The impact of translocations and gene fusions on cancer causation
Abstract
Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions involving 337 different genes have been identified. An increasing number of gene fusions are being recognized as important diagnostic and prognostic parameters in malignant haematological disorders and childhood sarcomas. The biological and clinical impact of gene fusions in the more common solid tumour types has been less appreciated. However, an analysis of available data shows that gene fusions occur in all malignancies, and that they account for 20% of human cancer morbidity. With the advent of new and powerful investigative tools that enable the detection of cytogenetically cryptic rearrangements, this proportion is likely to increase substantially.
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Chromosomal translocations are very common in hematologic malignancies.
“Chromosomal translocations are very common in hematologic malignancies [200, 201].”
From Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies (2020) · cites this paper as [200]
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“Gene fusion detection RNA-seq combined with computational analyses analogous to the ones described above for splice-site detection can also be used to identify gene fusion events in disease tissues, which has particular importance for cancer researc”
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- Authors
- Mitelman, F., Johansson, B., & Mertens, F.
- Affiliations
- Lund University (SE)
- Corresponding author
- Mitelman, Felix
- Venue
- Nature Reviews Cancer
- Published
- 2007-03-15
- Volume
- 7
- Issue
- 4
- Pages
- 233-245
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2082534286
- Cited by
- 1,400
- References
- 144
- Citations by year
- 2026: 37 · 2025: 51 · 2024: 61 · 2023: 67 · 2022: 81 · 2021: 77 · 2020: 88 · 2019: 70 · 2018: 66 · 2017: 73 · 2016: 96 · 2015: 82 · 2014: 80 · 2013: 84 · 2012: 97
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Swedish Cancer Foundation
- Cancerfonden
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- gene fusion, chromosomal translocation, cancer etiology, carcinogenesis, chromosomal abnormalities, solid tumors, pediatric sarcoma, diagnostic biomarkers, prognostic factors, cancer morbidity
- MeSH terms
- Chromosome Aberrations, Humans, Models, Genetic, Neoplasms, Terminology as Topic, Translocation, Genetic, Gene Fusion
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