The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes
Open accessAbstract
Recurrent chromosomal translocations underlie both haematopoietic and solid tumours. Their origin has been ascribed to selection of random rearrangements, targeted DNA damage, or frequent nuclear interactions between translocation partners; however, the relative contribution of each of these elements has not been measured directly or on a large scale. Here we examine the role of nuclear architecture and frequency of DNA damage in the genesis of chromosomal translocations by measuring these parameters simultaneously in cultured mouse B lymphocytes. In the absence of recurrent DNA damage, translocations between Igh or Myc and all other genes are directly related to their contact frequency. Conversely, translocations associated with recurrent site-directed DNA damage are proportional to the rate of DNA break formation, as measured by replication protein A accumulation at the site of damage. Thus, non-targeted rearrangements reflect nuclear organization whereas DNA break formation governs the location and frequency of recurrent translocations, including those driving B-cell malignancies.
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Cites
The impact of translocations and gene fusions on cancer causation
Mitelman, F., Johansson, B., & Mertens, F. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2091 · Cited by 1,400
Simonis, M., Klous, P., Splinter, E., Moshkin, Y., Willemsen, R., de Wit, E., van Steensel, B., & de Laat, W. (2006) · Nature Genetics · doi:10.1038/ng1896 · Cited by 1,386
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Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.029 · Cited by 1,625
The genetic architecture of multiple myeloma
Morgan, G. J., Walker, B. A., & Davies, F. E. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3257 · Cited by 913
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
Frock, R. L., Hu, J., Meyers, R. M., Ho, Y.-J., Kii, E., & Alt, F. W. (2015) · Nature Biotechnology · doi:10.1038/nbt.3101 · Cited by 673
Chapman, J. R., Barral, P., Vannier, J.-B., Borel, V., Steger, M., Tomas-Loba, A., Sartori, A. A., Adams, I. R., Batista, F. D., & Boulton, S. J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.002 · Cited by 606
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
Crosetto, N., Mitra, A., Silva, M. J., Bienko, M., Dojer, N., Wang, Q., Karaca, E., Chiarle, R., Skrzypczak, M., Ginalski, K., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2408 · Cited by 465
Metadata
- Authors
- Hakim, O., Resch, W., Yamane, A., Klein, I., Kieffer-Kwon, K.-R., Jankovic, M., Oliveira, T., Bothmer, A., Voss, T. C., Ansarah-Sobrinho, C., Mathe, E., Liang, G., Cobell, J., Nakahashi, H., Robbiani, D. F., Nussenzweig, A., Hager, G. L., Nussenzweig, M. C., & Casellas, R.
- Venue
- Nature
- Published
- 2012-02-07
- Volume
- 484
- Issue
- 7392
- Pages
- 69-74
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2164278804
- Cited by
- 195
- References
- 2
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Hakim, O., Resch, W., Yamane, A., Klein, I., Kieffer-Kwon, K.-R., Jankovic, M., Oliveira, T., Bothmer, A., Voss, T. C., Ansarah-Sobrinho, C., Mathe, E., Liang, G., Cobell, J., Nakahashi, H., Robbiani, D. F., Nussenzweig, A., Hager, G. L., Nussenzweig, M. C., & Casellas, R. (2012). DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature. https://doi.org/10.1038/nature10909
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