The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Tumour heterogeneity in the clinic
Open accessAbstract
Recent therapeutic advances in oncology have been driven by the identification of tumour genotype variations between patients, called interpatient heterogeneity, that predict the response of patients to targeted treatments. Subpopulations of cancer cells with unique genomes in the same patient may exist across different geographical regions of a tumour or evolve over time, called intratumour heterogeneity. Sequencing technologies can be used to characterize intratumour heterogeneity at diagnosis, monitor clonal dynamics during treatment and identify the emergence of clinical resistance during disease progression. Genetic interpatient and intratumour heterogeneity can pose challenges for the design of clinical trials that use these data.
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Cites
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Cited by
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
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Roles of the immune system in cancer: From tumor initiation to metastatic progression
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Conquering the Hypoxia Limitation for Photodynamic Therapy
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Tumor Heterogeneity in Breast Cancer
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Metadata
- Authors
- Bedard, P. L., Hansen, A. R., Ratain, M. J., & Siu, L. L.
- Venue
- Nature
- Published
- 2013-09-18
- Volume
- 501
- Issue
- 7467
- Pages
- 355-364
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1987370132
- Cited by
- 1,211
- References
- 23
- FWCI
- 33.32
- Type
- journal article
- Language
- en
- Open access
- green
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