The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
Open accessAbstract
Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, which neutralizes ∼98% of tested viruses. An analysis of sera from 78 healthy HIV-1-infected donors demonstrated that 27% contained MPER-specific antibodies and 8% contained 10E8-like specificities. In contrast to other neutralizing MPER antibodies, 10E8 did not bind phospholipids, was not autoreactive, and bound cell-surface envelope. The structure of 10E8 in complex with the complete MPER revealed a site of vulnerability comprising a narrow stretch of highly conserved gp41-hydrophobic residues and a critical arginine or lysine just before the transmembrane region. Analysis of resistant HIV-1 variants confirmed the importance of these residues for neutralization. The highly conserved MPER is a target of potent, non-self-reactive neutralizing antibodies, suggesting that HIV-1 vaccines should aim to induce antibodies to this region of HIV-1 envelope glycoprotein.
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Metadata
- Authors
- Huang, J., Ofek, G., Laub, L., Louder, M. K., Doria-Rose, N. A., Longo, N. S., Imamichi, H., Bailer, R. T., Chakrabarti, B., Sharma, S. K., Alam, S. M., Wang, T., Yang, Y., Zhang, B., Migueles, S. A., Wyatt, R., Haynes, B. F., Kwong, P. D., Mascola, J. R., & Connors, M.
- Venue
- Nature
- Published
- 2012-09-18
- Volume
- 491
- Issue
- 7424
- Pages
- 406-412
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2070086938
- Cited by
- 828
- References
- 6
- FWCI
- 38.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, J., Ofek, G., Laub, L., Louder, M. K., Doria-Rose, N. A., Longo, N. S., Imamichi, H., Bailer, R. T., Chakrabarti, B., Sharma, S. K., Alam, S. M., Wang, T., Yang, Y., Zhang, B., Migueles, S. A., Wyatt, R., Haynes, B. F., Kwong, P. D., Mascola, J. R., & Connors, M. (2012). Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Nature. https://doi.org/10.1038/nature11544
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