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Single-cell Hi-C reveals cell-to-cell variability in chromosome structure
Open accessAbstract
Large-scale chromosome structure and spatial nuclear arrangement have been linked to control of gene expression and DNA replication and repair. Genomic techniques based on chromosome conformation capture (3C) assess contacts for millions of loci simultaneously, but do so by averaging chromosome conformations from millions of nuclei. Here we introduce single-cell Hi-C, combined with genome-wide statistical analysis and structural modelling of single-copy X chromosomes, to show that individual chromosomes maintain domain organization at the megabase scale, but show variable cell-to-cell chromosome structures at larger scales. Despite this structural stochasticity, localization of active gene domains to boundaries of chromosome territories is a hallmark of chromosomal conformation. Single-cell Hi-C data bridge current gaps between genomics and microscopy studies of chromosomes, demonstrating how modular organization underlies dynamic chromosome structure, and how this structure is probabilistically linked with genome activity patterns.
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In the citing paper
“Some types of epigenetic modifications, such as changes in chromosome conformation are still largely unexplored in MDD.414,415”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [414]
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“Similarly, single-cell Hi-C can derive a coherent three-dimensional chromosomal topology29 unattainable from bulk 3C data, which averages the chromosomal conformations in millions of cells.”
From Revealing the vectors of cellular identity with single-cell genomics (2016) · cites this paper as [29]
In the citing paper
“In our previous version of the single-cell Hi-C protocol12 we found that molecules supported by a single read (singleton contacts) usually represented spurious ligations and were therefore discarded.”
From Cell-cycle dynamics of chromosomal organization at single-cell resolution (2017) · cites this paper as [12]
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Cites
Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
Lieberman-Aiden, E., van Berkum, N. L., Williams, L., Imakaev, M., Ragoczy, T., Telling, A., Amit, I., Lajoie, B. R., Sabo, P. J., Dorschner, M. O., et al. (2009) · Science · doi:10.1126/science.1181369 · Cited by 8,898
Topological domains in mammalian genomes identified by analysis of chromatin interactions
Dixon, J. R., Selvaraj, S., Yue, F., Kim, A., Li, Y., Shen, Y., Hu, M., Liu, J. S., & Ren, B. (2012) · Nature · doi:10.1038/nature11082 · Cited by 6,829
Capturing Chromosome Conformation
Dekker, J., Rippe, K., Dekker, M., & Kleckner, N. (2002) · Science · doi:10.1126/science.1067799 · Cited by 3,652
Spatial partitioning of the regulatory landscape of the X-inactivation centre
Nora, E. P., Lajoie, B. R., Schulz, E. G., Giorgetti, L., Okamoto, I., Servant, N., Piolot, T., van Berkum, N. L., Meisig, J., Sedat, J., et al. (2012) · Nature · doi:10.1038/nature11049 · Cited by 2,895
Chromosome territories, nuclear architecture and gene regulation in mammalian cells
Cremer, T. J., & Cremer, C. G. (2001) · Nature Reviews Genetics · doi:10.1038/35066075 · Cited by 2,423
Three-dimensional folding and functional organization principles of the Drosophila genome
Sexton, T., Yaffe, E., Kenigsberg, E., Bantignies, F., Leblanc, B., Hoichman, M., Parrinello, H., Tanay, A., & Cavalli, G. (2012) · Cell · doi:10.1016/j.cell.2012.01.010 · Cited by 1,983
Self-citationSimonis, M., Klous, P., Splinter, E., Moshkin, Y., Willemsen, R., de Wit, E., van Steensel, B., & de Laat, W. (2006) · Nature Genetics · doi:10.1038/ng1896 · Cited by 1,386
Dostie, J., Richmond, T., Arnaout, R., Selzer, R. R., Lee, W. L., Honan, T., Rubio, E. D., Krumm, A., Lamb, J., Nusbaum, C., et al. (2006) · Genome Research · doi:10.1101/gr.5571506 · Cited by 1,237
Beyond the Sequence: Cellular Organization of Genome Function
Misteli, T. (2007) · Cell · doi:10.1016/j.cell.2007.01.028 · Cited by 1,140
Active genes dynamically colocalize to shared sites of ongoing transcription
Osborne, C. S., Chakalova, L., Brown, K. E., Carter, D., Horton, A., Debrand, E., Goyenechea, B., Mitchell, J. A., Lopes, S. M. C. D. S., Reik, W., et al. (2004) · Nature Genetics · doi:10.1038/ng1423 · Cited by 1,080
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Wang, F., Gao, T., Lin, J., Zheng, Z., Huang, L., Toseef, M., Li, X., & Wong, K. (2022) · iScience · doi:10.1016/j.isci.2022.105535 · Cited by 14
Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell
Lando, D., Basu, S., Stevens, T. J., Riddell, A., Wohlfahrt, K., Cao, Y., Boucher, W., Leeb, M., Atkinson, L. P., Lee, S. F., et al. (2018) · Nature Protocols · doi:10.1038/nprot.2018.017 · Cited by 13
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Umlauf, D., & Mourad, R. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.07.002 · Cited by 15
Gabitto, M. I., Rasmussen, A. W., Wapinski, O. L., Allaway, K. C., Carriero, N. J., Fishell, G., & Bonneau, R. (2020) · Nature Communications · doi:10.1038/s41467-020-14497-5 · Cited by 13
Discovery of new epigenomics-based biomarkers and the early diagnosis of neurodegenerative diseases
Lee, D., Choi, Y. H., Seo, J., Kim, J. K., & Lee, S. B. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101069 · Cited by 14
Cell type-specific interchromosomal interactions as a mechanism for transcriptional diversityPreprint
Horta, A., Monahan, K., Bashkirova, E., & Lomvardas, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/287532 · Cited by 14
Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamicsPreprint
Basu, S., Shukron, O., Hall, D., Parutto, P., Ponjavic, A., Shah, D., Boucher, W., Lando, D., Zhang, W., Reynolds, N., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.03.003178 · Cited by 14
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Ma, Y., Chen, T., Sun, T., Dilinuer, D., & Xiao, Y. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107091 · Cited by 14
Beckwith, K. S., Ødegård-Fougner, Ø., Morero, N. R., Barton, C., Schueder, F., Tang, W., Alexander, S., Peters, J. M., Jungmann, R., Birney, E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61689-y · Cited by 13
Single‐Cell and Spatial Omics: Methods and Applications
Cen, X., Huang, X., Deng, E., Gong, X., Tan, N., Ye, J. T., Wang, Y., Eils, R., Luo, Q., Li, Y., et al. (2026) · MedComm · doi:10.1002/mco2.70713 · Cited by 14
Polymer models are a versatile tool to study chromatin 3D organization
Esposito, A., Bianco, S., Fiorillo, L., Conte, M., Abraham, A., Musella, F., Nicodemi, M., Prisco, A., & Chiariello, A. M. (2021) · Biochemical Society Transactions · doi:10.1042/bst20201004 · Cited by 14
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Tuong, Z. K., Stewart, B. J., Guo, S. A., & Clatworthy, M. R. (2021) · Immunological Reviews · doi:10.1111/imr.13036 · Cited by 13
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Zheng, J., Yang, Y., & Dai, Z. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad379 · Cited by 14
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Liu, R., Xu, R., Yan, S., Li, P., Jia, C., Sun, H., Sheng, K., Wang, Y., Zhang, Q., Guo, J., et al. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1377238 · Cited by 13
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Yang, Q., Gao, J. T., Zhou, S. G., & Walsh, T. R. (2025) · Trends in Microbiology · doi:10.1016/j.tim.2024.12.013 · Cited by 13
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Wani, S. A., Khan, S. A., & Quadri, S. (2025) · Archives of Computational Methods in Engineering · doi:10.1007/s11831-025-10230-x · Cited by 13
Kefalopoulou, S., Rullens, P. M. J., de Luca, K. L., de Vries, S. S., Korthout, T., van Oudenaarden, A., Zeller, P. J., & Kind, J. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01687-w · Cited by 12
Lahbib-Mansais, Y., Barasc, H., Marti-Marimon, M., Mompart, F., Iannuccelli, E., Robelin, D., Riquet, J., & Martine Yerle, B. (2016) · BMC Cell Biology · doi:10.1186/s12860-016-0113-9 · Cited by 14
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Übelmesser, N., & Papantonis, A. (2019) · Briefings in Functional Genomics · doi:10.1093/bfgp/elz019 · Cited by 13
Jiang, K., Kessler, H. A., Park, Y., Sudman, M., Thompson, S. D., & Jarvis, J. N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235857 · Cited by 13
Scourzic, L., Salataj, E., & Apostolou, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669881 · Cited by 16
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Marti-Marimon, M., Vialaneix, N., Lahbib-Mansais, Y., Zytnicki, M., Camut, S., Robelin, D., Martine Yerle, B., & Foissac, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.748239 · Cited by 13
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Maslova, A., & Krasikova, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.753097 · Cited by 16
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Yu, M., Li, Y., & Hu, M. (2022) · Trends in Genetics · doi:10.1016/j.tig.2022.03.007 · Cited by 10
Comparison and critical assessment of single-cell Hi-C protocols
Gridina, M. M., Taskina, A., Lagunov, T. A., Nurislamov, A. R., Kulikova, T., Krasikova, A., & Fishman, V. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11023 · Cited by 12
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Tao, X., Li, S., Chen, G., Wang, J., & Xu, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065562 · Cited by 13
Wang, J., Meng, X., Chen, H., Yuan, C., Li, X., Zhou, Y., & Chen, M. (2016) · Briefings in Functional Genomics · doi:10.1093/bfgp/elv062 · Cited by 12
Li, X., Zhao, S., & Liu, Y. (2016) · ChemistrySelect · doi:10.1002/slct.201600748 · Cited by 13
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Ito, K., & Takizawa, T. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00308 · Cited by 13
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Luo, Z., Hu, T., Jiang, H., Wang, R., Xu, Q., Zhang, S. V., Cao, J., & Song, X. (2020) · Genome Research · doi:10.1101/gr.241687.118 · Cited by 17
Anthony, D. S.-B., Chen, C. J., Nixon, B., & Hondermarck, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00157-7 · Cited by 16
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Rivero-García, I., Torres, M., & Sánchez‐Cabo, F. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108561 · Cited by 13
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Nitz, A. A., Chavez, J. H. G., Eliason, Z. G., & Payne, S. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00091 · Cited by 16
Chen, X., Shi, C., Yammine, S., Göndör, A., Rönnlund, D., Fernandez-Woodbridge, A., Sumida, N., Widengren, J., & OHLSSON, R. I. (2014) · BioTechniques · doi:10.2144/000114145 · Cited by 12
Dily, F. L., Serra, F., & Martı́-Renom, M. A. (2017) · Wiley Interdisciplinary Reviews Computational Molecular Science · doi:10.1002/wcms.1308 · Cited by 14
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Capurso, D., & Segal, M. R. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-992 · Cited by 12
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Giorgetti, L., Servant, N., & Heard, É. (2013) · Genome biology · doi:10.1186/gb4147 · Cited by 11
Large-scale 3D chromatin reconstruction from chromosomal contacts
Zhang, Y., Liu, W., Lin, Y., Ng, Y. K., & Li, S. C. (2019) · BMC Genomics · doi:10.1186/s12864-019-5470-2 · Cited by 13
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Pratt, B. M., & Won, H. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.08.013 · Cited by 13
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Conte, M., Fiorillo, L., Annunziatella, C., Esposito, A., Musella, F., Abraham, A., Bianco, S., & Chiariello, A. M. (2021) · Physical review. E · doi:10.1103/physreve.104.054402 · Cited by 14
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Modeling three-dimensional genomic organization in evolution and pathogenesis
Diament, A., & Tuller, T. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.07.008 · Cited by 11
Zhou, T., Zhang, R., Jia, D., Doty, R. T., Munday, A. D., Gao, D., Xin, L., Abkowitz, J. L., Duan, Z., & Ma, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.20.549578 · Cited by 12
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zha, M., Wang, N., Zhang, C., & Wang, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115914 · Cited by 12
Mielczarek, O., Rogers, C. H., Zhan, Y., Matheson, L. S., Stubbington, M. J. T., Schoenfelder, S., Bolland, D. J., Javierre, B. M., Wingett, S., Várnai, C., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113074 · Cited by 12
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Ye, B., Qingping, G., Zeng, Z. R., Stary, C. M., Jian, Z., Xiong, X., & Gu, L. (2016) · Analytical Cellular Pathology · doi:10.1155/2016/9369240 · Cited by 11
Hu, X. S., Shi, C. H., & Yip, K. Y.-L. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw256 · Cited by 11
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Yusuf, M., Kaneyoshi, K., Fukui, K., & Robinson, I. K. (2018) · Chromosoma · doi:10.1007/s00412-018-0678-5 · Cited by 11
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Zaborowski, R., & Wilczyński, B. (2019) · Journal of Computational Biology · doi:10.1089/cmb.2018.0162 · Cited by 11
Li, J., & Pertsinidis, A. (2021) · Biochemical Society Transactions · doi:10.1042/bst20200963 · Cited by 10
Hi-CO: 3D genome structure analysis with nucleosome resolution
Ohno, M., Ando, T., Priest, D. G., & Taniguchi, Y. (2021) · Nature Protocols · doi:10.1038/s41596-021-00543-z · Cited by 12
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Yan, J., & Huangfu, D. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.12.001 · Cited by 11
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Uhler, C., & Shivashankar, G. V. (2022) · Proceedings of the IEEE · doi:10.1109/jproc.2022.3166132 · Cited by 11
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Czarnewski, P., Mahfouz, A. E., Calogero, R., Palagi, P. M., Portell-Silva, L., Gonzalez‐Uriarte, A., Soneson, C., Burdett, T., Szomolay, B., Videm, P., et al. (2022) · F1000Research · doi:10.12688/f1000research.122312.1 · Cited by 11
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Kim, E. T., & Kim, K.-D. (2022) · BMB Reports · doi:10.5483/bmbrep.2022.55.12.154 · Cited by 11
Chen, Q., Dai, J., & Bian, Q. (2022) · Science Advances · doi:10.1126/sciadv.abo3648 · Cited by 11
Dai, S., Liu, S., Zhou, C., Yu, F., Zhu, G., Zhang, W., Deng, H., Burlingame, A. L., Yu, W., Wang, T., et al. (2023) · Molecular Plant · doi:10.1016/j.molp.2023.03.013 · Cited by 11
Supervised learning method for predicting chromatin boundary associated insulator elements
Bednarz, P., & Wilczyński, B. (2014) · Journal of Bioinformatics and Computational Biology · doi:10.1142/s0219720014420062 · Cited by 11
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Gall, A. L., Valeri, A., & Nöllmann, M. (2015) · Nucleus · doi:10.1080/19491034.2015.1010962 · Cited by 11
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Shavit, Y., Merelli, I., Milanesi, L., & Lió, P. (2015) · Briefings in Bioinformatics · doi:10.1093/bib/bbv085 · Cited by 12
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Gao, J. T., Yang, X., Djekidel, M. N., Wang, Y., Xi, P., & Zhang, M. Q. (2016) · Quantitative Biology · doi:10.1007/s40484-016-0065-2 · Cited by 11
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Wettermann, S., Brems, M. A., Siebert, J. T., Vu, G. T., Stevens, T. J., & Virnau, P. (2019) · Computational Materials Science · doi:10.1016/j.commatsci.2019.109178 · Cited by 11
Self-citationTranscription Factors Indirectly Regulate Genes through Nuclear Colocalization
Dai, Z. (2019) · Cells · doi:10.3390/cells8070754 · Cited by 11
Yang, Y., Ku, M., & Lui, K. O. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.6mr0720-131r · Cited by 12
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Metadata
- Authors
- Nagano, T., Lubling, Y., Stevens, T. J., Schoenfelder, S., Yaffe, E., Dean, W., Laue, E. D., Tanay, A., & Fraser, P.
- Affiliations
- Babraham Institute (GB)
- Weizmann Institute of Science (IL)
- University of Cambridge (GB)
- Corresponding author
- Laue, Ernest D.
- Tanay, Amos
- Fraser, Peter
- ORCID
- Venue
- Nature
- Published
- 2013-09-25
- Volume
- 502
- Issue
- 7469
- Pages
- 59-64
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3869051
- OpenAlex
- W1965863160
- Cited by
- 1,589
- References
- 32
- Citations by year
- 2026: 75 · 2025: 100 · 2024: 118 · 2023: 115 · 2022: 120 · 2021: 177 · 2020: 132 · 2019: 143 · 2018: 147 · 2017: 126 · 2016: 116 · 2015: 125 · 2014: 86 · 2013: 8
- FWCI
- 50.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council (BBS/E/B/0000M241, BBS/E/B/000C0404, BBS/E/B/0000C151)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- single-cell Hi-C, chromosome conformation, cell-to-cell variability, chromosome structure, chromosome territories, X chromosome, 3D genome organization, chromatin interactions, interdomain contacts, nuclear organization
- MeSH terms
- Animals, Cell Nucleus, Chromatin, Chromosomes, Genetic Techniques, Male, Models, Molecular, Molecular Conformation, X Chromosome, Mice, Single-Cell Analysis
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