The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Molecular basis of infrared detection by snakes
Open accessAbstract
Snakes possess a unique sensory system for detecting infrared radiation, enabling them to generate a ‘thermal image’ of predators or prey. Infrared signals are initially received by the pit organ, a highly specialized facial structure that is innervated by nerve fibres of the somatosensory system. How this organ detects and transduces infrared signals into nerve impulses is not known. Here we use an unbiased transcriptional profiling approach to identify TRPA1 channels as infrared receptors on sensory nerve fibres that innervate the pit organ. TRPA1 orthologues from pit-bearing snakes (vipers, pythons and boas) are the most heat-sensitive vertebrate ion channels thus far identified, consistent with their role as primary transducers of infrared stimuli. Thus, snakes detect infrared signals through a mechanism involving radiant heating of the pit organ, rather than photochemical transduction. These findings illustrate the broad evolutionary tuning of transient receptor potential (TRP) channels as thermosensors in the vertebrate nervous system.
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A gene atlas of the mouse and human protein-encoding transcriptomes
Su, A. I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K. A., Block, D., Zhang, J., Soden, R., Hayakawa, M., Kreiman, G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400782101 · Cited by 3,475
Molecular mechanisms of nociception
Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685
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Chen, R., Romero, G., Christiansen, M. G., Mohr, A., & Anikeeva, P. (2015) · Science · doi:10.1126/science.1261821 · Cited by 685
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
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The thermo‐TRP ion channel family: properties and therapeutic implications
Vay, L., Gu, C., & McNaughton, P. A. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01601.x · Cited by 296
Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae
Ma, Y., Bao, J., Zhang, Y., Li, Z., Zhou, X., Wan, C., Huang, L., Zhao, Y., Han, G., & Xue, T. (2019) · Cell · doi:10.1016/j.cell.2019.01.038 · Cited by 292
Metadata
- Authors
- Gracheva, E. O., Ingolia, N. T., Kelly, Y. M., Cordero-Morales, J. F., Hollopeter, G., Chesler, A. T., Sánchez, E. E., Perez, J. C., Weissman, J. S., & Julius, D.
- Venue
- Nature
- Published
- 2010-03-14
- Volume
- 464
- Issue
- 7291
- Pages
- 1006-1011
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2031848382
- Cited by
- 482
- References
- 2
- FWCI
- 13.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Gracheva, E. O., Ingolia, N. T., Kelly, Y. M., Cordero-Morales, J. F., Hollopeter, G., Chesler, A. T., Sánchez, E. E., Perez, J. C., Weissman, J. S., & Julius, D. (2010). Molecular basis of infrared detection by snakes. Nature. https://doi.org/10.1038/nature08943
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