The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Odorant reception in the malaria mosquito Anopheles gambiae
Open accessAbstract
The mosquito Anopheles gambiae is the major vector of malaria in sub-Saharan Africa. It locates its human hosts primarily through olfaction, but little is known about the molecular basis of this process. Here we functionally characterize the Anopheles gambiae odorant receptor (AgOr) repertoire. We identify receptors that respond strongly to components of human odour and that may act in the process of human recognition. Some of these receptors are narrowly tuned, and some salient odorants elicit strong responses from only one or a few receptors, suggesting a central role for specific transmission channels in human host-seeking behaviour. This analysis of the Anopheles gambiae receptors permits a comparison with the corresponding Drosophila melanogaster odorant receptor repertoire. We find that odorants are differentially encoded by the two species in ways consistent with their ecological needs. Our analysis of the Anopheles gambiae repertoire identifies receptors that may be useful targets for controlling the transmission of malaria.
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Cites
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Combinatorial Receptor Codes for Odors
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Or83b Encodes a Broadly Expressed Odorant Receptor Essential for Drosophila Olfaction
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Self-citationThe Molecular Basis of Odor Coding in the Drosophila Antenna
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Self-citationODOR-MEDIATED BEHAVIOR OF AFROTROPICAL MALARIA MOSQUITOES
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G Protein-Coupled Receptors in Anopheles gambiae
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Self-citationOlfactory Perception: Receptors, Cells, and Circuits
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Self-citationOdor Coding by a Mammalian Receptor Repertoire
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orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET
DeGennaro, M., McBride, C. S., Seeholzer, L., Nakagawa, T., Dennis, E. J., Goldman, C., Jasinskiene, N., James, A. A., & Vosshall, L. B. (2013) · Nature · doi:10.1038/nature12206 · Cited by 473
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Metadata
- Authors
- Carey, A. F., Wang, G., Su, C.-Y., Zwiebel, L. J., & Carlson, J. R.
- Venue
- Nature
- Published
- 2010-02-03
- Volume
- 464
- Issue
- 7285
- Pages
- 66-71
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2034711534
- Cited by
- 613
- References
- 45
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- green
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