Cited by 854Cancer Cells and MetastasisDevelopmental Biology and Gene RegulationMesenchymal stem cell research

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Distinct stem cells contribute to mammary gland development and maintenance

Abstract

The mammary epithelium is composed of several cell lineages including luminal, alveolar and myoepithelial cells. Transplantation studies have suggested that the mammary epithelium is maintained by the presence of multipotent mammary stem cells. To define the cellular hierarchy of the mammary gland during physiological conditions, we performed genetic lineage-tracing experiments and clonal analysis of the mouse mammary gland during development, adulthood and pregnancy. We found that in postnatal unperturbed mammary gland, both luminal and myoepithelial lineages contain long-lived unipotent stem cells that display extensive renewing capacities, as demonstrated by their ability to clonally expand during morphogenesis and adult life as well as undergo massive expansion during several cycles of pregnancy. The demonstration that the mammary gland contains different types of long-lived stem cells has profound implications for our understanding of mammary gland physiology and will be instrumental in unravelling the cells at the origin of breast cancers.

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Crossref · 10.1038/nature10573

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38 of 38 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Van Keymeulen, A., Rocha, A. S., Ousset, M., Beck, B., Bouvencourt, G., Rock, J., Sharma, N., Dekoninck, S., & Blanpain, C.
Affiliations
  • Université Libre de Bruxelles (BE)
  • Duke Medical Center (US)
Corresponding author
Blanpain, Cédric
Venue
Nature
Published
2011-10-09
Volume
479
Issue
7372
Pages
189-193
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2082161467
Cited by
854
References
38
Citations by year
2026: 24 · 2025: 38 · 2024: 41 · 2023: 44 · 2022: 30 · 2021: 55 · 2020: 62 · 2019: 51 · 2018: 73 · 2017: 55 · 2016: 54 · 2015: 91 · 2014: 83 · 2013: 81 · 2012: 68
FWCI
36.95
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
  • HAL (submittedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords
mammary stem cells, mammary gland development, mammary epithelium, cellular hierarchy, lineage tracing, clonal expansion, multipotent stem cells, luminal cells, myoepithelial cells, alveolar cells, mammary gland morphogenesis, pregnancy, lactation
MeSH terms
Aging, Animals, Cell Differentiation, Epithelium, Female, Homeostasis, Lactation, Mammary Glands, Animal, Pregnancy, Stem Cells, Cell Transplantation, Cell Lineage, Multipotent Stem Cells, Mice

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