Cited by 1,898Tuberculosis Research and EpidemiologyInfectious Diseases and TuberculosisImmune responses and vaccinations

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

Open access

Berry, Matthew P. R., Graham, Christine M., McNab, Finlay W., Xu, Zhaohui, Bloch, Susannah A. A., Oni, Tolu, Wilkinson, Katalin A., Banchereau, Romain, Skinner, Jason, Wilkinson, Robert J., Quinn, Charles, Blankenship, Derek, Dhawan, Ranju, Cush, John J., Mejias, Asuncion, Ramilo, Octavio, Kon, Onn M., Pascual, Virginia, Banchereau, Jacques, Chaussabel, Damien, O’Garra, Anne·2010·Nature

DOI 10.1038/nature09247PMC PMC3492754

Open this paper in CoChat — free account

Abstract

Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment. Most people infected with M. tuberculosis remain asymptomatic, termed latent TB, with a 10% lifetime risk of developing active TB disease. Current tests, however, cannot identify which individuals will develop disease. The immune response to M. tuberculosis is complex and incompletely characterized, hindering development of new diagnostics, therapies and vaccines. Here we identify a whole-blood 393 transcript signature for active TB in intermediate and high-burden settings, correlating with radiological extent of disease and reverting to that of healthy controls after treatment. A subset of patients with latent TB had signatures similar to those in patients with active TB. We also identify a specific 86-transcript signature that discriminates active TB from other inflammatory and infectious diseases. Modular and pathway analysis revealed that the TB signature was dominated by a neutrophil-driven interferon (IFN)-inducible gene profile, consisting of both IFN-gamma and type I IFN-alphabeta signalling. Comparison with transcriptional signatures in purified cells and flow cytometric analysis suggest that this TB signature reflects changes in cellular composition and altered gene expression. Although an IFN-inducible signature was also observed in whole blood of patients with systemic lupus erythematosus (SLE), their complete modular signature differed from TB, with increased abundance of plasma cell transcripts. Our studies demonstrate a hitherto underappreciated role of type I IFN-alphabeta signalling in the pathogenesis of TB, which has implications for vaccine and therapeutic development. Our study also provides a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the TB epidemic.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature09247

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Baechler, E. C., Batliwalla, F., Karypis, G., Gaffney, P. M., Ortmann, W. A., Espe, K. J., Shark, K. B., Grande, W. J., Hughes, K. M. H., Kapur, V., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337679100 · Cited by 2,246
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Bennett, L. B., Palucka, K., Arce, E., Cantrell, V., Borvák, J., Banchereau, J., & Pascual, V. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021553 · Cited by 1,990
Self-citation
Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,744
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
Barry, C. E., Boshoff, H. I., Dartois, V. A., Dick, T., Ehrt, S., Flynn, J. L., Schnappinger, D., Wilkinson, R. J., & Young, D. B. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2236 · Cited by 1,441
Self-citation
Cell-Mediated Immune Responses in Tuberculosis
Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,194
Immunology of tuberculosis.
Flynn, J., & Chan, J. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.93 · Cited by 1,144
Genetic Dissection of Immunity to Mycobacteria: The Human Model
Casanova, J., & Abel, L. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.081501.125851 · Cited by 1,006
A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus
Chaussabel, D., Quinn, C., Shen, J., Patel, P., Glaser, C., Baldwin, N., Stichweh, D., Blankenship, D., Li, L., Munagala, I., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.012 · Cited by 649
Self-citation
Immunisation against infectious disease
SALISBURY, D. M., Ramsay, M. E., & Noakes, K. (2006) · Stationery Office eBooks · Cited by 636
Tuberculosis. Clinical diagnosis and management of tuberculosis and measures for its prevention and control
Newsom, S. W. B. (2006) · Journal of Hospital Infection · doi:10.1016/j.jhin.2006.06.003 · Cited by 636

Flagged first, then by citations

Show all 29 references

Research works printed but not linked: 2

Dye, C., Floyd, K. & Uplekar, M. in Global Tuberculosis Control: Surveillance, Planning, Financing Ch. 1, 17–37 (World Health Organization, 2008)
Falk, A. & O’Connor, J. B. in Diagnosis Standards and Classification of Tuberculosis, vol. 12 (eds Falk, A. et al.), 68–76 (National Tuberculosis and Respiratory Disease Association, 1969)

Sorted by citations

Items 601–700 of 1,000

Quantitative Lipid Droplet Proteomics Reveals Mycobacterium tuberculosis Induced Alterations in Macrophage Response to Infection
Menon, D., Singh, K., Pinto, S. M., Nandy, A., Jaisinghani, N., Kutum, R., Dash, D., Prasad, T. S. K., & Gandotra, S. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.8b00301 · Cited by 50
GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity
Bartlett, S., Gemiarto, A. T., Ngo, M. D., Sajiir, H., Hailu, S. G., Sinha, R., Foo, C. X., Kleynhans, L., Tshivhula, H., Webber, T., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.601534 · Cited by 47
Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes
DiNardo, A. R., Gandhi, T., Heyckendorf, J., Grimm, S. L., Rajapakshe, K., Nishiguchi, T., Reimann, M., Kirchner, H. L., Kahari, J., Dlamini, Q., et al. (2022) · European Respiratory Journal · doi:10.1183/13993003.02263-2021 · Cited by 47
The immunopathogenesis of the HIV tuberculosis immune reconstitution inflammatory syndrome
Lai, R., Nakiwala, J. K., Meintjes, G., & Wilkinson, R. J. (2013) · European Journal of Immunology · doi:10.1002/eji.201343632 · Cited by 46
Self-citation
Comprehensive identification of immuno-related transcriptional signature for active pulmonary tuberculosis by integrated analysis of array and single cell RNA-seq
Xu, Y., Tan, Y., Zhang, X., Cheng, M., Hu, J., Liu, J., Chen, X., & Zhu, J. (2022) · Journal of Infection · doi:10.1016/j.jinf.2022.08.017 · Cited by 46
Single-cell RNA-sequencing reveals heterogeneity and intercellular crosstalk in human tuberculosis lung
Wang, L., Ma, H., Wen, Z., Niu, L., Chen, X., Liu, H., Zhang, S., Xu, J., Zhu, Y., Li, H., et al. (2023) · Journal of Infection · doi:10.1016/j.jinf.2023.09.004 · Cited by 46
Autophagy promotes efficient T cell responses to restrict high-dose Mycobacterium tuberculosis infection in mice
Feng, S., McNehlan, M. E., Kinsella, R. L., Chowdhury, C. S., Chavez, S. M., Naik, S. K., McKee, S. R., Winkle, J. A. V., Dubey, N., Samuels, A. N., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01608-x · Cited by 46
Diagnosis and treatment of latent infection with M ycobacterium tuberculosis
Chee, C. B.-E., Sester, M., Zhang, W., & Lange, C. G. (2012) · Respirology · doi:10.1111/resp.12002 · Cited by 46
A hemocyte gene expression signature correlated with predictive capacity of oysters to survive Vibrio infections
Rosa, R. D., de Lorgeril, J., Tailliez, P., Bruno, R., Piquemal, D., & Bachère, E. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-252 · Cited by 46
Type I, II, and III Interferons: Regulating Immunity to Mycobacterium tuberculosis Infection
Travar, M., Petković, M. R., & Verhaz, A. (2015) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0365-7 · Cited by 47
Transcriptomic Biomarkers for Tuberculosis: Evaluation of DOCK9. EPHA4, and NPC2 mRNA Expression in Peripheral Blood
de Araujo, L. S., Vaas, L. A. I., Alves, M. R., Geffers, R., Mello, F. C. D. Q., de Almeida, A. S., Moreira, A. D. S. R., Kritski, A. L., Silva, J. R. L. E., Moraes, M. O., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01586 · Cited by 46
Diagnostic accuracy of a selected signature gene set that discriminates active pulmonary tuberculosis and other pulmonary diseases
Francisco, N. M., Fang, Y., Ding, L., Feng, S., Yang, Y., Wu, M., Jacobs, M., Ryffel, B., & Huang, X. (2017) · Journal of Infection · doi:10.1016/j.jinf.2017.09.012 · Cited by 46
Isoniazid and host immune system interactions: A proposal for a novel comprehensive mode of action
Khan, S. R., Manialawy, Y. M., & Siraki, A. G. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14867 · Cited by 46
Genetics and evolution of tuberculosis pathogenesis: New perspectives and approaches
McHenry, M. L., Williams, S. M., & Stein, C. M. (2020) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2020.104204 · Cited by 48
Diagnostic performance of multiplex cytokine and chemokine assay for tuberculosis
Wang, X., Jiang, J., Cao, Z., Yang, B., Zhang, J., & Cheng, X. (2012) · Tuberculosis · doi:10.1016/j.tube.2012.06.005 · Cited by 46
Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes
Killick, K. E., Browne, J. A., Park, S. D. E., Magee, D. A., Martin, I., Meade, K. G., Gordon, S. V., Gormley, E. P., O’Farrelly, C., Hokamp, K., et al. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-611 · Cited by 48
Exploring the potential of adjunct therapy in tuberculosis
Rayasam, G. V., & Balganesh, T. S. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.05.005 · Cited by 45
The Role of Host Genetics (and Genomics) in Tuberculosis
Naranbhai, V. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.tbtb2-0011-2016 · Cited by 45
Transcriptomic Analysis of CD4+ T Cells Reveals Novel Immune Signatures of Latent Tuberculosis
Burel, J. G., Arlehamn, C. S. L., Khan, N., Seumois, G., Greenbaum, J., Taplitz, R., Gilman, R. H., Saito, M., Vijayanand, P., Sette, A., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800118 · Cited by 45
Host Transcriptomics as a Tool to Identify Diagnostic and Mechanistic Immune Signatures of Tuberculosis
Burel, J. G., Babor, M., Pomaznoy, M., Arlehamn, C. S. L., Khan, N. A., Sette, A., & Peters, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00221 · Cited by 47
An RNA-seq Based Machine Learning Approach Identifies Latent Tuberculosis Patients With an Active Tuberculosis Profile
Estévez, O., Anibarro, L., Garet, E., Pallarés, Á., Barcia, L., Calviño, L., Maueia, C., Mussá, T., Fdez‐Riverola, F., Glez‐Peña, D., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01470 · Cited by 45
Fourteen-day PET/CT imaging to monitor drug combination activity in treated individuals with tuberculosis
Xie, Y. L., Jager, V. R. D., Chen, R. Y., Dodd, L. E., Paripati, P., Via, L. E., Follmann, D. A., Wang, J., Lumbard, K., Lahouar, S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd7618 · Cited by 45
The Intestinal Commensal, Bacteroides fragilis, Modulates Host Responses to Viral Infection and Therapy: Lessons for Exploration during Mycobacterium tuberculosis Infection
Eribo, O. A., du Plessis, N., & Chegou, N. N. (2021) · Infection and Immunity · doi:10.1128/iai.00321-21 · Cited by 45
Toward a Unified Biosignature for TuberculosisPreprint
Maertzdorf, J., Kaufmann, S. H. E., & Weiner, J. M. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018531 · Cited by 45
Autophagy prevents early proinflammatory responses and neutrophil recruitment during Mycobacterium tuberculosis infection without affecting pathogen burden in macrophages
Kinsella, R. L., Kimmey, J. M., Smirnov, A., Woodson, R., Gaggioli, M. R., Chavez, S. M., Kreamalmeyer, D., & Stallings, C. L. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002159 · Cited by 47
Mycobacterium tuberculosis Specific CD8+ T Cells Rapidly Decline with Antituberculosis Treatment
Nyendak, M. R., Park, B. S., Null, M. D., Baseke, J., Swarbrick, G. M., Mayanja‐Kizza, H., Nsereko, M., Johnson, D. F., Gitta, P., Okwera, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081564 · Cited by 44
Can early host responses to mycobacterial infection predict eventual disease outcomes?
de Silva, K., Begg, D. J., Plain, K. M., Purdie, A. C., Kawaji, S., Dhand, N. K., & Whittington, R. J. (2013) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2013.08.006 · Cited by 44
Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection
Raeven, R. H. M., Brummelman, J., Pennings, J. L. A., Nijst, O. E. M., Kuipers, B., Blok, L. E. R., Helm, K., van Riet, E., Jiskoot, W., van Els, C. A. C. M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104548 · Cited by 45
The dual role of biomarkers for understanding basic principles and devising novel intervention strategies in tuberculosis
Weiner, J. M., Maertzdorf, J., & Kaufmann, S. H. E. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06802.x · Cited by 44
A Projection Pursuit framework for supervised dimension reduction of high dimensional small sample datasets
Espezua, S., Villanueva, E., Maciel, C. D., & de Carvalho, A. C. P. L. F. (2014) · Neurocomputing · doi:10.1016/j.neucom.2014.07.057 · Cited by 44
Interferon-α as Antiviral and Antitumor Vaccine Adjuvants: Mechanisms of Action and Response Signature
Aricò, E., & Belardelli, F. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0077 · Cited by 44
Evidence for a Role for Interleukin-17, Th17 Cells and Iron Homeostasis in Protective Immunity against Tuberculosis in Cynomolgus Macaques
Wareham, A., Tree, J. A., Marsh, P. D., Butcher, P. D., Dennis, M. J., & Sharpe, S. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088149 · Cited by 45
M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection
Piñeros, A. R., Campos, L. W., da Fonseca, D. M., Bertolini, T. B., Gembre, A. F., Prado, R. Q., Alves-Filho, J. C., Ramos, S. G., Russo, M., & Bonato, V. L. D. (2017) · Scientific Reports · doi:10.1038/srep41240 · Cited by 44
Effector Mechanisms of Neutrophils within the Innate Immune System in Response to Mycobacterium tuberculosis Infection
Warren, E., Teskey, G., & Venketaraman, V. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6020015 · Cited by 44
Type I Interferons, Autophagy and Host Metabolism in Leprosy
de Toledo-Pinto, T. G., Batista-Silva, L. R., Medeiros, R. C. A., Lara, F. A., & Moraes, M. O. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00806 · Cited by 44
Impact of Type I Interferons on Susceptibility to Bacterial Pathogens
Peignier, A., & Parker, D. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.007 · Cited by 44
Molecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas
Sandhu, V., Lothe, I. M. B., Labori, K. J., Lingjærde, O. C., Buanes, T. A., Dalsgaard, A. M., Skrede, M., Hamfjord, J., Haaland, T., Eide, T. J., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.12.002 · Cited by 43
Predictive markers of safety and immunogenicity of adjuvanted vaccines
Mastelic, B., Garçon, N., Giudice, G. D., Golding, H., Gruber, M. F., Neels, P., & Fritzell, B. (2013) · Biologicals · doi:10.1016/j.biologicals.2013.08.006 · Cited by 43
Procollagen III N-terminal Propeptide and Desmosine are Released by Matrix Destruction in Pulmonary Tuberculosis
Seddon, J., Kasprowicz, V. O., Walker, N. F., Yuen, H. M., Sunpath, H., Tezera, L. B., Meintjes, G., Wilkinson, R. J., Bishai, W. R., Friedland, J. S., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit343 · Cited by 43
Self-citation
Oral Administration of Heat-Killed Mycobacterium manresensis Delays Progression toward Active Tuberculosis in C3HeB/FeJ Mice
Cardona, P., Marzo, E., Tapia, G., Dı́az, J., Garcia, V. V., Varela, I., Vilaplana, C., & Cardona, P.-J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01482 · Cited by 43
Status of vaccine research and development of vaccines for tuberculosis
Evans, T. G., Schrager, L. E., & Thole, J. E. R. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.02.079 · Cited by 43
Concordant and discordant gene expression patterns in mouse strains identify best-fit animal model for human tuberculosis
Domaszewska, T., Scheuermann, L., Hahnke, K., Mollenkopf, H., Dorhoi, A., Kaufmann, S. H. E., & Weiner, J. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-11812-x · Cited by 43
Pretreatment Cerebrospinal Fluid Bacterial Load Correlates With Inflammatory Response and Predicts Neurological Events During Tuberculous Meningitis Treatment
Thương, N. T. T., Vinh, D. N., Hai, H. T., Thu, D. D. A., Nhat, L. T. H., Heemskerk, D., Bang, N. D., Caws, M., Mai, N. T. H., & Thwaites, G. E. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy588 · Cited by 41
Molecular Distance to Health Transcriptional Score and Disease Severity in Children Hospitalized With Community-Acquired Pneumonia
Wallihan, R. G., Suárez, N. M., Cohen, D. M., Marcon, M. J., Moore‐Clingenpeel, M., Mejías, A., & Ramilo, O. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00382 · Cited by 43
Self-citation
Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis
Chinta, K. C., Rahman, M. A., Saini, V., Glasgow, J. N., Reddy, V. P., Lever, J. M., Nhamoyebonde, S., Leslie, A. J., Wells, R. M., Traylor, A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.073 · Cited by 43
Towards new TB vaccines
Brazier, B., & McShane, H. (2020) · Seminars in Immunopathology · doi:10.1007/s00281-020-00794-0 · Cited by 43
Transcriptional Profiling and Deriving a Seven-Gene Signature That Discriminates Active and Latent Tuberculosis: An Integrative Bioinformatics Approach
Natarajan, S., Ranganathan, M., Hanna, L. E., & Tripathy, S. P. (2022) · Genes · doi:10.3390/genes13040616 · Cited by 43
Systems immunology of human malaria
Tran, T. M., Samal, B. B., Kirkness, E. F., & Crompton, P. D. (2012) · Trends in Parasitology · doi:10.1016/j.pt.2012.03.006 · Cited by 46
Clinical Immunology and Multiplex Biomarkers of Human TuberculosisPreprint
Walzl, G., Haks, M. C., Joosten, S. A., Kleynhans, L., Ronacher, K., & Ottenhoff, T. H. M. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018515 · Cited by 43
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection
Bromley, J. D., Ganchua, S. K. C., Nyquist, S. K., Maiello, P. A., Chao, M. C., Borish, H. J., Rodgers, M., Tomko, J. A., Kracinovsky, K. B., Mugahid, D., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.08.002 · Cited by 42
Mycobacterium tuberculosis virulence lipid PDIM inhibits autophagy in mice
Mittal, E., Prasad, G. V. R. K., Upadhyay, S., Sadadiwala, J., Olive, A. J., Yang, G., Sassetti, C. M., & Philips, J. A. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01797-5 · Cited by 42
The key role of exudative lesions and their encapsulation: lessons learned from the pathology of human pulmonary tuberculosis
Cardona, P.-J. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00612 · Cited by 42
Molecular signatures at imminent death: Hemocyte gene expression profiling of shrimp succumbing to viral and fungal infections
Gonçalves, P., Guertler, C., Bachère, E., de Souza, C. R. B., Rosa, R. D., & Perazzolo, L. M. (2013) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2013.09.017 · Cited by 42
Getting Personal Perspectives on Individualized Treatment Duration in Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis
Heyckendorf, J., Olaru, I. D., Rühwald, M., & Lange, C. G. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201402-0363pp · Cited by 44
MAIT cells are reduced in frequency and functionally impaired in human T lymphotropic virus type 1 infection: Potential clinical implications
Paquin‐Proulx, D., Greenspun, B. C., Costa, E. A. S., Segurado, A. A. C., Kallas, E. G., Nixon, D. F., & Leal, F. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175345 · Cited by 42
Peripheral Blood Cells, a Transcriptomic Tool in Nutrigenomic and Obesity Studies: Current State of the Art
Reynés, B., Priego, T., Cifre, M., Oliver, P., & Palou, A. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12363 · Cited by 42
Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens
Lai, Y., Babunovic, G. H., Cui, L., Dedon, P. C., Doench, J. G., Fortune, S. M., & Lu, T. K. (2020) · Cell Systems · doi:10.1016/j.cels.2020.08.010 · Cited by 42
BloodGen3Module: blood transcriptional module repertoire analysis and visualization using R
Rinchai, D., Roelands, J. P., Toufiq, M., Hendrickx, W., Altman, M. C., Bedognetti, D., & Chaussabel, D. (2021) · Bioinformatics · doi:10.1093/bioinformatics/btab121 · Cited by 47
Self-citation
Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic? - A review of evidence and the technological landscape
Hamada, Y., Penn‐Nicholson, A., Krishnan, S., Cirillo, D. M., Matteelli, A., Wyss, R., Denkinger, C. M., Rangaka, M. X., Rühwald, M., & Schumacher, S. G. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104174 · Cited by 42
Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa
Bah, S. Y., Morang’a, C. M., Kengne-Ouafo, J. A., Amenga-Etego, L. N.-K., & Awandare, G. A. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00575 · Cited by 42
Mild Plasmodium falciparum Malaria following an Episode of Severe Malaria Is Associated with Induction of the Interferon Pathway in Malawian Children
Krupka, M., Seydel, K. B., Feintuch, C. M., Yee, K., Kim, R. S., Lin, C., Calder, R. B., Petersen, C. A., Taylor, T. E., & Daily, J. P. (2012) · Infection and Immunity · doi:10.1128/iai.06008-11 · Cited by 41
Coincident Pre-Diabetes Is Associated with Dysregulated Cytokine Responses in Pulmonary Tuberculosis
Kumar, N. P., Banurekha, V. V., Nair, D., Sridhar, R., Kornfeld, H., Nutman, T. B., & Babu, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112108 · Cited by 41
How to use: interferon γ release assays for tuberculosis
Pollock, L., Roy, R. B., & Kampmann, B. (2013) · Archives of Disease in Childhood Education & Practice · doi:10.1136/archdischild-2013-303641 · Cited by 41
TLR2 Signaling Depletes IRAK1 and Inhibits Induction of Type I IFN by TLR7/9
Liu, Y. C., Simmons, D. P., Li, X., Abbott, D. W., Boom, W. H., & Harding, C. V. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102181 · Cited by 41
STING-Dependent 2′-5′ Oligoadenylate Synthetase–Like Production Is Required for IntracellularMycobacterium lepraeSurvival
de Toledo-Pinto, T. G., Ferreira, A. B. R., Alves, M. R., Rodrigues, L. S., Batista-Silva, L. R., Silva, B. J. D. A., Lemes, R. M. R., Martinez, A. N., Sandoval, F., Alvarado-Arnez, L. E., et al. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw144 · Cited by 41
Clostridium difficile infection in diabetes
Qu, H., & Jiang, Z. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.06.002 · Cited by 41
Biomarkers in diagnosing and therapeutic monitoring of tuberculosis: a review
Leo, S., Narasimhan, M., Rathinam, S., & Banerjee, A. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2386030 · Cited by 40
A vision and a prescription for big data–enabled medicine
Chaussabel, D., & Pulendran, B. (2015) · Nature Immunology · doi:10.1038/ni.3151 · Cited by 41
Self-citation
Network approaches to drug discovery
Chandra, N. R., & Padiadpu, J. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.741119 · Cited by 42
Identification of Cyclin‐Dependent Kinase 1 as a Novel Regulator of Type I Interferon Signaling in Systemic Lupus Erythematosus
Wu, L., Qin, Y., Xia, S., Dai, M., Han, X., Wu, Y., Zhang, X., Ma, J., Wang, Y., Tang, Y., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39543 · Cited by 40
Early Whole Blood Transcriptional Signatures Are Associated with Severity of Lung Inflammation in Cynomolgus Macaques with Mycobacterium tuberculosis Infection
Gideon, H. P., Skinner, J. A., Baldwin, N. E., Flynn, J. L., & Lin, P. L. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601138 · Cited by 40
Self-citation
Molecular signatures in systemic lupus erythematosus: distinction between disease flare and infection
Mackay, M. C., Oswald, M., Sánchez‐Guerrero, J., Lichauco, J. J., Aranow, C. B., Kotkin, S., Korsunsky, I., Gregersen, P. K., & Diamond, B. (2016) · Lupus Science & Medicine · doi:10.1136/lupus-2016-000159 · Cited by 42
Getting “Inside” Type I IFNs: Type I IFNs in Intracellular Bacterial Infections
Snyder, D. T., Hedges, J. F., & Jutila, M. A. (2017) · Journal of Immunology Research · doi:10.1155/2017/9361802 · Cited by 43
Stratification of Latent Mycobacterium tuberculosis Infection by Cellular Immune Profiling
Halliday, A., Whitworth, H. S., Kottoor, S. H., Niazi, U. H. K., Menzies, S., Kunst, H., Bremang, S., Badhan, A., Beverley, P. C. L., Kon, O. M., et al. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix107 · Cited by 40
Self-citation
Circulating HLA-DR+CD4+ effector memory T cells resistant to CCR5 and PD-L1 mediated suppression compromise regulatory T cell function in tuberculosis
Ahmed, A., Adiga, V., Nayak, S., Kumar, J. A. J. U., Dhar, C., Sahoo, P. N., Sundararaj, B. K., Souza, G. D., & Vyakarnam, A. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007289 · Cited by 41
An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans
Delgobo, M., Mendes, D. A. G. B., Gonzalez‐Kozlova, E., da Rocha, E. L., Rodrigues-Luiz, G. F., Mascarin, L. Z., Dias, G. B. M., Patricio, D. D. O., Dierckx, T., Bicca, M. A., et al. (2019) · eLife · doi:10.7554/elife.47013 · Cited by 42
Transfection of hard-to-transfect primary human macrophages with Bax siRNA to reverse Resveratrol-induced apoptosis
Dong, S. X. M., Caballero, R. E., Ali, H., Roy, D. L. F., Cassol, E., & Kumar, A. (2020) · RNA Biology · doi:10.1080/15476286.2020.1730081 · Cited by 40
Blood genome expression profiles in infants with congenital cytomegalovirus infection
Ouellette, C. P., Sánchez, P. J., Xu, Z., Blankenship, D., Zeray, F., Ronchi, A., Shimamura, M., Chaussabel, D., Lee, L. E., Owen, K. E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17178-5 · Cited by 41
Self-citation
Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature
Amorim, C. F., Novais, F. O., Nguyen, B. T., Nascimento, M. T., Lago, J., Lago, A. S., Carvalho, L. P., Beiting, D. P., & Scott, P. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009321 · Cited by 41
Multi-country evaluation of RISK6, a 6-gene blood transcriptomic signature, for tuberculosis diagnosis and treatment monitoring
Bayaa, R., Ndiaye, M. D., Chedid, C., Kokhreidze, E., Tukvadze, N., Banu, S., Uddin, M. K. M., Biswas, S., Nasrin, R., Ranaivomanana, P. P., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-93059-1 · Cited by 40
Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx
Kang, T. G., Kwon, K. W., Kim, K. S., Lee, I., Kim, M. J., Ha, S., & Shin, S. J. (2022) · Nature Communications · doi:10.1038/s41467-022-30914-3 · Cited by 40
RNA Transcriptional Biosignature Analysis for Identifying Febrile Infants With Serious Bacterial Infections in the Emergency Department
Mahajan, P., Kuppermann, N., Suárez, N. M., Mejías, A., Casper, C., Dean, J. M., & Ramilo, O. (2014) · Pediatric Emergency Care · doi:10.1097/pec.0000000000000324 · Cited by 40
Self-citation
Monocyte Responses in the Context of Q Fever: From a Static Polarized Model to a Kinetic Model of Activation
Mehraj, V., Textoris, J., Amara, A. B., Ghigo, É., Raoult, D., Capo, C., & Mège, J. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit266 · Cited by 40
Genomics of Human Pulmonary Tuberculosis: from Genes to Pathways
Stein, C. M., Sausville, L. N., Wejse, C. M., Sobota, R. S., Zetola, N. M., Hill, P. C., Boom, W. H., Scott, W. K., Sirugo, G., & Williams, S. M. (2017) · Current Genetic Medicine Reports · doi:10.1007/s40142-017-0130-9 · Cited by 40
Cell-Autonomous Effector Mechanisms against Mycobacterium tuberculosisPreprint
MacMicking, J. D. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018507 · Cited by 42
A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients’ plasma
Khaenam, P., Rinchai, D., Altman, M. C., Chiche, L., Buddhisa, S., Kewcharoenwong, C., Suwannasaen, D., Mason, M. J., Whalen, E., Presnell, S., et al. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-65 · Cited by 39
Self-citation
Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment
Cliff, J. M., Cho, J.-E., Lee, J., Ronacher, K., King, E. C., van Helden, P. D., Walzl, G., & Dockrell, H. M. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv447 · Cited by 39
T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties
Lindenstrøm, T., Moguche, A. O., Damborg, M., Agger, E. M., Urdahl, K. B., & Andersen, P. L. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.12.004 · Cited by 39
Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease
Zheng, X., O’Connell, C. M., Zhong, W., Nagarajan, U. M., Tripathy, M. K., Lee, D., Russell, A. N., Wiesenfeld, H. C., Hillier, S. L., & Darville, T. L. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701658 · Cited by 42
Monocyte-to-Lymphocyte Ratio Is Associated With Tuberculosis Disease and Declines With Anti-TB Treatment in HIV-Infected Children
Choudhary, R. K., Wall, K. M., Njuguna, I. N., Pavlinac, P. B., LaCourse, S. M., Otieno, V. O., Gatimu, J., Stern, J., Maleche‐Obimbo, E., Wamalwa, D. C., et al. (2018) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000001893 · Cited by 39
Mycobacterium tuberculosis Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival
Banks, D. A., Ahlbrand, S. E., Hughitt, V. K., Shah, S., Mayer-Barber, K. D., Vogel, S. N., El-Sayed, N. M., & Briken, V. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801303 · Cited by 39
Neutrophil autophagy during human active tuberculosis is modulated by SLAMF1
Pellegrini, J. M., Sabbione, F., Morelli, M. P., Tateosian, N. L., Castello, F. A., Amiano, N. O., Palmero, D., Levi, A., Ciallella, L. M., Colombo, M. I., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1825273 · Cited by 39
Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection
Xu, W., Snell, L. M., Guo, M., Boukhaled, G. M., Macleod, B. L., Li, M., Tullius, M. V., Guidos, C. J., Tsao, M., Divangahi, M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.003 · Cited by 40
Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils
Stegelmeier, A. A., Darzianiazizi, M., Hanada, K., Sharif, S., Wootton, S. K., Bridle, B. W., & Karimi, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094726 · Cited by 41
Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets
Reichmann, M. T., Tezera, L. B., Vallejo, A. F., Vukmirovic, M., Xiao, R., Reynolds, J., Jogai, S., Wilson, S. C., Marshall, B. G., Jones, M. G., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148136 · Cited by 39
Transcriptomics for child and adolescent tuberculosis*
Kaforou, M., Broderick, C. M., Vito, O., Levin, M., Scriba, T. J., & Seddon, J. A. (2022) · Immunological Reviews · doi:10.1111/imr.13116 · Cited by 39
A robust host-response-based signature distinguishes bacterial and viral infections across diverse global populations
Rao, A., Popper, S. J., Gupta, S., Davong, V., Vaidya, K., Chanthongthip, A., Dittrich, S., Robinson, M. T., Vongsouvath, M., Mayxay, M., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100842 · Cited by 40
Identification of promising plasma immune biomarkers to differentiate active pulmonary tuberculosis
Zambuzi, F. A., Cardoso-Silva, P. M., Espíndola, M. S., Soares, L. S., Galvão-Lima, L. J., Brauer, V. S., Gomes, M. D. S., do Amaral, L. R., Schaller, M. A., Bóllela, V. R., et al. (2016) · Cytokine · doi:10.1016/j.cyto.2016.08.030 · Cited by 39
Identification of a 251 Gene Expression Signature That Can Accurately Detect M. tuberculosis in Patients with and without HIV Co-Infection
Dawany, N. B., Showe, L. C., Kossenkov, A. V., Chang, C., Ive, P., Conradie, F., Stevens, W. S., Sanne, I., Azzoni, L., & Montaner, L. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089925 · Cited by 38
Systems approaches to studying the immune response in tuberculosis
Berry, M. P. R., Blankley, S., Graham, C. M., Bloom, C. I., & O’Garra, A. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.08.003 · Cited by 38
Self-citation

Authors: Berry, M. P. R., Graham, C. M., McNab, F. W., Xu, Z., Bloch, S. A. A., Oni, T., Wilkinson, K. A., Banchereau, R., Skinner, J., Wilkinson, R. J., Quinn, C., Blankenship, D., Dhawan, R., Cush, J. J., Mejias, A., Ramilo, O., Kon, O. M., Pascual, V., Banchereau, J., Chaussabel, D., & O’Garra, A.
Affiliations: National Institute for Medical Research (GB)
Inserm (FR)
Imperial College Healthcare NHS Trust (GB)
University of Cape Town (ZA)
The University of Texas Southwestern Medical Center (US)
Baylor Scott & White Health (US)
Nationwide Children's Hospital (US)
Corresponding author: O’Garra, Anne
ORCID: Graham, Christine M.
Xu, Zhaohui
Oni, Tolu
Wilkinson, Katalin A.
Banchereau, Romain
Skinner, Jason
Wilkinson, Robert J.
Quinn, Charles
Dhawan, Ranju
Ramilo, Octavio
Kon, Onn M.
Pascual, Virginia
Banchereau, Jacques
Chaussabel, Damien
O’Garra, Anne
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2010-08
Volume: 466
Issue: 7309
Pages: 973-977
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature09247
PMC: PMC3492754
OpenAlex: W2109543073
Cited by: 1,898
References: 29
Citations by year: 2026: 104 · 2025: 105 · 2024: 112 · 2023: 108 · 2022: 99 · 2021: 121 · 2020: 113 · 2019: 127 · 2018: 137 · 2017: 134 · 2016: 149 · 2015: 126 · 2014: 119 · 2013: 127 · 2012: 114
FWCI: 70.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Wellcome Trust (088316, 84323)
Imperial College Healthcare NHS Trust
U.S. Public Health Service (U19 AIO57234-02, P50 ARO54083)
Medical Research Council
National Cancer Institute (P01CA084512)
National Institute of Allergy and Infectious Diseases (U19AI057234, U01AI082110, U19AI082715)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR050770, P50AR054083)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: tuberculosis, Mycobacterium tuberculosis, latent tuberculosis infection, active tuberculosis, whole blood transcriptome, interferon-stimulated genes, neutrophils, interferon-gamma signaling, type I interferon, transcriptomic biomarkers, diagnostic biomarkers, prognostic factors, systemic lupus erythematosus, cell composition, treatment response monitoring
MeSH terms: Blood, Gene Expression Regulation, Humans, Interferon Type I, Lupus Erythematosus, Systemic, Mycobacterium tuberculosis, Neutrophils, Transcription, Genetic, Tuberculosis, Tuberculosis, Pulmonary, Signal Transduction, Case-Control Studies, Gene Expression Profiling, Latent Tuberculosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks