The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Open accessAbstract
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment. Most people infected with M. tuberculosis remain asymptomatic, termed latent TB, with a 10% lifetime risk of developing active TB disease. Current tests, however, cannot identify which individuals will develop disease. The immune response to M. tuberculosis is complex and incompletely characterized, hindering development of new diagnostics, therapies and vaccines. Here we identify a whole-blood 393 transcript signature for active TB in intermediate and high-burden settings, correlating with radiological extent of disease and reverting to that of healthy controls after treatment. A subset of patients with latent TB had signatures similar to those in patients with active TB. We also identify a specific 86-transcript signature that discriminates active TB from other inflammatory and infectious diseases. Modular and pathway analysis revealed that the TB signature was dominated by a neutrophil-driven interferon (IFN)-inducible gene profile, consisting of both IFN-gamma and type I IFN-alphabeta signalling. Comparison with transcriptional signatures in purified cells and flow cytometric analysis suggest that this TB signature reflects changes in cellular composition and altered gene expression. Although an IFN-inducible signature was also observed in whole blood of patients with systemic lupus erythematosus (SLE), their complete modular signature differed from TB, with increased abundance of plasma cell transcripts. Our studies demonstrate a hitherto underappreciated role of type I IFN-alphabeta signalling in the pathogenesis of TB, which has implications for vaccine and therapeutic development. Our study also provides a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the TB epidemic.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Therefore, it is no surprise that IFN-β transcriptome signatures were found to be associated with active but not latent TB (101).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [101]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Baechler, E. C., Batliwalla, F., Karypis, G., Gaffney, P. M., Ortmann, W. A., Espe, K. J., Shark, K. B., Grande, W. J., Hughes, K. M. H., Kapur, V., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337679100 · Cited by 2,246
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
Bennett, L. B., Palucka, K., Arce, E., Cantrell, V., Borvák, J., Banchereau, J., & Pascual, V. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021553 · Cited by 1,990
Self-citationBlood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,744
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
Barry, C. E., Boshoff, H. I., Dartois, V. A., Dick, T., Ehrt, S., Flynn, J. L., Schnappinger, D., Wilkinson, R. J., & Young, D. B. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2236 · Cited by 1,441
Self-citationCell-Mediated Immune Responses in Tuberculosis
Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,194
Flynn, J., & Chan, J. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.93 · Cited by 1,144
Genetic Dissection of Immunity to Mycobacteria: The Human Model
Casanova, J., & Abel, L. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.081501.125851 · Cited by 1,006
A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus
Chaussabel, D., Quinn, C., Shen, J., Patel, P., Glaser, C., Baldwin, N., Stichweh, D., Blankenship, D., Li, L., Munagala, I., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.012 · Cited by 649
Self-citationImmunisation against infectious disease
SALISBURY, D. M., Ramsay, M. E., & Noakes, K. (2006) · Stationery Office eBooks · Cited by 636
Newsom, S. W. B. (2006) · Journal of Hospital Infection · doi:10.1016/j.jhin.2006.06.003 · Cited by 636
Research works printed but not linked: 2
- Dye, C., Floyd, K. & Uplekar, M. in Global Tuberculosis Control: Surveillance, Planning, Financing Ch. 1, 17–37 (World Health Organization, 2008)
- Falk, A. & O’Connor, J. B. in Diagnosis Standards and Classification of Tuberculosis, vol. 12 (eds Falk, A. et al.), 68–76 (National Tuberculosis and Respiratory Disease Association, 1969)
Cited by
Sorted by citations
Items 301–400 of 1,000
Arlehamn, C. S. L., Seumois, G., Gerasimova, A. V., Huang, C. C., Fu, Z., Yue, X., Sette, A., Vijayanand, P., & Peters, B. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401151 · Cited by 104
Post-infectious group A streptococcal autoimmune syndromes and the heart
Martin, W. J., Steer, A. C., Smeesters, P. R., Keeble, J., Inouye, M., Carapetis, J. R., & Wicks, I. P. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.04.005 · Cited by 100
Slight-Webb, S. R., Lu, R., Ritterhouse, L. L., Munroe, M. E., Maecker, H. T., Fathman, C. G., Utz, P. J., Merrill, J. T., Guthridge, J. M., & James, J. A. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39706 · Cited by 100
Blood transcriptomic diagnosis of pulmonary and extrapulmonary tuberculosis
Roe, J. K., Thomas, N., Gil, E., Best, K., Tsaliki, E., Morris-Jones, S. D., Stafford, S. L., Simpson, N., Witt, K. D., Chain, B., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.87238 · Cited by 100
Tryptophan catabolism reflects disease activity in human tuberculosis
Collins, J. M., Siddiqa, A., Jones, D. P., Liu, K., Kempker, R. R., Nizam, A., Shah, N. S., Ismail, N. A., Ouma, S. G., Tukvadze, N., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.137131 · Cited by 103
Autophagy in TuberculosisPreprint
Deretic, V. P. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018481 · Cited by 100
Cutting Edge: Vitamin D Regulates Lipid Metabolism in Mycobacterium tuberculosis Infection
Salamon, H., Bruiners, N., Lakehal, K., Shi, L., Ravi, J., Yamaguchi, K. D., Pine, R., & Gennaro, M. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400736 · Cited by 99
Moreira-Teixeira, L., Sousa, J., McNab, F. W., Torrado, E., Cardoso, F., Machado, H., Castro, F., Cardoso, V., Gaifem, J., Wu, X., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600584 · Cited by 99
Self-citationSambarey, A., Devaprasad, A., Mohan, A., Ahmed, A., Nayak, S., Swaminathan, S., D′Souza, G., Jesuraj, A., Dhar, C., Babu, S., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.12.009 · Cited by 99
Macrophage and neutrophil death programs differentially confer resistance to tuberculosis
Stutz, M. D., Allison, C. C., Ojaimi, S., Preston, S., Doerflinger, M., Arandjelovic, P., Whitehead, L. W., Bader, S. M., Batey, D., Asselin-Labat, M.-L., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.06.009 · Cited by 100
Protection and pathology in TB: learning from the zebrafish model
Meijer, A. H. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0522-4 · Cited by 103
Malireddi, R. K. S., & Kanneganti, T. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00077 · Cited by 101
Identification of biomarkers for tuberculosis disease using a novel dual-color RT–MLPA assay
Joosten, S. A., Goeman, J. J., Sutherland, J. S., Opmeer, L., de Boer, K. G., Jacobsen, M., Kaufmann, S. H. E., Finos, L., Magis-Escurra, C., Ota, M. O. C., et al. (2011) · Genes and Immunity · doi:10.1038/gene.2011.64 · Cited by 99
Granulocytes act as a niche for Mycobacterium tuberculosis growth
Lovewell, R. R., Baer, C. E., Mishra, B. B., Smith, C. M., & Sassetti, C. M. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0300-z · Cited by 98
Yang, S., Li, F., Jia, S., Zhang, K., Jiang, W., Shang, Y. M., Chang, K., Deng, S., & Chen, M. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373950 · Cited by 99
HIV-1 and the Immune Response to TB
Walker, N. F., Meintjes, G., & Wilkinson, R. J. (2012) · Future Virology · doi:10.2217/fvl.12.123 · Cited by 101
Self-citationBystander Chronic Infection Negatively Impacts Development of CD8+ T Cell Memory
Stelekati, E., Shin, H., Doering, T. A., Dolfi, D. V., Ziegler, C. G. K., Beiting, D. P., Dawson, L. A., Liboon, J., Wolski, D., Ali, M.-A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.010 · Cited by 101
Understanding latent tuberculosis: the key to improved diagnostic and novel treatment strategies
Esmail, H., Barry, C. E., & Wilkinson, R. J. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.12.013 · Cited by 97
Self-citationEsmail, H., Lai, R., Lesosky, M., Wilkinson, K. A., Graham, C. M., Horswell, S. D., Coussens, A. K., Barry, C. E., O’Garra, A., & Wilkinson, R. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711853115 · Cited by 97
Self-citationThe Interplay Between Systemic Inflammation, Oxidative Stress, and Tissue Remodeling in Tuberculosis
Amaral, E. P., Vinhaes, C. L., Oliveira-de-Souza, D., Nogueira, B. M. F., Akrami, K., & Andrade, B. B. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8124 · Cited by 101
Chemokines shape the immune responses to tuberculosis
Slight-Webb, S. R., & Khader, S. A. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.10.002 · Cited by 102
Fernández, R. R., Tapia, L. I., Yang, C., Torres, J. P., Chávez‐Bueno, S., García, C., Jaramillo, L., Moore‐Clingenpeel, M., Jafri, H. S., Peeples, M. E., et al. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix543 · Cited by 100
Self-citationPenn‐Nicholson, A., Hraha, T. H., Thompson, E. G., Sterling, D., Mbandi, S. K., Wall, K. M., Fisher, M., Suliman, S., Shankar, S., Hanekom, W. A., et al. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002781 · Cited by 96
Joosten, S. A., Fletcher, H. A., & Ottenhoff, T. H. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073230 · Cited by 95
Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics
Banchereau, R., Cepika, A., Banchereau, J., & Pascual, V. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052225 · Cited by 98
Self-citationMcNab, F. W., Ewbank, J., Rajsbaum, R., Stavropoulos, E., Մարտիրոսյան, Ա., Redford, P. S., Wu, X., Graham, C. M., Saraiva, M., Tsichlis, P. N., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300146 · Cited by 96
Self-citationMycobacterium tuberculosis and the host cell inflammasome: a complex relationship
Briken, V., Ahlbrand, S. E., & Shah, S. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00062 · Cited by 92
Genome‐wide host RNA signatures of infectious diseases: discovery and clinical translation
Gliddon, H. D., Herberg, J. A., Levin, M., & Kaforou, M. (2017) · Immunology · doi:10.1111/imm.12841 · Cited by 94
Role of neutrophils in tuberculosis: A bird's eye view
Hilda, J. N., Das, S. D., Tripathy, S. P., & Hanna, L. E. (2019) · Innate Immunity · doi:10.1177/1753425919881176 · Cited by 92
The Role of Natural Killer Cells in Sepsis
Chiche, L., Forel, J.-M., Thomas, G., Farnarier, C., Vely, F., Bléry, M., Papazian, L., & Vivier, É. (2011) · BioMed Research International · doi:10.1155/2011/986491 · Cited by 92
Dallenga, T. K., & Schaible, U. E. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw012 · Cited by 96
Recent advances towards tuberculosis control: vaccines and biomarkers
Weiner, J. M., & Kaufmann, S. H. E. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12212 · Cited by 92
The role of type I interferons in intestinal infection, homeostasis, and inflammation
Cho, H., & Kelsall, B. L. (2014) · Immunological Reviews · doi:10.1111/imr.12195 · Cited by 94
El-Sherbiny, Y. M., Psarras, A., Yusof, M. Y. M., Hensor, E. M. A., Tooze, R. M., Doody, G. M., Mohamed, A. A. A., McGonagle, D., Wittmann, M., Emery, P., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24198-1 · Cited by 91
Can we predict tuberculosis cure? What tools are available?
Goletti, D., Arlehamn, C. S. L., Scriba, T. J., Anthony, R. M., Cirillo, D. M., Alonzi, T., Denkinger, C. M., & Cobelens, F. G. J. (2018) · European Respiratory Journal · doi:10.1183/13993003.01089-2018 · Cited by 94
Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis
Amorim, C. F., Novais, F. O., Nguyen, B. T., Misic, A. M., Carvalho, L. P., Carvalho, E. M., Beiting, D. P., & Scott, P. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aax4204 · Cited by 91
McLaren, P. J., Gawanbacht, A., Pyndiah, N., Krapp, C., Hotter, D., Kluge, S. F., Götz, N., Heilmann, J., Mack, K., Sauter, D., et al. (2015) · Retrovirology · doi:10.1186/s12977-015-0165-5 · Cited by 95
Immune correlates of tuberculosis disease and risk translate across species
Ahmed, M., Thirunavukkarasu, S., Rosa, B. A., Thomas, K. A., Das, S., Rangel-Moreno, J., Lu, L., Mehra, S., Mbandi, S. K., Thackray, L. B., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay0233 · Cited by 89
Crosstalk between Mycobacterium tuberculosis and the host cell
Dey, B., & Bishai, W. R. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.09.002 · Cited by 92
Lu, C., Wu, J., Wang, H., Wang, S., Diao, N., Wang, F., Gao, Y., Chen, J., Shao, L., Weng, X., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024290 · Cited by 89
Dorhoi, A., & Kaufmann, S. H. E. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.10.002 · Cited by 90
Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages
Roy, S., Schmeier, S., Kaczkowski, B., Arner, E., Alam, T., Ozturk, M., Tamgue, O., Parihar, S. P., Kawaji, H., Itoh, M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24509-6 · Cited by 90
Bell, S. L., Lopez, K. L., Cox, J. S., Patrick, K. L., & Watson, R. O. (2021) · mBio · doi:10.1128/mbio.01871-20 · Cited by 92
B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis
Bénard, A., Sakwa, I., Schierloh, P., Colom, A., Mercier, I., Tailleux, L., Jouneau, L., Boudinot, P., Saati, T. A., Lang, R., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201707-1475oc · Cited by 89
Self-citationTuberculosis Treatment Monitoring and Outcome Measures: New Interest and New Strategies
Heyckendorf, J., Georghiou, S. B., Frahm, N., Heinrich, N., Kontsevaya, I., Reimann, M., Holtzman, D., Imperial, M. Z., Cirillo, D. M., Gillespie, S. H., et al. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00227-21 · Cited by 87
Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study
Subbian, S., Tsenova, L., Kim, M. J., Wainwright, H., Visser, A., Bandyopadhyay, N., Bader, J. S., Karakousis, P. C., Murrmann, G. B., Bekker, L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132249 · Cited by 87
Interferon Signature in the Blood in Inflammatory Common Variable Immune Deficiency
Park, J., Munagala, I. D., Xu, H., Blankenship, D., Maffucci, P., Chaussabel, D., Banchereau, J., Pascual, V., & Cunningham‐Rundles, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074893 · Cited by 87
Self-citationGupta, N., Kumar, R. K., & Agrawal, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00709 · Cited by 91
Lai, R., Meintjes, G., Wilkinson, K. A., Graham, C. M., Marais, S., van der Plas, H., Deffur, A., Schutz, C., Bloom, C. I., Munagala, I. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms9451 · Cited by 88
Self-citationDoxycycline host-directed therapy in human pulmonary tuberculosis
Miow, Q. H., Vallejo, A. F., Wang, Y., Hóng, J., Bai, C. G., Teo, F. S. W., Wang, D. A., Loh, H. R., Tan, T. Z., Ding, Y., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci141895 · Cited by 86
Deng, Y., Ye, J., Luo, Q., Huang, Z., Peng, Y., Xiong, G., Guo, Y., Jiang, H., & Li, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153567 · Cited by 86
Benchmarking Sepsis Gene Expression Diagnostics Using Public Data*
Sweeney, T. E., & Khatri, P. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000002021 · Cited by 87
Moshe, N. B. B., Hen‐Avivi, S., Levitin, N., Yehezkel, D., Oosting, M., Joosten, L. A. B., Netea, M. G., & Avraham, R. (2019) · Nature Communications · doi:10.1038/s41467-019-11257-y · Cited by 88
miRNA Signatures in Sera of Patients with Active Pulmonary Tuberculosis
Miotto, P., Mwangoka, G., Valente, I. C., Norbis, L., Sotgiu, G., Bosu, R., Ambrosi, A., Codecasa, L. R., Goletti, D., Matteelli, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080149 · Cited by 85
Changing Concepts of “Latent Tuberculosis Infection” in Patients Living with HIV Infection
Lawn, S. D., Wood, R., & Wilkinson, R. J. (2010) · Clinical and Developmental Immunology · doi:10.1155/2011/980594 · Cited by 85
Self-citationPetri, M., Fu, W., Ranger, A. M., Allaire, N., Cullen, P. F., Magder, L. S., & Zhang, Y. (2019) · BMC Medical Genomics · doi:10.1186/s12920-018-0468-1 · Cited by 85
Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis
Tabone, O., Verma, R., Singhania, A., Chakravarty, P., Branchett, W. J., Graham, C. M., Lee, J., Trang, T., Reynier, F., Leissner, P., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210915 · Cited by 87
Self-citationSOCS3 and STAT3, major controllers of the outcome of infection with Mycobacterium tuberculosis
Rottenberg, M. E., & Carow, B. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.10.004 · Cited by 84
The Role of ESX-1 in Mycobacterium tuberculosis Pathogenesis
Wong, K. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.tbtb2-0001-2015 · Cited by 92
Sousa, J., Cá, B., Maceiras, A. R., Costa, A. L., Fonseca, K. L., Fernandes, A. I., Ramos, A., Carvalho, T., Barros, L., Magalhães, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15832-6 · Cited by 83
Th1 cytokines, true functional signatures for protective immunity against TB?
Zeng, G., Zhang, G., & Chen, X. (2017) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.113 · Cited by 82
Subbian, S., Bandyopadhyay, N., Tsenova, L., O’Brien, P. E., Khetani, V., Kushner, N. L., Peixoto, B., Soteropoulos, P., Bader, J. S., Karakousis, P. C., et al. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-60 · Cited by 84
Assessment of treatment response in tuberculosis
Rockwood, N., Bruyn, E. D., Morris, T., & Wilkinson, R. J. (2016) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2016.1166960 · Cited by 82
Self-citationMycobacterium tuberculosis : Rewiring host cell signaling to promote infection
Stutz, M. D., Clark, M. P., Doerflinger, M., & Pellegrini, M. (2017) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr0717-277r · Cited by 83
Carmona, J. A., Cruz, A., Moreira-Teixeira, L., Sousa, C., Sousa, J., Osório, N. S., Saraiva, A. L., Svenson, S. B., Källenius, G., Pedrosa, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067277 · Cited by 84
Mycobacterium tuberculosis biology, pathogenicity and interaction with the host
Warner, D. F., Barczak, A. K., Gutierrez, M. G., & Mizrahi, V. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01201-x · Cited by 81
Vorkas, C. K., Wipperman, M. F., Li, K., Bean, J. M., Bhattarai, S. K., Adamow, M. J., Wong, P., Aubé, J., Juste, M. A. J., Bucci, V., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.121899 · Cited by 83
Sex differences in the C57BL/6 model of Mycobacterium tuberculosis infection
Dibbern, J., Eggers, L. F., & Schneider, B. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-11438-z · Cited by 80
Binding of CXCL8/IL‐8 to Mycobacterium tuberculosis Modulates the Innate Immune Response
Krupa, A., Fol, M., Dziadek, B. R., Kępka, E., Wojciechowska, D., Brzostek, A. M., Torzewska, A., Dziadek, J., Baughman, R. P., Griffith, D. E., et al. (2015) · Mediators of Inflammation · doi:10.1155/2015/124762 · Cited by 80
Integrating exosomal microRNAs and electronic health data improved tuberculosis diagnosis
Hu, X. L., Liao, S., Bai, H., Wu, L., Wang, M., Wu, Q., Zhou, J., Jiao, L., Chen, X., Zhou, Y., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.01.023 · Cited by 79
Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis
Eckold, C., Kumar, V., Weiner, J. M., Alisjahbana, B., Riza, A., Ronacher, K., Coronel, J., Kerry-Barnard, S. R., Malherbe, S. T., Kleynhans, L., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa751 · Cited by 80
Herrera-Uribe, J., Wiarda, J. E., Sivasankaran, S. K., Daharsh, L., Liu, H., Byrne, K. A., Smith, T. P. L., Lunney, J. K., Loving, C. L., & Tuggle, C. K. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.689406 · Cited by 82
Cao, R. G., Suárez, N. M., Obermoser, G., Lopez, S. M. C., Flaño, E., Mertz, S. E., Albrecht, R. A., García‐Sastre, A., Mejías, A., Xu, H., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu079 · Cited by 79
Self-citationRozot, V., Amelio, P., Viganó, S., Mazza‐Stalder, J., Idrizi, E., Day, C. L., Perreau, M., Lazor‐Blanchet, C., Ohmiti, K., Goletti, D., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu795 · Cited by 79
Gene expression profiling identifies candidate biomarkers for active and latent tuberculosis
Lee, S.-W., Wu, L. S., Huang, G.-M., Huang, K., Lee, T.-Y., & Weng, J. T.-Y. (2016) · BMC Bioinformatics · doi:10.1186/s12859-015-0848-x · Cited by 82
Queval, C. J., Song, O., Deboosère, N., Delorme, V., Debrie, A., Iantomasi, R., Veyron‐Churlet, R., Jouny, S., Redhage, K. R., Deloison, G., et al. (2016) · Scientific Reports · doi:10.1038/srep29297 · Cited by 82
Jourde‐Chiche, N., Whalen, E., Gondouin, B., Speake, C., Gersuk, V. H., Dussol, B., Burtey, S., Pascual, V., Chaussabel, D., & Chiche, L. (2016) · Rheumatology · doi:10.1093/rheumatology/kew439 · Cited by 79
Self-citationtmod: an R package for general and multivariate enrichment analysisPreprint
rd, J. W., & Domaszewska, T. (2016) · doi:10.7287/peerj.preprints.2420v1 · Cited by 79
Hoek, K. L., Samir, P., Howard, L. M., Niu, X., Prasad, N., Galassie, A. C., Liu, Q., Allos, T. M., Floyd, K. A., Guo, Y. P., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118528 · Cited by 78
Freches, D., Korf, H., Denis, O., Havaux, X., Huygen, K., & Romano, M. (2013) · Immunology · doi:10.1111/imm.12130 · Cited by 78
Diagnosis and Management of Latent Tuberculosis Infection: Table 1.Preprint
Muñoz, L., Stagg, H. R., & Abubakar, I. I. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a017830 · Cited by 78
Interfering with immunity: detrimental role of type I IFNs during infection
Stifter, S. A., & Feng, C. G. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402794 · Cited by 78
Recombinant live vaccine candidates against tuberculosis
Kaufmann, S. H. E., & Gengenbacher, M. (2012) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.03.007 · Cited by 77
Systems vaccinology and big data in the vaccine development chain
Raeven, R. H. M., van Riet, E., Meiring, H. D., Metz, B., & Kersten, G. F. A. (2018) · Immunology · doi:10.1111/imm.13012 · Cited by 79
A role for systems epidemiology in tuberculosis research
Comas, I., & Gagneux, S. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.07.002 · Cited by 77
Rachow, A., Ivanova, O., Wallis, R. S., Charalambous, S., Jani, I. V., Bhatt, N., Kampmann, B., Sutherland, J. S., Ntinginya, N. E., Evans, D. H., et al. (2019) · BMC Pulmonary Medicine · doi:10.1186/s12890-018-0777-3 · Cited by 77
Experimentally induced blood stage malaria infection as a tool for clinical research
Engwerda, C. R., Minigo, G., Amante, F. H., & McCarthy, J. S. (2012) · Trends in Parasitology · doi:10.1016/j.pt.2012.09.001 · Cited by 77
Mulenga, H., Zauchenberger, C.-Z., Bunyasi, E. W., Mbandi, S. K., Mendelsohn, S. C., Kagina, B. M. N., Penn‐Nicholson, A., Scriba, T. J., & Hatherill, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237574 · Cited by 77
Host Cell Targets of Released Lipid and Secreted Protein Effectors of Mycobacterium tuberculosis
Augenstreich, J., & Briken, V. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.595029 · Cited by 79
Circulating Biomarkers of Pulmonary and Extrapulmonary Tuberculosis in Children
Kumar, N. P., Rajamanickam, A., Andrade, B. B., Suresh, N., Ganesh, R., Shankar, J., Kumaraswami, V., Nutman, T. B., & Babu, S. (2013) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00038-13 · Cited by 76
Interferons and inflammasomes: Cooperation and counterregulation in disease
Labzin, L. I., Lauterbach, M., & Latz, E. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.010 · Cited by 77
New Molecular Diagnostic Approaches to Bacterial Infections and Antibacterial Resistance
Tsalik, E. L., Bonomo, R. A., & Fowler, V. G. (2018) · Annual Review of Medicine · doi:10.1146/annurev-med-052716-030320 · Cited by 76
Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis
Ong, C. W. M., Fox, K., Ettorre, A., Elkington, P. T., & Friedland, J. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-29659-1 · Cited by 80
Immune profiles provide insights into respiratory syncytial virus disease severity in young children
Heinonen, S., Velazquez, V. M., Ye, F., Mertz, S. E., Acero‐Bedoya, S., Smith, B., Bunsow, E., García-Mauriño, C., Oliva, S., Cohen, D. M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw0268 · Cited by 77
Self-citationSankar, P., & Mishra, B. B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1260859 · Cited by 83
Alsina, L., Israelsson, E., Altman, M. C., Dang, K. K., Ghandil, P., Israël, L., von Bernuth, H., Baldwin, N. E., Qin, H., Jin, Z., et al. (2014) · Nature Immunology · doi:10.1038/ni.3028 · Cited by 75
Self-citationBlankley, S., Berry, M. P. R., Graham, C. M., Bloom, C. I., Lipman, M. C. I., & O’Garra, A. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0427 · Cited by 78
Self-citationGr1intCD11b+ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection
Obregón-Henao, A., Henao-Tamayo, M., Orme, I. M., & Ordway, D. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080669 · Cited by 74
Singhania, A., Graham, C. M., Gabryšová, L., Moreira-Teixeira, L., Stavropoulos, E., Pitt, J. M., Chakravarty, P., Warnatsch, A., Branchett, W. J., Conejero, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10601-6 · Cited by 74
Self-citationA century of BCG: Impact on tuberculosis control and beyond
Ahmed, A., Rakshit, S., Adiga, V., Dias, M., Dwarkanath, P., D′Souza, G., & Vyakarnam, A. (2021) · Immunological Reviews · doi:10.1111/imr.12968 · Cited by 74
Metadata
- Authors
- Berry, M. P. R., Graham, C. M., McNab, F. W., Xu, Z., Bloch, S. A. A., Oni, T., Wilkinson, K. A., Banchereau, R., Skinner, J., Wilkinson, R. J., Quinn, C., Blankenship, D., Dhawan, R., Cush, J. J., Mejias, A., Ramilo, O., Kon, O. M., Pascual, V., Banchereau, J., Chaussabel, D., & O’Garra, A.
- Affiliations
- National Institute for Medical Research (GB)
- Inserm (FR)
- Imperial College Healthcare NHS Trust (GB)
- University of Cape Town (ZA)
- The University of Texas Southwestern Medical Center (US)
- Baylor Scott & White Health (US)
- Nationwide Children's Hospital (US)
- Corresponding author
- O’Garra, Anne
- ORCID
- Venue
- Nature
- Published
- 2010-08
- Volume
- 466
- Issue
- 7309
- Pages
- 973-977
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3492754
- OpenAlex
- W2109543073
- Cited by
- 1,898
- References
- 29
- Citations by year
- 2026: 104 · 2025: 105 · 2024: 112 · 2023: 108 · 2022: 99 · 2021: 121 · 2020: 113 · 2019: 127 · 2018: 137 · 2017: 134 · 2016: 149 · 2015: 126 · 2014: 119 · 2013: 127 · 2012: 114
- FWCI
- 70.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Wellcome Trust (088316, 84323)
- Imperial College Healthcare NHS Trust
- U.S. Public Health Service (U19 AIO57234-02, P50 ARO54083)
- Medical Research Council
- National Cancer Institute (P01CA084512)
- National Institute of Allergy and Infectious Diseases (U19AI057234, U01AI082110, U19AI082715)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR050770, P50AR054083)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- tuberculosis, Mycobacterium tuberculosis, latent tuberculosis infection, active tuberculosis, whole blood transcriptome, interferon-stimulated genes, neutrophils, interferon-gamma signaling, type I interferon, transcriptomic biomarkers, diagnostic biomarkers, prognostic factors, systemic lupus erythematosus, cell composition, treatment response monitoring
- MeSH terms
- Blood, Gene Expression Regulation, Humans, Interferon Type I, Lupus Erythematosus, Systemic, Mycobacterium tuberculosis, Neutrophils, Transcription, Genetic, Tuberculosis, Tuberculosis, Pulmonary, Signal Transduction, Case-Control Studies, Gene Expression Profiling, Latent Tuberculosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
