The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
The Polycomb complex PRC2 and its mark in life
Open accessAbstract
Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist - Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the monoubiquitylation of histone H2A. PRC2 also contributes to chromatin compaction, and catalyses the methylation of histone H3 at lysine 27. PRC2 is involved in various biological processes, including differentiation, maintaining cell identity and proliferation, and stem-cell plasticity. Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes.
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“That said, we do not wish to imply that DNA methylation is the only epigenetic mark involved in this process. It likely involves other transcription factors and epigenetic modifications, such as the PRC2 complex and H3K27me3, both of which are involved in maintaining stem cell plasticity and are associated with DNAm clock sites4,49,50.”
From Reprogramming to recover youthful epigenetic information and restore vision (2020) · cites this paper as [49]
Experimental — accuracy not yet measuredIn the citing paper
“EZH2 catalyzes nucleosome compaction via H3K27 trimethylation11”
From Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens (2021) · cites this paper as [11]
In the citing paper
“The suppression of clearance genes in striatal microglia is governed by Polycomb repressive complex 2 (PRC2), which catalyzes the repressive chromatin modification histone H3 lysine 27 tri-methylation (H3K27me3)16.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [16]
In the citing paper
“H3K27me3 is mediated by PRC2, which has a well-established role in the regulation of cell differentiation during development16.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [16]
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Citations
Cites
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X. H., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,246
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129
A gene complex controlling segmentation in Drosophila
Lewis, E. B. (1978) · Nature · doi:10.1038/276565a0 · Cited by 3,813
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 1×
“Long ncRNA could also promote PRC2 binding in trans as shown for the RNA HOTAI”
BackgroundKhalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
The polycomb group protein EZH2 is involved in progression of prostate cancer
Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,568
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536
Research works printed but not linked: 1
- Lewis, P. Pc: Polycomb. Drosoph. Inf. Ser. 21, 69 (1949).
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Dawson, M. A., & Kouzarides, T. (2012) · Cell · doi:10.1016/j.cell.2012.06.013 · Cited by 3,203
The molecular hallmarks of epigenetic control
Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809
The Emergence of lncRNAs in Cancer Biology
Prensner, J. R., & Chinnaiyan, A. M. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0209 · Cited by 1,771
Transcriptional Regulation and Its Misregulation in Disease
Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.02.014 · Cited by 1,676
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., Easton, J., Chen, X., Wang, J., Rusch, M., et al. (2012) · Nature · doi:10.1038/nature10725 · Cited by 1,596
“EZH2 catalyses trimethylation of histone 3 lysine 27 (H3K27), resulting in transcriptional repression of genes involved in development, stem cell maintenance and differentiatio”
Background
Metadata
- Authors
- Margueron, R., & Reinberg, D.
- Affiliations
- Institut Curie (FR)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Reinberg, Danny
- Venue
- Nature
- Published
- 2011-01-19
- Volume
- 469
- Issue
- 7330
- Pages
- 343-349
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3760771
- OpenAlex
- W2060608189
- Cited by
- 3,347
- References
- 97
- Citations by year
- 2026: 145 · 2025: 188 · 2024: 231 · 2023: 211 · 2022: 236 · 2021: 274 · 2020: 260 · 2019: 260 · 2018: 214 · 2017: 236 · 2016: 221 · 2015: 220 · 2014: 202 · 2013: 207 · 2012: 177
- FWCI
- 18.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of General Medical Sciences (R37GM037120, R01GM064844)
- Institute of Cancer Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- polycomb repressive complex 2, Polycomb group proteins, histone H3 lysine 27 methylation, chromatin condensation, gene expression regulation, cell identity, stem cell plasticity, non-coding RNA, chromatin structure
- MeSH terms
- Animals, Cell Differentiation, Chromatin, Histones, Humans, Methylation, Neoplasms, Histone-Lysine N-Methyltransferase, Repressor Proteins, Genome, Evolution, Molecular, Polycomb-Group Proteins
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