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Molecular mechanisms and clinical applications of angiogenesis
Open accessAbstract
Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish diseases such as cancer. Over the past decade, our understanding of the molecular mechanisms of angiogenesis (blood vessel growth) has increased at an explosive rate and has led to the approval of anti-angiogenic drugs for cancer and eye diseases. So far, hundreds of thousands of patients have benefited from blockers of the angiogenic protein vascular endothelial growth factor, but limited efficacy and resistance remain outstanding problems. Recent preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
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“In clinical settings, this approach has been proven to be ineffective when used alone [23].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [23]
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“This disparity is, in part, attributed to VEGF-independent nonangiogenic mechanisms of vascularization (such as vessel co-option) that are exploited by cancer cells at the early stages of metastasis formation6,9,55,56”
From Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges (2018) · cites this paper as [9]
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“In addition to increasing drug resistance, a high SS could influence tumor cells' gene expression, comprise immune cells ability to kill cancerous cells or even turn macrophages to tumorfriendly cells, thereby enhancing the metastatic potential of cancer cells [180-184].”
From Microfluidic modelling of the tumor microenvironment for anti-cancer drug development (2019) · cites this paper as [184]
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“Several cellular and molecular mechanisms of escape from antiangiogenic therapies have been postulated and investigated, including activation of alternative angiogenic pathways, recruitment of proangiogenic myeloid cells, increased pericyte cell coverage of tumour blood vessels, increased tumour cell invasion, and alternative modes of vessel recruitment7,9,80”
From Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges (2018) · cites this paper as [9]
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Cites
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
Jain, R. K. (2005) · Science · doi:10.1126/science.1104819 · Cited by 5,527 · cited 1×
“Tumour vessels become abnormal in almost all aspects of their structure and functio”
BackgroundSelf-citationAngiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,379
Self-citationIntegrins in cancer: biological implications and therapeutic opportunities
Desgrosellier, J. S., & Cheresh, D. A. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2748 · Cited by 3,815
Microenvironmental regulation of metastasis
Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684
Angiogenesis in life, disease and medicine
Carmeliet, P. (2005) · Nature · doi:10.1038/nature04478 · Cited by 3,551
Self-citationVEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288
Modes of resistance to anti-angiogenic therapy
Bergers, G., & Hanahan, D. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2442 · Cited by 2,953 · cited 1×
“Aberrant FGF signalling promotes tumour angiogenesis and mediates the escape of tumour vascularization from VEGF- or epidermal growth factor receptor (EGFR)-inhibitor treatmen”
BackgroundMatrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., et al. (2000) · Nature Cell Biology · doi:10.1038/35036374 · Cited by 2,797
Molecular regulation of vessel maturation
Jain, R. K. (2003) · Nature Medicine · doi:10.1038/nm0603-685 · Cited by 2,594
Self-citationHypoxia-inducible factors and the response to hypoxic stress
Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380
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O’Neill, H. S., Herron, C., Hastings, C. L., Deckers, R., Noriega, A. L., Kelly, H. M., Hennink, W. E., McDonnell, C. O., O’Brien, F. J., Ruiz‐Hernández, E., et al. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.10.001 · Cited by 84
Sadremomtaz, A., Mansouri, K., Alemzadeh, G., Safa, M., Rastaghi, A. R. E., & Asghari, S. M. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.08.013 · Cited by 84
Non-invasive imaging for studying anti-angiogenic therapy effects
Ehling, J., Lammers, T., & Kiessling, F. M. (2013) · Thrombosis and Haemostasis · doi:10.1160/th12-10-0721 · Cited by 83
Pancreatic duct cells as a source of VEGF in mice
Xiao, X., Prasadan, K. L., Guo, P., El‐Gohary, Y., Fischbach, S., Wiersch, J. C., Gaffar, I. M., Shiota, C., & Gittes, G. K. (2014) · Diabetologia · doi:10.1007/s00125-014-3179-y · Cited by 83
Hypoxia and Dysregulated Angiogenesis in Kidney Disease
Tanaka, S., Tanaka, T., & Nangaku, M. (2015) · Kidney Diseases · doi:10.1159/000381515 · Cited by 83
Tual‐Chalot, S., Allinson, K. R., Fruttiger, M., & Arthur, H. M. (2013) · Journal of Visualized Experiments · doi:10.3791/50546 · Cited by 83
Ghorab, M. M., Alsaid, M. S., Soliman, A. M., & Ragab, F. A.-F. (2017) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2017.1334650 · Cited by 83
The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition
Blackwell, R. H., Foreman, K. E., & Gupta, G. N. (2017) · Cancers · doi:10.3390/cancers9080105 · Cited by 84
Engineering Tumor-Targeting Nanoparticles as Vehicles for Precision Nanomedicine
Gonda, A., Zhao, N., Shah, J. V., Calvelli, H. R., Kantamneni, H., Francis, N. L., & Ganapathy, V. (2019) · Med One · doi:10.20900/mo.20190021 · Cited by 83
van Buul, J. D., Geerts, D., & Huveneers, S. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.27599 · Cited by 84
Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes
Kawakami, T., Mimura, I., Shoji, K., Tanaka, T., & Nangaku, M. (2014) · Kidney International Supplements · doi:10.1038/kisup.2014.20 · Cited by 83
Spanberger, T., Berghoff, A. S., Dinhof, C., Ilhan‐Mutlu, A., Magerle, M., Hutterer, M., Pichler, J., Wöehrer, A., Hackl, M., Widhalm, G., et al. (2012) · Clinical & Experimental Metastasis · doi:10.1007/s10585-012-9542-9 · Cited by 83
Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma
Kalpathy–Cramer, J., Chandra, V., Da, X., Ou, Y., Emblem, K. E., Muzikansky, A., Cai, X., Douw, L., Evans, J. G., Dietrich, J., et al. (2016) · Journal of Neuro-Oncology · doi:10.1007/s11060-016-2332-5 · Cited by 83
Self-citationWang, M., Yan, J., Cao, X., Hua, P., & Li, Z. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113775 · Cited by 83
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Hooglugt, A., van der Stoel, M. M., Boon, R. A., & Huveneers, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.612802 · Cited by 82
Xue, C., Xie, J., Zhao, D., Lin, S., Zhou, T., Shi, S., Shao, X., Lin, Y., Zhu, B., & Cai, X. (2016) · Cell Proliferation · doi:10.1111/cpr.12307 · Cited by 82
Andreuzzi, E., Colladel, R., Pellicani, R., Tarticchio, G., Cannizzaro, R., Spessotto, P., Bussolati, B., Brossa, A., Paoli, P. D., Canzonieri, V., et al. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.04.002 · Cited by 82
RetractedLiu, J., Deng, W., Chen, L., Li, Y., Wu, L., Ma, S., Zhang, W., Bu, L., & Sun, Z. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22767 · Cited by 82
Li, Y., Deng, L., Zhao, X., Li, B., Ren, D., Yu, L., Pan, H., Gong, Q., Song, L., Zhou, X., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5144 · Cited by 82
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Graupera, M., & Claret, M. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.09.003 · Cited by 82
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Coalson, E., Bishop, E. S., Liu, W., Feng, Y., Spezia, M., Liu, B., Shen, Y., Wu, D., Du, S., Li, A. J., et al. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.09.008 · Cited by 82
Therapeutic vascularization in regenerative medicine
Giannì-Barrera, R., Maggio, N. D., Melly, L., Burger, M. G., Mujagić, E., Gürke, L., Schaefer, D. J., & Banfi, A. (2020) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0319 · Cited by 82
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Dumas, S. J., García‐Caballero, M., & Carmeliet, P. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.05.009 · Cited by 82
Self-citationAngiogenic hydrogels for dental pulp revascularization
Siddiqui, Z., Sarkar, B., Kim, K.-K., Kadincesme, N., Paul, R., Kumar, A., Kobayashi, Y., Roy, A., Choudhury, M., Yang, J. Y., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.001 · Cited by 82
Binet, F., Mawambo, G., Sitaras, N., Tetreault, N., Lapalme, E., Favret, S., Cerani, A., Leboeuf, D., Tremblay, S., Rezende, F., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.003 · Cited by 82
Techniques and assays for the study of angiogenesis
Irvin, M., Zijlstra, A., Wikswo, J. P., & Pozzi, A. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214529386 · Cited by 82
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Dewerchin, M. A., & Carmeliet, P. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.948420 · Cited by 82
Self-citationKim, G. D., Oh, J., Park, H.-J., Bae, K., & Lee, S. K. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1959 · Cited by 82
Stamati, K., Priestley, J. V., Mudera, V., & Cheema, U. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.05.012 · Cited by 82
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Shenoy, A. K., Jin, Y., Luo, H., Tang, M., Pampo, C., Shao, R., Siemann, D. W., Wu, L., Heldermon, C. D., Law, B. K., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86623 · Cited by 82
Ekambaram, P., Lee, J.-Y. L., Hubel, N. E., Hu, D. G., Yerneni, S. S., Campbell, P. G., Pollock, N., Klei, L. R., Concel, V. J., Delekta, P. C., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1089 · Cited by 82
EphrinB2/EphB4 signaling regulates non‐sprouting angiogenesis by VEGF
Groppa, E., Brkić, Š., Uccelli, A., Wirth, G., Korpisalo, P., Filippova, M., Dasen, B., Sacchi, V., Muraro, M. G., Trani, M., et al. (2018) · EMBO Reports · doi:10.15252/embr.201745054 · Cited by 81
Mechanisms of Vasculogenic Mimicry in Ovarian Cancer
Ayala-Domínguez, L., Olmedo‐Nieva, L., Muñoz-Bello, J. O., Contreras‐Paredes, A., Manzo-Merino, J., Martínez-Ramírez, I., & Lizano, M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00998 · Cited by 81
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Cheng, Z. A., & Kishore, R. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101704 · Cited by 81
Weigel, R., Schilling, L., & Krauss, J. K. (2022) · GeroScience · doi:10.1007/s11357-022-00570-y · Cited by 81
Chauhan, V. P., Stylianopoulos, T., Martin, J. D., Popović, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., & Jain, R. K. (2020) · doi:10.1201/9780429399039-10 · Cited by 81
Self-citationMarina, M. E., Roman, I. I., Constantin, A.-M., Mihu, C. M., & Tataru, A. D. (2015) · Medicine and Pharmacy Reports · doi:10.15386/cjmed-494 · Cited by 81
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Shahneh, F. Z., Baradaran, B., Zamani, F., & Maleki, L. A. (2013) · Human Antibodies · doi:10.3233/hab-130267 · Cited by 81
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Wang, L., Benedito, R., Bixel, M. G., Zeuschner, D., Stehling, M., Savendahl, L. S., Haigh, J. J., Snippert, H. J. G., Clevers, H. C., Breier, G., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.308 · Cited by 81
Tumor microenvironment and lymphocyte infiltration
Rahir, G., & Moser, M. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1253-1 · Cited by 81
He, L., Zhou, J. P., Chen, M., Lin, C., Kim, S. G., Zhou, Y., Xiang, L., Xie, M., Bai, H., Yao, H., et al. (2019) · Nature Materials · doi:10.1038/s41563-019-0368-6 · Cited by 81
VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways
Weddell, J. C., Chen, S., & Imoukhuede, P. I. (2017) · npj Systems Biology and Applications · doi:10.1038/s41540-017-0037-9 · Cited by 80
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Venur, V. A., Peereboom, D. M., & Ahluwalia, M. S. (2014) · Cancer treatment and research · doi:10.1007/978-3-319-12048-5_7 · Cited by 80
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Wroblewski, M., Bauer, R., Cubas‐Cordova, M., Udonta, F., Batalla, I. B., Legler, K., Hauser, C., Egberts, J. H., Janning, M., Velthaus, J.-L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00327-8 · Cited by 80
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Fu, J., & Wang, D. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.02.012 · Cited by 80
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Yu, Y., & Cui, J. (2018) · Oncology Letters · doi:10.3892/ol.2018.9219 · Cited by 80
Rijal, G., & Li, W. (2018) · Journal of Biological Engineering · doi:10.1186/s13036-018-0114-7 · Cited by 80
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Liu, J.-Y., Chiang, T., Liu, C.-H., Chern, G.-G., Lin, T.-T., Gao, D.-Y., & Chen, Y. (2015) · Molecular Therapy · doi:10.1038/mt.2015.147 · Cited by 80
Thomas, D., Fontana, G., Chen, X., Sanz‐Nogués, C., Zeugolis, D. I., Dockery, P., O’Brien, T., & Pandit, A. S. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.06.053 · Cited by 80
Natural product inhibitors of ocular angiogenesis
Sulaiman, R. S., Basavarajappa, H. D., & Corson, T. W. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.10.002 · Cited by 80
Wang, W.-Q., Liu, L., Xu, H., Luo, G., Chen, T., Wu, C., Xu, Y.-F., Xu, J., Liu, C., Zhang, B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071189 · Cited by 80
HIF-1α Overexpression Induces Angiogenesis in Mesenchymal Stem Cells
Razban, V., Lotfi, A. S., Soleimani, M., Ahmadi, H., Massumi, M., Khajeh, S., Ghaedi, M., Arjmand, S., Najavand, S., & Khoshdel, A. (2012) · BioResearch open access · doi:10.1089/biores.2012.9905 · Cited by 80
Evidence for Pro-angiogenic Functions of VEGF-Ax
Xin, H., Zhong, C., Nudleman, E., & Ferrara, N. (2016) · Cell · doi:10.1016/j.cell.2016.08.054 · Cited by 80
Acute Limb Ischemia—Much More Than Just a Lack of Oxygen
Simon, F., Oberhuber, A., Floros, N., Busch, A., Wagenhäuser, M. U., Schelzig, H., & Duran, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020374 · Cited by 80
Molecular Regulation of Sprouting Angiogenesis
Duran, C. L., Howell, D. W., Dave, J. M., Smith, R. L., Torrie, M. E., Essner, J. J., & Bayless, K. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160048 · Cited by 80
Peeters, M., Strickland, A. H., Lichinitser, M., Suresh, A. V. S., Manikhas, G., Shapiro, J., Rogowski, W., Huang, X., Wu, B., Warner, D., et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2012.594 · Cited by 79
Self-citationA perspective on the role of class III semaphorin signaling in central nervous system trauma
Mecollari, V., Nieuwenhuis, B., & Verhaagen, J. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00328 · Cited by 79
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Chiavenna, S. M., Jaworski, J. P., & Vendrell, A. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-016-0311-y · Cited by 79
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Tsai, H., Tzeng, H.-E., Huang, C.-Y., Huang, Y., Tsai, C., Wang, S., Wang, P., Chang, A., Fong, Y., & Tang, C. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.421 · Cited by 79
Zhang, X., Sun, J., Yao, J., Shan, K. Y., Liu, B.-H., Yao, M.-D., Ge, H., Jiang, Q. L., Zhao, C., & Yan, B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.092 · Cited by 79
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Wälchli, T., Bisschop, J., Miettinen, A., Ulmann‐Schuler, A., Hintermüller, C., Meyer, E. P., Krucker, T., Waelchli, R., Monnier, P. P., Carmeliet, P., et al. (2021) · Nature Protocols · doi:10.1038/s41596-021-00587-1 · Cited by 79
Self-citationAspriţoiu, V. M., Stoica, I., Bleoţu, C., & Diaconu, C. C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.689962 · Cited by 79
Creating a kidney organoid-vasculature interaction model using a novel organ-on-chip system
Menéndez, A. B.-C., Du, Z., van den Bosch, T. P. P., Othman, A., Gaio, N., Silvestri, C., Quirós-Solano, W. F., Lin, H., Korevaar, S. S., Merino, A. M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-24945-5 · Cited by 79
Wise, L. M., Inder, M. K., Real, N. C., Stuart, G. S., Fleming, S. B., & Mercer, A. A. (2012) · Cellular Microbiology · doi:10.1111/j.1462-5822.2012.01802.x · Cited by 79
Integrative models of vascular remodeling during tumor growth
Rieger, H., & Welter, M. (2015) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1295 · Cited by 79
A mathematical model of tumour angiogenesis: growth, regression and regrowth
Vilanova, G., Colominas, I., & Gómez, H. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2016.0918 · Cited by 79
Matrix stiffness enhances VEGFR-2 internalization, signaling, and proliferation in endothelial cells
LaValley, D. J., Zanotelli, M. R., Bordeleau, F., Wang, W., Schwager, S. C., & Reinhart‐King, C. A. (2017) · Convergent Science Physical Oncology · doi:10.1088/2057-1739/aa9263 · Cited by 79
Cesca, M., Bizzaro, F., Zucchetti, M., & Giavazzi, R. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00259 · Cited by 78
Pro‐ and antiangiogenic therapies: current status and clinical implications
Rust, R., Gantner, C., & Schwab, M. E. (2018) · The FASEB Journal · doi:10.1096/fj.201800640rr · Cited by 78
Liu, F.-Y., Fan, D., Yang, Z., Tang, N., Guo, Z., Ma, S., Ma, Z., Wu, H., Deng, W., & Tang, Q. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1718-7 · Cited by 78
YAP promotes ocular neovascularization by modifying PFKFB3-driven endothelial glycolysis
Feng, Y., Zou, R., Zhang, X., Shen, M., Chen, X., Wang, J., Niu, W., Yuan, Y., & Yuan, F. (2021) · Angiogenesis · doi:10.1007/s10456-020-09760-8 · Cited by 78
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von Au, A., Vasel, M., Kraft, S., Sens, C., Hackl, N., Marx, A., Ströbel, P., Hennenlotter, J., Todenhöfer, T., Stenzl, A., et al. (2013) · Neoplasia · doi:10.1593/neo.13762 · Cited by 78
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Onodera, R., Motoyama, K., Okamatsu, A., Higashi, T., & Arima, H. (2013) · Scientific Reports · doi:10.1038/srep01104 · Cited by 78
Charpentier, M. S., Christine, K. S., Amin, N. M., Dorr, K. M., Kushner, E. J., Bautch, V. L., Taylor, J. M., & Conlon, F. L. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.03.003 · Cited by 79
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Park, K. M., & Gerecht, S. (2014) · Development · doi:10.1242/dev.102194 · Cited by 78
Gene delivery nanoparticles to modulate angiogenesis
Kim, J., Mirando, A. C., Popel, A. S., & Green, J. J. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.11.003 · Cited by 78
TFEB controls vascular development by regulating the proliferation of endothelial cells
Doronzo, G., Astanina, E., Corà, D., Chiabotto, G., Comunanza, V., Noghero, A., Neri, F., Puliafito, A., Primo, L., Spampanato, C., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201798250 · Cited by 78
Liao, Z.-H., Zhu, H., Chen, Y., Chen, R.-L., Fu, L.-X., Li, L., Zhou, H., Zhou, J., & Liang, G. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112852 · Cited by 77
Une, N., Takano-Kasuya, M., Kitamura, N., Ohta, M., Inose, T., Kato, C., Nishimura, R., Tada, H., Miyagi, S., Ishida, T., et al. (2021) · Medical Oncology · doi:10.1007/s12032-021-01503-z · Cited by 77
FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis
Zhu, X., Qiu, C., Wang, Y., Jiang, Y., Chen, Y., Fan, L., Ren, R., Wang, Y., Chen, Y., Feng, Y., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2202631119 · Cited by 77
Ge, Y., Wang, Q., Yao, Y., Qin, X., Sun, J., Chen, W., Lin, Y., & Cai, X. (2024) · Advanced Science · doi:10.1002/advs.202308701 · Cited by 77
Insulin-like Growth Factor 1 (IGF-1) Stabilizes Nascent Blood Vessels
Jacobo, S. M. P., & Kazlauskas, A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.634154 · Cited by 77
Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations
Murakami, M. (2011) · International Journal of Vascular Medicine · doi:10.1155/2012/293641 · Cited by 77
Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma
Wang, S.-Y., Ke, Y., Lu, G., Song, Z., Li, Y., Xiao, S., Sun, X., Jiang, X., Yang, Z., & Hu, C. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1077-7 · Cited by 77
Pro-angiogenic Role of Insulin: From Physiology to Pathology
Escudero, C., Herlitz, K., Troncoso, F., Guevara, K., Acurio, J., Aguayo, C. R., Godoy, A., & González, M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00204 · Cited by 77
miRNAs: micro-managers of anticancer combination therapies
B, J. R. V. B., Giovannetti, E., Poel, D., Nowak-Sliwinska, P. M., & Griffioen, A. W. (2017) · Angiogenesis · doi:10.1007/s10456-017-9545-x · Cited by 77
Gao, S., Zheng, G., Wang, L., Liang, Y., Zhang, S., Lao, X., Li, K., & Liao, G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179248 · Cited by 77
Wang, H., Zhu, H., Guo, Q., Qian, T., Zhang, P., Li, S., Xue, C., & Gu, X. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00323 · Cited by 77
Nanomedicines for developing cancer nanotherapeutics: from benchtop to bedside and beyond
Iqbal, J., Abbasi, B. A., Ahmad, R., Mahmood, T., Ali, B., Khalil, A. T., Kanwal, S., Shah, S. A., Alam, M. M., Badshah, H., et al. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9352-3 · Cited by 77
PFKFB3 is involved in breast cancer proliferation, migration, invasion and angiogenesis
Peng, F., Li, Q., Sun, J.-Y., Luo, Y., Chen, M., & Bao, Y. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4257 · Cited by 76
Tan, X., Zhang, Z., Yao, H., & Shen, L. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.08.012 · Cited by 76
RetractedAzad, T., Nouri, K., van Rensburg, H. J. J., Maritan, S. M., Wu, L., Hao, Y., Montminy, T., Yu, J., Khanal, P., Mulligan, L. M., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0988-y · Cited by 76
Gas and gas-generating nanoplatforms in cancer therapy
Jing, Y.-Z., Li, S., & Sun, Z. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01661j · Cited by 76
Introduction to cancer and treatment approaches
Chandraprasad, M. S., Dey, A., & Swamy, M. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90951-8.00010-2 · Cited by 76
Metadata
- Authors
- Carmeliet, P., & Jain, R. K.
- Affiliations
- Harvard University (US)
- Corresponding author
- Carmeliet, Peter
- Jain, Rakesh K.
- ORCID
- Carmeliet, Peter
- Venue
- Nature
- Published
- 2011-05
- Volume
- 473
- Issue
- 7347
- Pages
- 298-307
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4049445
- OpenAlex
- W1992112921
- Semantic Scholar
- cc1723f25e863386b91340ea03cd76a22de359ae
- Cited by
- 5,467
- References
- 100
- Citations by year
- 2026: 238 · 2025: 316 · 2024: 308 · 2023: 364 · 2022: 393 · 2021: 442 · 2020: 399 · 2019: 399 · 2018: 384 · 2017: 454 · 2016: 369 · 2015: 375 · 2014: 326 · 2013: 342 · 2012: 284
- FWCI
- 29.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Cancer Institute (R01CA115767, R01CA085140, P01CA080124, R01CA126642, R01CA163815)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
- Keywords
- angiogenesis, angiogenesis inhibitors, vascular endothelial growth factor, VEGF inhibitors, drug resistance, molecular targets, cancer, eye diseases, blood vessel development
- MeSH terms
- Animals, Blood Vessels, Fibroblast Growth Factors, Humans, Platelet-Derived Growth Factor, Transforming Growth Factor beta, Neovascularization, Physiologic, Angiogenesis Inhibitors, Vesicular Transport Proteins, Vascular Endothelial Growth Factor A
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