Cited by 705Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsCancer, Hypoxia, and Metabolism

Conquering the Hypoxia Limitation for Photodynamic Therapy

Wan, Yilin, Fu, Lian‐Hua, Li, Chunying, Lin, Jing, Huang, Peng·2021·Advanced Materials

Abstract

Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due to the hypoxic nature characteristic of many solid tumors, PDT is frequently limited in therapeutic effect. Moreover, the consumption of O 2 during PDT may further aggravate the tumor hypoxic condition, which promotes tumor proliferation, metastasis, and invasion resulting in poor prognosis of treatment. Therefore, numerous efforts have been made to increase the O 2 content in tumor with the goal of enhancing PDT efficacy. Herein, these strategies developed in past decade are comprehensively reviewed to alleviate tumor hypoxia, including 1) delivering exogenous O 2 to tumor directly, 2) generating O 2 in situ, 3) reducing tumor cellular O 2 consumption by inhibiting respiration, 4) regulating the TME, (e.g., normalizing tumor vasculature or disrupting tumor extracellular matrix), and 5) inhibiting the hypoxia‐inducible factor 1 (HIF‐1) signaling pathway to relieve tumor hypoxia. Additionally, the O 2 ‐independent Type‐I PDT is also discussed as an alternative strategy. By reviewing recent progress, it is hoped that this review will provide innovative perspectives in new nanomaterials designed to combat hypoxia and avoid the associated limitation of PDT.

Integrity signals

Registry

Crossref · 10.1002/adma.202103978

Cites

289 of 289 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Inhibition of cellular respiration oxygen consumption provides a different type of intratumoral oxygen supply protocol to conserve endogenous oxygen and overcome hypoxia.

    “Inhibition of cellular respiration oxygen consumption provides a different type of intratumoral oxygen supply protocol to conserve endogenous oxygen and overcome hypoxia.”

Cites

2 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P.
Affiliations
Shenzhen University (CN)
Corresponding author
Huang, Peng
Venue
Advanced Materials
Publisher
Wiley
Published
2021-09-27
Volume
33
Issue
48
Pages
e2103978-e2103978
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W3204514388
Cited by
705
References
289
Citations by year
2026: 132 · 2025: 158 · 2024: 194 · 2023: 124 · 2022: 97
FWCI
16.65
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (21807074, 51802202, 82071985)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords
photodynamic therapy, tumor hypoxia, oxygen delivery, oxygen production, oxygen consumption, tumor microenvironment, tumor vasculature normalization, extracellular matrix disruption, HIF-1, type I photodynamic therapy, nanomaterials, solid tumors
MeSH terms
Tumor Hypoxia, Extracellular Matrix, Humans, Neoplasms, Oxygen, Photochemotherapy, Signal Transduction, Photosensitizing Agents, Hypoxia-Inducible Factor 1, alpha Subunit, Tumor Microenvironment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review