Epidermal homeostasis: a balancing act of stem cells in the skin

Chromatin modifications and their function

Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

Rheinwatd, J. G., & Green, H. (1975) · Cell · doi:10.1016/s0092-8674(75)80001-8 · Cited by 4,528 · see citing works

Wnt signalling in stem cells and cancer

Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666 · see citing works

Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis

Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276 · see citing works

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R. T., Tabin, C. J., Sharpe, A. H., Caput, D., Crum, C. P., et al. (1999) · Nature · doi:10.1038/19539 · Cited by 2,224 · see citing works

Defining the Epithelial Stem Cell Niche in Skin

Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031 · see citing works

p63 is a p53 homologue required for limb and epidermal morphogenesis

Mills, A. A., Zheng, B., Wang, X., Vogel, H. S., Roop, D. R., & Bradley, A. (1999) · Nature · doi:10.1038/19531 · Cited by 1,974 · see citing works

The cornified envelope: a model of cell death in the skin

Candi, E., Schmidt, R., & Melino, G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1619 · Cited by 1,776 · see citing works

Mutation selection and the natural history of cancer

Cairns, J. (1975) · Nature · doi:10.1038/255197a0 · Cited by 1,592 · see citing works

Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche

Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428 · see citing works

Asymmetric and symmetric stem-cell divisions in development and cancer

Morrison, S. J., & Kimble, J. E. (2006) · Nature · doi:10.1038/nature04956 · Cited by 1,393 · see citing works

β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352 · see citing works

Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,317 · see citing works

Capturing and profiling adult hair follicle stem cells

Morris, R. J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J. S., Sawicki, J. A., & Cotsarelis, G. (2004) · Nature Biotechnology · doi:10.1038/nbt950 · Cited by 1,283 · see citing works

Permanent Coverage of Large Burn Wounds with Autologous Cultured Human Epithelium

Gallico, G. G., O'Connor, N. E., Compton, C. C., Kehinde, O., & Green, H. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408163110706 · Cited by 1,179 · see citing works

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

Jones, P. H., & Watt, F. M. (1993) · Cell · doi:10.1016/0092-8674(93)90251-k · Cited by 1,100 · see citing works

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089 · see citing works

WNT Signals Are Required for the Initiation of Hair Follicle Development

Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088 · see citing works

Changes in keratin gene expression during terminal differentiation of the keratinocyte

Fuchs, E. V., & Green, H. (1980) · Cell · doi:10.1016/0092-8674(80)90094-x · Cited by 1,064 · see citing works

Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding

Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,064 · see citing works

Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

Oshima, H., Rochat, A., Kedzia, C., Kobayashi, K., & Barrandon, Y. (2001) · Cell · doi:10.1016/s0092-8674(01)00208-2 · Cited by 1,043 · see citing works

Permanent coverage of large burn wounds with autologous cultured human epithelium

Gallico, G. G. (1985) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198511000-00093 · Cited by 1,033 · see citing works

Mechanisms of Asymmetric Stem Cell Division

Knoblich, J. A. (2008) · Cell · doi:10.1016/j.cell.2008.02.007 · Cited by 1,020 · see citing works

Asymmetric cell divisions promote stratification and differentiation of mammalian skin

Lechler, T., & Fuchs, E. (2005) · Nature · doi:10.1038/nature03922 · Cited by 998 · see citing works

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995 · see citing works

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J., Clevers, H., & Toftgård, R. (2008) · Nature Genetics · doi:10.1038/ng.239 · Cited by 966 · see citing works

The secret life of the hair follicle

Hardy, M. H. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90350-d · Cited by 931 · see citing works

p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia

Senoo, M., Pinto, F., Crum, C. P., & McKeon, F. (2007) · Cell · doi:10.1016/j.cell.2007.02.045 · Cited by 881 · see citing works

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

Rangarajan, A., Talora, C., Okuyama, R., Nicolas, M., Mammucari, C., Oh, H., Aster, J. C., Krishna, S., METZGER, D., Chambon, P., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.13.3427 · Cited by 867 · see citing works

A single type of progenitor cell maintains normal epidermis

Clayton, E., Doupé, D. P., Klein, A. M., Winton, D. J., Simons, B. D., & Jones, P. H. (2007) · Nature · doi:10.1038/nature05574 · Cited by 853 · see citing works

Epidermal Stem Cells of the Skin

Blanpain, C., & Fuchs, E. V. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104357 · Cited by 845 · see citing works

A skin microRNA promotes differentiation by repressing ‘stemness’

Yi, R., Poy, M. N., Stoffel, M., & Fuchs, E. (2008) · Nature · doi:10.1038/nature06642 · Cited by 790 · see citing works

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration

Plikus, M. V., Mayer, J. A., de la Cruz, D., Baker, R. E., Maini, P. K., Maxson, R. E., & Chuong, C. (2008) · Nature · doi:10.1038/nature06457 · Cited by 768 · see citing works

Sonic hedgehog signaling is essential for hair development

St‐Jacques, B., Dassule, H. R., Karavanova, I. D., Botchkarev, V. A., Li, J., Danielian, P. S., McMahon, J. A., Lewis, P. M., Paus, R., & McMahon, A. P. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70443-9 · Cited by 764 · see citing works

p63 is the molecular switch for initiation of an epithelial stratification programPreprint

Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J., & Roop, D. R. (2004) · Genes & Development · doi:10.1101/gad.1165104 · Cited by 622 · see citing works

A common human skin tumour is caused by activating mutations in β-catenin

Chan, E., Gat, U., McNiff, J. M., & Fuchs, E. (1999) · Nature Genetics · doi:10.1038/7747 · Cited by 612 · see citing works

WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism

Sick, S., Reinker, S., Timmer, J., & Schlake, T. (2006) · Science · doi:10.1126/science.1130088 · Cited by 612 · see citing works

Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling

Malanchi, I., Peinado, H., Kassen, D., Hussenet, T., METZGER, D., Chambon, P., Huber, M., Hohl, D., Cano, A., Birchmeier, W., et al. (2008) · Nature · doi:10.1038/nature06835 · Cited by 597 · see citing works

Epithelial Stem Cells: Turning over New Leaves

Blanpain, C., Horsley, V., & Fuchs, E. V. (2007) · Cell · doi:10.1016/j.cell.2007.01.014 · Cited by 593 · see citing works

Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34

Morris, R. J., Bortner, C. D., Cotsarelis, G., Reece, J. M., Trempus, C. S., Faircloth, R. S., & Tennant, R. W. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12088.x · Cited by 567 · see citing works

Links between signal transduction, transcription and adhesion in epithelial bud development

Jamora, C., DasGupta, R., Kocieniewski, P., & Fuchs, E. V. (2003) · Nature · doi:10.1038/nature01458 · Cited by 567 · see citing works

Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skinPreprint

Merrill, B. J., Gat, U., DasGupta, R., & Fuchs, E. V. (2001) · Genes & Development · doi:10.1101/gad.891401 · Cited by 559 · see citing works

Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs

Yi, R., O'Carroll, D., Pasolli, H. A., Zhang, Z., Dietrich, F. S., Tarakhovsky, A., & Fuchs, E. (2006) · Nature Genetics · doi:10.1038/ng1744 · Cited by 555 · see citing works

Hair follicle stem cells are specified and function in early skin morphogenesis

Nowak, J. A., Polak, L., Pasolli, H. A., & Fuchs, E. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.05.009 · Cited by 554 · see citing works

Location of stem cells of human hair follicles by clonal analysis

Rochat, A., Kobayashi, K., & Barrandon, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90383-2 · Cited by 532 · see citing works

Mechanisms of asymmetric cell division: flies and worms pave the way

Gönczy, P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2388 · Cited by 487 · see citing works

p63 regulates proliferation and differentiation of developmentally mature keratinocytesPreprint

Truong, A. B., Kretz, M., Ridky, T. W., Kimmel, R. A., & Khavari, P. A. (2006) · Genes & Development · doi:10.1101/gad.1463206 · Cited by 480 · see citing works

Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

Rendl, M., Lewis, L. E., & Fuchs, E. V. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030331 · Cited by 476 · see citing works

Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.Preprint

Zhou, P., Byrne, C. R., Jacobs, J., & Fuchs, E. V. (1995) · Genes & Development · doi:10.1101/gad.9.6.700 · Cited by 474 · see citing works

Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype

Li, A. S., Simmons, P. J., & Kaur, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3902 · Cited by 472 · see citing works

Canonical notch signaling functions as a commitment switch in the epidermal lineagePreprint

Blanpain, C., Lowry, W. E., Pasolli, H. A., & Fuchs, E. V. (2006) · Genes & Development · doi:10.1101/gad.1477606 · Cited by 431 · see citing works

Sox9 Is Essential for Outer Root Sheath Differentiation and the Formation of the Hair Stem Cell Compartment

Vidal, V., Chaboissier, M., Lützkendorf, S., Cotsarelis, G., Mill, P., Hui, C., Ortonne, N., Ortonne, J. P., & Schedl, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.06.064 · Cited by 427 · see citing works

Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland

Horsley, V., O'Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., & Fuchs, E. (2006) · Cell · doi:10.1016/j.cell.2006.06.048 · Cited by 426 · see citing works

Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

Braun, K. M., Niemann, C., Jensen, U. B., Sundberg, J. P., Silva-Vargas, V., & Watt, F. M. (2003) · Development · doi:10.1242/dev.00703 · Cited by 425 · see citing works

NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells

Horsley, V., Aliprantis, A. O., Polak, L., Glimcher, L. H., & Fuchs, E. (2008) · Cell · doi:10.1016/j.cell.2007.11.047 · Cited by 424 · see citing works

BMP signaling in dermal papilla cells is required for their hair follicle-inductive propertiesPreprint

Rendl, M., Polak, L., & Fuchs, E. V. (2008) · Genes & Development · doi:10.1101/gad.1614408 · Cited by 423 · see citing works

Distinct Stem Cell Populations Regenerate the Follicle and Interfollicular Epidermis

Levy, V., Lindon, C., Harfe, B. D., & Morgan, B. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.11.003 · Cited by 419 · see citing works

Noggin is a mesenchymally derived stimulator of hair-follicle induction

Botchkarev, V. A., Botchkareva, N. V., Roth, W., Nakamura, M., Chen, L.-H., Herzog, W., Lindner, G., McMahon, J. A., Peters, C., Lauster, R., et al. (1999) · Nature Cell Biology · doi:10.1038/11078 · Cited by 414 · see citing works

Defining the impact of β-catenin/Tcf transactivation on epithelial stem cellsPreprint

Lowry, W. E., Blanpain, C., Nowak, J. A., Guasch, G., Lewis, L. E., & Fuchs, E. V. (2005) · Genes & Development · doi:10.1101/gad.1324905 · Cited by 392 · see citing works

miR-203 represses ‘stemness’ by repressing ΔNp63

Lena, A. M., Shalom-Feuerstein, R., di Val Cervo, P. R., Aberdam, D., Knight, R. A., Melino, G., & Candi, E. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.69 · Cited by 389 · see citing works

Epidermal stem cells arise from the hair follicle after wounding

Levy, V., Lindon, C., Zheng, Y., Harfe, B. D., & Morgan, B. A. (2007) · The FASEB Journal · doi:10.1096/fj.06-6926com · Cited by 386 · see citing works

EpithelialBmpr1aregulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development

Andl, T., Ahn, K. J., Kairo, A., Chu, E. Y., Lee, L. W., Reddy, S. T., Croft, N. J., Cebra‐Thomas, J. A., METZGER, D., Chambon, P., et al. (2004) · Development · doi:10.1242/dev.01125 · Cited by 380 · see citing works

Cell size as a determinant of the clone-forming ability of human keratinocytes.

Barrandon, Y., & Green, H. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.16.5390 · Cited by 363 · see citing works

The miRNA-Processing Enzyme Dicer Is Essential for the Morphogenesis and Maintenance of Hair Follicles

Andl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., Andl, C. D., Seykora, J. T., Hannon, G. J., & Millar, S. E. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.005 · Cited by 359 · see citing works

Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin

Ghazizadeh, S., & Taichman, L. B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1215 · Cited by 347 · see citing works

Lhx2 Maintains Stem Cell Character in Hair Follicles

Rhee, H. H., Polak, L., & Fuchs, E. V. (2006) · Science · doi:10.1126/science.1128004 · Cited by 345 · see citing works

GATA-3: an unexpected regulator of cell lineage determination in skinPreprint

Kaufman, C. K., Zhou, P., Pasolli, H. A., Rendl, M., Bolotin, D., Lim, K.-C., Dai, X., Alegre, M., & Fuchs, E. V. (2003) · Genes & Development · doi:10.1101/gad.1115203 · Cited by 345 · see citing works

c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

Arnold, I., & Watt, F. M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00154-3 · Cited by 341 · see citing works

Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours

Celso, C. L., Prowse, D. M., & Watt, F. M. (2004) · Development · doi:10.1242/dev.01052 · Cited by 339 · see citing works

γ-Secretase Functions through Notch Signaling to Maintain Skin Appendages but Is Not Required for Their Patterning or Initial Morphogenesis

Pan, Y., Lin, M., Tian, X., Cheng, H., Gridley, T., Shen, J., & Kopan, R. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.014 · Cited by 326 · see citing works

Mechanisms Regulating Epithelial Stratification

Koster, M. I., & Roop, D. R. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123357 · Cited by 324 · see citing works

In search of the “hair cycle clock”: a guided tour

Paus, R., & Foitzik, K. (2004) · Differentiation · doi:10.1111/j.1432-0436.2004.07209004.x · Cited by 324 · see citing works

Deregulated expression of c-Myc depletes epidermal stem cells

Waikel, R. L., Kawachi, Y., Waikel, P. A., Wang, X.-J., & Roop, D. R. (2001) · Nature Genetics · doi:10.1038/88889 · Cited by 318 · see citing works

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling

Kobielak, K., Stokes, N., Cruz-Racelis, J. D., Polak, L., & Fuchs, E. V. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703004104 · Cited by 308 · see citing works

Long-term renewal of hair follicles from clonogenic multipotent stem cells

Claudinot, S., Nicolas, M., Oshima, H., Rochat, A., & Barrandon, Y. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507250102 · Cited by 308 · see citing works

Epidermal Notch signalling: differentiation, cancer and adhesion

Watt, F. M., Estrach, S., & Ambler, C. A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.010 · Cited by 294 · see citing works

Tcf3 Governs Stem Cell Features and Represses Cell Fate Determination in Skin

Nguyen, H., Rendl, M., & Fuchs, E. V. (2006) · Cell · doi:10.1016/j.cell.2006.07.036 · Cited by 287 · see citing works

Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3Preprint

Sen, G. L., Webster, D. E., Barragan, D. I., Chang, H. Y., & Khavari, P. A. (2008) · Genes & Development · doi:10.1101/gad.1673508 · Cited by 268 · see citing works

Transient activation of β-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice

Van Mater, D., Kolligs, F. T., Dlugosz, A. A., & Fearon, E. R. (2003) · Genes & Development · doi:10.1101/gad.1076103 · Cited by 263 · see citing works

Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA

Kobielak, K., Pasolli, H. A., Alonso, L. C., Polak, L., & Fuchs, E. V. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200309042 · Cited by 261 · see citing works

Noggin is required for induction of the hair follicle growth phase in postnatal skin

Botchkarev, V. A., Botchkareva, N. V., Nakamura, M., Huber, O., Funa, K., Lauster, R., Paus, R., & Gilchrest, B. A. (2001) · The FASEB Journal · doi:10.1096/fj.01-0207com · Cited by 251 · see citing works

The secret life of the hair follicle

Hardy, M. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90044-5 · Cited by 244 · see citing works

Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen

Ito, M., Cotsarelis, G., Kizawa, K., & Hamada, K. (2004) · Differentiation · doi:10.1111/j.1432-0436.2004.07209008.x · Cited by 242 · see citing works

β-Catenin and Hedgehog Signal Strength Can Specify Number and Location of Hair Follicles in Adult Epidermis without Recruitment of Bulge Stem Cells

Silva-Vargas, V., Celso, C. L., Giangreco, A., Ofstad, T. A., Prowse, D. M., Braun, K. M., & Watt, F. M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.013 · Cited by 237 · see citing works

Hair cycle regulation of Hedgehog signal reception

Oro, A. E., & Higgins, K. M. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00042-8 · Cited by 228 · see citing works

The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells

Nijhof, J. G. W., Braun, K. M., Giangreco, A., van Pelt, C., Kawamoto, H., Boyd, R. L., Willemze, R., Mullenders, L. H. F., Watt, F. M., de Gruijl, F. R., et al. (2006) · Development · doi:10.1242/dev.02443 · Cited by 211 · see citing works

Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa.

Kobayashi, K., Rochat, A., & Barrandon, Y. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7391 · Cited by 207 · see citing works

Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/β-catenin signaling

Yang, S. H., Andl, T., Grachtchouk, V., Wang, A., Liu, J., Syu, L.-J., Ferris, J., Wang, T. S., Glick, A. B., Millar, S. E., et al. (2008) · Nature Genetics · doi:10.1038/ng.192 · Cited by 195 · see citing works

Evidence for keratinocyte stem cells in vitro : Long term engraftment and persistence of transgene expression from retrovirus-transduced keratinocytes

Kolodka, T. M., Garlick, J. A., & Taichman, L. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4356 · Cited by 194 · see citing works

Activation of β-catenin signaling programs embryonic epidermis to hair follicle fate

Zhang, Y., Andl, T., Yang, S. H., Teta, M., Liu, F., Seykora, J. T., Tobias, J. W., Piccolo, S., Schmidt‐Ullrich, R., Nagy, A., et al. (2008) · Development · doi:10.1242/dev.017459 · Cited by 193 · see citing works

Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

Zhang, J., He, X., Tong, W., Johnson, T., Wiedemann, L. M., Mishina, Y. M., Feng, J. Q., & Li, L. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0544 · Cited by 174 · see citing works

A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus

Jensen, U. B., Yan, X., Triel, C., Woo, S., Christensen, R., & Owens, D. M. (2008) · Journal of Cell Science · doi:10.1242/jcs.025502 · Cited by 174 · see citing works

Hair follicle renewal: organization of stem cells in the matrix and the role of stereotyped lineages and behaviors

Legué, E., & Nicolas, J.-F. (2005) · Development · doi:10.1242/dev.01975 · Cited by 169 · see citing works

MYC in mammalian epidermis: how can an oncogene stimulate differentiation?

Watt, F. M., Frye, M., & Benitah, S. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2328 · Cited by 157 · see citing works

Multiple Roles of Notch Signaling in the Regulation of Epidermal Development

Moriyama, M., Durham, A., Moriyama, H., Hasegawa, K., Nishikawa, S., Radtke, F., & Osawa, M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.017 · Cited by 150 · see citing works

Retroviral Transduction of Murine Epidermal Stem Cells Demonstrates Clonal Units of Epidermal Structure

Mackenzie, I. C. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12336255 · Cited by 138 · see citing works

A Guided Tour

Broy, M., & Stølen, K. (2001) · Texts and monographs in computer science · doi:10.1007/978-1-4613-0091-5_2 · Cited by 136 · see citing works

Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles

Wilson, C. L., Cotsarelis, G., Wei, Z.-G., Fryer, E., Margolis-Fryer, J., Ostead, M., Tokarek, R., Sun, T., & Lavker, R. M. (1994) · Differentiation · doi:10.1046/j.1432-0436.1994.5520127.x · Cited by 134 · see citing works

Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells

Waghmare, S. K., Bansal, R., Lee, J., Zhang, Y. V., McDermitt, D. J., & Tumbar, T. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.72 · Cited by 130 · see citing works

VARIATION IN THE PLANE OF CELL CLEAVAGE DURING THE PROCESS OF STRATIFICATION IN THE MOUSE EPIDERMIS

Smart, I. H. M. (1970) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1970.tb12437.x · Cited by 117 · see citing works

Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation

Osorio, K. M., Lee, S. E., McDermitt, D. J., Waghmare, S. K., Zhang, Y. V., Woo, H. N., & Tumbar, T. (2008) · Development · doi:10.1242/dev.012799 · Cited by 112 · see citing works

Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation

Frye, M., Fisher, A. G., & Watt, F. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000763 · Cited by 100 · see citing works

E‐ and P‐cadherin expression during murine hair follicle morphogenesis and cycling

Müller‐Röver, S., Tokura, Y., Welker, P., Furukawa, F., Wakita, H., Takigawa, M., & Paus, R. (1999) · Experimental Dermatology · doi:10.1111/j.1600-0625.1999.tb00377.x · Cited by 86 · see citing works

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis

Wang, X., Pasolli, H. A., Williams, T., & Fuchs, E. V. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200804030 · Cited by 85 · see citing works

in vitroでのケラチノサイト幹細胞の証拠 レトロウイルス導入ケラチノサイトの長期移植とトランス遺伝子発現持続

Kolodka, T. M., Garlick, J. A., & Taichman, L. B. (1998) · Cited by 80 · see citing works

Hair cycle clock

Wei-xi, F. (2006) · Linchuang pifuke zazhi · Cited by 72 · see citing works

The Majority of Multipotent Epidermal Stem Cells Do Not Protect Their Genome by Asymmetrical Chromosome Segregation

Sotiropoulou, P. A., Candi, A., & Blanpain, C. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0634 · Cited by 67 · see citing works

A stop‐EGFP transgenic mouse to detect clonal cell lineages generated by mutation

Ro, S. W., & Rannala, B. H. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400218 · Cited by 44 · see citing works

Evidence from the stop‐EGFP mouse supports a niche‐sharing model of epidermal proliferative units

Ro, S. W., & Rannala, B. H. (2005) · Experimental Dermatology · doi:10.1111/j.1600-0625.2005.00366.x · Cited by 28 · see citing works

A Rare Bone Dysplasia and Chronic Lung Disease

Dawson, K., Al-Gazali, L. I., & Bakalinová, D. (1999) · Medical Principles and Practice · doi:10.1159/000026098 · Cited by 21 · see citing works

Wound repair and regeneration: Mechanisms, signaling, and translation

Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562 · see citing works

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti, C., & Vogelstein, B. (2015) · Science · doi:10.1126/science.1260825 · Cited by 1,927 · see citing works

Distinct stem cells contribute to mammary gland development and maintenance

Van Keymeulen, A., Rocha, A. S., Ousset, M., Beck, B., Bouvencourt, G., Rock, J., Sharma, N., Dekoninck, S., & Blanpain, C. (2011) · Nature · doi:10.1038/nature10573 · Cited by 854 · see citing works

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

Ali, N., Zirak, B., Rodriguez, R. S., Pauli, M. L., Truong, H.-A., Lai, K., Ahn, R., Corbin, K., Lowe, M. M., Scharschmidt, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.002 · Cited by 680 · see citing works

Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues

Simons, B. D., & Clevers, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.033 · Cited by 489 · see citing works

Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury

Dulauroy, S., Di Carlo, S. E., Langa, F., Eberl, G., & Peduto, L. (2012) · Nature Medicine · doi:10.1038/nm.2848 · Cited by 418 · see citing works

Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging

Panich, U., Sittithumcharee, G., Rathviboon, N., & Jirawatnotai, S. (2016) · Stem Cells International · doi:10.1155/2016/7370642 · Cited by 374 · see citing works

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging

Castilho, R. M., Squarize, C. H., Chodosh, L. A., Williams, B. O., & Gutkind, J. S. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.06.017 · Cited by 371 · see citing works

The tortoise and the hair: slow-cycling cells in the stem cell race

Fuchs, E. (2009) · Cell · doi:10.1016/j.cell.2009.05.002 · Cited by 371 · see citing works

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

Ezhkova, E., Lien, W.-H., Stokes, N., Pasolli, H. A., Silva, J. M., & Fuchs, E. (2011) · Genes & Development · doi:10.1101/gad.2019811 · Cited by 357 · see citing works

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2003638 · Cited by 315 · see citing works

Mitotic and mitogenic Wnt signalling

Niehrs, C., & Acebron, S. P. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.124 · Cited by 305 · see citing works

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis

Iglesias-Bartolome, R., Patel, V., Cotrim, A., Leelahavanichkul, K., Molinolo, A. A., Mitchell, J. B., & Gutkind, J. S. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.06.007 · Cited by 284 · see citing works

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

Victorelli, S., Lagnado, A., Halim, J., Moore, W., Talbot, D., Barrett, K., Chapman, J., Birch, J., Ogrodnik, M., Meves, A., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2019101982 · Cited by 258 · see citing works

Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

Lien, W.-H., Guo, X., Polak, L., Lawton, L. N., Young, R. A., Zheng, D., & Fuchs, E. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.07.015 · Cited by 199 · see citing works

From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?

vel Szic, K. S., Declerck, K., Vidaković, M., & Vanden Berghe, W. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0068-2 · Cited by 192 · see citing works

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

Franzke, C.-W., Cobzaru, C., Triantafyllopoulou, A., Löffek, S., Horiuchi, K., Threadgill, D. W., Kurz, T., van Rooijen, N., Bruckner-Tuderman, L., & Blobel, C. P. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112258 · Cited by 186 · see citing works

PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration

Chen, Y., Fan, Z., Wang, X., Mo, M., Zeng, S. B., Xu, R.-H., Wang, X., & Wu, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01650-6 · Cited by 130 · see citing works

Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures

Boonekamp, K. E., Kretzschmar, K., Wiener, D. J., Asra, P., Derakhshan, S., Puschhof, J., López-Iglesias, C., Peters, P. J., Basak, O., & Clevers, H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715272116 · Cited by 96 · see citing works

Concise Review: Kidney Stem/Progenitor Cells: Differentiate, Sort Out, or Reprogram?

Pleniceanu, O., Harari-Steinberg, O., & Dekel, B. (2010) · Stem Cells · doi:10.1002/stem.486 · Cited by 100 · see citing works

MIRA: joint regulatory modeling of multimodal expression and chromatin accessibility in single cells

Lynch, A. W., Theodoris, C. V., Long, H. W., Brown, M., Liu, X. S., & Meyer, C. A. (2022) · Nature Methods · doi:10.1038/s41592-022-01595-z · Cited by 80 · see citing works

Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis

Rübe, C. E., Bäumert, C., Schuler, N., Isermann, A., Schmal, Z., Glanemann, M., Mann, C., & Scherthan, H. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00060-z · Cited by 76 · see citing works

Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor network

Perdigoto, C. N., Bardot, E. S., Valdes, V. J., Santoriello, F. J., & Ezhkova, E. (2014) · Development · doi:10.1242/dev.112169 · Cited by 66 · see citing works

Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

Ben-Yehuda Greenwald, M., Ben-Sasson, S., Bianco-Peled, H., & Kohen, R. (2016) · Cosmetics · doi:10.3390/cosmetics3010001 · Cited by 49 · see citing works

Ras signaling is essential for skin development

Drosten, M., Lechuga, C. G., & Barbacid, M. (2014) · Oncogene · doi:10.1038/onc.2013.254 · Cited by 46 · see citing works

BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny

Sotiropoulou, P. A., Karambelas, A. E., Debaugnies, M., Candi, A., Bouwman, P., Moers, V., Revenco, T., Rocha, A. S., Sekiguchi, K., Jonkers, J., et al. (2013) · Genes & Development · doi:10.1101/gad.206573.112 · Cited by 42 · see citing works

Removing all obstacles: A critical role for p53 in promoting tissue renewal

Schoppy, D. W., Ruzankina, Y., & Brown, E. J. (2010) · Cell Cycle · doi:10.4161/cc.9.7.11194 · Cited by 32 · see citing works

State-dependent signaling by Ca_v1.2 regulates hair follicle stem cell function

Yucel, G., Altindag, B., Gomez-Ospina, N., Rana, A., Panagiotakos, G., Lara, M. F., Dolmetsch, R., & Oro, A. E. (2013) · Genes & Development · doi:10.1101/gad.216556.113 · Cited by 31 · see citing works

Epidermal Stem Cells and Their Epigenetic Regulation

Shen, Q., Jin, H., & Wang, X. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917861 · Cited by 21 · see citing works

Damage at the root of cell renewal—UV sensitivity of human epidermal stem cells

Ruetze, M., Dunckelmann, K., Schade, A., Reuschlein, K., Mielke, H., Weise, J. M., Gallinat, S., Wenck, H., & Knott, A. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2011.06.010 · Cited by 14 · see citing works

Early Stages ofwe/we wal/walMouse Hair Morphogenesis: Light and Fluorescent Microscopy of the Whole-Mount Epidermis

Rippa, A., Leonova, O. G., Попенко, В. И., Vasiliev, A. V., Terskikh, V. V., & Vorotelyak, E. A. (2014) · BioMed Research International · doi:10.1155/2014/856978 · Cited by 2 · see citing works

Research Progress on Signal Factors Correlate to Hair Follicle Morphogenesis and Cyclical Variation in Cashmere Goat

Li, W. (2013) · China Animal Husbandry & Veterinary Medicine

The TGF-β2 Isoform Is Both a Required and Sufficient Inducer of Murine Hair Follicle Morphogenesis

Foitzik, K., Paus, R., Doetschman, T. C., & Dotto, G. P. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9325 · Cited by 170 · see citing works

The effect of flavonoids on regenerated hair follicles with pigmentation

Taguchi, N., Yuriguchi, M., Honma, T., et al. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.02.184

Promoting effect of hair follicle stem cells in the wound healing of skin

Pei, Z., Zhou, C., Zhang, Y., & Li, Y. (2017) · Chin J Cell Stem Cell (Electronic Edition) · doi:10.3877/cma.j.issn.2095-1221.2017.06.010