Cited by 1,400Genomic variations and chromosomal abnormalitiesCancer Genomics and DiagnosticsChromatin Remodeling and Cancer

The impact of translocations and gene fusions on cancer causation

Mitelman, Felix, Johansson, Bertil, Mertens, Fredrik·2007·Nature Reviews Cancer

Abstract

Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions involving 337 different genes have been identified. An increasing number of gene fusions are being recognized as important diagnostic and prognostic parameters in malignant haematological disorders and childhood sarcomas. The biological and clinical impact of gene fusions in the more common solid tumour types has been less appreciated. However, an analysis of available data shows that gene fusions occur in all malignancies, and that they account for 20% of human cancer morbidity. With the advent of new and powerful investigative tools that enable the detection of cytogenetically cryptic rearrangements, this proportion is likely to increase substantially.

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Crossref · 10.1038/nrc2091

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Authors
Mitelman, F., Johansson, B., & Mertens, F.
Affiliations
Lund University (SE)
Corresponding author
Mitelman, Felix
Venue
Nature Reviews Cancer
Published
2007-03-15
Volume
7
Issue
4
Pages
233-245
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2082534286
Cited by
1,400
References
144
Citations by year
2026: 37 · 2025: 51 · 2024: 61 · 2023: 67 · 2022: 81 · 2021: 77 · 2020: 88 · 2019: 70 · 2018: 66 · 2017: 73 · 2016: 96 · 2015: 82 · 2014: 80 · 2013: 84 · 2012: 97
FWCI
7.34
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
  • Swedish Cancer Foundation
  • Cancerfonden
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
gene fusion, chromosomal translocation, cancer etiology, carcinogenesis, chromosomal abnormalities, solid tumors, pediatric sarcoma, diagnostic biomarkers, prognostic factors, cancer morbidity
MeSH terms
Chromosome Aberrations, Humans, Models, Genetic, Neoplasms, Terminology as Topic, Translocation, Genetic, Gene Fusion

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