Conquering the Hypoxia Limitation for Photodynamic Therapy
Abstract
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due to the hypoxic nature characteristic of many solid tumors, PDT is frequently limited in therapeutic effect. Moreover, the consumption of O 2 during PDT may further aggravate the tumor hypoxic condition, which promotes tumor proliferation, metastasis, and invasion resulting in poor prognosis of treatment. Therefore, numerous efforts have been made to increase the O 2 content in tumor with the goal of enhancing PDT efficacy. Herein, these strategies developed in past decade are comprehensively reviewed to alleviate tumor hypoxia, including 1) delivering exogenous O 2 to tumor directly, 2) generating O 2 in situ, 3) reducing tumor cellular O 2 consumption by inhibiting respiration, 4) regulating the TME, (e.g., normalizing tumor vasculature or disrupting tumor extracellular matrix), and 5) inhibiting the hypoxia‐inducible factor 1 (HIF‐1) signaling pathway to relieve tumor hypoxia. Additionally, the O 2 ‐independent Type‐I PDT is also discussed as an alternative strategy. By reviewing recent progress, it is hoped that this review will provide innovative perspectives in new nanomaterials designed to combat hypoxia and avoid the associated limitation of PDT.
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Inhibition of cellular respiration oxygen consumption provides a different type of intratumoral oxygen supply protocol to conserve endogenous oxygen and overcome hypoxia.
“Inhibition of cellular respiration oxygen consumption provides a different type of intratumoral oxygen supply protocol to conserve endogenous oxygen and overcome hypoxia.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [135]
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Phototherapy in cancer treatment: strategies and challenges
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- Authors
- Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P.
- Affiliations
- Shenzhen University (CN)
- Corresponding author
- Huang, Peng
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2021-09-27
- Volume
- 33
- Issue
- 48
- Pages
- e2103978-e2103978
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W3204514388
- Cited by
- 705
- References
- 289
- Citations by year
- 2026: 132 · 2025: 158 · 2024: 194 · 2023: 124 · 2022: 97
- FWCI
- 16.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21807074, 51802202, 82071985)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- photodynamic therapy, tumor hypoxia, oxygen delivery, oxygen production, oxygen consumption, tumor microenvironment, tumor vasculature normalization, extracellular matrix disruption, HIF-1, type I photodynamic therapy, nanomaterials, solid tumors
- MeSH terms
- Tumor Hypoxia, Extracellular Matrix, Humans, Neoplasms, Oxygen, Photochemotherapy, Signal Transduction, Photosensitizing Agents, Hypoxia-Inducible Factor 1, alpha Subunit, Tumor Microenvironment
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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