The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Generation of functional thyroid from embryonic stem cells
Open accessAbstract
The primary function of the thyroid gland is to metabolize iodide by synthesizing thyroid hormones, which are critical regulators of growth, development and metabolism in almost all tissues. So far, research on thyroid morphogenesis has been missing an efficient stem-cell model system that allows for the in vitro recapitulation of the molecular and morphogenic events regulating thyroid follicular-cell differentiation and subsequent assembly into functional thyroid follicles. Here we report that a transient overexpression of the transcription factors NKX2-1 and PAX8 is sufficient to direct mouse embryonic stem-cell differentiation into thyroid follicular cells that organize into three-dimensional follicular structures when treated with thyrotropin. These in vitro-derived follicles showed appreciable iodide organification activity. Importantly, when grafted in vivo into athyroid mice, these follicles rescued thyroid hormone plasma levels and promoted subsequent symptomatic recovery. Thus, mouse embryonic stem cells can be induced to differentiate into thyroid follicular cells in vitro and generate functional thyroid tissue.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The subsequent overexpression of the transcription factors NKX2.1 and PAX8 (67) led to fully differentiated follicular cells that express thyroid-specific genes such as TSH receptor, sodium/iodide symporter, and thyroglobulin.”
From Emerging Therapies in Hypothyroidism (2024) · cites this paper as [67]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Exposure to human TSH causes these cells to organize in a 3D follicular architecture that was grafted under the kidney capsules of hypothyroid mice.”
From Emerging Therapies in Hypothyroidism (2024) · cites this paper as [67]
The cited source says what the claim attributes to it.
In the citing paper
“Four weeks later, T4 levels became detectable and serum TSH levels were reduced when compared to levels before grafting (67).”
From Emerging Therapies in Hypothyroidism (2024) · cites this paper as [67]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Establishment in culture of pluripotential cells from mouse embryos
Evans, M. J., & Kaufman, M. H. (1981) · Nature · doi:10.1038/292154a0 · Cited by 8,623
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
Martin, G. R. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.12.7634 · Cited by 5,756
Disease-Specific Induced Pluripotent Stem Cells.
Park, I.-H., Arora, N., Huo, H., Maherali, N., Ahfeldt, T., Shimamura, A., Lensch, M. W., Cowan, C., Hochedlinger, K., & Daley, G. Q. (2008) · Cell · doi:10.1016/j.cell.2008.07.041 · Cited by 2,196
Self-organizing optic-cup morphogenesis in three-dimensional culture
Eiraku, M., Takata, N., Ishibashi, H., Kawada, M., Sakakura, E., Okuda, S., Sekiguchi, K., Adachi, T., & Sasai, Y. (2011) · Nature · doi:10.1038/nature09941 · Cited by 2,001
Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
D’Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O., Agulnick, A. D., Smart, N. G., Moorman, M. A., KROON, E. J., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,913
Directed differentiation of embryonic stem cells into motor neurons.
Wichterle, H., Lieberam, I., Porter, J. A., & Jessell, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00835-8 · Cited by 1,792
Murry, C. E., & Keller, G. M. (2008) · Cell · doi:10.1016/j.cell.2008.02.008 · Cited by 1,760
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 360
Single‐cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland
Gillotay, P., Shankar, M., Haerlingen, B., Eski, S. E., Pozo‐Morales, M., Suñer, I. G., Reinhardt, S., Kränkel, A., Bläsche, J., Petzold, A., et al. (2020) · EMBO Reports · doi:10.15252/embr.202050612 · Cited by 42
Self-citationModeling Human Thyroid Development by Fetal Tissue‐Derived Organoid Culture
Liang, J., Qian, J., Yang, L. C., Chen, X., Wang, X., Lin, X., Wang, X., & Zhao, B. T. (2022) · Advanced Science · doi:10.1002/advs.202105568 · Cited by 40
Villacorte-Tabelin, M., Delmarcelle, A.-S., Lernoux, M., Bouquet, M., Lemoine, P., Bolsée, J., Umans, L., Lopes, S. M. C. D. S., Smissen, P. V. D., Sasaki, T., et al. (2016) · Development · doi:10.1242/dev.134171 · Cited by 38
Self-citationSingle-cell analysis of embryoid body heterogeneity using microfluidic trapping array
Wilson, J. L., Suri, S., Singh, A. K., Rivet, C. A., Lu, H., & McDevitt, T. C. (2013) · Biomedical Microdevices · doi:10.1007/s10544-013-9807-3 · Cited by 38
Emerging Therapies in Hypothyroidism
Bianco, A. C. (2024) · Annual Review of Medicine · doi:10.1146/annurev-med-060622-101007 · Cited by 36
Induction of TTF-1 or PAX-8 expression on proliferation and tumorigenicity in thyroid carcinomas
Dupain, C., Ali, H. M., Mouhoub, T. A., Urbinati, G., & Massaad-Massade, L. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3617 · Cited by 36
Bioengineering Self-Organizing Signaling Centers to Control Embryoid Body Pattern Elaboration
Glykofrydis, F., Cachat, É., Berzanskyte, I., Dzierzak, E. A., & Davies, J. A. (2021) · ACS Synthetic Biology · doi:10.1021/acssynbio.1c00060 · Cited by 36
New Model Systems to Illuminate Thyroid Organogenesis. Part I: An Update on the Zebrafish Toolbox
Opitz, R., Antonica, F., & Costagliola, S. (2013) · European Thyroid Journal · doi:10.1159/000357079 · Cited by 36
Self-citationModeling Cancer with Pluripotent Stem Cells
Gingold, J. A., Zhou, R., Lemischka, I. R., & Lee, D. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.07.007 · Cited by 35
DNA microbeads for spatio-temporally controlled morphogen release within organoids
Afting, C., Walther, T., Drozdowski, O. M., Schlagheck, C., Schwarz, U. S., Wittbrodt, J., & Göpfrich, K. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01779-y · Cited by 38
Mineral particles modulate osteo-chondrogenic differentiation of embryonic stem cell aggregates
Wang, Y., Yu, X., Baker, C., Murphy, W. L., & McDevitt, T. C. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.10.039 · Cited by 34
Bazin-Lopez, N., Valdivia, L. E., Wilson, S. W., & Gestri, G. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.02.004 · Cited by 34
The Complexity of Thyroid Transcription Factor 1 with Both Pro- and Anti-oncogenic Activities
Mu, D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.491647 · Cited by 33
Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System
Mariniello, K., Ruiz‐Babot, G., McGaugh, E. C., Nicholson, J. G., Gualtieri, A., Gaston‐Massuet, C., Nostro, M. C., & Guasti, L. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00772 · Cited by 33
Kaitsuka, T., & Tomizawa, K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125986 · Cited by 34
Derivation of Endodermal Progenitors From Pluripotent Stem Cells
Ikonomou, L., & Kotton, D. N. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24771 · Cited by 34
Thyroid Cell Differentiation from Murine Induced Pluripotent Stem Cells
Ma, R., MORSHED, S. A., Latif, R., & Davies, T. F. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00056 · Cited by 31
In vitro organogenesis from pluripotent stem cells
Li, Y., Xu, C., & Ma, T. (2014) · Organogenesis · doi:10.4161/org.28918 · Cited by 31
Gao, L., Chen, X., Zeng, Y., Li, Q., Zou, T., Chen, S., Wu, Q., Fu, C., Xu, H., & Yin, Z. Q. (2016) · Scientific Reports · doi:10.1038/srep29944 · Cited by 33
Three-Dimensional Cell Cultures in Drug Discovery and Development
Ye, F., & Eglen, R. M. (2017) · SLAS DISCOVERY · doi:10.1177/2472555217696795 · Cited by 35
Sustained release T3 therapy: animal models and translational applications
Idrees, T., Price, J. D., Piccariello, T., & Bianco, A. C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00544 · Cited by 30
Self-organization of organoids from endoderm-derived cells
Lewis, A. C., Keshara, R., Kim, Y. H., & Grapin‐Botton, A. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-02010-w · Cited by 33
Lopez-Campistrous, A., Adewuyi, E. E., Benesch, M. G. K., Ko, Y. M., Lai, R. L., Thiesen, A., Dewald, J. W., Wang, P., Chu, K. P.-M., Ghosh, S., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.09.007 · Cited by 29
Organ regeneration based on developmental biology: past and future
Takeo, M., & Tsuji, T. (2018) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2018.05.008 · Cited by 31
Generation of Functional Thyroid Tissue Using 3D-Based Culture of Embryonic Stem Cells
Antonica, F., Kasprzyk, D. F., Schiavo, A. A., Romitti, M., & Costagliola, S. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6949-4_7 · Cited by 28
Self-citationCheaito, K. A., Bahmad, H. F., Hadadeh, O., Msheik, H., Monzer, A., Ballout, F., Dagher, C., Telvizian, T., Saheb, N., Tawil, A. N., et al. (2021) · Oncology Letters · doi:10.3892/ol.2021.13124 · Cited by 29
Risks and safety of combination therapy for hypothyroidism
Jonklaas, J. (2016) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2016.1182019 · Cited by 27
Serrano‐Nascimento, C., Nicola, J. P., Teixeira, S. D. S., Poyares, L. L., Lellis‐Santos, C., Bordin, S. A., Masini-Repiso, A. M., & Nunes, M. T. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.02.006 · Cited by 29
Romitti, M., Eski, S. E., Fonseca, B. F., Gillotay, P., Singh, S. P., & Costagliola, S. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.657195 · Cited by 27
Self-citationNormal vs cancer thyroid stem cells: the road to transformation
Zane, M., Scavo, E., Catalano, V., Bonanno, M., Todaro, M., Maria, R. D., & Stassi, G. (2015) · Oncogene · doi:10.1038/onc.2015.138 · Cited by 27
Microencapsulation of porcine thyroid cell organoids within a polymer microcapsule construct
Yang, Y., Opara, E. C., Liu, Y., Atala, A., & Zhao, W. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370216673746 · Cited by 28
S-Nitrosylation of NF-κB p65 Inhibits TSH-Induced Na+/I− Symporter Expression
Nicola, J. P., Peyret, V., Nazar, M., Romero, J. M., Lucero, A. M., Montesinos, M. M., Bocco, J. L., Pellizas, C. G., & Masini-Repiso, A. M. (2015) · Endocrinology · doi:10.1210/en.2015-1192 · Cited by 26
Regenerative therapy for hypothyroidism: Mechanisms and possibilities
Hollenberg, A. N., Choi, J., Serra, M., & Kotton, D. N. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.012 · Cited by 26
Animal-free strategies in food safety & nutrition: What are we waiting for? Part I: Food safety
de Boer, A., Krul, L., Fehr, M., Geurts, L., Kramer, N. I., Urbieta, M. A. T., van der Harst, J. E., van de Water, B., Venema, K., Schütte, K., et al. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.10.034 · Cited by 26
Liver organoids: updates on generation strategies and biomedical applications
Liu, S., Cheng, C., Zhu, L., Zhao, T., Wang, Z., Yi, X., Yan, F., Wang, X., Li, C., Cui, T., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03865-3 · Cited by 29
Treatment of congenital thyroid dysfunction: Achievements and challenges
Krude, H., Kühnen, P., & Biebermann, H. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.04.004 · Cited by 25
Werner, K., Weitz, J., & Stange, D. E. (2016) · Current Pathobiology Reports · doi:10.1007/s40139-016-0100-z · Cited by 25
Pluripotent Stem Cells and Other Innovative Strategies for the Treatment of Ocular Surface Diseases
Erbani, J. M., Aberdam, D., Larghero, J., & Vanneaux, V. (2016) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9643-y · Cited by 25
Gaining New Biological and Therapeutic Applications into the Liver with 3D In Vitro Liver Models
Lee, S. W., Jung, D. J., & Jeong, G. S. (2020) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-020-00245-9 · Cited by 26
Arauchi, A., Matsuura, K., Shimizu, T., & Okano, T. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00103 · Cited by 24
Functions of stem cells of thyroid glands in health and disease
Al-Suhaimi, E. A., & Al-Khater, K. M. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09496-x · Cited by 24
The Swinging Pendulum in Treatment for Hypothyroidism: From (and Toward?) Combination Therapy
McAninch, E. A., & Bianco, A. C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00446 · Cited by 27
Moroni, L., Barbaro, F., Caiment, F., Coleman, O., Costagliola, S., Conza, G. D., Elviri, L., Giselbrecht, S., Krause, C., Mota, C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103648 · Cited by 26
Self-citationThyroid Regeneration: How Stem Cells Play a Role?
Kimura, S. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00055 · Cited by 23
Stoupa, A., Carré, A., Polak, M., Szinnai, G., & Schoenmakers, N. A. (2025) · European Thyroid Journal · doi:10.1530/etj-24-0348 · Cited by 25
Organoids for tissue repair and regeneration
Yu, B., Zhou, D., Wang, F., Chen, X., Li, M., & Su, J. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102013 · Cited by 27
On the road to bioartificial organs
Ren, X., & Ott, H. C. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1504-4 · Cited by 22
Nagel, S., Ehrentraut, S., Tomasch, J., Quentmeier, H., Meyer, C., Kaufmann, M., Drexler, H. G., & MacLeod, R. A. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061447 · Cited by 21
A Stem Cell Surge During Thyroid Regeneration
Ma, R., MORSHED, S. A., Latif, R., & Davies, T. F. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.606269 · Cited by 22
Posabella, A., Alber, A. B., Undeutsch, H. J., Droeser, R. A., Hollenberg, A. N., Ikonomou, L., & Kotton, D. N. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.666565 · Cited by 21
Jang, D., Marcus-Samuels, B., Morgan, S. J., Klubo-Gwiezdzinska, J., Neumann, S., & Gershengorn, M. C. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111032 · Cited by 22
The PAX Genes: Roles in Development, Cancer, and Other Diseases
Shaw, T., Barr, F. G., & Üren, A. (2024) · Cancers · doi:10.3390/cancers16051022 · Cited by 23
Zhang, W., Ruan, X., Huang, Y., Zhang, W., Xu, G., Zhao, J., Hao, J., Qin, N., Liu, J., Su, Q., et al. (2024) · Advanced Science · doi:10.1002/advs.202401712 · Cited by 20
TAZ Induction Directs Differentiation of Thyroid Follicular Cells from Human Embryonic Stem Cells
Ma, R., MORSHED, S. A., Latif, R., & Davies, T. F. (2016) · Thyroid · doi:10.1089/thy.2016.0264 · Cited by 21
Brain Organoids: Expanding Our Understanding of Human Development and Disease
Chuye, L. E. B., Dimitri, A. J., Desai, A., Handelmann, C. R., Bae, Y., Johari, P., Jornet, J. M., Klejbor, I., Stachowiak, M. K., & Stachowiak, E. K. (2018) · Results and problems in cell differentiation · doi:10.1007/978-3-319-93485-3_8 · Cited by 20
Regeneration of a Bioengineered Thyroid Using Decellularized Thyroid Matrix
Pan, J., Li, H., Yun, F., Shen, Y.-B., Zhou, X., Zhu, F., Zhu, L.-X., Du, Y., Yu, X., Wang, Y., et al. (2018) · Thyroid · doi:10.1089/thy.2018.0068 · Cited by 20
Cheaito, K. A., Bahmad, H. F., Jalloul, H. A., Hadadeh, O., Msheik, H., Hajj, A. E., Mukherji, D., Al‐Sayegh, M., & Abou-Kheir, W. G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.571677 · Cited by 21
Bahmad, H. F., Poppiti, R., & Alexis, J. B. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.02.025 · Cited by 21
Dom, G., Dmitriev, P., Lambot, M.-A., Vliet, G. V., Glinoer, D., Libert, F., Lefort, A., Dumont, J. E., & Maenhaut, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.669354 · Cited by 20
Recent advances in endocrine organoids for therapeutic application
Jeon, S., Lee, Y.-S., Oh, S. R., Jeong, J., Lee, D., So, K., & Hwang, N. S.-Y. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114959 · Cited by 20
A Decade of Organoid Research: Progress and Challenges in the Field of Organoid Technology
Ahammed, B., & Kalangi, S. K. (2024) · ACS Omega · doi:10.1021/acsomega.4c03683 · Cited by 25
Current concepts and challenges to unravel the role of iodothyronine deiodinases in human neoplasias
Goemann, I. M., Marczyk, V. R., Romitti, M., Wajner, S. M., & Maia, A. L. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0097 · Cited by 20
Dominant and context-specific control of endodermal organ allocation by Ptf1a
Willet, S. G., Hale, M. A., Grapin‐Botton, A., Magnuson, M. A., MacDonald, R. J., & Wright, C. V. E. (2014) · Development · doi:10.1242/dev.114165 · Cited by 19
Derivation and 97% Purification of Human Thyroid Cells From Dermal Fibroblasts
Ma, R., Shi, R., MORSHED, S. A., Latif, R., & Davies, T. F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00446 · Cited by 19
Li, H., Bai, B., Zhang, Q., Bao, Y., Guo, J., Chen, S., Miao, C., Liu, X., & Zhang, T. (2015) · Gene · doi:10.1016/j.gene.2015.07.048 · Cited by 19
Constitutive TSH receptor activation as a hallmark of thyroid autonomy
Führer, D. (2020) · Endocrine · doi:10.1007/s12020-020-02270-z · Cited by 18
Brain Organoids: Tiny Mirrors of Human Neurodevelopment and Neurological Disorders
Yadav, A., Seth, B., & Chaturvedi, R. K. (2020) · The Neuroscientist · doi:10.1177/1073858420943192 · Cited by 19
A systematic review on thyroid organoid models: time-trend and its achievements
Samimi, H., Atlasi, R., Parichehreh-Dizaji, S., Khazaei, S., Rahnama, M. A., Seifirad, S., & Haghpanah, V. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00479.2020 · Cited by 19
Generation of Thyroid Tissues From Embryonic Stem Cells via Blastocyst Complementation In Vivo
Ran, Q., Zhou, Q., Oda, K., Yasue, A., Abe, M., Ye, X., Li, Y., Sasaoka, T., Sakimura, K., Ajioka, Y., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.609697 · Cited by 16
Thyroid Gland Organoids: Current Models and Insights for Application in Tissue Engineering
Ogundipe, V. M. L., Plukker, J. T. M., Links, T. P., & Coppes, R. P. (2022) · Tissue Engineering Part A · doi:10.1089/ten.tea.2021.0221 · Cited by 16
Willems, C., & Vankelecom, H. (2014) · Regenerative medicine · doi:10.2217/rme.14.19 · Cited by 17
Disorders of the thyroid in the newborn and infant
Vliet, G. V., & Deladoëy, J. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-4858-7.00016-0 · Cited by 16
Homuth, G., Lietzow, J., Schanze, N., Golchert, J., & Köhrle, J. (2020) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1139-9200 · Cited by 15
Establishment and maintenance of thyroid organoids from human cancer cells
Pecce, V., Sponziello, M., Bini, S., Grani, G., Durante, C., & Verrienti, A. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101393 · Cited by 15
Thyrotropin receptor, still much to be learned from the patients
Briet, C., Suteau, V., Munier, M., & Rodien, P. (2018) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2018.03.002 · Cited by 15
An in vivo model for thyroid regeneration and folliculogenesis
Iwadate, M., Takizawa, Y., Shirai, Y.-T., & Kimura, S. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0068-x · Cited by 15
Functional ectodermal organ regeneration as the next generation of organ replacement therapy
Ikeda, E., Ogawa, M., Takeo, M., & Tsuji, T. (2019) · Open Biology · doi:10.1098/rsob.190010 · Cited by 15
Delcorte, O., Degosserie, J., & Pierreux, C. E. (2022) · Biomedicines · doi:10.3390/biomedicines10102585 · Cited by 14
Bioengineering toolkits for potentiating organoid therapeutics
Park, S., & Cho, S. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115238 · Cited by 18
Advancing Glioblastoma Research with Innovative Brain Organoid-Based Models
Correia, C. D., Calado, S. M., Matos, A., Esteves, F., Sousa‐Coelho, A. L. D., Campinho, M. A., & Fernandes, M. T. (2025) · Cells · doi:10.3390/cells14040292 · Cited by 16
Rupik, W., Kowalska, M., Swadźba, E., & Maślak, R. (2015) · Zoology · doi:10.1016/j.zool.2015.12.005 · Cited by 14
Practical applications of studies on the TSH receptor and TSH receptor autoantibodies
Furmaniak, J., Sanders, J. F., Sanders, P. W., Miller-Gallacher, J., Ryder, M. M., & Smith, B. R. (2020) · Endocrine · doi:10.1007/s12020-019-02180-9 · Cited by 14
Value of Organoids from Comparative Epithelia Models.
Schwarz, J., de Jonge, H. R., & Forrest, J. N. (2015) · PubMed Central · Cited by 14
Genetically modified cell spheroids for tissue engineering and regenerative medicine
Jiang, Z., Xu, Y., Fu, M., Zhu, D., Li, N., & Yang, G. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.033 · Cited by 12
Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration
Romitti, M., & Costagliola, S. (2023) · Endocrinology · doi:10.1210/endocr/bqad136 · Cited by 13
Self-citationTosatto, L., & Coscia, F. (2022) · European Thyroid Journal · doi:10.1530/etj-22-0046 · Cited by 13
Modeling Human Organ Development and Diseases With Fetal Tissue–Derived Organoids
Liang, J., Li, X., Dong, Y., & Zhao, B. T. (2022) · Cell Transplantation · doi:10.1177/09636897221124481 · Cited by 13
Fridley, K. M., Nair, R., & McDevitt, T. C. (2014) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2013.0392 · Cited by 13
Establishment of an Effective Radioiodide Thyroid Ablation Protocol in Mice
Schmohl, K. A., Müller, A. M., Schwenk, N., Knoop, K., Rijntjes, E., Köhrle, J., Heuer, H., Bartenstein, P., Göke, B., Nelson, P. J., et al. (2015) · European Thyroid Journal · doi:10.1159/000381019 · Cited by 13
de Boer, A., van der Harst, J. E., Fehr, M., Geurts, L., Knipping, K., Kramer, N. I., Krul, L., Urbieta, M. A. T., van de Water, B., Venema, K., et al. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.02.014 · Cited by 13
Dumont, J. E., Maenhaut, C., Christophe, D., & Roger, P. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00075-5 · Cited by 13
Is Thyroid Transplantation on the Distant Horizon?
Davies, T. F. (2013) · Thyroid · doi:10.1089/thy.2013.2302.ed2 · Cited by 13
Endocrinology of Fetal Development
Dattani, M., & Gevers, E. F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00022-8 · Cited by 13
Iwahashi-Odano, M., Nagasaki, K., Fukami, M., Nishioka, J., Yatsuga, S., Asakura, Y., Adachi, M., Muroya, K., Hasegawa, T., & Narumi, S. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa584 · Cited by 13
Geysels, R. C., Peyret, V., Martín, M., Nazar, M., Reale, C., Barquero, C. E. B., Miranda, L., Marti, M. A., Vito, P., Masini-Repiso, A. M., et al. (2020) · Thyroid · doi:10.1089/thy.2020.0208 · Cited by 12
An Ex vivo Culture System to Study Thyroid Development
Delmarcelle, A.-S., Villacorte-Tabelin, M., Hick, A.-C., & Pierreux, C. E. (2014) · Journal of Visualized Experiments · doi:10.3791/51641 · Cited by 12
Li, Y., Eggermont, K., Vanslembrouck, V., & Verfaillie, C. M. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0620 · Cited by 12
Sewell, W., & Lin, R.-Y. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00096 · Cited by 12
Hu, A., Yang, L., Liang, J., Lü, D., & Cao, F. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.06.050 · Cited by 11
Pluripotent stem cell‐derived organoids: A brief history of curiosity‐led discoveries
Lancaster, M. A. (2024) · BioEssays · doi:10.1002/bies.202400105 · Cited by 11
Metadata
- Authors
- Antonica, F., Kasprzyk, D. F., Opitz, R., Iacovino, M., Liao, X.-H., Dumitrescu, A. M., Refetoff, S., Peremans, K., Manto, M., Kyba, M., & Costagliola, S.
- Affiliations
- Université Libre de Bruxelles (BE)
- University of Minnesota (US)
- University of Chicago (US)
- Ghent University (BE)
- Corresponding author
- Costagliola, Sabine
- ORCID
- Venue
- Nature
- Published
- 2012-10-10
- Volume
- 491
- Issue
- 7422
- Pages
- 66-71
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3687105
- OpenAlex
- W2155574792
- Cited by
- 359
- References
- 78
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 23 · 2023: 26 · 2022: 33 · 2021: 28 · 2020: 33 · 2019: 24 · 2018: 19 · 2017: 18 · 2016: 26 · 2015: 35 · 2014: 27 · 2013: 25 · 2012: 3
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Iris (University of Trento) (submittedVersion)
- Funders
- Fonds De La Recherche Scientifique - FNRS
- National Institutes of Health (DK 15070)
- Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 15070, R37DK015070, F32DK091016, DK91016, R01DK015070)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- embryonic stem cells, thyroid follicular cells, TTF-1, PAX8, transcription factors, thyroid-stimulating hormone, iodide organification, thyroid hormone synthesis, thyroid development, congenital hypothyroidism, regenerative medicine, stem cell differentiation
- MeSH terms
- PAX8 Transcription Factor, Thyroid Nuclear Factor 1, Animals, Cell Differentiation, Disease Models, Animal, Female, Humans, Hypothyroidism, Nuclear Proteins, Thyroid Gland, Thyrotropin, Thyroxine, Transcription Factors, Mice, Paired Box Transcription Factors, Embryonic Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
