The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
Open accessAbstract
Genotypic differences greatly influence susceptibility and resistance to disease. Understanding genotype-phenotype relationships requires that phenotypes be viewed as manifestations of network properties, rather than simply as the result of individual genomic variations. Genome sequencing efforts have identified numerous germline mutations, and large numbers of somatic genomic alterations, associated with a predisposition to cancer. However, it remains difficult to distinguish background, or 'passenger', cancer mutations from causal, or 'driver', mutations in these data sets. Human viruses intrinsically depend on their host cell during the course of infection and can elicit pathological phenotypes similar to those arising from mutations. Here we test the hypothesis that genomic variations and tumour viruses may cause cancer through related mechanisms, by systematically examining host interactome and transcriptome network perturbations caused by DNA tumour virus proteins. The resulting integrated viral perturbation data reflects rewiring of the host cell networks, and highlights pathways, such as Notch signalling and apoptosis, that go awry in cancer. We show that systematic analyses of host targets of viral proteins can identify cancer genes with a success rate on a par with their identification through functional genomics and large-scale cataloguing of tumour mutations. Together, these complementary approaches increase the specificity of cancer gene identification. Combining systems-level studies of pathogen-encoded gene products with genomic approaches will facilitate the prioritization of cancer-causing driver genes to advance the understanding of the genetic basis of human cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Nearly 3800 virus–host protein interactions were identified by Rozenblatt-Rosen et al. in a single study of DNA tumor virus proteins from four viruses, HPV, EBV, adenovirus Ad5, and human polyomavirus [91].”
From Proteomic approaches to uncovering virus–host protein interactions during the progression of viral infection (2016) · cites this paper as [91]
In the citing paper
“the cellular transcriptional regulators cAMP-response element binding protein and EP300 were only found to associate with the E6 oncoprotein of HPV from cutaneous subtypes and not mucosal subtypes.”
From Proteomic approaches to uncovering virus–host protein interactions during the progression of viral infection (2016) · cites this paper as [91]
In the citing paper
“The identified associations stemmed from 54 viral and 1079 host proteins that pointed to viral subtype-specificity in interactions.”
From Proteomic approaches to uncovering virus–host protein interactions during the progression of viral infection (2016) · cites this paper as [91]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
A method and server for predicting damaging missense mutations.
Adzhubei, I. A., Schmidt, S., Peshkin, L., Ramensky, V. E., Gerasimova, A., Bork, P., Kondrashov, A. S., & Sunyaev, S. R. (2010) · Nature Methods · doi:10.1038/nmeth0410-248 · Cited by 13,194
The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017
Self-citationCOSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
Forbes, S. A., Bindal, N., Bamford, S., Cole, C., Kok, C. Y., Beare, D., Jia, M., Shepherd, R., Leung, K., Menzies, A., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq929 · Cited by 2,278
Interactome Networks and Human Disease
Vidal, M., Cusick, M. E., & Barabási, A.-L. (2011) · Cell · doi:10.1016/j.cell.2011.02.016 · Cited by 1,771
Self-citationGenomewide Association Studies and Assessment of the Risk of Disease
Manolio, T. A. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0905980 · Cited by 1,512
Notch signalling in solid tumours: a little bit of everything but not all the time
Ranganathan, P., Weaver, K. L., & Capobianco, A. J. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3035 · Cited by 841
Exploring the Genomes of Cancer Cells: Progress and Promise
Stratton, M. R. (2011) · Science · doi:10.1126/science.1204040 · Cited by 711
A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection
Shapira, S. D., Gat‐Viks, I., Shum, B. O. V., Dricot, A., DeGrace, M. M., Wu, L., Gupta, P. B., Hao, T., Silver, S. J., Root, D. E., et al. (2009) · Cell · doi:10.1016/j.cell.2009.12.018 · Cited by 630
Self-citationMolecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli
Wu, Z., Shi, Y., Tibbetts, R. S., & Miyamoto, S. (2006) · Science · doi:10.1126/science.1121513 · Cited by 515
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–375 of 375
Tumors of the Avian Immune System
Nair, V. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-396965-1.00019-4 · Cited by 4
Pang, C. N. I., Goel, A., & Wilkins, M. R. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00649 · Cited by 4
Sarwar, Z., Nabi, N., Bhat, S. A., Gillani, S. Q., Reshi, I., Nisa, M. U., Adelmant, G., Marto, J. A., & Andrabi, S. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101496 · Cited by 4
Self-citationRaffa, S., Mancini, V., French, D., Rollo, F., Benevolo, M., Giuliani, E., Donà, M. G., Ranieri, D., & Belleudi, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212085 · Cited by 4
Morais, F. S. (2014) · Cancer Research Journal · doi:10.11648/j.crj.s.2014020601.11 · Cited by 4
Interactomes – Scaffolds of Cellular Systems
Luck, K., Jailkhani, N., Cusick, M. E., Rolland, T., Calderwood, M. A., Charloteaux, B., & Vidal, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.40037-4 · Cited by 4
Self-citationMetabolic Modeling Elucidates Phenformin and Atpenin A5 as Broad-Spectrum Antiviral DrugsPreprint
Renz, A., Hohner, M., Breitenbach, M., Josephs‐Spaulding, J., Dürrwald, J., Best, L., Jami, R., Μαρίνος, Γ., Cabreiro, F., Dräger, A., et al. (2022) · Preprints.org · doi:10.20944/preprints202210.0223.v1 · Cited by 4
Broniarczyk, J. K., Massimi, P., Trejo-Cerro, Ó., Myers, M. P., & Banks, L. (2022) · Journal of Virology · doi:10.1128/jvi.01365-22 · Cited by 3
Kirschberg, M., Syed, A. S., Dönmez, H. G., Heuser, S., Wilbrand‐Hennes, A., Alonso, Á., Hufbauer, M., & Akgũl, B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.672201 · Cited by 3
Network-Based Analysis for Uncovering Mechanisms Underlying Alzheimer’s Disease
Kikuchi, M., Ogishima, S., Mizuno, S., Miyashita, A., Kuwano, R., Nakaya, J., & Tanaka, H. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2627-5_29 · Cited by 3
Analysis of Codon Usage Patterns in the Human Papillomavirus Oncogenes
Cho, M., Kim, H., Je, M., & Son, H. S. (2020) · Current Bioinformatics · doi:10.2174/1574893615999200614173136 · Cited by 3
Methods of Computational Interactomics for Investigating Interactions of Human Proteoforms
Poverennaya, E. V., Kiseleva, O. I., Ivanov, A. S., & Ponomarenko, E. A. (2020) · Biochemistry (Moscow) · doi:10.1134/s000629792001006x · Cited by 3
Hinchcliff, M., Frech, T., Wood, T. A., Huang, C., Lee, J. J., Aren, K., Ryan, J. J., Wilson, B. D., Beussink‐Nelson, L., Whitfield, M. L., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/213678 · Cited by 3
Self-citationSome characterizations for the wrapped butterfly
Wu, Y., & Li, Q. (2002) · Cited by 3
NeuroViOme: a viral orfeome collection for studies of neurodegenerative disease
Weller, B., Lin, C., Rothballer, S. T., Calderwood, M. A., Falter‐Braun, P., & Falter, C. (2026) · Journal of NeuroVirology · doi:10.1007/s13365-025-01303-5 · Cited by 2
Self-citationStructural Hole Spanner in HumanNet Identifies Disease Gene and Drug targets
Zeng, X., Lin, J., Lin, C., Liu, X., & Rodríguez‐Patón, A. (2018) · IEEE Access · doi:10.1109/access.2018.2849216 · Cited by 2
Manipulation of the Host Immune Response by Small DNA Tumor Viruses
White, E. A., Shanmugasundaram, S., & You, J. (2019) · Current cancer research · doi:10.1007/978-3-030-04155-7_13 · Cited by 2
HPV16 E7 modulates the cell surface expression of MET and CD109 via the AP2 complex
Trejo-Cerro, Ó., Basukala, O., Myers, M. P., & Banks, L. (2024) · Tumour Virus Research · doi:10.1016/j.tvr.2024.200279 · Cited by 2
The HPV101 E7 protein shares host cellular targets and biological activities with high-risk HPV16 E7
Gelbard, M. K., Grace, M. R., von Schoeler-Ames, A., Gnanou, I., & Münger, K. (2024) · Tumour Virus Research · doi:10.1016/j.tvr.2024.200300 · Cited by 2
Self-citationManzo-Merino, J., Massimi, P., Banks, L., & Lizano, M. (2014) · Virology · doi:10.1016/j.virol.2014.11.025 · Cited by 2
Cancer gene discovery goes viral
Nawy, T. (2012) · Nature Methods · doi:10.1038/nmeth.2155 · Cited by 2
Roles of dysregulated Notch pathway and small DNA tumor viruses in cancer initiation and progression
Tognon, M. G., Clementz, A. G., Rizzo, P., & Martini, F. (2015) · Journal of Cancer Metastasis and Treatment · doi:10.4103/2394-4722.171982 · Cited by 2
Liang, K. (2013) · Elsevier eBooks · doi:10.1533/9781908818232.83 · Cited by 2
Commentary: Induction of Dormancy in Hypoxic Human Papillomavirus-Positive Cancer Cells
Szalmás, A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00077 · Cited by 2
Kenaston, M. W., Cherkashchenko, L., Skawinski, C. L. S., Fishburn, A. T., Peddamallu, V., Florio, C. J., Robertson, A. E., Bhattacharya, T., Young, J. M., Malik, H. S., et al. (2025) · SSRN Electronic Journal · doi:10.1101/2025.06.14.659623 · Cited by 3
The mitochondrial carrier homolog 2 is involved in down-regulation of influenza A virus replication
Ulupınar, P., Çağlayan, E., Rayaman, E., Nagata, K., & Turan, K. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09584-5 · Cited by 1
Kumar, N., & Mukhtar, M. S. (2024) · Data · doi:10.3390/data9080101 · Cited by 1
Systems of implications obtained using the Carve decomposition of a formal context
López-Rodríguez, D., Ojeda-Hernández, M., & Pattison, T. R. (2025) · Knowledge-Based Systems · doi:10.1016/j.knosys.2025.113475 · Cited by 1
Moore, M., Kong, J., Akmel, A., & Thomas, M. A. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013202 · Cited by 1
Pharmacologic reversion of Merkel cell carcinoma via CBP/p300 inhibition
Collura, J. L., Lei, K. C., Chandra, M., Kervarrec, T., Park, H. Y., Dalkoohi, M., Becker, J. C., Chang, Y., Moore, P. S., & Shuda, M. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2516667122 · Cited by 1
The Landscape of DNA Virus Associations Across Human Cancers
Chen, J., Mishra, L., & Su, X. (2015) · Springer eBooks · doi:10.1007/978-3-319-15811-2_18 · Cited by 1
Transfer Learning for Gene Prioritization
Xia, Z., & Ma, X. (2019) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm47256.2019.8983154 · Cited by 1
Yeast proteins do not practice social distancing as species hybridize
Berger, C., & Landry, C. R. (2021) · Current Genetics · doi:10.1007/s00294-021-01188-x · Cited by 1
Virus‐Induced Human Oncogenesis
Bedi, M.-S., & Ploubidou, A. (2015) · Wiley eBooks · doi:10.1002/9780470015902.a0021851.pub2 · Cited by 1
Role of cellular ion channels in the BK polyomavirus life cycle
Panou, M.-M. (2018) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York) · Cited by 1
Interactomes-Scaffolds of Cellular Systems
Luck, K., Jailkhani, N., Cusick, M. E., Rolland, T., Calderwood, M. A., Charloteaux, B., & Vidal, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.40037-4 · Cited by 1
Self-citationMetabolic Modeling Elucidates Phenformin and Atpenin A5 as Broad-Spectrum Antiviral DrugsPreprint
Renz, A., Hohner, M., Breitenbach, M., Josephs‐Spaulding, J., Dürrwald, J., Best, L., Jami, R., Μαρίνος, Γ., Cabreiro, F., Dräger, A., et al. (2023) · Preprints.org · doi:10.20944/preprints202210.0223.v2 · Cited by 1
The diverse functions of viral microproteinsPreprint
Chen, Y. H., Grauvogel, L., Zhang, A. S., Michaelis, A. C., Heymann, T., Zollbrecht, E., Engel, P., Pensl, C., Yost, K. E., Suen, W., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.23.746553 · Cited by 1
Fonseca, G. J. (2013) · Scholarship@Western (Western University)
Genomic Approaches to Dissect Innate Immune Pathways
Lee, M. N. (2013) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Identifying driver mutations with the help of viruses
Razzak, M. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.144
McCarthy, N. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3346
Exploration of Panviral Proteome: High-Throughput Cloning and Functional Implications in Virus-host
Bian, X., Throop, A. L., Song, L., Moral, L. D., Park, J., Fiacco, M., Steel, J. C., Hunter, P. D., Saul, J. M., Wang, J., et al. (2014)
Comparative Oncogenomics for Peripheral Nerve Sheath Cancer Gene Discovery
Carroll, S. L. (2015) · Defense Technical Information Center (DTIC) · doi:10.21236/ada624248
Human Papillomavirus Infection and Human Cancer
Rubinstein, E., & Järveläinen, M. (2012) · Journal of Virology and Microbiology · doi:10.5171/2012.298411
Systems Medicine of Autoimmune Diseases
Fernández, J. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803302-9.00009-9
Signaling network analysis of genomic alterations predicts breast cancer drug targets
Zaman, N., & Wang, E. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781107337459.020
Nunes, E. M. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2016.tde-09082016-145147
Ivan, F. X., Kwoh, C.-K., Chow, V. T. K., & Zheng, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.20124-6
LKB1 negatively regulates AKT1 signaling via DBC1 and TRB3Preprint
Sarwar, Z., Bhat, S. A., Gillani, S. Q., Reshi, I., Nisa, M. U., Adelmant, G., Marto, J. A., & Andrabi, S. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/691402
Self-citationSoriano, A. M. (2018) · Mspace (University of Manitoba)
Propriedades biológicas e bioquímicas de variantes naturais de HPV-18
Nunes, E. M. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2020.tde-28102020-163337
BIOCHEMICAL PROFILE-BASED COMPUTATIONAL INFERENCE OF PROTEIN COMPLEXES
Zhong-ming, H. (2020) · TSpace (University of Toronto)
Maseko, S. B., Molle, I. V., Blibek, K., Gorgulla, C., Olivet, J., Blavier, J., Vandermeulen, C., Skupiewski, S., Saha, D., Ntombela, T., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.25.457680
Role of RRV ORF52 in Virion Maturation
Anderson, M. (2014) · doi:10.18130/v30f96
Updating the classification of cutaneous squamous cell carcinoma
Vasilev, P. (2023) · Varna Medical Forum · doi:10.14748/vmf.v12i2.9133
The Genomics Evolutionary of Cancer-Associated Pathogens
Velazquéz‐Marquez, S., & Núñez‐Farfán, J. (2024) · Springer eBooks · doi:10.1007/978-3-031-62558-9_23
Rosas-Murrieta, N. H., Camacho, I. H., Millán-Pérez-Peña, L., & Benítez, J. F. R. (2024) · Springer eBooks · doi:10.1007/978-3-031-62558-9_5
Identification of new host factors supporting the human papillomavirus life cycle
Ishii, Y., Mori, S., & Kukimoto, I. (2023) · Uirusu · doi:10.2222/jsv.73.189
Identification of Genes Involved in Host-Pathogen Protein-Protein Interaction Networks
Ivan, F. X., Kwoh, C.-K., Chow, V. T. K., & Zheng, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-95502-7.00300-6
Ramesh, P. S., Nicolaci, A. A., Graham, L. E., Nouel, J., Xu, K., Binning, J. M., Münger, K., & White, E. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.16.712171
Self-citationDécouverte de biomarqueurs prédictifs en cancer du sein par intégration transcriptome-interactome
Garcia, M. (2013) · theses.fr (ABES) · doi:10.70675/118a1aa0zabe2z417dz866fz3c56693a7dc3
Interplay between influenza viruses and the cellular splicing machinery
Ashraf, U. (2019) · theses.fr (ABES) · doi:10.70675/7bebe296zefe3z4022z8223z494e2e90e576
La différenciation érythrocytaire : caractérisation moléculaire de l'engagement cellulaire
Zreika, S. (2021) · theses.fr (ABES) · doi:10.70675/7799c3d9zd903z4452z86a9zf360a695053d
Modeling Chronic Myelomonocytic Leukemia with the Aim of Identifying Novel Therapeutic Targets
Alawieh, D. (2025) · theses.fr (ABES) · doi:10.70675/c7daf13fz397fz4894zbafezd95092b27414
Éles, Z. B., Rahmani, L., Gyöngyösi, E., Szarka, K., Rebenku, I., Veress, G., Major, T., Kónya, J., & Szalmás, A. (2026) · Journal of Medical Virology · doi:10.1002/jmv.70997
Li, B., Liu, J., Tian, S., Zhu, L. L., Duan, D. D., & Wang, Z. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00517-1
Luo, C., Xia, N., Hui, S. Y., Wong, U. S., Tsang, J. Y., Hu, H., Tsang, C. M., Lo, K. W., Sun, P., Shao, M., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02763-x
Metadata
- Authors
- Rozenblatt-Rosen, O., Deo, R. C., Padi, M., Adelmant, G., Calderwood, M. A., Rolland, T., Grace, M., Dricot, A., Askenazi, M., Tavares, M., Pevzner, S. J., Abderazzaq, F., Byrdsong, D., Carvunis, A.-R., Chen, A. A., Cheng, J., Correll, M., Duarte, M., Fan, C., Feltkamp, M. C., Ficarro, S. B., Franchi, R., Garg, B. K., Gulbahce, N., Hao, T., Holthaus, A. M., James, R., Korkhin, A., Litovchick, L., Mar, J. C., Pak, T. R., Rabello, S., Rubio, R., Shen, Y., Singh, S., Spangle, J. M., Tasan, M., Wanamaker, S., Webber, J. T., Roecklein-Canfield, J., Johannsen, E., Barabási, A.-L., Beroukhim, R., Kieff, E., Cusick, M. E., Hill, D. E., Münger, K., Marto, J. A., Quackenbush, J., Roth, F. P., DeCaprio, J. A., & Vidal, M.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Boston University (US)
- Dana-Farber Cancer Institute (US)
- Leiden University Medical Center (NL)
- Simmons University (US)
- Northeastern University (US)
- Mount Sinai Hospital (CA)
- Broad Institute (US)
- Corresponding author
- Marto, Jarrod A.
- Quackenbush, John
- Roth, Frederick P.
- DeCaprio, James A.
- Vidal, Marc
- ORCID
- Deo, Rahul C.
- Padi, Megha
- Adelmant, Guillaume
- Calderwood, Michael A.
- Rolland, Thomas
- Askenazi, Manor
- Carvunis, Anne-Ruxandra
- Chen, Alyce A.
- Cheng, Jingwei
- Feltkamp, Mariet C.
- Ficarro, Scott B.
- Gulbahce, Natali
- Hao, Tong
- Litovchick, Larisa
- Mar, Jessica C.
- Pak, Theodore R.
- Spangle, Jennifer M.
- Wanamaker, Shelly
- Webber, James T.
- Johannsen, Eric
- Beroukhim, Rameen
- Hill, David E.
- Münger, Karl
- Marto, Jarrod A.
- Quackenbush, John
- Roth, Frederick P.
- DeCaprio, James A.
- Vidal, Marc
- Venue
- Nature
- Published
- 2012-07
- Volume
- 487
- Issue
- 7408
- Pages
- 491-495
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3408847
- OpenAlex
- W2085540051
- Cited by
- 378
- References
- 32
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 18 · 2023: 14 · 2022: 18 · 2021: 24 · 2020: 32 · 2019: 24 · 2018: 31 · 2017: 31 · 2016: 31 · 2015: 36 · 2014: 43 · 2013: 42 · 2012: 16
- FWCI
- 17.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K08HL098361, T32HL007208)
- National Human Genome Research Institute (R01HG001715, K25HG006031, P50HG004233)
- National Cancer Institute (R01CA081135, R01CA093804, P01CA050661, R01CA047006, R01CA085180, K08CA122833, R01CA131354, R01CA066980, R01CA063113, U01CA141583)
- National Institute of General Medical Sciences (F32GM095284)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Keywords
- cancer driver genes, DNA tumor viruses, human papillomavirus, Epstein-Barr virus, adenovirus, polyomavirus, Notch signaling, apoptosis, passenger mutations, genotype-phenotype correlation, host-virus interaction
- MeSH terms
- Adenoviridae, Herpesvirus 4, Human, Humans, Neoplasms, Oncogenic Viruses, Polyomavirus, Viral Proteins, Signal Transduction, Genome, Human, Gene Expression Regulation, Neoplastic, Open Reading Frames, Two-Hybrid System Techniques, Gene Expression Profiling, Papillomaviridae, Receptors, Notch, Genes, Neoplasm, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
