The Polycomb complex PRC2 and its mark in life

High-Resolution Profiling of Histone Methylations in the Human Genome

Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361

Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs

Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X. H., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,246

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129

A gene complex controlling segmentation in Drosophila

Lewis, E. B. (1978) · Nature · doi:10.1038/276565a0 · Cited by 3,813

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 1×

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872

The polycomb group protein EZH2 is involved in progression of prostate cancer

Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717

Polycomb complexes repress developmental regulators in murine embryonic stem cells

Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,568

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R., Chevalier, B. S., Johnstone, S. E., Cole, M. F., Isono, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,296

Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation

Zemach, A., McDaniel, I. E., Silva, P., & Zilberman, D. (2010) · Science · doi:10.1126/science.1186366 · Cited by 1,829

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

Morin, R. D., Johnson, N. A., Severson, T., Mungall, A. J. J., An, J., Goya, R., Paul, J. E., Boyle, M., Woolcock, B. W., Kuchenbauer, F. C., et al. (2010) · Nature Genetics · doi:10.1038/ng.518 · Cited by 1,719

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Kleer, C. G., Cao, Q., Varambally, S., Shen, R., Ota, I., Tomlins, S. A., Ghosh, D., Sewalt, R. G. A. B., Otte, A. P., Hayes, D. F., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1933744100 · Cited by 1,649

Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome

Zhao, J. C., Sun, B. K., Erwin, J. A., Song, J., & Lee, J. T. (2008) · Science · doi:10.1126/science.1163045 · Cited by 1,580

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

Yap, K. L., Li, S., Muñoz-Cabello, A. M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M. J., & Zhou, M.-M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.021 · Cited by 1,391

Mechanisms of Polycomb gene silencing: knowns and unknowns

Simon, J. A., & Kingston, R. E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2763 · Cited by 1,360

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsPreprint

Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., & Helin, K. (2006) · Genes & Development · doi:10.1101/gad.381706 · Cited by 1,286

Role of the polycomb protein EED in the propagation of repressive histone marks

Margueron, R., Justin, N., Ohno, K., Sharpe, M. L., Son, J., Drury, W. J., Voigt, P., Martin, S. R., Taylor, W. R., Marco, V. D., et al. (2009) · Nature · doi:10.1038/nature08398 · Cited by 1,281

Role of Histone H3 Lysine 27 Methylation in X Inactivation

Plath, K., Fang, J., Mlynarczyk‐Evans, S., Cao, R., Worringer, K. A., Wang, H., de la Cruz, C. C., Otte, A. P., Panning, B., & Zhang, Y. (2003) · Science · doi:10.1126/science.1084274 · Cited by 1,241

Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin

Peters, A. H. F. M., Kubicek, S., Mechtler, K., O’Sullivan, R. J., Derijck, A. A. H. A., Perez-Burgos, L., Kohlmaier, A., Opravil, S., Tachibana, M., Shinkai, Y., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00477-5 · Cited by 1,208

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.

Bracken, A. P., Pasini, D., Capra, M., Prosperini, E., Colli, E., & Helin, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg542 · Cited by 1,196

Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation

Pandey, R. R., Mondal, T., Mohammad, F., Enroth, S., Redrup, L., Komorowski, J., Nagano, T., Mancini‐DiNardo, D., & Kanduri, C. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.022 · Cited by 1,192

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

Ernst, T., Chase, A. J., Score, J., Hidalgo-Curtis, C. E., Bryant, C., Jones, A. V., Waghorn, K., Zoi, K., Ross, F. M., Reiter, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.621 · Cited by 1,139

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

Ku, M., Koche, R. P., Rheinbay, E., Mendenhall, E. M., Endoh, M., Mikkelsen, T. S., Aiden, A. P., Nusbaum, C., Xie, X. S., Chi, A. S., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000242 · Cited by 1,053

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

Shen, X., Liu, Y., Hsu, Y.-J., Fujiwara, Y., Kim, J., Mao, X., Yuan, G.-C., & Orkin, S. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.016 · Cited by 1,021

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

Mohn, F., Weber, M., Rebhan, M., Roloff, T. C., Richter, J., Stadler, M. B., Bibel, M., & Schübeler, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.007 · Cited by 970

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

Margueron, R., Li, G., Sarma, K., Blais, A., Zavadil, J., Woodcock, C. L. F., Dynlacht, B. D., & Reinberg, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.11.004 · Cited by 930

SUZ12 Is Required for Both the Histone Methyltransferase Activity and the Silencing Function of the EED-EZH2 Complex

Cao, R., & Zhang, Y. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.020 · Cited by 856

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., et al. (2007) · Genes & Development · doi:10.1101/gad.415507 · Cited by 850

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

Scheuermann, J. C., Alonso, A. G. D. A., Oktaba, K., Ly‐Hartig, N., McGinty, R. K., Fraterman, S., Wilm, M. S., Muir, T. W., & Müller, J. (2010) · Nature · doi:10.1038/nature08966 · Cited by 816

Distinct epigenomic landscapes of pluripotent and lineage-committed human cells

Hawkins, R. D., Hon, G. C., Lee, L. K., Ngo, Q., Lister, R., Pelizzola, M., Edsall, L. E., Kuan, S., Luu, Y., Klugman, S., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.018 · Cited by 806

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

Nikoloski, G., Langemeijer, S. M. C., Kuiper, R. P., Knops, R., Massop, M., Tönnissen, E., van der Heijden, A., Scheele, T. N., Vandenberghe, P., de Witte, T., et al. (2010) · Nature Genetics · doi:10.1038/ng.620 · Cited by 777

Chromatin structure and the inheritance of epigenetic information

Margueron, R., & Reinberg, D. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2752 · Cited by 761

A model for transmission of the H3K27me3 epigenetic mark

Hansen, K. H., Bracken, A. P., Pasini, D., Dietrich, N., Gehani, S. S., Monrad, A., Rappsilber, J., Lerdrup, M., & Helin, K. (2008) · Nature Cell Biology · doi:10.1038/ncb1787 · Cited by 748

The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation

Pasini, D., Bracken, A. P., Hansen, J. B., Capillo, M., & Helin, K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01432-06 · Cited by 714

Whole-Genome Analysis of Histone H3 Lysine 4 and Lysine 27 Methylation in Human Embryonic Stem Cells

Pan, G., Tian, S., Nie, J., Yang, C., Ruotti, V., Wei, H., Jonsdottir, G. A., Stewart, R., & Thomson, J. A. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.003 · Cited by 711

Facultative Heterochromatin: Is There a Distinctive Molecular Signature?

Trojer, P., & Reinberg, D. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.011 · Cited by 686

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

Stock, J. K., Giadrossi, S., Casanova, M., Brookes, E., Vidal, M., Koseki, H., Brockdorff, N., Fisher, A. G., & Pombo, A. (2007) · Nature Cell Biology · doi:10.1038/ncb1663 · Cited by 650

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

Cui, K., Zang, C., Roh, T., Schones, D. E., Childs, R. W., Peng, W., & Zhao, K. (2009) · Cell stem cell · doi:10.1016/j.stem.2008.11.011 · Cited by 646

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement

Su, I.-H., Basavaraj, A., Krutchinsky, A. N., Hobert, O., Ullrich, A., Chait, B. T., & Tarakhovsky, A. (2002) · Nature Immunology · doi:10.1038/ni876 · Cited by 635

Whole-Genome Mapping of Histone H3 Lys4 and 27 Trimethylations Reveals Distinct Genomic Compartments in Human Embryonic Stem Cells

Zhao, X. D., Han, X., Chew, J. L., Liu, J., Chiu, K. P., Choo, A. B. H., Orlov, Y. L., Sung, W.-K. K., Shahab, A., Kuznetsov, V. A., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.08.004 · Cited by 626

Genome-wide analysis of Polycomb targets in Drosophila melanogaster

Schwartz, Y. B., Kahn, T. G., Nix, D. A., Li, X., Bourgon, R., Biggin, M. D., & Pirrotta, V. (2006) · Nature Genetics · doi:10.1038/ng1817 · Cited by 623

Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells

Ezhkova, E., Pasolli, H. A., Parker, J. S., Stokes, N., Su, I.-H., Hannon, G. J., Tarakhovsky, A., & Fuchs, E. V. (2009) · Cell · doi:10.1016/j.cell.2008.12.043 · Cited by 613

CBP-mediated acetylation of histone H3 lysine 27 antagonizesDrosophilaPolycomb silencing

Tie, F., Banerjee, R., Stratton, C. A., Prasad-Sinha, J., Stepanik, V. A., Zlobin, A., Dı́az, M. O., Scacheri, P. C., & Harte, P. J. (2009) · Development · doi:10.1242/dev.037127 · Cited by 612

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiationPreprint

G, C., Padova, M. D., GE, L., Lyons, G. E., & Sartorelli, V. (2004) · Genes & Development · doi:10.1101/gad.1241904 · Cited by 611

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

Pasini, D., Cloos, P. A., Walfridsson, J., Olsson, L., Bukowski, J., Johansen, J. V., Bak, M., Tommerup, N., Rappsilber, J., & Helin, K. (2010) · Nature · doi:10.1038/nature08788 · Cited by 584

Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

Eskeland, R., Leeb, M., Grimes, G. R., Kress, C., Boyle, S., Sproul, D., Gilbert, N., Fan, Y., Skoultchi, A. I., Wutz, A., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.02.032 · Cited by 571

Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells

Peng, J. C., Valouev, A., Swigut, T., Zhang, J., Zhao, Y., Sidow, A., & Wysocka, J. (2009) · Cell · doi:10.1016/j.cell.2009.12.002 · Cited by 548

Jarid2 and PRC2, partners in regulating gene expressionPreprint

Li, G., Margueron, R., Ku, M., Chambon, P., Bernstein, B., & Reinberg, D. (2010) · Genes & Development · doi:10.1101/gad.1886410 · Cited by 521

Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice

Schuettengruber, B., & Cavalli, G. (2009) · Development · doi:10.1242/dev.033902 · Cited by 443

A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activitiesPreprint

Klymenko, T., Papp, B., Fischle, W., Köcher, T., Schelder, M., Fritsch, C., Wild, B., Wilm, M. S., & Müller, J. (2006) · Genes & Development · doi:10.1101/gad.377406 · Cited by 430

Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells

Shen, X., Kim, W., Fujiwara, Y., Simon, M. D., Liu, Y., Mysliwiec, M. R., Yuan, G., Lee, Y., & Orkin, S. H. (2009) · Cell · doi:10.1016/j.cell.2009.12.003 · Cited by 426

Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing

Schoeftner, S., Sengupta, A. K., Kubicek, S., Mechtler, K., Spahn, L., Koseki, H., Jenuwein, T., & Wutz, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601187 · Cited by 424

A Chromosomal Memory Triggered by Xist Regulates Histone Methylation in X Inactivation

Kohlmaier, A., Savarese, F., Lachner, M., Martens, J. H. A., Jenuwein, T., & Wutz, A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020171 · Cited by 408

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNAPreprint

Kaneko, S., Li, G., Son, J., Xu, C., Margueron, R., Neubert, T. A., & Reinberg, D. (2010) · Genes & Development · doi:10.1101/gad.1983810 · Cited by 399

Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2

Kanhere, A., Viiri, K. M., Araújo, C. C., Rasaiyaah, J., Bouwman, R. D., Whyte, W. A., Pereira, C., Brookes, E., Walker, K., Bell, G. W., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.019 · Cited by 386

Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

Tolhuis, B., Muijrers, I., de Wit, E., Teunissen, H., Talhout, W., van Steensel, B., & van Lohuizen, M. (2006) · Nature Genetics · doi:10.1038/ng1792 · Cited by 380

Chromatin signature of embryonic pluripotency is established during genome activation

Vastenhouw, N. L., Zhang, Y., Woods, I. G., Imam, F. B., Regev, A., Liu, X. S., Rinn, J. L., & Schier, A. F. (2010) · Nature · doi:10.1038/nature08866 · Cited by 379

Polycomb Repressive Complex 2 Is Dispensable for Maintenance of Embryonic Stem Cell Pluripotency

Chamberlain, S. J., Yee, D., & Magnuson, T. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0102 · Cited by 350

H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment

Creyghton, M. P., Markoulaki, S., Levine, S. S., Hanna, J. H., Lodato, M. A., Sha, K., Young, R. A., Jaenisch, R., & Boyer, L. A. (2008) · Cell · doi:10.1016/j.cell.2008.09.056 · Cited by 350

Functional Anatomy of Polycomb and Trithorax Chromatin Landscapes in Drosophila Embryos

Schuettengruber, B., Ganapathi, M., Leblanc, B., Portoso, M., Jaschek, R., Tolhuis, B., van Lohuizen, M., Tanay, A., & Cavalli, G. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000013 · Cited by 339

Polycomb complexes act redundantly to repress genomic repeats and genes

Leeb, M., Pasini, D., Novatchkova, M., Jaritz, M., Helin, K., & Wutz, A. (2010) · Genes & Development · doi:10.1101/gad.544410 · Cited by 335

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

Landeira, D., Sauer, S., Poot, R. A., Dvorkina, M., Mazzarella, L., Jørgensen, H. F., Pereira, C., Leleu, M., Piccolo, F. M., Spivakov, M., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2065 · Cited by 335

A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness

Woo, C. J., Kharchenko, P. V., Daheron, L. M., Park, P. J., & Kingston, R. E. (2010) · Cell · doi:10.1016/j.cell.2009.12.022 · Cited by 333

H3K27 Demethylases, at Long Last

Swigut, T., & Wysocka, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.026 · Cited by 327

Suz12 binds to silenced regions of the genome in a cell-type-specific mannerPreprint

Squazzo, S. L., O’Geen, H., Komashko, V., Krig, S. R., Jin, V. X., Jang, S.-W., Margueron, R., Reinberg, D., Green, R., & Farnham, P. (2006) · Genome Research · doi:10.1101/gr.5306606 · Cited by 324

ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing

Jacob, Y., Feng, S., LeBlanc, C., Bernatavichute, Y. V., Stroud, H., Cokus, S. J., Johnson, L. M., Pellegrini, M. A., Jacobsen, S. E., & Michaels, S. D. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1611 · Cited by 319

Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity

Endoh, M., Endo, T. A., Endoh, T., Fujimura, Y., Ohara, O., Toyoda, T., Otte, A. P., Okano, M., Brockdorff, N., Vidal, M., et al. (2008) · Development · doi:10.1242/dev.014340 · Cited by 308

Pcl‐PRC2 is needed to generate high levels of H3‐K27 trimethylation at Polycomb target genes

Nekrasov, M., Klymenko, T., Fraterman, S., Papp, B., Oktaba, K., Köcher, T., Cohen, A., Stunnenberg, H. G., Wilm, M. S., & Müller, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601837 · Cited by 303

Ezh2 Requires PHF1 To Efficiently Catalyze H3 Lysine 27 Trimethylation In Vivo

Sarma, K., Margueron, R., Ivanov, A. V., Pirrotta, V., & Reinberg, D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02017-07 · Cited by 303

Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis

Wang, L., Jin, Q., Lee, J., Su, I.-H., & Ge, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000031107 · Cited by 299

Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

Chen, D., Bohrer, L. R., Rai, A. N., Pan, Y., Gan, L., Zhou, X., Bagchi, A., Simon, J. A., & Huang, H. (2010) · Nature Cell Biology · doi:10.1038/ncb2116 · Cited by 292

Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liverPreprint

Brunner, A. L., Johnson, D. S., Kim, S. W., Valouev, A., Reddy, T. E., Neff, N. F., Anton, E., Medina, C., Nguyen, L., Chiao, E. T., et al. (2009) · Genome Research · doi:10.1101/gr.088773.108 · Cited by 289

Diversity of Polycomb group complexes in plants: same rules, different players?

Hennig, L., & Derkacheva, M. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.07.002 · Cited by 272

In Vivo Residue-specific Histone Methylation Dynamics

Zee, B. M., Levin, R. S., Xu, B., LeRoy, G., Wingreen, N. S., & Garcia, B. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.063784 · Cited by 270

Determination of enriched histone modifications in non-genic portions of the human genome

Rosenfeld, J., Wang, Z., Schones, D. E., Zhao, K., DeSalle, R., & Zhang, M. Q. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-143 · Cited by 258

2-D Structure of the A Region of Xist RNA and Its Implication for PRC2 Association

Maenner, S., Blaud, M., Fouillen, L., Savoye, A., Marchand, V., Dubois, A., Cianférani, S., DORSSELAER, A. V., Clerc, P., Avner, P. R., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000276 · Cited by 254

A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain

Sing, A., Pannell, D., Karaiskakis, A., Sturgeon, K., Djabali, M., Ellis, J., Lipshitz, H. D., & Cordes, S. P. (2009) · Cell · doi:10.1016/j.cell.2009.08.020 · Cited by 250

AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2

Kim, H., Kang, K., & Kim, J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp149 · Cited by 214

Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation

Walker, E. M., Chang, W. Y., Hunkapiller, J., Cagney, G., Garcha, K., Torchia, J., Krogan, N. J., Reiter, J. F., & Stanford, W. L. (2010) · Cell stem cell · doi:10.1016/j.stem.2009.12.014 · Cited by 203

Polycomb recruitment to DNA in vivo by the YY1 REPO domain

Wilkinson, F. H., Park, K., & Atchison, M. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603564103 · Cited by 191

Polycomb Group proteins: an evolutionary perspective

Whitcomb, S. J., Basu, A., Allis, C. D., & Bernstein, E. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.08.006 · Cited by 191

Origin of the polycomb repressive complex 2 and gene silencing by an E(z) homolog in the unicellular alga Chlamydomonas

Shaver, S., Casas-Mollano, J. A., Cerny, R. L., & Cerutti, H. D. (2010) · Epigenetics · doi:10.4161/epi.5.4.11608 · Cited by 186

Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro

Francis, N. J., Follmer, N. E., Simon, M. D., Aghia, G., & Butler, J. D. (2009) · Cell · doi:10.1016/j.cell.2009.02.017 · Cited by 183

ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency

Pereira, C., Piccolo, F. M., Tsubouchi, T., Sauer, S., Ryan, N. K., Bruno, L., Landeira, D., Santos, J. D., Banito, A., Gil, J., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.04.013 · Cited by 174

Structural basis of histone H4 recognition by p55Preprint

Song, J., Garlick, J. D., & Kingston, R. E. (2008) · Genes & Development · doi:10.1101/gad.1653308 · Cited by 153

Chromatin plasticity and genome organization in pluripotent embryonic stem cells

Mattout, A., & Meshorer, E. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.02.001 · Cited by 132

Targeted Overexpression of EZH2 in the Mammary Gland Disrupts Ductal Morphogenesis and Causes Epithelial Hyperplasia

Li, X., González, M. E., Toy, K. A., Filzen, T. M., Merajver, S. D., & Kleer, C. G. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090042 · Cited by 130

Analysis of overrepresented motifs in human core promoters reveals dual regulatory roles of YY1Preprint

Xi, H. S., Yu, Y., Fu, Y., Foley, J., Halees, A. S., & Weng, Z. (2007) · Genome Research · doi:10.1101/gr.5754707 · Cited by 115

The Polycomb Complex Protein mes-2/E(z) Promotes the Transition from Developmental Plasticity to Differentiation in C. elegans Embryos

Yuzyuk, T., Fakhouri, T. H. I., Kiefer, J. C., & Mango, S. E. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.03.008 · Cited by 106

A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers

Wang, S., Robertson, G. P., & Zhu, J. (2004) · Gene · doi:10.1016/j.gene.2004.09.006 · Cited by 98

Recruitment ofDrosophilaPolycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae

Savla, U., Benes, J. J., Zhang, J., & Jones, R. S. (2008) · Development · doi:10.1242/dev.016006 · Cited by 81

Roles of JUMONJI in mouse embryonic development

Jung, J., Mysliwiec, M. R., & Lee, Y. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20204 · Cited by 72

Comprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell lines

Karanikolas, B. D. W., Figueiredo, M. L., & Wu, L. (2010) · The Prostate · doi:10.1002/pros.21112 · Cited by 69

Polycomb Group Protein Enhancer of Zeste 2 Is an Oncogene That Promotes the Neoplastic Transformation of a Benign Prostatic Epithelial Cell Line

Karanikolas, B. D. W., Figueiredo, M. L., & Wu, L. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0121 · Cited by 68

ESC, ESCL and their roles in Polycomb Group mechanisms

Ohno, K., McCabe, D., Czermin, B., Imhof, A., & Pirrotta, V. (2008) · Mechanisms of Development · doi:10.1016/j.mod.2008.01.002 · Cited by 49

Cancer epigenetics: from mechanism to therapy

Dawson, M. A., & Kouzarides, T. (2012) · Cell · doi:10.1016/j.cell.2012.06.013 · Cited by 3,203

The molecular hallmarks of epigenetic control

Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809

The Emergence of lncRNAs in Cancer Biology

Prensner, J. R., & Chinnaiyan, A. M. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0209 · Cited by 1,771

Transcriptional Regulation and Its Misregulation in Disease

Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.02.014 · Cited by 1,676

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Zhang, J., Ding, L., Holmfeldt, L., Wu, G., Heatley, S. L., Payne-Turner, D., Easton, J., Chen, X., Wang, J., Rusch, M., et al. (2012) · Nature · doi:10.1038/nature10725 · Cited by 1,596

Role of PRC 2‐associated factors in stem cells and disease

Vizán, P., Beringer, M., Ballaré, C., & Croce, L. D. (2014) · FEBS Journal · doi:10.1111/febs.13083 · Cited by 84

Polycomb Repressive Complex 2 Structure and Function

Holoch, D., & Margueron, R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809737-3.00009-x · Cited by 3

A Structural Perspective on Gene Repression by Polycomb Repressive Complex 2

Liu, X. (2020) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-58971-4_17 · Cited by 11

Structural and Mechanistic Insights into Polycomb Repressive Complex 2 Regulation in Gene Silencing

Cookis, T. (2026) · eScholarship (California Digital Library)

PRC2 activity, recruitment, and silencing: a comparative perspective

Bieluszewski, T., Xiao, J. Y., Yang, Y., & Wagner, D. (2021) · Trends in Plant Science · doi:10.1016/j.tplants.2021.06.006 · Cited by 100