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Cited by 466

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

Open access
Zhang, Xu, Ren, Wenlin, DeCaen, Paul, Yan, Chuangye, Tao, Xiao, Tang, Lin, Wang, Jingjing, Hasegawa, Kazuya, Kumasaka, Takashi, He, Jianhua, Wang, Jiawei, Clapham, David E., Yan, Nieng·2012·Nature
DOI 10.1038/nature11054
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Abstract

Voltage-gated sodium (Nav) channels are essential for the rapid depolarization of nerve and muscle, and are important drug targets. Determination of the structures of Nav channels will shed light on ion channel mechanisms and facilitate potential clinical applications. A family of bacterial Nav channels, exemplified by the Na+-selective channel of bacteria (NaChBac), provides a useful model system for structure–function analysis. Here we report the crystal structure of NavRh, a NaChBac orthologue from the marine alphaproteobacterium HIMB114 (Rickettsiales sp. HIMB114; denoted Rh), at 3.05 Å resolution. The channel comprises an asymmetric tetramer. The carbonyl oxygen atoms of Thr 178 and Leu 179 constitute an inner site within the selectivity filter where a hydrated Ca2+ resides in the crystal structure. The outer mouth of the Na+ selectivity filter, defined by Ser 181 and Glu 183, is closed, as is the activation gate at the intracellular side of the pore. The voltage sensors adopt a depolarized conformation in which all the gating charges are exposed to the extracellular environment. We propose that NavRh is in an ‘inactivated’ conformation. Comparison of NavRh with NavAb reveals considerable conformational rearrangements that may underlie the electromechanical coupling mechanism of voltage-gated channels.

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Metadata

Authors
Zhang, X., Ren, W., DeCaen, P., Yan, C., Tao, X., Tang, L., Wang, J., Hasegawa, K., Kumasaka, T., He, J., Wang, J., Clapham, D. E., & Yan, N.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2012-05-20
Volume
486
Issue
7401
Pages
130-134
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature11054
OpenAlex
W2054058473
Cited by
466
References
44
FWCI
20.45
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. https://app.cochat.ai/papers/10.1038/nature11054
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Zhang, X., Ren, W., DeCaen, P., Yan, C., Tao, X., Tang, L., Wang, J., Hasegawa, K., Kumasaka, T., He, J., Wang, J., Clapham, D. E., & Yan, N. (2012). Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature. https://doi.org/10.1038/nature11054

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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