The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
Chromatin dynamics during cellular reprogramming
Open accessAbstract
Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it provides a unique assay to study the interplay between transcription factors and chromatin structure. Here, we review the latest insights into chromatin dynamics that are inherent to induced pluripotency. Moreover, we compare and contrast these events with other physiological and pathological processes that involve changes in chromatin and cell state, including germ cell maturation and tumorigenesis. We propose that an integrated view of these seemingly diverse processes could provide mechanistic insights into cell fate transitions in general and might lead to new approaches in regenerative medicine and cancer treatment.
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Cites
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells
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Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
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Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
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Crypt stem cells as the cells-of-origin of intestinal cancer
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Mediator and cohesin connect gene expression and chromatin architecture
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Self-citationTET enzymes, TDG and the dynamics of DNA demethylation
Kohli, R. M., & Zhang, Y. (2013) · Nature · doi:10.1038/nature12750 · Cited by 1,623
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
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Transcriptional Amplification in Tumor Cells with Elevated c-Myc
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Cited by
TET enzymes, TDG and the dynamics of DNA demethylation
Kohli, R. M., & Zhang, Y. (2013) · Nature · doi:10.1038/nature12750 · Cited by 1,623
Epigenetic plasticity and the hallmarks of cancer
Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340
Induced Pluripotent Stem Cells Meet Genome Editing
Hockemeyer, D., & Jaenisch, R. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.04.013 · Cited by 499
“…equally potent in reprogramming cells to a pluripotent state, providing valuable insights into the transcriptional pluripotency networks and how cells establish pluripotency (Buganim et al., 2012) (Apostolou and Hochedlinger, 2013; Park et al., 2008; Takahashi and Yamanaka, 2015; Yu et al., 2007).”
BackgroundInduced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
Cerneckis, J., Cai, H., & Shi, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01809-0 · Cited by 452
The 3D genome in transcriptional regulation and pluripotency
Gorkin, D. U., Leung, D., & Ren, B. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.05.017 · Cited by 391
Metadata
- Authors
- Apostolou, E., & Hochedlinger, K.
- Venue
- Nature
- Published
- 2013-10-23
- Volume
- 502
- Issue
- 7472
- Pages
- 462-471
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2072859865
- Cited by
- 398
- References
- 125
- FWCI
- 18.15
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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