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Cited by 475Spectroscopy Techniques in Biomedical and Chemical ResearchLaser-Matter Interactions and ApplicationsSpectroscopy and Laser Applications

The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.

Coherent Raman spectro-imaging with laser frequency combs

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Ideguchi, Takuro, Holzner, Simon, Bernhardt, Birgitta, Guelachvili, Guy, Picqué, Nathalie, Hänsch, Theodor W.·2013·Nature
DOI 10.1038/nature12607
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Abstract

Advances in optical spectroscopy and microscopy have had a profound impact throughout the physical, chemical and biological sciences. One example is coherent Raman spectroscopy, a versatile technique interrogating vibrational transitions in molecules. It offers high spatial resolution and three-dimensional sectioning capabilities that make it a label-free tool for the non-destructive and chemically selective probing of complex systems. Indeed, single-colour Raman bands have been imaged in biological tissue at video rates by using ultra-short-pulse lasers. However, identifying multiple, and possibly unknown, molecules requires broad spectral bandwidth and high resolution. Moderate spectral spans combined with high-speed acquisition are now within reach using multichannel detection or frequency-swept laser beams. Laser frequency combs are finding increasing use for broadband molecular linear absorption spectroscopy. Here we show, by exploring their potential for nonlinear spectroscopy, that they can be harnessed for coherent anti-Stokes Raman spectroscopy and spectro-imaging. The method uses two combs and can simultaneously measure, on the microsecond timescale, all spectral elements over a wide bandwidth and with high resolution on a single photodetector. Although the overall measurement time in our proof-of-principle experiments is limited by the waiting times between successive spectral acquisitions, this limitation can be overcome with further system development. We therefore expect that our approach of using laser frequency combs will not only enable new applications for nonlinear microscopy but also benefit other nonlinear spectroscopic techniques.

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Research works printed but not linked: 2

  1. Cheng J. X., Xie X. S., eds. Coherent Raman Scattering Microscopy (CRC Press, 2012)
  2. Boyd, R. W. Nonlinear Optics 3rd edn, Ch. 10.3 (Academic, 2008)

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Metadata

Authors
Ideguchi, T., Holzner, S., Bernhardt, B., Guelachvili, G., Picqué, N., & Hänsch, T. W.
Affiliations
  • Max Planck Institute of Quantum Optics (DE)
  • Université Paris-Sud (FR)
Corresponding author
Picqué, Nathalie
ORCID
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2013-10-16
Volume
502
Issue
7471
Pages
355-358
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature12607
OpenAlex
W2074049639
Cited by
475
References
39
Citations by year
2026: 16 · 2025: 30 · 2024: 38 · 2023: 47 · 2022: 33 · 2021: 35 · 2020: 38 · 2019: 43 · 2018: 44 · 2017: 48 · 2016: 38 · 2015: 34 · 2014: 26 · 2013: 5
FWCI
20.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • arXiv (Cornell University) (submittedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • arXiv (Cornell University)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
  • Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Laser-Matter Interactions and Applications
  • Physical Sciences › Chemistry › Spectroscopy › Spectroscopy and Laser Applications
Keywords
coherent anti-Stokes Raman spectroscopy, laser frequency combs, label-free molecular imaging, nonlinear optical microscopy
MeSH terms
Lasers, Spectrum Analysis, Raman, Time Factors, Vibration

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