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Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
Open accessAbstract
The basolateral amygdala (BLA) has a crucial role in emotional learning irrespective of valence. The BLA projection to the nucleus accumbens (NAc) is thought to modulate cue-triggered motivated behaviours, but our understanding of the interaction between these two brain regions has been limited by the inability to manipulate neural-circuit elements of this pathway selectively during behaviour. To circumvent this limitation, we used in vivo optogenetic stimulation or inhibition of glutamatergic fibres from the BLA to the NAc, coupled with intracranial pharmacology and ex vivo electrophysiology. Here we show that optical stimulation of the pathway from the BLA to the NAc in mice reinforces behavioural responding to earn additional optical stimulation of these synaptic inputs. Optical stimulation of these glutamatergic fibres required intra-NAc dopamine D1-type receptor signalling, but not D2-type receptor signalling. Brief optical inhibition of fibres from the BLA to the NAc reduced cue-evoked intake of sucrose, demonstrating an important role of this specific pathway in controlling naturally occurring reward-related behaviour. Moreover, although optical stimulation of glutamatergic fibres from the medial prefrontal cortex to the NAc also elicited reliable excitatory synaptic responses, optical self-stimulation behaviour was not observed by activation of this pathway. These data indicate that whereas the BLA is important for processing both positive and negative affect, the glutamatergic pathway from the BLA to the NAc, in conjunction with dopamine signalling in the NAc, promotes motivated behavioural responding. Thus, optogenetic manipulation of anatomically distinct synaptic inputs to the NAc reveals functionally distinct properties of these inputs in controlling reward-seeking behaviours.
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“This work has, for instance, proposed that BLA PNs innervating the NAc and vHPC primarily encode information with positive and negative valence, respectively (17,20,22,23).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [23]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The amygdala is important in learning the emotional significance of cues in the environment, and can facilitate ventral striatal activity through its direct inputs, leading to motivated action (Stuber et al., 2011).”
From Beyond simple models of adolescence to an integrated circuit-based account: A commentary (2016) · cites this paper as Stuber et al., 2011
In the citing paper
“Thus circuits associated with motivated action (Stuber et al., 2011) may be strengthened before top-down projections to these regions have matured with experience and age (Casey, 2015).”
From Beyond simple models of adolescence to an integrated circuit-based account: A commentary (2016) · cites this paper as Stuber et al., 2011
In the citing paper
“Recent optogenetic studies have shown that photostimulating BLA PNs targeting the vHPC increases anxiety-like behavior and reduces social interaction, whereas photosilencing this pathway has the opposite effects, and, conversely, stimulating NAc-targeting BLA PNs promotes reward-seeking (20,22,23,39).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [23]
In the citing paper
“Recent optogenetic studies have shown that photostimulating BLA PNs targeting the vHPC increases anxiety-like behavior and reduces social interaction, whereas photosilencing this pathway has the opposite effects, and, conversely, stimulating NAc-targeting BLA PNs promotes reward-seeking (20,22,23,39).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [23]
In the citing paper
“Recent optogenetic studies have shown that photostimulating BLA PNs targeting the vHPC increases anxiety-like behavior and reduces social interaction, whereas photosilencing this pathway has the opposite effects, and, conversely, stimulating NAc-targeting BLA PNs promotes reward-seeking (20,22,23,39).”
From Chronic Stress Remodels Synapses in an Amygdala Circuit-Specific Manner (2019) · cites this paper as [23]
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Citations
Cites
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
The Emotional Brain, Fear, and the Amygdala
LeDoux, J. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1025048802629 · Cited by 1,818
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428
Amygdala circuitry mediating reversible and bidirectional control of anxiety
Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature · doi:10.1038/nature09820 · Cited by 1,289
Self-citationPhasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266
Self-citationSubsecond dopamine release promotes cocaine seeking
Phillips, P. E. M., Stuber, G. D., Heien, M. L. A. V., Wightman, R. M., & Carelli, R. M. (2003) · Nature · doi:10.1038/nature01476 · Cited by 1,113
Self-citationMolecular and Cellular Approaches for Diversifying and Extending Optogenetics
Gradinaru, V., Zhang, F., Ramakrishnan, C., Mattis, J., Prakash, R., Diester, I., Goshen, I., Thompson, K. R., & Deisseroth, K. A. (2010) · Cell · doi:10.1016/j.cell.2010.02.037 · Cited by 1,040
Self-citationAravanis, A. M., Wang, L., Zhang, F., Meltzer, L. A., Mogri, M., Schneider, M. B., & Deisseroth, K. A. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/3/s02 · Cited by 960
Self-citationThe primate amygdala represents the positive and negative value of visual stimuli during learning
Paton, J. J., Belova, M. A., Morrison, S. E., & Salzman, C. D. (2006) · Nature · doi:10.1038/nature04490 · Cited by 917
McFarland, K., Lapish, C. C., & Kalivas, P. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03531.2003 · Cited by 884
Cited by
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Items 501–600 of 871
Wu, H., Tambuyzer, T., Nica, I. G., Deprez, M., van Kuyck, K., Aerts, J., Huffel, S. V., & Nuttin, B. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1872-15.2016 · Cited by 15
Optogenetic investigation of neural mechanisms for alcohol-use disorder
Juarez, B., Liu, Y., Zhang, L., & Han, M. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.05.005 · Cited by 15
Wisłowska-Stanek, A., Płaźnik, A., Kołosowska, K., Skórzewska, A., Turzyńska, D., Liguz‐Lecznar, M., Krząścik, P., Gryz, M., Szyndler, J., Sobolewska, A., et al. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.10.027 · Cited by 15
Han, M., & Friedman, A. K. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.009 · Cited by 15
Quintana, G. R., Guizar, A., Rassi, S. Z., & Pfaus, J. G. (2018) · Learning & Memory · doi:10.1101/lm.048090.118 · Cited by 15
Ravinder, S., Donckels, E. A., Ramirez, J. S. B., Christakis, D., Ramirez, J., & Ferguson, S. M. (2016) · eNeuro · doi:10.1523/eneuro.0199-16.2016 · Cited by 19
Endocannabinoid markers in autism spectrum disorder: A scoping review of human studies
Pol, M. D., & Kolla, N. J. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114256 · Cited by 15
Djerdjaj, A., Ng, A. J., Rieger, N. S., & Christianson, J. P. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114050 · Cited by 15
The representational geometry of emotional states in basolateral amygdala
O’Neill, P.-K., Posani, L., Mészáros, J., Warren, P., Schoonover, C. E., Fink, A. J. P., Fusi, S., & Salzman, C. D. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02315-y · Cited by 17
Weber, S. J., Kawa, A. B., Beutler, M. M., Kuhn, H. M., Moutier, A. L., Westlake, J. G., Koyshman, L. M., Moreno, C. D., Wunsch, A. M., & Wolf, M. E. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01992-2 · Cited by 15
Krämer, B., & Gruber, O. (2015) · Neuropsychobiology · doi:10.1159/000437436 · Cited by 15
Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior
Lafferty, C. K., & Britt, J. P. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.00010 · Cited by 13
Noradrenergic Activity in the Olfactory Bulb Is a Key Element for the Stability of Olfactory Memory
Linster, C., Midroit, M., Forest, J., Thenaisie, Y., Cho, C., Richard, M. B., Didier, A., & Mandairon, N. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1769-20.2020 · Cited by 14
The neurobiology of abstinence-induced reward-seeking in males and females
Alonso‐Caraballo, Y., Guha, S. K., & Chartoff, E. H. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173088 · Cited by 15
Laurent, V., & Balleine, B. W. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15339 · Cited by 15
Tsubota, T., Ohashi, Y., & Tamura, K. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.019 · Cited by 17
Manipulating neural activity in physiologically classified neurons: triumphs and challenges
Gore, F., Schwartz, E. C., & Salzman, C. D. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0216 · Cited by 15
Viral labeling of neurons synaptically connected to nucleus accumbens somatostatin interneurons
Ribeiro, E., Nectow, A. R., Pomeranz, L. E., Ekstrand, M. I., Koo, J. W., & Nestler, E. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213476 · Cited by 15
Energy sensors in drug addiction: A potential therapeutic target
López-Gambero, A. J., de Fonseca, F. R., & Suárez, J. (2020) · Addiction Biology · doi:10.1111/adb.12936 · Cited by 14
Chen, Y., Ou, Y., Lv, D., Ma, J., Zhan, C., Yang, R., Jia, C., Shang, T., Sun, L., Wang, Y., et al. (2021) · Neural Plasticity · doi:10.1155/2021/9966378 · Cited by 14
Temporal dynamics of affect in the brain: Evidence from human imaging and animal models
Puccetti, N. A., Villano, W. J., Fadok, J. P., & Heller, A. S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.014 · Cited by 15
Li, J., Yu, Y., Su, C.-L., Shen, Y., Chang, C., & Gean, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01417-y · Cited by 13
Selective Modulation of Hippocampal Theta Oscillations in Response to Morphine versus Natural Reward
Jamali, S., Parto-Dezfouli, M., Kalbasi, A., Daliri, M. R., & Haghparast, A. (2023) · Brain Sciences · doi:10.3390/brainsci13020322 · Cited by 13
Adkins, A. M., Colby, E. M., Kim, W., Wellman, L. L., & Sanford, L. D. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02813-x · Cited by 15
Advanced neurobiological tools to interrogate metabolism
Mirabella, P. N., & Fenselau, H. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00885-6 · Cited by 13
McDevitt, D. S., & Graziane, N. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.08.025 · Cited by 13
Pochechuev, M. S., Solotenkov, M. A., Fedotov, I. V., Ivashkina, O. I., Anokhin, K. V., & Zheltikov, A. M. (2020) · Journal of Biophotonics · doi:10.1002/jbio.202000081 · Cited by 13
Jin, D., Chen, H., Chen, S., & Pan, H. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15706 · Cited by 14
Ou, Y., Su, Q., Liu, F., Ding, Y., Chen, J., Zhang, Z., Zhao, J., & Guo, W. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00585 · Cited by 13
Machida, M., Wellman, L. L., Fitzpatrick, M. E., Hallum, O. Y., Sutton, A. M., Lónárt, G., & Sanford, L. D. (2017) · SLEEP · doi:10.1093/sleep/zsx020 · Cited by 15
Regulation of dendritic spines in the amygdala following sleep deprivation
Rexrode, L., Tennin, M., Babu, J., Young, C., Bollavarapu, R., Lawson, L. A., Valeri, J., Pantazopoulos, H., & Gisabella, B. (2023) · Frontiers in Sleep · doi:10.3389/frsle.2023.1145203 · Cited by 15
Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens
He, Y., Huang, Y. H., Schlüter, O. M., & Dong, Y. (2023) · eLife · doi:10.7554/elife.89766 · Cited by 12
Forcelli, P. A., Wellman, L. L., & Málková, L. (2017) · Behavioral Neuroscience · doi:10.1037/bne0000187 · Cited by 14
Fragility of reward vs antifragility of defense brain systems in drug dependence
Prospero-Garcia, O. E., Ruiz‐Contreras, A. E., Morelos, J. C., Herrera-Solís, A., & Méndez‐Díaz, M. (2021) · Social Neuroscience · doi:10.1080/17470919.2021.1876759 · Cited by 12
Optogenetics: Emerging strategies for neuropathic pain treatment
Li, S., Feng, X., & Bian, H. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.982223 · Cited by 12
Montañez‐Miranda, C., Bramlett, S. N., & Hepler, J. R. (2022) · Hippocampus · doi:10.1002/hipo.23492 · Cited by 12
The emerging neuroscience of appetitive and drug cue extinction in humans
Konova, A. B., & Goldstein, R. Z. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5098-y · Cited by 15
Ebrahimi, Z., Kahvandi, N., Komaki, A., Karimi, S. A., Naderishahab, M., & Sarihi, A. (2021) · BMC Neuroscience · doi:10.1186/s12868-021-00627-2 · Cited by 12
Fakira, A. K., Lueptow, L. M., Trimbake, N. A., & Devi, L. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.675769 · Cited by 11
Hervig, M. E.-S., Jensen, N. C. H., Rasmussen, N. B., Rydbirk, R., Olesen, M. V., Hay‐Schmidt, A., Pakkenberg, B., & Aznar, S. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.050 · Cited by 13
Ohene‐Nyako, M., Persons, A. L., & Napier, T. C. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1701-6 · Cited by 11
Opioid Withdrawal Abruptly Disrupts Amygdala Circuit Function by Reducing Peptide Actions
Gregoriou, G. C., Patel, S., Pyne, S., Winters, B. L., & Bagley, E. E. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1317-22.2022 · Cited by 11
Namba, M. D., Xie, Q., & Barker, J. M. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.07.021 · Cited by 10
Gálosi, R., Hajnal, A. S., Petykó, Z., Hartmann, G., Karádi, Z., & Lénárd, L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.03.017 · Cited by 11
Importin α3 (KPNA3) Deficiency Augments Effortful Reward-Seeking Behavior in Mice
Aomine, Y., Sakurai, K., Macpherson, T., Ozawa, T., Miyamoto, Y., Yoneda, Y., Oka, M., & Hikida, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.905991 · Cited by 11
Identification of neuronal loci involved with displays of affective aggression in NC900 mice
Nehrenberg, D. L., Sheikh, A., & Ghashghaei, H. T. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0445-y · Cited by 12
Song, J., Chen, M., Dong, Y. W., Lai, B., & Zheng, P. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.005 · Cited by 11
Méndez‐Díaz, M., Belmont, O. A., Gonzalez, V. E., Ruiz‐Contreras, A. E., & Prospero-Garcia, O. E. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.05.033 · Cited by 11
Failure of Placebo Analgesia Model in Rats with Inflammatory Pain
Yin, X., Yang, J., Cao, S., & Wang, Y. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00420-6 · Cited by 12
Hogeveen, J., Aragon, D., Rogge-Obando, K., Campbell, R. A., Shuttleworth, C. W., Avila-Rieger, R., Yeo, R. A., Wilson, J. K., Fratzke, V., Brandt, E., et al. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2020.7363 · Cited by 13
Reconnectable fiberscopes for chronic in vivo deep‐brain imaging
Pochechuev, M. S., Федотов, И. В., Ivashkina, O. I., Roshchina, M. A., Meshchankin, D. V., Sidorov-Biryukov, D. A., Fedotov, A. B., Anokhin, K. V., & Zheltikov, A. M. (2017) · Journal of Biophotonics · doi:10.1002/jbio.201700106 · Cited by 11
Thomas, A. W., Delevich, K. M., Chang, I., & Wilbrecht, L. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2019.100737 · Cited by 11
Shao, D., Cao, Z., Fu, Y., Yang, H., Gao, P., Zheng, P., & Lai, B. (2021) · Addiction Biology · doi:10.1111/adb.13048 · Cited by 11
Basolateral Amygdala Regulates EEG Theta-activity During Rapid Eye Movement Sleep
Machida, M., Sweeten, B. L. W., Adkins, A. M., Wellman, L. L., & Sanford, L. D. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.06.018 · Cited by 13
The influence of insight on risky decision making and nucleus accumbens activation
Becker, M., Yu, Y., & Cabeza, R. E. L. (2023) · Scientific Reports · doi:10.1038/s41598-023-44293-2 · Cited by 10
Identification of a stress-responsive subregion of the basolateral amygdala in male rats
Aukema, R. J., Petrie, G. N., Matarasso, A. K., Baglot, S. L., Molina, L. A., Füzesi, T., Kadhim, S., Nastase, A. S., Reyes, I. R., Bains, J. S., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01927-x · Cited by 10
The therapeutic potential of low-intensity focused ultrasound for treating substance use disorder
Olaitan, G. O., Lynch, W. J., & Venton, B. J. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1466506 · Cited by 11
Integrating Aversive Memories in the Basolateral Amygdala
Liu, J., Totty, M. S., Bayer, H., & Maren, S. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.03.019 · Cited by 13
A neural substrate of comorbid depressive symptoms in alcohol use
Chen, Z., Yang, S., Leng, L., Ding, J., Yuan, Z., Zhuang, K., Can, D., Zou, T., Wang, Y., Li, H., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03061-6 · Cited by 11
Gangal, H., Iannucci, J., Huang, Y., Chen, R., Purvines, W., Davis, W. T., Rivera, A., Johnson, G., Xie, X., Mukherjee, S., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03650-7 · Cited by 11
Truckenbrod, L. M., Betzhold, S. M., Wheeler, A.-R., Shallcross, J., Singhal, S. M., Harden, S. W., Schwendt, M., Frazier, C. J., Bizon, J. L., Setlow, B., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0276-23.2023 · Cited by 11
Schmill, M. P., Thompson, Z., Lee, D., Haddadin, L., Mitra, S., Ezzat, R., Shelton, S. M., Levin, P., Behnam, S., Huffman, K. J., et al. (2023) · Brain Behavior and Evolution · doi:10.1159/000533524 · Cited by 10
A Selective Role for Lmo4 in Cue-Reward Learning
Maiya, R., Mangieri, R. A., Morrisett, R. A., Heberlein, U., & Messing, R. O. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1740-15.2015 · Cited by 10
Wright, L., & Kutcher, S. (2016) · Colloquium Series on The Developing Brain · doi:10.4199/c00133ed1v01y201602dbr012 · Cited by 12
Joshi, A., Kool, T., Diepenbroek, C., Koekkoek, L. L., Eggels, L., Kalsbeek, A., Mul, J. D., Barrot, M., & la Fleur, S. E. (2021) · Appetite · doi:10.1016/j.appet.2021.105597 · Cited by 10
Viral Vectors for Optogenetics of Hypothalamic Neuropeptides
Knobloch, H. S., Charlet, A., Stoop, R., & Grinevich, V. (2013) · Neuromethods · doi:10.1007/978-1-62703-610-8_16 · Cited by 9
Parker, N. F., Baidya, A., Cox, J., Haetzel, L. M., Zhukovskaya, A., Murugan, M., Engelhard, B., Goldman, M. S., & Witten, I. B. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/725382 · Cited by 10
A nociceptive amygdala-striatal pathway for chronic pain aversionPreprint
Wojick, J. A., Paranjapye, A., Chiu, J. K., Mahmood, M., Oswell, C. S., Kimmey, B. A., Wooldridge, L. M., McCall, N. M., Han, A., Ejoh, L. L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.12.579947 · Cited by 10
Servonnet, A., Rompré, P.-P., & Samaha, A. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114254 · Cited by 9
A nociceptive amygdala-striatal pathway modulating affective-motivational pain
Wojick, J. A., Paranjapye, A., Chiu, J. K., Oswell, C. S., Mahmood, M., Wooldridge, L. M., Kimmey, B. A., Ortega, R. A. S., McCall, N. M., Han, S., et al. (2025) · Science Advances · doi:10.1126/sciadv.ado2837 · Cited by 19
Hoffman, J. L., Faccidomo, S., Taylor, S. M., DeMiceli, K. G., May, A. M., Smith, E. N., Whindleton, C. M., & Hodge, C. W. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06365-z · Cited by 6
A novel perspective on the role of nucleus accumbens neurons in encoding associative learning
Domingues, A. V., Rodrigues, A. J., & Soares‐Cunha, C. (2023) · FEBS Letters · doi:10.1002/1873-3468.14727 · Cited by 7
Lighting up the brain's reward circuitry
Lobo, M. K. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06368.x · Cited by 8
Accumbal Adenosine A2A Receptors Enhance Cognitive Flexibility by Facilitating Strategy Shifting
Zhou, J., Wu, B., Lin, X., Dai, Y., Li, T., Zheng, W., Guo, W. M., Vakal, S., Chen, X., & Chen, J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00130 · Cited by 9
Reward-related dynamical coupling between basolateral amygdala and nucleus accumbens
Hsu, C.-C., Madsen, T. E., O’Gorman, E., Gourley, S. L., & Rainnie, D. G. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02099-2 · Cited by 9
Optogenetics in neuroscience: what we gain from studies in mammals
Chen, Q., Zeng, Z., & Hu, Z. (2012) · Neuroscience Bulletin · doi:10.1007/s12264-012-1250-6 · Cited by 9
Walters, J. L., Chelonis, J. J., Fogle, C. M., Orser, B. A., & Paule, M. G. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.07.012 · Cited by 9
Wang, S., Wang, X., Lin, W., Bao, S., Wang, B., Wu, B., Su, Y., & Lian, Q. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2667-8 · Cited by 9
Rodríguez-Romaguera, J., Namboodiri, V. M. K., Basiri, M. L., Stamatakis, A. M., & Stuber Garret, D. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039792 · Cited by 9
Self-citationNarayanaswamy, J. C., Jose, D., Kalmady, S., Venkatasubramanian, G., & Reddy, Y. J. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413491153 · Cited by 8
Ventral Pallidum and Amygdala Cooperate to Restrain Reward Approach under Threat
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Ishikawa, Y., Oishi, N., Kyuragi, Y., Hatakoshi, M., Hirano, J., Noda, T., Yoshihara, Y., Ito, Y., Miyata, J., Nemoto, K., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02874-1 · Cited by 11
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Yan, Y., Aierken, A., Wang, C., Jin, W., Quan, Z., Wang, Z., Qing, H., Ni, J., & Zhao, J. (2022) · The Neuroscientist · doi:10.1177/10738584211069977 · Cited by 9
Horovitz, O., & Richter‐Levin, G. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00053 · Cited by 8
Carr, M. R., Vries, T. J. D., & Pattij, T. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000425 · Cited by 9
Amygdalostriatal coupling underpins positive but not negative coloring of ambiguous affect
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Sadeghi-Adl, M., Sadat‐Shirazi, M., Shahini, F., Akbarabadi, A., Khalifeh, S., Borzabadi, S., Nasehi, M., & Zarrindast, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118430 · Cited by 8
Massaly, N., Markovic, T., Creed, M. C., Al‐Hasani, R., Cahill, C. M., & Morón, J. A. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.002 · Cited by 12
Kolpakova, J., van der Vinne, V., Giménez‐Gómez, P., Le, T., You, I., Zhao-Shea, R., Velázquez‐Marrero, C., Tapper, A. R., & Martin, G. E. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.742207 · Cited by 7
Circuits underlying social function and dysfunction
Wang, Z., Yueh, H., Chau, M., Veenstra-VanderWeele, J. M., & O’Reilly, K. C. (2023) · Autism Research · doi:10.1002/aur.2978 · Cited by 9
Long-range GABAergic neurons in the prefrontal cortex modulate behavior
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Within-subject neural reactivity to reward and threat is inverted in young adolescents
Thomason, M. E., & Marusak, H. A. (2017) · Psychological Medicine · doi:10.1017/s0033291716003111 · Cited by 9
Федотов, И. В., Ivashkina, O. I., Pochechuev, M. S., Roshchina, M. A., Toropova, K. A., Fedotov, A. B., Anokhin, K. V., & Zheltikov, A. M. (2017) · Journal of Biophotonics · doi:10.1002/jbio.201600225 · Cited by 8
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McCool, B. A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108750 · Cited by 7
Faccidomo, S., Saunders, B. L., May, A. M., Eastman, V. R., Kim, M. H., Taylor, S. M., Hoffman, J. L., McElligott, Z. A., & Hodge, C. W. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06740-4 · Cited by 7
GluN2B-mediated regulation of silent synapses for receptor specification and addiction memory
Kim, H. J., Lee, S., Kim, G. H., Sung, K., Yoo, T., Pyo, J. H., Jo, H.-J., Lee, S., Lee, H. Y., Jung, J. H., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01399-z · Cited by 8
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Basolateral amygdala dopamine transmits emotional salience
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Endocannabinoid system and aggression across animal species
Migliaro, M., Ruiz‐Contreras, A. E., Herrera-Solís, A., Méndez‐Díaz, M., & Prospero-Garcia, O. E. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105375 · Cited by 8
Metadata
- Authors
- Stuber, G. D., Sparta, D. R., Stamatakis, A. M., van Leeuwen, W. A., Hardjoprajitno, J. E., Cho, S., Tye, K. M., Kempadoo, K. A., Zhang, F., Deisseroth, K., & Bonci, A.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of California, San Francisco (US)
- Stanford University (US)
- National Institute on Drug Abuse (US)
- Corresponding author
- Stuber, Garret D.
- ORCID
- Venue
- Nature
- Published
- 2011-06-29
- Volume
- 475
- Issue
- 7356
- Pages
- 377-380
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3775282
- OpenAlex
- W2069090835
- Cited by
- 878
- References
- 26
- Citations by year
- 2026: 32 · 2025: 46 · 2024: 54 · 2023: 40 · 2022: 46 · 2021: 64 · 2020: 50 · 2019: 51 · 2018: 65 · 2017: 81 · 2016: 67 · 2015: 80 · 2014: 53 · 2013: 78 · 2012: 53
- FWCI
- 26.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UNC Libraries
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Foundation of Hope for Research and Treatment of Mental Illness
- University of North Carolina at Chapel Hill
- University of California, San Francisco
- National Institute on Alcohol Abuse and Alcoholism (F32AA018610)
- National Institute on Drug Abuse (R01DA032750, DA029325, R21DA029325)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP2DK102256)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- basolateral amygdala, nucleus accumbens, glutamatergic projections, reward seeking, dopamine D1 receptor, dopamine D2 receptor, optogenetic manipulation, sucrose intake, self-stimulation, medial prefrontal cortex, emotional learning, motivated behavior, aversive behavior
- MeSH terms
- Channelrhodopsins, Amygdala, Animals, Cues, Dopamine, Drinking, Light, Male, Mice, Inbred C57BL, Nerve Fibers, Neural Pathways, Neurons, Nucleus Accumbens, Photic Stimulation, Reward, Sucrose, Behavior, Addictive, Receptors, Dopamine D1, Patch-Clamp Techniques, Glutamic Acid, Excitatory Postsynaptic Potentials, Mice
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