The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Acid sensing by the Drosophila olfactory system
Open accessAbstract
The odour of acids has a distinct quality that is perceived as sharp, pungent and often irritating. How acidity is sensed and translated into an appropriate behavioural response is poorly understood. Here we describe a functionally segregated population of olfactory sensory neurons in the fruitfly, Drosophila melanogaster, that are highly selective for acidity. These olfactory sensory neurons express IR64a, a member of the recently identified ionotropic receptor (IR) family of putative olfactory receptors. In vivo calcium imaging showed that IR64a+ neurons projecting to the DC4 glomerulus in the antennal lobe are specifically activated by acids. Flies in which the function of IR64a+ neurons or the IR64a gene is disrupted had defects in acid-evoked physiological and behavioural responses, but their responses to non-acidic odorants remained unaffected. Furthermore, artificial stimulation of IR64a+ neurons elicited avoidance responses. Taken together, these results identify cellular and molecular substrates for acid detection in the Drosophila olfactory system and support a labelled-line mode of acidity coding at the periphery.
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Sweeney, S. T., Broadie, K., Keane, J., Niemann, H., & O'Kane, C. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90290-2 · Cited by 938
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Metadata
- Authors
- Ai, M., Min, S., Grosjean, Y., Leblanc, C., Bell, R., Benton, R., & Suh, G. S. B.
- Venue
- Nature
- Published
- 2010-11-17
- Volume
- 468
- Issue
- 7324
- Pages
- 691-695
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2074561441
- Cited by
- 339
- References
- 1
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Ai, M., Min, S., Grosjean, Y., Leblanc, C., Bell, R., Benton, R., & Suh, G. S. B. (2010). Acid sensing by the Drosophila olfactory system. Nature. https://doi.org/10.1038/nature09537
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