The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses
Open accessAbstract
SUMMARY The vast majority of currently licensed human vaccines work on the basis of long-term protective antibody responses. It is now conceivable that an antibody-dependent HIV vaccine might be possible, given the discovery of HIV broadly neutralizing antibodies (bnAbs) in some HIV-infected individuals. However, these antibodies are difficult to develop and have characteristics indicative of a high degree of affinity maturation in germinal centers (GCs). CD4+ T follicular helper (Tfh) cells are specialized for B cell help and necessary for GCs. Therefore, the development of HIV bnAbs might depend on Tfh cells. Here, we identified in normal individuals a subpopulation of circulating memory PD-1+CXCR5+ CD4+ T cells that are resting memory cells most related to bona fide GC Tfh cells by gene expression profile, cytokine profile, and functional properties. Importantly, the frequency of these cells correlated with the development of bnAbs against HIV in a large cohort of HIV+ individuals.
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Citations
Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 2×
“Resting CD45RO CD4 T cells are usually classified as central-memory T (TCM) or effector-memory T (TEM) cells (Sallusto et al., 1999), although amore sophisticated subsetting is more accurate.”
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Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target
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Broad neutralization coverage of HIV by multiple highly potent antibodies
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Cited by
T follicular helper cell differentiation, function, and roles in disease
Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847
Self-citationT follicular helper cell biology: a decade of discovery and diseases
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Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
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Metadata
- Authors
- Locci, M., Havenar-Daughton, C., Landais, E., Wu, J., Kroenke, M. A., Arlehamn, C. L., Su, L. F., Cubas, R., Davis, M. M., Sette, A., Haddad, E. K., Poignard, P., & Crotty, S.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 39
- Issue
- 4
- Pages
- 758-769
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1981732254
- Cited by
- 868
- References
- 56
- FWCI
- 33.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Locci, M., Havenar-Daughton, C., Landais, E., Wu, J., Kroenke, M. A., Arlehamn, C. L., Su, L. F., Cubas, R., Davis, M. M., Sette, A., Haddad, E. K., Poignard, P., & Crotty, S. (2013). Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses. Immunity. https://doi.org/10.1016/j.immuni.2013.08.031
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
