 60S components

Wang, B., Yanez, A. G., & Novina, C. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801102105 · Cited by 120 · see citing works

Translation initiation by factor-independent binding of eukaryotic ribosomes to internal ribosomal entry sites

Pisarev, A. V., Shirokikh, N. E., & Hellen, C. U. T. (2005) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2005.02.004 · Cited by 112 · see citing works

Structural basis of ligand recognition by PABC, a highly specific peptide‐binding domain found in poly(A)‐binding protein and a HECT ubiquitin ligase

Kozlov, G., Crescenzo, G. D., Lim, N. S., Siddiqui, N., Fantus, D., Kahvejian, A., Trempe, J., Elias, D., Ekiel, I. H., Sonenberg, N., et al. (2003) · The EMBO Journal · doi:10.1038/sj.emboj.7600048 · Cited by 110 · see citing works

microRNA-Mediated Messenger RNA Deadenylation Contributes to Translational Repression in Mammalian Cells

Beilharz, T. H., Humphreys, D. T., Clancy, J. L., Thermann, R., Martin, D. I. K., Hentze, M. W., & Preiß, T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006783 · Cited by 108 · see citing works

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

Jínek, M., Fabian, M. R., Coyle, S. M., Sonenberg, N., & Doudna, J. A. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1768 · Cited by 106 · see citing works

Functional Dissection of the Human TNRC6 (GW182-Related) Family of Proteins

Baillat, D., & Shiekhattar, R. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00380-09 · Cited by 103 · see citing works

GERp95, a Membrane-associated Protein that Belongs to a Family of Proteins Involved in Stem Cell Differentiation

Cikaluk, D. E., Tahbaz, N., Hendricks, L. C., DiMattia, G. E., Hansen, D., Pilgrim, D. B., & Hobman, T. C. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.10.3357 · Cited by 99 · see citing works

Function and Localization of MicroRNAs in Mammalian CellsPreprint

Leung, A. K. L., & Sharp, P. A. (2006) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2006.71.049 · Cited by 96 · see citing works

Importance of Translation and Nonnucleolytic Ago Proteins for On-Target RNA Interference

Wu, L., Fan, J., & Belasco, J. G. (2008) · Current Biology · doi:10.1016/j.cub.2008.07.072 · Cited by 82 · see citing works

Back to basics: the untreated rabbit reticulocyte lysate as a competitive system to recapitulate cap/poly(A) synergy and the selective advantage of IRES-driven translation

Soto‐Rifo, R., Ricci, E. P., Décimo, D., Moncorgé, O., & Ohlmann, T. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm682 · Cited by 79 · see citing works

Drosophila miR2 Primarily Targets the m7GpppN Cap Structure for Translational Repression

Zdanowicz, A., Thermann, R., Kowalska, J., Jemielity, J., Duncan, K. E., Preiß, T., Darżynkiewicz, E., & Hentze, M. W. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.009 · Cited by 79 · see citing works

Activation of hepatitis c virus translation by a liver-specific microRNA

Niepmann, M. (2009) · Cell Cycle · doi:10.4161/cc.8.10.8349 · Cited by 79 · see citing works

The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3′UTR-mediated repression of the let-7 microRNA target gene, hbl-1

Nolde, M. J., Saka, N., Reinert, K. L., & Slack, F. J. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.040 · Cited by 72 · see citing works

GERp95 Belongs to a Family of Signal-transducing Proteins and Requires Hsp90 Activity for Stability and Golgi Localization

Tahbaz, N., Carmichael, J. B., & Hobman, T. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107808200 · Cited by 71 · see citing works

Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila

Chekulaeva, M., Filipowicz, W., & Parker, R. (2009) · RNA · doi:10.1261/rna.1364909 · Cited by 71 · see citing works

Regulating the Regulators: Posttranslational Modifications of RNA Silencing Factors

Heo, I., & Kim, V. N. (2009) · Cell · doi:10.1016/j.cell.2009.09.013 · Cited by 67 · see citing works

Translation of Encephalomyocarditis Virus RNA by Internal Ribosomal Entry

Hellen, C. U. T., & Wimmer, E. (1995) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79663-0_2 · Cited by 66 · see citing works

Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing

Li, S., Lian, S. L., Moser, J. J., Fritzler, M. L., Fritzler, M. J., Satoh, M., & Chan, E. K. L. (2008) · Journal of Cell Science · doi:10.1242/jcs.036905 · Cited by 64 · see citing works

Computational analysis of miRNA-mediated repression of translation: Implications for models of translation initiation inhibition

Nissan, T. A., & Parker, R. (2008) · RNA · doi:10.1261/rna.1072808 · Cited by 62 · see citing works

The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing

Eulálio, A., Tritschler, F., Büttner, R., Weichenrieder, O., Izaurralde, E., & Truffault, V. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp173 · Cited by 59 · see citing works

Mitogenic and nutritional signals are transduced into translational efficiency of TOP mRNAs.Preprint

Hornstein, E., Tang, H., & Meyuhas, O. (2001) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2001.66.477 · Cited by 58 · see citing works

GW Bodies, MicroRNAs and the Cell Cycle

Lian, S., Jakymiw, A., Eystathioy, T., Hamel, J. C., Fritzler, M. J., & Chan, E. K. L. (2006) · Cell Cycle · doi:10.4161/cc.5.3.2410 · Cited by 57 · see citing works

Translation of nonSTOP mRNA is repressed post‐initiation in mammalian cells

Akimitsu, N., Tanaka, J., & Pelletier, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601679 · Cited by 54 · see citing works

The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation

Ding, X. C., Slack, F. J., & Großhans, H. (2008) · Cell Cycle · doi:10.4161/cc.7.19.6778 · Cited by 54 · see citing works

MicroRNAs tell an evo–devo story

Kosik, K. S. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2713 · Cited by 51 · see citing works

Functions of Eukaryotic Factors in Initiation of TranslationPreprint

Pestova, T. V., & Hellen, C. U. T. (2001) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2001.66.389 · Cited by 40 · see citing works

The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif

Kinch, L. N., & Grishin, N. V. (2009) · Biology Direct · doi:10.1186/1745-6150-4-2 · Cited by 38 · see citing works

Phosphorylation of Argonaute proteins: regulating gene regulators

Rüdel, S., & Meister, G. (2008) · Biochemical Journal · doi:10.1042/bj20081244 · Cited by 17 · see citing works

The widespread regulation of microRNA biogenesis, function and decay

Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672 · see citing works

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works

The host shapes the gut microbiota via fecal microRNA

Liu, S., da Cunha, A. P., Rezende, R. M., Cialic, R., Wei, Z., Bry, L., Comstock, L. E., Gandhi, R., & Weiner, H. L. (2016) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2015.12.005 · Cited by 808 · see citing works

Codon optimality, bias and usage in translation and mRNA decay

Hanson, G., & Coller, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.91 · Cited by 825 · see citing works

IntaRNA 2.0: enhanced and customizable prediction of RNA–RNA interactions

Mann, M., Wright, P. R., & Backofen, R. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx279 · Cited by 725 · see citing works

Antisense technology: an overview and prospectus

Crooke, S. T., Baker, B. F., Crooke, R. M., & Liang, X.-H. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00162-z · Cited by 775 · see citing works

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

Bazzini, A. A., Lee, M. T., & Giraldez, A. J. (2012) · Science · doi:10.1126/science.1215704 · Cited by 709 · see citing works

Mechanisms and Consequences of Alternative Polyadenylation

Di Giammartino, D. C., Nishida, K., & Manley, J. L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.017 · Cited by 737 · see citing works

MicroRNAs in the p53 network: micromanagement of tumour suppression

Hermeking, H. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3318 · Cited by 518 · see citing works

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation

Pandolfini, L., Barbieri, I., Bannister, A. J., Hendrick, A., Andrews, B., Webster, N., Murat, P., Mach, P., Brandi, R., Robson, S. C., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.03.040 · Cited by 491 · see citing works

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

Tumaneng, K., Schlegelmilch, K., Russell, R. C., Yimlamai, D., Basnet, H., Mahadevan, N., Fitamant, J., Bardeesy, N., Camargo, F. D., & Guan, K.-L. (2012) · Nature Cell Biology · doi:10.1038/ncb2615 · Cited by 453 · see citing works

The epigenetics of aging and neurodegeneration

Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381 · see citing works

miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity

Moore, M. J., Scheel, T. K. H., Luna, J. M., Park, C. Y., Fak, J. J., Nishiuchi, E., Rice, C. M., & Darnell, R. B. (2015) · Nature Communications · doi:10.1038/ncomms9864 · Cited by 326 · see citing works

Dysregulation and restoration of translational homeostasis in fragile X syndrome

Richter, J. D., Bassell, G. J., & Klann, E. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4001 · Cited by 275 · see citing works

Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis

Moore, M. J., Zhang, C., Gantman, E. C., Mele, A., Darnell, J. C., & Darnell, R. B. (2014) · Nature Protocols · doi:10.1038/nprot.2014.012 · Cited by 251 · see citing works

microRNA as Repressors of Stress-Induced Anxiety: The Case of Amygdalar miR-34

Haramati, S., Navon, I., Issler, O., Ezra-Nevo, G., Gil, S., Zwang, R., Hornstein, E., & Chen, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1673-11.2011 · Cited by 252 · see citing works

The regulation of mRNA stability in mammalian cells: 2.0

Wu, X., & Brewer, G. (2012) · Gene · doi:10.1016/j.gene.2012.03.021 · Cited by 239 · see citing works

MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways

He, X., Jing, Z., & Cheng, G. (2014) · BioMed Research International · doi:10.1155/2014/945169 · Cited by 238 · see citing works

An RNA toolbox for cancer immunotherapy

Pastor, F., Berraondo, P., Etxeberria, I., Frederick, J., Sahin, U., Gilboa, E., & Melero, I. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.132 · Cited by 229 · see citing works

General Principals of miRNA Biogenesis and Regulation in the Brain

O'Carroll, D., & Schaefer, A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.87 · Cited by 205 · see citing works

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

Kundu, P., Fabian, M. R., Sonenberg, N., Bhattacharyya, S. N., & Filipowicz, W. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks148 · Cited by 180 · see citing works

The gut microbiome and mental health: implications for anxiety- and trauma-related disorders

Malan-Muller, S., Valles-Colomer, M., Raes, J., Lowry, C. A., Seedat, S., & Hemmings, S. M. J. (2018) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2017.0077 · Cited by 161 · see citing works

NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

Eom, T., Zhang, C., Wang, H., Lay, K., Fak, J., Noebels, J. L., & Darnell, R. B. (2013) · eLife · doi:10.7554/elife.00178 · Cited by 118 · see citing works

Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging

Wei, Y.-N., Hu, H.-Y., Xie, G.-C., Fu, N., Ning, Z.-B., Zeng, R., & Khaitovich, P. (2015) · Genome Biology · doi:10.1186/s13059-015-0608-2 · Cited by 117 · see citing works

Translation Regulation as a Therapeutic Target in Cancer

Grzmil, M., & Hemmings, B. A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0026 · Cited by 103 · see citing works

Identification of MicroRNAs Involved in Hypoxia- and Serum Deprivation-Induced Apoptosis in Mesenchymal Stem Cells

Nie, Y., Han, B.-M., Liu, X.-B., Yang, J.-J., Wang, F., Cong, X.-F., & Chen, X. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.762 · Cited by 104 · see citing works

TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer

Gong, K., Guo, G., Gerber, D. E., Gao, B., Peyton, M., Huang, C., Minna, J. D., Hatanpaa, K. J., Kernstine, K., Cai, L., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96148 · Cited by 98 · see citing works

Brain‐derived neurotrophic factor expression is repressed during myogenic differentiation by miR‐206

Miura, P., Amirouche, A., Clow, C., Bélanger, G., & Jasmin, B. J. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07583.x · Cited by 92 · see citing works

Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode

Agrawal, P., Kurcon, T., Pilobello, K. T., Rakus, J. F., Koppolu, S., Liu, Z., Batista, B. S., Eng, W. S., Hsu, K.-L., Liang, Y., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321524111 · Cited by 77 · see citing works

miRNAs in immune responses to Mycobacterium tuberculosis infection

Yang, T., & Ge, B. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.028 · Cited by 78 · see citing works

BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis

Dong, X., Hu, X., Chen, J., Hu, D., & Chen, L.-F. (2018) · Cell Death &amp; Disease · doi:10.1038/s41419-017-0181-6 · Cited by 75 · see citing works

Reprogramming macrophage orientation by microRNA 146b targeting transcription factor IRF5

Peng, L., Zhang, H., Hao, Y., Xu, F., Yang, J., Zhang, R., Lu, G., Zheng, Z., Cui, M., Qi, C.-F., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.10.041 · Cited by 67 · see citing works

miRTex: A Text Mining System for miRNA-Gene Relation Extraction

Li, G., Ross, K. E., Arighi, C. N., Peng, Y., Wu, C. H., & Vijay-Shanker, K. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004391 · Cited by 61 · see citing works

An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4

Fehler, O., Singh, P., Haas, A., Ulrich, D., Müller, J. P., Ohnheiser, J., & Klempnauer, K.-H. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku800 · Cited by 35 · see citing works

Monocytes/macrophages as one of the sources of myofibroblasts in the development of tissue fibrosis: the role of noncoding RNAs

Balan, O. V., Malysheva, I. E., & Fedorenko, O. M. (2025) · Russian Journal of Genetics · doi:10.1134/s1022795424701643 · Cited by 1 · see citing works

Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR

Lebedeva, S., Jens, M., Theil, K., Schwanhäusser, B., Selbach, M., Landthaler, M., & Rajewsky, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.008 · Cited by 716 · see citing works

Regulation and dysregulation of 3′UTR-mediated translational control

Jia, J., Yao, P., Arif, A., & Fox, P. L. (2013) · Current Opinion in Genetics &amp; Development · doi:10.1016/j.gde.2012.12.004 · Cited by 92 · see citing works

Post-Transcriptional Regulation of Connexin43 in H-Ras-Transformed Cells

Kandouz, M., Zhao, J., Bier, A., Marco, S. D., Landaverde, I. O., Gallouzi, I., & Batist, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058500 · Cited by 9 · see citing works

RNA-binding protein-mediated post-transcriptional controls of gene expression: Integration of molecular mechanisms at the 3′ end of mRNAs?

Vindry, C., Ngoc, L. V., Kruys, V., & Gueydan, C. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.04.003 · Cited by 9 · see citing works

3′untranslated regions: regulation at the end of the road

Mouali, Y. E., & Balsalobre, C. (2018) · Current Genetics · doi:10.1007/s00294-018-0877-x · Cited by 18 · see citing works